检索结果-南通市图书馆

Overview of angiogenesis and oxidative stress in cancer

World Journal of Meta-Analysis 2023年第6期11卷 253-265页

作者： Luigi Gaetano Andriolo Vittoria Cammisotto Alessandra Spagnoli Danilo Alunni Fegatelli Michele Chicone Gaetano Di Rienzo vladimiro dell’anna Giambattista Lobreglio Giovanni Serio Pasquale Pignatelli Department of General and Specialistic Surgery Paride Stefanini Policlinico Umberto IUniversity of Rome SapienzaRome 06100Italy UnitàOperativa Complessa Chirurgia Toracica Ospedale Vito FazziLecce 73100Italy Department of Clinical Internal Anaesthesiological and Cardiovascular SciencesUniversity of Rome SapienzaRome 06100Italy Department of Public Health and Infectious Diseases University of Rome SapienzaRome 06100Italy Department of Clinical Pathology and Microbiology Ospedale Vito FazziLecce 73100Italy Pathological Anatomy Unit Ospedale Vito FazziLecce 73100Italy

Neoplasms can be considered as a group of aberrant cells that need more vascular supply to fulfill all their ***,they promote angiogenesis through the same neovascularization pathway used *** is a process characterized by a heterogeneous distribution of oxygen caused by the tumor and oxidative stress;the latter being one of the most powerful stimuli of *** a result of altered tumor metabolism due to hypoxia,acidosis *** angiogenic process and oxidative stress can be detected by measuring serum and tissue *** study of the mechanisms underlying angiogenesis and oxidative stress could lead to the identification of new biomarkers,ameliorating the selection of patients with neoplasms and the prediction of their response to possible anti-tumor *** particular,in the treatment of patients with similar clinical tumor phenotypes but different prognoses,the new biomarkers could be ***,they may lead to a better understanding of the mechanisms underlying drug *** studies show that blocking the vascular supply results in antiproliferative activity in vivo in neuroendocrine tumor cells,which require a high vascular supply.

关键词： Neuroendocrine lung tumors Angiogenesis Oxidative stress Neuroendocrine serum markers Neuroendocrine tissue markers Future therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization

引用

Journal of Animal Science and Biotechnology 2023年第1期14卷 152-165页

作者： anna Rita Piras Federica Ariu Alessio Maltana Giovanni Giuseppe Leoni Nicola Antonio Martino Antonella Mastrorocco Maria Elena dell’Aquila Luisa Bogliolo Department of Veterinary Medicine University of Sassari07100 SassariSardiniaItaly. Department of Biosciences Biotechnologies&BiopharmaceuticsUniversity of Bari Aldo Moro70125 BariItaly.

Background:Heavy metal cadmium(Cd)is a widespread environmental contaminant with a potential toxicity that might negatively affect female reproduction and *** has been reported that Cd exposure impaired the quality of oocytes and led to a defective maturation and fertilization,through oxidative stress ***(Res)is a natural polyphenol with strong antioxidant properties that exhibited protective role in preventing oocyte redox homeostasis disruption and quality ***,we explored whether the addition of Res to in vitro maturation(IVM)medium might act as a protection against Cd-induced toxicity on ovine oocyte maturation and ***,we evaluated the effect of supplementing IVM medium with two different Res concentrations(1and 2μmol/L)on nuclear maturation and fertilization of oocytes matured under CdCl2(2μmol/L)***,the concentration of 1μmol/L Res was selected to analyse the effects of this compound on intracellular ROS levels,mitochondrial(mt)distribution and activity,chromatin configuration,cytoskeleton morphology,cortical granules(CGs)distribution and mRNA expression of genes associated with cellular response to oxidative stress(***1,SOD 1,GPX1,GSR,CAT)in Cd-exposed in vitro matured ***:We found that 1μmol/L Res restored the reduced oocyte meiotic competence induced by Cd exposure as well as,Res sustained oocyte ability to be normally fertilized and decreased polyspermic fertilization at both tested ***,we demonstrated that 1μmol/L Res mitigated Cd-induced alterations of oocyte cytoplasmic maturation by reducing reactive oxygen species(ROS)accumulation,preventing mt dysfunction,maintaining the correct meiotic spindle and cortical F-actin assembly and the normal cortical granule distribution as well as up-regulating SIRT1,SOD1 and GPX1 ***:Taken together,our findings highlighted the beneficial influence exerted by Res in preventing Cdinduced disturbance of

关键词： Cadmium In vitro maturation Oocyte Ovine Resveratrol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Successful management of an asymptomatic bilateral synchronous testicular carcinoid tumor with a testicular-sparing surgery

引用

Asian Journal of Andrology 2017年第4期19卷 507-508页

作者： Lucio dell'Atti Department of Urology University Hospital 'St. Anna' Ferrara Italy.

