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Extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing

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International Journal of Oral Science 2023年第3期15卷 450-461页

作者： Anamaria Balic Dilara Perver Pierfrancesco Pagella Hubert Rehrauer Bernd Stadlinger Andreas E.Moor viola vogel Thimios A.Mitsiadis Orofacial Development and Regeneration Institute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurichSwitzerland Department of Health Sciences and Technology Institute of Translational MedicineETH ZurichZurichSwitzerland Functional Genomics Center Zurich ETH Zurich and University of ZurichZurichSwitzerland Clinic of Cranio-Maxillofacial and Oral Surgery University of ZurichZurichSwitzerland Department of Biosystems Science and Engineering ETH ZurichBaselSwitzerland

Carious lesions are bacteria-caused destructions of the mineralised dental tissues,marked by the simultaneous activation of immune responses and regenerative events within the soft dental pulp *** major molecular players in tooth decay have been uncovered during the past years,a detailed map of the molecular and cellular landscape of the diseased pulp is still *** this study we used single-cell RNA sequencing analysis,supplemented with immunostaining,to generate a comprehensive single-cell atlas of the pulp of carious human *** data demonstrated modifications in the various cell clusters within the pulp of carious teeth,such as immune cells,mesenchymal stem cells(MSC)and fibroblasts,when compared to the pulp of healthy human *** immune response in the carious pulp tissue is accompanied by specific changes in the fibroblast and MSC *** changes include the upregulation of genes encoding extracellular matrix(ECM)components,including COL1A1 and Fibronectin(FN1),and the enrichment of the fibroblast cluster with *** incremental changes in the ECM composition of carious pulp tissues were further confirmed by immunostaining *** of the Fibronectin fibres under mechanical strain conditions showed a significant tension reduction in carious pulp tissues,compared to the healthy *** present data demonstrate molecular,cellular and biomechanical alterations in the pulp of human carious teeth,indicative of extensive ECM remodelling,reminiscent of fibrosis observed in other *** comprehensive atlas of carious human teeth can facilitate future studies of dental pathologies and enable comparative analyses across diseased organs.

关键词： organs pulp matrix

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机械力作用下蛋白质结构和功能的转换

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生命科学 2008年第3期20卷 390-395页

作者： viola vogel 从怀萍(译述) 1ETH Zurich Biologically Oriented Materials Swizerland 中国科技大学合肥230026

机械力作用下蛋白质结构和功能的转换涉及到纳米尺度范围内机械化学信号之间的转换。本文从以下几个方面对这一领域进行了综述:局部外力和几何感觉控制细胞功能:多结构域蛋白——纤连素在机械转化中的优点:将外力转化成生化信号;活细胞... 详细信息

机械力作用下蛋白质结构和功能的转换涉及到纳米尺度范围内机械化学信号之间的转换。本文从以下几个方面对这一领域进行了综述:局部外力和几何感觉控制细胞功能:多结构域蛋白——纤连素在机械转化中的优点:将外力转化成生化信号;活细胞中细胞外基质中的纤连素在力诱导下的展开;纤连素Ⅲ型结构域通过序列变化调节机械稳定性:大肠杆菌Ⅰ型毛缘的展开结构有利于捕获键形成以及在药物和技术领域的应用。

关键词：机械力蛋白质结构功能化学信号

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Phytochemicals, polyphenols content, in vitro antioxidant and antibacterial activities of Albizia coriaria Welw ex. Oliver flowers

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Traditional Medicine Research 2023年第2期8卷 1-6页

作者： Timothy Omara Ambrose K.Kiprop viola J.Kosgei Department of Chemistry and Biochemistry School of Sciences and Aerospace StudiesMoi UniversityP.O.Box 3900-30100EldoretKenya Africa Center of Excellence II in Phytochemicals Textile and Renewable Energy(ACE II PTRE)Moi UniversityP.O.Box 3900-30100EldoretKenya Institute of Chemistry of Renewable Resources Department of ChemistryUniversity of Natural Resources and Life Sciences Vienna3430TullnAustria Testing Department Uganda National Bureau of StandardsBweyogerere Industrial and Business ParkP.O.Box 6329KampalaUganda

Albizia coriaria Welw ***(hereafter ***)is a revered medicinal tree whose organs are used by indigenous African societies for managing various ***,we assessed the secondary metabolites,total polyphenolics,free radical scavenging and antimicrobial activities of *** *** dry powdered sample was extracted serially with ethyl acetate,ethanol and distilled *** of classical phytochemical screening showed that saponins,phenols,alkaloids,flavonoids,tannins and terpenes were the dominant *** highest total polyphenolic content(10.37±0.02 mg QE/g DW and 72.09±0.09 mg GAE/g DW)and free radical scavenging potential(IC50=24.23±0.04 mg/mL)were for the ethyl acetate *** also had a higher bacteriostatic activity than the ethanolic extract against Pseudomonas aeruginosa,Salmonella typhi,Escherichia coli and Staphylococcus aureus with diameters of inhibition ranging from 7.00±0.00 to 22.00±1.73 *** aqueous extract showed no appreciable antibacterial effect on the tested *** is the first report which support the use of floral extracts of this species in the management of ailments in African traditional medicine.

