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Retrospective analysis of anti-inflammatory therapies during the first wave of COvID-19 at a community hospital

World Journal of Critical Care Medicine 2021年第5期10卷 244-259页

作者： Jose I Iglesias Andrew v vassallo Jesse B Sullivan Yasmine Elbaga vishal v patel Nikunjkumar patel Lydia Ayad Payam Benson Marina Pittiglio Emad Gobran Alexander Clark Wajahat Khan Kaliope Damalas Rajesh Mohan Satyendra P Singh Department of Critical Care Community Medical CenterToms RiverNJ 08757United States Department of Nephrology Community Medical CenterToms RiverNJ 08757United States Department of Nephrology Jersey Shore University Medical CenterHackensack Meridian School of Medicine at Seton HallNeptuneNJ 07753United States Department of Pharmacy Community Medical CenterToms RiverNJ 08757United States Fairleigh Dickinson University School of Pharmacy&Health Sciences Fairleigh Dickinson UniversityFlorham ParkNJ 07932United States Department of Pharmancy Monmouth Medical Center Southern CampusLakewoodNJ 08701United States Department of Medicine Community Medical CenterToms RiverNJ 08757United States Department of Cardiology Monmouth Medical Center Southern CampusLakewoodNJ 08701United States Department of Medicine Monmouth Medical Center Southern CampusLakewoodNJ 08701United States

BACKGROUND Our understanding of the severe acute respiratory syndrome coronavirus 2 has evolved since the first reported cases in December 2019,and a greater emphasis has been placed on the hyper-inflammatory response in severely ill *** purpose of this study was to determine risk factors for mortality and the impact of anti-inflammatory therapies on *** To determine the impact of various therapies on outcomes in severe coronavirus disease 2019 patients with a focus on anti-inflammatory and immune-modulating *** A retrospective analysis was conducted on 261 patients admitted or transferred to the intensive care unit in two community hospitals between March 12,2020 and June 17,*** 167 patients received glucocorticoid(GC)*** patients received GC alone,94 received GC and tocilizumab,28 received tocilizumab monotherapy,and 66 received no anti-inflammatory *** Patient survival was associated with GC use,either alone or with tocilizumab,and decreased vasopressor *** administration of GC was found to decrease the survival benefit of GC *** difference in survival was found with varying anticoagulant doses,convalescent plasma,tocilizumab monotherapy;prone ventilation,hydroxychloroquine,azithromycin,or intravenous ascorbic acid *** This analysis demonstrated the survival benefit associated with anti-inflammatory therapy of GC,with or without tocilizumab,with the combination providing the most *** studies are needed to assess the optimal timing of anti-inflammatory therapy initiation.

关键词： COvID-19 Corticosteroids Intensive care unit Methylprednisolone Tociluzimab Anti-inflammatory

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Fully flexible implantable neural probes for electrophysiology recording and controlled neurochemical modulation

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Microsystems & Nanoengineering 2024年第3期10卷 317-333页

作者： Mohammad Hassan Malekoshoaraie Bingchen Wu Daniela DKrahe Zabir Ahmed Stephen Pupa vishal Jain Xinyan Tracy Cui Maysamreza Chamanzar Electrical and Computer Engineering Carnegie Mellon UniversityPittsburghPA 15213USA Bioengineering University of PittsburghPittsburghPA 15260USA Center for Neural Basis of Cognition University of Pittsburgh and Carnegie Mellon UniversityPittburgh 15213USA McGowan Institute for Regenerative Medicine University of PittsburghPittsburgh 15219USA Carnegie Mellon Neuroscience Institute Carnegie Mellon UniversityPittsburgh 15213USA

Targeted delivery of neurochemicals and biomolecules for neuromodulation of brain activity is a powerful technique that,in addition to electrical recording and stimulation,enables a more thorough investigation of neural circuit *** have designed a novel,flexible,implantable neural probe capable of controlled,localized chemical stimulation and electrophysiology *** neural probe was implemented using planar micromachining processes on Parylene C,a mechanically flexible,biocompatible *** probe shank features two large microelectrodes(chemical sites)for drug loading and sixteen small microelectrodes for electrophysiology recording to monitor neuronal response to drug *** reduce the impedance while keeping the size of the microelectrodes small,poly(3,4-ethylenedioxythiophene)(PEDOT)was electrochemically coated on recording *** addition,PEDOT doped with mesoporous sulfonated silica nanoparticles(SNPs)was used on chemical sites to achieve controlled,electrically-actuated drug loading and *** neurotransmitters,including glutamate(Glu)and gamma-aminobutyric acid(GABA),were incorporated into the SNPs and electrically triggered to release *** in vitro experiment was conducted to quantify the stimulated release profile by applying a sinusoidal voltage(0.5 v,2 Hz).The flexible neural probe was implanted in the barrel cortex of the wild-type Sprague Dawley *** expected,due to their excitatory and inhibitory effects,Glu and GABA release caused a significant increase and decrease in neural activity,respectively,which was recorded by the recording *** novel flexible neural probe technology,combining on-demand chemical release and high-resolution electrophysiology recording,is an important addition to the neuroscience toolset used to dissect neural circuitry and investigate neural network connectivity.