Dear Editor, Carcinoid tumors have been described in a large range of organs, but they most commonly involve the gastrointestinal and bronchopulmonary systems.1 These tumors of the testis are rare entity comprising 〈1% of all testis tumors and can arise as a metastasis from an extratesticular primary as a part of a teratoma or as primary tumor.2 Patients affected by carcinoid tumors present symptoms of carcinoid syndrome, such as diarrhea, flushings, and bronchospasm.3 We report a first case described in scientific literature of primary bilateral synchronous testicular carcinoid tumor that does not associated with carcinoid syndrome. From this publication, at the time of writing,

关键词： Successful synchronous surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feasibility of therapeutic endoscopic ultrasound in the bridge-to-surgery scenario:The example of pancreatic adenocarcinoma

引用

World Journal of Gastroenterology 2022年第10期28卷 976-984页

作者： Giuseppe Vanella Domenico Tamburrino Gabriele Capurso Michiel Bronswijk Michele Reni Giuseppe dell'anna Stefano Crippa Schalk Van der Merwe Massimo Falconi Paolo Giorgio Arcidiacono Pancreatobiliary Endoscopy and EUS Division Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilan 20132Italy Pancreatic Surgery Unit Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilan 20132Italy Department of Gastroenterology and Hepatology University Hospital GasthuisbergUniversity of LeuvenLeuven 3000Belgium Department of Gastroenterology and Hepatology Imelda HospitalBonheiden 2820Belgium Department of Medical Oncology Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteMilan 20132Italy

Upfront resection is becoming a rarer indication for pancreatic ductal adenocarcinoma,as biologic behavior and natural history of the disease has boosted indications for neoadjuvant ***,gastric outlet obstruction and acute cholecystitis can frequently complicate this window of opportunity,resulting in potentially deleterious chemotherapy discontinuation,whose resumption relies on effective,prompt and long-lasting management of these *** therapeutic endoscopic ultrasound(t-EUS)can potentially offer some advantages over comparators,its use in potentially resectable patients is primal and has unfairly been restricted for fear of potential technical difficulties during subsequent *** is a narrative review of available evidence regarding EUS-guided choledochoduodenostomy,gastrojejunostomy and gallbladder drainage in the bridge-to-surgery ***-ofconcept evidence suggests no influence of t-EUS procedures on outcomes of eventual subsequent ***,the very high efficacy-invasiveness ratio over comparators in managing pancreatic cancer-related symptoms or complications can provide a powerful weapon against chemotherapy discontinuation,potentially resulting in higher subsequent *** evidence is discussed in this short paper,together with technical notes that might be useful for endoscopists and surgeons operating in this *** published evidence supports restricting t-EUS in potential surgical candidates,especially in the setting of pancreatic cancer patients undergoing neoadjuvant ***-to-surgery tEUS deserves further prospective evaluation.

关键词： Endosonography Gastrojejunostomy Choledochoduodenostomy Gallbladder drainage Pancreatic cancer Pancreatic surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Can radical prostatectomy shortly after prostate biopsy affect intra-operative and postoperative outcomes？

引用

Asian Journal of Andrology 2016年第3期18卷 496-497页

作者： Lucio dell'Atti Gaetano Capparelli Stefano Papa Carmelo Ippolito Department of Urology University Hospital St. Anna Ferrara 44124 Italy.

Dear Editor, We retrospectively evaluated the patients who underwent radical prostatectomy （RP） for prostate cancer （PCa） if the interval between PB and RP had any impact on immediate outcomes after surgery treatment. The study population comprised 473 patients with localized or locally advanced PCa （clinical stage Tlc to T3c） diagnosed via a transrectal ultrasound-guided prostate biopsy （TPB） conducted by three urologists.