关键词： bacteriostatic Albizia coriaria DPPH assay traditional medicine oxidative stress

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Magnetoelectric coupling at microwave frequencies observed in bismuth ferrite-based multiferroics at room temperature

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Journal of Materials Science & Technology 2023年第6期137卷 100-103页

作者： Man Zhang Vladimir Koval Yu Shi Yajun Yue Chenglong Jia Jiagang Wu Giuseppe viola Haixue Yan School of Engineering and Materials Science Queen Mary University of LondonMile End RoadLondon E14NSUK Institute of Materials Research Slovak Academy of SciencesWatsonova 47Kosice 04001Slovakia Key Laboratory for Magnetism and Magnetic Materials of MOE Lanzhou UniversityLanzhou 730000China Department of Chemistry Queen Mary University of LondonMile End RoadLondon E14NSUK Department of Materials Science Sichuan UniversityChengdu 610064China

***,In the search for advanced multifunctional materials for next generation sensors and logic devices,magnetoelectric multifer-roics exhibiting simultaneously ferromagnetism and ferroelectric-ity within the same phas... 详细信息

关键词： microwave coupling ferroelectric

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Clausena anisata(Willd.)*** Benth.(Rutaceae):ethnomedicinal uses,phytochemistry,pharmacological activities,toxicity,and clinical application

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Traditional Medicine Research 2022年第6期7卷 12-42页

作者： Timothy Omara Ambrose K.Kiprop viola J.Kosgei Sarah Kagoya Department of Chemistry and Biochemistry School of Sciences and Aerospace StudiesMoi UniversityEldoret 3900-30100Kenya Africa Centre of ExcellenceⅡin Phytochemicals Textile and Renewable Energy(ACE II PTRE)Moi UniversityEldoret 3900-30100Kenya Institute of Chemistry of Renewable Resources Department of ChemistryUniversity of Natural Resources and Life Sciences Vienna(BOKU)Tulln 3430Austria Department of Chemistry Faculty of ScienceKyambogo UniversityKampala 1Uganda

Clausena anisata(Willd.)*** *** a plant extensively used in traditional ***,a synopsis of the research on various aspects of Clausena anisata(Willd.)*** *** *** electronic literature review revealed that formulations containing Clausena anisata(Willd.)*** *** used to manage and treat diabetes,eye problems,malaria,snake envenomation,malignancies,as well as venereal,gastrointestinal,reproductive,respiratory,dermatological,and odonatological *** date,90 compounds have been isolated and characterized from extracts of Clausena anisata(Willd.)*** *** extracts and isolated compounds from Clausena anisata(Willd.)*** *** anti-inflammatory,antimicrobial,antioxidant,antiplasmodial,antiproliferative,anti-human immunodeficiency virus-1,antimycobacterial,antihypertensive,and antidiabetic *** bioactivities can be attributed to alkaloids,coumarins,limonoids,and phenylpropanoids present in different parts of the *** some studies have indicated moderate toxicity of the extracts,some of the dominant compounds in this species,such as estragole and carbazole alkaloids,are mutagenic or cytotoxic.A clinical trial utilizing a Ghanaian herbal formulation containing Clausena anisata(Willd.)*** *** found to be effective in reducing pain associated with *** progress to date supports the traditional use of this species in herbal ***,these studies do not explain the relationships between traditional uses,pharmacological activities,and mechanisms of ***,further studies should be designed to understand the biochemical properties and physiological effects of Clausena anisata(Willd.)*** ***,facilitating the development and utilization of this medicinal resource.

关键词： carbazole alkaloid coumarin limonoid phenylpropanoid essential oil

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High pressure organic colloid method for the preparation of high performance carbon nanotube-supported Pt and PtRu catalysts for fuel cell applications

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Science China(Technological Sciences) 2010年第1期53卷 264-271页

作者： WANG KateNing viola BIRSS College of Chemistry South China University of Technology Department of Chemistry University of CalgaryCalgary T2N1N4Canada

Highly dispersed,high performance Pt and PtRu catalysts,supported on multiwalled carbon nanotubes(CNTs),were prepared by a high pressure organic colloid *** particle sizes of the active components were as small as 1.2 nm for Pt and 1.1 nm for PtRu,and the active Pt surface areas were 295 and 395 m2/g,*** catalysts showed very high activities toward the anodic oxidation of methanol,evaluated by cyclic voltammetry,being up to 4 times higher than that of commercial Johnson Matthey Hispec 2000 Pt/XC-72R and 5 times better than Hispec 5000 PtRu/XC-72R *** a full air/hydrogen fuel cell,a membrane-electrode assembly prepared using our Pt/CNT and PtRu/CNT catalysts showed 50% and 100% higher performances than those prepared with commercial Johnson Matthey Pt/XC-72R and PtRu/XC-72R catalysts for the same Pt loading and operating conditions.