关键词： Parylene recording release

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Ethanolic extract of Azadirachta indica ameliorates ovarian defects through phosphoinositide-3 kinase inhibition in a rat model of polycystic ovary syndrome

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Asian pacific Journal of Reproduction 2021年第1期10卷 21-28页

作者： Shraddha v.patel Harsh Maru vishal K.Chavda Jigar N.Shah Snehal S.patel Department of Pharmacology Institute of PharmacyNirma UniversityAhmadabadGujarat382481India

Objective:To assess the therapeutic potential of ethanolic extract of Azadirachta(A.)indica in rats with polycystic ovary syndrome(PCOS).Methods:Thirty-five prepubertal female Sprague Dawley rats were randomly divided into five groups with 7 animals in each *** 1 received 0.5%carboxy methyl cellulose *** 2 to 5 received testosterone propionate(0.2 mg/kg,s.c.)dissolved in olive oil daily for 42 days to induce *** addition,group 3 was administered with *** extract(100 mg/kg,0.5%carboxy methyl cellulose orally)from the 7th to 12th week,group 4 received quercetin(100 mg/kg,0.5%carboxy methyl cellulose orally)and group 5 received wartmannin(100 mg/kg,0.5%carboxy methyl cellulose orally).At the end of treatment,blood was collected for biochemical *** follicular count and uterus corpus luteum count followed by PI3K gene expression in the ovary and uterus were ***:The ethanolic extracts of *** significantly reduced body weight,ovary weight and uterus weight of *** of *** also significantly increased the levels of serum glucose,total cholesterol,triglyceride,low-density lipoprotein,very low-density lipoprotein,insulin,testosterone,and luteinizing *** also reduced lipid peroxidation and increased antioxidant parameters in the liver homogenates of PCOS-induced *** examination of the ovary and uterus confirmed PCOS occurrence and remission state in the PCOS-induced and treated groups,***,*** and quercetin significantly downregulated PI3K gene *** results of the ovary and uterus also proved the protective role of ***:*** leaf extract has beneficial effects in the treatment of PCOS by downregulation of PI3K gene expression.

关键词： Azadirachta indica PI3 kinase Quercetin Steroidogenesis Testosterone propionate Wartmannin

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Association between Exposure to Metals during Pregnancy,Childhood Gut Microbiome,and Risk of Intestinal Inflammation in Late Childhood

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Environment & Health 2024年第10期2卷 739-749页

作者： vishal Midya Manasi Agrawal Jamil M.Lane Chris Gennings Leonid Tarassishin Libni A.Torres-Olascoaga Joseph Eggers Jill K.Gregory Mellissa Picker Inga Peter Jeremiah J.Faith Manish Arora Martha M.Tellez-Rojo Robert O.Wright Jean-Frederic Colombel Shoshannah Eggers Department of Environmental Medicine and Climate Science Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Division of Gastroenterology Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Center for Molecular Prediction of Inflammatory Bowel Disease(PREDICT) Department of Clinical MedicineAalborg UniversityCopenhagen 9220Denmark Department of Genetics and Genomic Sciences Icahn School of MedicineNew York 10029-6574New YorkUnited States Center for Research on Nutrition and Health National Institute of Public HealthCuernavaca 62508Mexico Department of Immunology and Immunotherapy Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Department of Epidemiology University of Iowa College of Public HealthIowa City 52242 IowaUnited States Instructional Technology Group Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States

Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel ***,how prenatal exposure to metals eventually results in long-term effects on the gut microbiome,leading to subclinical intestinal inflammation,particularly during late childhood,has not been *** is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal *** used an amalgamation of machine-learning techniques with a regression-based framework to explore if children with distinct sets of gut microbes and certain patterns of exposure to metals during pregnancy(metal−microbial clique signature)had a higher likelihood of intestinal inflammation,measured based on fecal calprotectin(FC)in late *** obtained samples from a well-characterized longitudinal birth cohort from Mexico City(n=108),*** the second and third trimesters of pregnancy,11 metals were measured in whole *** microbial abundances and FC were measured in stool samples from children 9−11 years of *** FC was defined as having FC above 100μg/g of *** identified subgroups of children in whom microbial and metal−microbial clique signatures were associated with elevated FC(false discovery rate(FDR)vated FC:(1)low cesium(Cs)and copper(Cu)in the third trimester and low relative abundance of Eubacterium ventriosum(OR[95%CI]:10.27[3.57,29.52],FDRve abundances of Roseburia inulinivorans and Ruminococcus torques(OR[95%CI]:7.21[1.81,28.77],FDRve higher fecal calprotectin levels in late childhood,denoting an elevated risk of intestinal inflammation.