关键词： @@

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LEBESGUE DECOMPOSITION AND BARTLE-DUNFORD-SCHWARTZ THEOREM IN PSEUDO-D-LATTICES

引用

Acta Mathematica Scientia 2013年第3期33卷 653-677页

作者： anna AVALLONE Paolo VITOLO Dipartimento di Matematica e Informatica Università della BasilicataViale dell'Ateneo Lucano 10 85100 Potenza Italy

Let L be a pseudo-D-lattice. We prove that the exhaustive lattice uniformities on L which makes the operations of L uniformly continuous form a Boolean algebra isomorphic to the centre of a suitable complete pseudo-D-lattice associated to L. As a consequence, we obtain decomposition theorems such as Lebesgue and Hewitt-Yosida decompositions--and control theorems such as Bartle-Dunford Schwartz and Rybakov theorems--for modular measures on L.

关键词： Pseudo-effect algebra pseudo-D-lattice D-uniformity lattice uniformity mod-ular measure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Options for Evaluating Treatment Benefit in MCI and Prodromal Alzheimer’s Disease: Content Validity of the Perceived Deficits Questionnaire (PDQ) in Patients with Early Symptoms of Cognitive Decline

引用

Advances in Alzheimer's Disease 2014年第1期3卷 1-10页

作者： William R. Lenderking anna Steenrod Katja Rüdell Stephanie Klapper Kellee Howard Maren Gaudig Evidera Bethesda USA Health Economics & Market Access Janssen Alzheimer Immunotherapy Lower Grand Canal Street Dublin Ireland Pfizer Ltd. Tadworth UK

Background: Many instruments used to assess outcomes of treatment for Alzheimer’s disease (AD) have no published evidence of their relevance and content validity in earlier stages of the disease, i.e., mild cognitive impairment, or prodromal AD (pAD). The objective of this project was to evaluate the applicability and usefulness of the Perceived Deficits Questionnaire (PDQ) as an outcome measure in this population using qualitative methodology to support content validity. Method: Two waves of qualitative interviews were conducted in patients with MCI and pAD. Results: Evidence for content validity and usefulness of the instrument was demonstrated in the patient interviews. Minor modifications to the wording of several items were suggested for the PDQ and the recall period was changed. Conclusion: With these modifications, the PDQ has improved content validity and relevance. It is therefore a potentially useful outcome measure to evaluate therapeutic benefit in interventional studies of patients in the early stages of AD.

关键词： MCI Prodromal AD Content Validity Perceived Deficits Questionnaire

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complexation of As(Ⅲ)by phosphonate ligands in aqueous fluids:Thermodynamic behavior,chemical binding forms and sequestering abilities

引用

Journal of Environmental Sciences 2020年第8期32卷 100-110页

作者： Donatella Chillè Donatella Aiello Giuseppa Ida Grasso Ottavia Giuffrè anna Napoli Carmelo Sgarlata Claudia Foti Dipartimento di Scienze Chimiche BiologicheFarmaceutiche ed AmbientaliUniversitàdi MessinaViale F.Stagno d’Alcontres 3198166 MessinaItaly Dipartimento di Chimica e Tecnologie Chimiche Universitàdella CalabriaVia P.Bucci87036 Arcavacata di Rende(CS)Italy Dipartimento di Scienze Chimiche Universitàdegli Studi di CataniaViale A.Doria 695125 CataniaItaly

In recent years,the contamination of water by arsenic reached alarming levels in many countries of the world,attracting the interest of many researchers engaged in testing methodologies able to remove this harmful *** important aspect that must be taken into consideration is the possibility to find arsenic in different chemical forms which could require different approaches for its *** this aim,a speciation analysis appears to be crucial for better understanding the behavior of arsenic species in aqueous solutions,especially in presence of compounds with marked chelating *** can be identified as good sequestering agents and,at this purpose,this manuscript intends to investigate the interaction of As(Ⅲ)with three phosphonic acids derived from nitrilotriacetic acid(NTA)by replacements of one(N-(Phosphonomethyl)iminodiacetic acid,NTAP),two(N,N-Bis-(phosphonomethyl)glycine,NTA2P)and three(Nitrilotri(methylphosphonic acid),NTA3P)carboxylic groups with the same number of phosphonate *** in-depth potentiometric and calorimetric investigation allowed to determine speciation models featured by simple ML,MLH i and ML(OH)species.A complete thermodynamic characterization of the systems is reported together with the definition of coordination mode by mass spectrometry *** the light of the speciation models,the possibility of using these ligands in arsenic removal techniques was assessed by determining the pL 0.5(the concentration of ligand able to remove the 50%of metal ion present in trace).All ligands show a good sequestering ability,in particular under the conditions of fresh water,following the trend NTA3P>NTA2P>NTAP.