关键词： direct methanol fuel cell hydrogen fuel cells anodes catalysts methanol oxidation carbon nanotubes organic colloidal method

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On the electrophysiology of the atrial fast conduction system:an uncertain quantification study

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Acta Mechanica Sinica 2021年第2期37卷 264-278页

作者： Giulio Del Corso Roberto Verzicco Francesco viola GSSI(Gran Sasso Science Institute) L'AquilaItaly University of Roma Tor Vergata RomeItaly POF Group University of TwenteEnschedeThe Netherlands

Cardiac modeling entails the epistemic uncertainty of the input parameters,such as bundles and chambers geometry,electrical conductivities and cell parameters,thus calling for an uncertainty quantification(UQ)*** the cardiac activation and the subsequent muscular contraction is provided by a complex electrophysiology system made of interconnected conductive media,we focus here on the fast conductivity structures of the atria(internodal pathways)with the aim of identifying which of the uncertain inputs mostly influence the propagation of the depolarization ***,the distributions of the input parameters are calibrated using data available from the literature taking into account gender *** output quantities of interest(Qols)of medical relevance are defined and a set of metamodels(one for each Qol)is then trained according to a polynomial chaos expansion(PCE)in order to run a global sensitivity analysis with non-linear variance-based SoboF indices with confidence intervals evaluated through the bootstrap *** most sensitive parameters on each Qol are then identified for both genders showing the same order of importance of the model inputs on the electrical ***,the probability distributions of the Qols are obtained through a forward sensitivity analysis using the same trained *** results that several input parameters-including the position of the internodal pathways and the electrical impulse applied at the sinoatrial node一have a little influence on the Qols ***-versa the electrical activation of the atrial fast conduction system is sensitive on the bundles geometry and electrical conductivities that need to be carefully measured or calibrated in order for the electrophysiology model to be accurate and predictive.

关键词： Uncertainty quantification Global sensitivity analysis Forward analysis Atrial modelling Electrophysiology Monodomain model

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Design and Robust Performance Evaluation of a Fractional Order PID Controller Applied to a DC Motor

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IEEE/CAA Journal of Automatica Sinica 2017年第2期4卷 304-314页

作者： J.viola L.Angel J.M.Sebastian Universidad Pontificia Bolivariana Universidad Politecnica de Madrid Centre for Automation and Robotics (CAR) UPM-CSIC

This paper proposes a methodology for the quantitative robustness evaluation of PID controllers employed in a DC motor. The robustness analysis is performed employing a 2~3 factorial experimental design for a fractional order proportional integral and derivative controller(FOPID), integer order proportional integral and derivative controller(IOPID)and the Skogestad internal model control controller(SIMC). The factors assumed in experiment are the presence of random noise,external disturbances in the system input and variable load. As output variables, the experimental design employs the system step response and the controller action. Practical implementation of FOPID and IOPID controllers uses the MATLAB stateflow toolbox and a NI data acquisition system. Results of the robustness analysis show that the FOPID controller has a better performance and robust stability against the experiment factors.

关键词： Factorial experimental design fractional-order PID controller robustness analysis SIMC PID controller

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Metabolic Control of Chloroplast Gene Expression： An Emerging Theme

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Molecular Plant 2017年第1期10卷 1-3页

作者： Alexandra-viola Bohne Jörg Nickelsen Department Biology I Molecular Plant Sciences LMU Munich Grosshaderner Strasse 2-4 82152 Planegg-Martinsried Germany

In all organisms, regulation of gene expression plays an essential part in acclimation to changes in the environment and the meta-bolic status of cells. However, little is known about the mecha-nisms by which nutritio... 详细信息

关键词： Control Expression Theme

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Management of single pulmonary metastases from colorectal cancer:State of the art

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 820-832页

作者： Marco Chiappetta Lisa Salvatore Maria Teresa Congedo Maria Bensi viola De Luca Leonardo PetraccaCiavarella Floriana Camarda Jessica Evangelista Vincenzo Valentini Giampaolo Tortora StefanoMargaritora Filippo Lococo Department of Thoracic Surgery Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Oncologia Medica Comprehensive Cancer Center Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Radiation Therapy Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy

Colorectal cancer(CRC)is one of the most common causes of death from *** seeding occurs in approximately 10%of patients surgically treated for primary CRC with radical intent:the lung is the most common site of metastases after the *** surgical treatment of liver metastases is widely accepted to affect long-term outcomes,more controversial and not standardized is the therapy for CRC patients developing lung *** suggests the potential curative role of pulmonary metastasectomy,especially in oligometastatic ***,the optimal strategy of care and the definition of prognostic factors after treatment still need to be *** review focused on the uncommon scenario of single pulmonary metastases from *** explored pertinent literature and provide an overview of the epidemiology,clinical characteristics and imaging of single pulmonary metastases from ***,we identified the best available evidence for overall *** particular,we analyzed the role and results of locoregional approaches(surgery,radiotherapy or ablative procedures)and their integration with systemic therapy.

关键词： Colorectal cancer Pulmonary metastases Oligometastases Chemotherapy Surgery Radiotherapy

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