关键词： exposome metals machine learning microbiome environmental epidemiology intestinal inflammation

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Advancements in Fixed Point Theorems for α-Geraghty Contractions in Complete Metric Space

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Journal of Mathematical Research with Applications 2024年第5期 697-710页

作者： v.C.BORKAR Mohammed M.A.TALEB Saeed A.A.AL-SALEHI School of Mathematical at Yeshwant Mahavidyalaya Swami Ramanand Teerth Marathwada University School of Mathematical at Science College Swami Ramanand Teerth Marathwada University Department of Mathematics Hodeidah University Department of Mathematics Aden University

This article improves and advances the results achieved by vishal and Naveen, leveraging the use of Lebesgue integrable functions. Going beyond, we investigate fixed point theorems associated with a concept introduced by Ovidiu Popescu. Our research not only bolsters the theoretical framework but also unveils practical applications in the domain of Lebesgue integrals as in Example 3.6. Furthermore, our contribution enhances the understanding of fixed point theorems in metric spaces and introduces novel perspectives in the study of generalized α-Geraghty contractive mappings on Lebesgue integrals.

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Optimization of friction and wear characteristics of varied cryogenically treated hot die steel grade AISI-H13 under dry condition

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Friction 2017年第1期5卷 66-86页

作者： Sanjeev KATOCH Rakesh SEHGAL vishal SINGH Centre for Materials Science and Engineering National Institute of Technology Hamirpur(HP)177005 IndiaInstitute for Auto Parts & Hand Tools Technology A-9 Phase V Focal Point Ludhiana(Punjab)141010 India Department of Mechanical Engineering National Institute of Technology Hamirpur(HP)177005 India Centre for Materials Science and Engineering National Institute of Technology Hamirpur(HP)177005 India

Cryogenic treatment (CT) is a relatively new field,which has emerged during the last three decades of the twentieth ***,its impact on material shaping and making tool life,and enhancement of their mechanical properties are quite *** selection of appropriate process parameters for CT is essential for cost reduction and optimum *** study focuses on the influence of key parameters of CT cycles (i.e.,soaking temperature and duration) on the friction and wear behavior of AISI H13 hot die steel under dry sliding conditions against hardened and tempered AISI D3 cold work tool steel (counter face) at varying sliding speeds and *** models have been developed for wear rate,the average coefficient of friction,and maximum contact temperature using the Box-Cox *** developed mathematical models have been validated by comparing with the experimental ***,the optimum values of the process parameter have been employed to maximize the output and validate the same by confirmation of the *** the best of our knowledge,this is the first study that demonstrates the modeling and optimization of sliding friction and wear characteristics of AISI H13 under varied CT cycles.

关键词： cryogenics treatment hot die steel friction wear modeling Box-Cox method optimization

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Beneficial and detrimental effects of processed dietary fibers on intestinal and liver health:health benefits of refined dietary fibers need to be redefined!

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Gastroenterology Report 2020年第2期8卷 85-89,I0001页

作者： vishal Singh Matam vijay-Kumar Department of Nutritional Sciences The Pennsylvania State UniversityUniversity ParkPAUSA UT-Microbiome Consortium Department of Physiology and PharmacologyThe University of Toledo College of Medicine and Life SciencesOHUSA Department of Medical Microbiology&Immunology The University of ToledoOHUSA

Consumption of processed foods—which are generally composed of nutritionally starved refined ingredients—has increased exponentially worldwide.A rise in public health awareness that low fiber intake is strongly linked to new-age disorders has spurred food manufacturers to fortify processed foods with refined dietary fibers(RDFs).Consumption of whole foods rich in natural fibers undoubtedly confers an array of health ***,it is not clear whether RDFs extracted from the whole plant,kernel,and fruit peels exert similar physiological effects to their naturally occurring *** studies caution that RDFs are not universally beneficial and that inappropriate consumption of RDFs may risk both gastrointestinal and liver ***,we briefly summarize the beneficial and detrimental effects of RDFs on digestive health and discuss the contribution of metabolites derived from microbial fermentation of RDFs in driving such positive or negative health outcomes.