关键词： Phosphonate ligands Arsenic Thermodynamic interaction parameters Sequestering ability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

From individual elements to macroscopic materials: in search of new superconductors via machine learning

引用

npj Computational Materials 2023年第1期9卷 1640-1648页

作者： Claudio Pereti Kevin Bernot Thierry Guizouarn František Laufek anna Vymazalová Luca Bindi Roberta Sessoli Duccio Fanelli Dipartimento di Fisica e Astronomia Universitàdi FirenzeINFN and CSDCVia Sansone 150019 Sesto FiorentinoFirenzeItaly Univ.Rennes Universitéde Rennes 1INSA RennesCNRSISCR(Institut des Sciences Chimiques de Rennes)UMR 6226F-35000 RennesFrance Institut Universitaire de France 1 rue DescartesParisFrance Czech Geological Survey Geologická615200 Praha 5Czech Republic Dipartimento di Science della Terra Universitàdi FirenzeVia G.La Pira450121 FirenzeItaly Dipartimento di Chimica U.Schiff-DICUS and INSTM Research Unit Universitàdi FirenzeVia della Lastruccia 3-13Sesto Fiorentino 50019 FirenzeItaly

An approach to supervised classification and regression of superconductive materials is proposed which builds on the DeepSet *** enables us to provide the chemical constituents of the examined compounds as an input to the algorithm,while avoiding artefacts that could originate from the chosen ordering in the *** performance of the method are successfully challenged for both classification(tag a given material as superconducting)and regression(quantifying the associated critical temperature).We then searched through the International Mineralogical Association list with the trained neural *** the obtained superconducting candidates,three materials were selected to undergo a thorough experimental *** has been indeed confirmed for the synthetic analogue of michenerite,PdBiTe,and observed for the first time in monchetundraite,Pd2NiTe2,at critical temperatures in good agreement with the theory *** latter is the first certified superconducting material to be identified by artificial intelligence methodologies.

关键词： artificial Deep neural

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cross-linked self-assembling peptide scaffolds

引用

Nano Research 2018年第1期11卷 586-602页

作者： Raffaele Pugliese Amanda Marchini Gloria anna Ada Saracino1 Ronald N. Zuckermann3, Fabrizio Gelain IRCCS Casa Sollievo della Sofferenza Opera di San Pio da Pietralcina Viale Capuccini I San Giovanni Rotondo Foggia 71013 Italy Center for Nanomedicine and Tissue Engineering (CNTE) A. O. Ospedale Niguarda Cd Granda Piazza dell' Ospedale Maggiore 3 Milan 20162 Italy The Molecular Foundry Lawrence Berkeley National Laboratory 1 Cyclotron Road Berkeley California 94720 USA

Self-assembling peptides （SAPs） are synthetic bioinspired biomaterials that can be feasibly multi-functionalized for cell transplantation and/or drug delivery therapies. Despite their superior biocompatibility and ease of scaling-up for production, they are unfortunately hampered by weak mechanical properties due to transient non-covalent interactions among and within the self-assembled peptide chains, thus limiting their potential applications as fillers, hemostat solutions, and fragile scaffolds for soft tissues. Here, we have developed and characterized a cross-linking strategy that increases both the stiffness and the tailorability of SAP hydrogels, enabling the preparation of transparent flexible threads, discs, channels, and hemispherical constructs. Empirical and computational results, in close agreement with each other, confirmed that the cross-linking reaction does not affect the previously self-assembled secondary structures. In vitro tests also provided a first hint of satisfactory biocompatibility by favoring viability and differentiation of human neural stem cells. This work could bring self-assembling peptide technology to many applications that have been precluded so far, especially in regenerative medicine.

关键词： self-assembling peptide co-assembling peptide cross-linking sulfo-SMCC supramolecularself-assembly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：