TDP-43 is a key molecule accelerating development of Alzheimer’s disease following traumatic brain injury

作     者：Chu Chen Chu Chen

作者机构：Department of Cellular and Integrative PhysiologyLong School of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第5期

页      面：955-956页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：supported by National Institutes of Health grants RF1NS076815 and R01AG058621 

主　　题：Alzheimer traumatic 

摘      要：Currently,more than 55 million people have dementia worldwide and Alzheimer’s disease(AD)is one of the most common causes of dementia in ***,no effective therapies are currently available for the prevention and treatment of *** is largely due to our limited understanding of the mechanisms underlying the neuropathogenesis of *** has widely been recognized that AD is heterogeneous and that multi-factors are contributing to the pathogenesis of *** evidence suggests that traumatic brain injury(TBI)is an important risk factor for the development of AD and dementia later in life(Guo et al.,2000;Johnson et al.,2010).However,the precise mechanism by which TBI contributes to developing AD has yet to be elucidated.