关键词： gut microbiota fermentation IBD metabolic syndrome liver cancer

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Slope mass rating and kinematic analysis of slopes along the national highway-58 near Jonk, Rishikesh, India

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第5期7卷 600-606页

作者： Tariq Siddique M.Masroor Alam M.E.A.Mondal v.vishal Department of Earth Sciences Indian Institute of Technology Roorkee Department of Geology Aligarh Muslim University Department of Civil Engineering Aligarh Muslim University

The ro ad n etw o rk in th e H im alayan terrain , connecting re m o te areas e ith e r in th e valleys o r on th e hillslopes, plays a pivotal role in socio-econom ic d e v elo p m en t ofIn d ia. The planning, d ev elo p m en t an d evenm ain ten an ce o f ro ad an d rail netw o rk s in such precarious terrain s are alw ays a challenging task becauseo f com plexities p osed by topography, geological stru ctu res, varied lithology an d neotectonics. Increasingp o p u latio n an d c o n stru ctio n o f roads have led to destab ilisatio n o f slopes, th u s leading to m ass w astingand m ovem ent, fu rth e r aggravation d u e to recen t events o f cloud bu rsts and u n p re c e d e n te d flash floods.v ulnerability analysis o f slopes is an im p o rta n t co m p o n e n t for th e ＂Landslide H azard A ssessm ent＂ and＂Slope Mass C h aracterisation＂ guide p lan n ers to p red ict an d choose suitable w ays for c o n stru ctio n ofroads and o th e r en g in eerin g stru ctu res. The pro b lem o f landslides along th e n ational highw ay-58 （NH-58） from Rishikesh to D evprayag is a co m m o n scene. The slopes along th e NH-58 b e tw e e n Jonk andRishikesh w ere investigated, w h ich experienced v ery heavy traffic especially from M arch to A ugust dueto pilgrim age to K edarnath shrine. On th e basis o f slope m ass rating （SMR） investigation, th e area falls instable class, an d landslide susceptibility score （LSS） values also indicate th a t th e slopes u n d e r investigationfall in low to m o d erate v ulnerability to landslide. More atte n tio n s should be paid to th e slopes toachieve g reater safe an d econom ic b enefits along th e highw ay.

关键词： Slope mass rating(SMR) Kinematic analysis Landslide susceptibility score(LSS) vulnerability to landslide

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The expression of proteins involved in digestion and detoxification are regulated in Helicoverpa armigera to cope up with chlorpyrifos insecticide

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Insect Science 2016年第1期23卷 68-77页

作者： vishal v. Dawkar Yojana R. Chikate Tushar H. More vidya S. Gupta Ashok P. Giri Plant Molecular Biology Unit Division of Biochemical Sciences CSIR-National Chemical Laboratory Dr. Homi Bhabha Road Pun e 411008(MS) India

Helicoverpa armigera is a key pest in many vital crops, which is mainly controlled by chemical strategies, To manage this pest is becoming challenging due to its ability and evolution of resistance against insecticides. Further, its subsequent spread on nonhost plant is remarkable in recent times. Hence, decoding resistance mechanism against phytochemicals and synthetic insecticides is a major challenge. The present work describes that the digestion, defense and immunity related enzymes are associated with chlorpyrifos resistance in 11. armigera. Proteomic analysis of/-/, armigera gut tissue upon feeding on chlorpyrifos containing diet （CH） and artificial diet （AD） using nano-liquid chromatography-mass spectrometry identified upregulated 23-proteins in CH fed larvae. Database searches combined with gene ontology analysis revealed that the identified gut proteins engrossed in digestion, proteins crucial for immunity, adaptive responses to stress, and detoxification. Biochemical and quantitative real-time polymerase chain reaction anal- ysis of candidate proteins indicated that insects were struggling to get nutrients and energy in presence of CH, while at the same time endeavoring to metabolize chlorpyrifos. More- over, we proposed a potential processing pathway of chlorpyrifos in H. armigera gut by examining the metabolites using gas chromatography-mass spectrometry. 1f. armigera exhibit a range of intriguing behavioral, morphological adaptations and resistance to in- secticides by regulating expression of proteins involved in digestion and detoxification mechanisms to cope up with chlorpyrifos. In these contexts, as gut is a rich repository of biological information; profound analysis of gut tissues can give clues of detoxification and resistance mechanism in insects.

关键词： chlorpyrifos Helicoverpa armigera insecticide resistance proteomics real-time PCR

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Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity

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Open Journal of Metal 2012年第3期2卷 49-59页

作者： Ketan S. patel Jiten C. patel Hitesh R. Dholariya vishal K. patel Kanuprasad D. patel Chemistry Department Shree P. M. Patel College of Peramedical Science & Technology Sardar Patel University Gujarat- India Chemistry Department V. P. & R. P. T. P. Science College Sardar Patel University Vallabh Vidhyanagar Gujarat-India

Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.

关键词： Transition Metal Complex Ciprofloxacin Biological Activity

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