Clausena anisata(Willd.)*** Benth.(Rutaceae):ethnomedicinal uses,phytochemistry,pharmacological activities,toxicity,and clinical application
作者机构：Department of Chemistry and BiochemistrySchool of Sciences and Aerospace StudiesMoi UniversityEldoret 3900-30100Kenya Africa Centre of ExcellenceⅡin PhytochemicalsTextile and Renewable Energy(ACE II PTRE)Moi UniversityEldoret 3900-30100Kenya Institute of Chemistry of Renewable ResourcesDepartment of ChemistryUniversity of Natural Resources and Life Sciences Vienna(BOKU)Tulln 3430Austria Department of ChemistryFaculty of ScienceKyambogo UniversityKampala 1Uganda
出 版 物：《Traditional Medicine Research》 (TMR传统医学研究)
年 卷 期：2022年第7卷第6期
页 面：12-42页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：Inter-University Council of East Africa (IUCEA) World Bank
主 题：carbazole alkaloid coumarin limonoid phenylpropanoid essential oil
摘 要：Clausena anisata(Willd.)*** *** a plant extensively used in traditional ***,a synopsis of the research on various aspects of Clausena anisata(Willd.)*** *** *** electronic literature review revealed that formulations containing Clausena anisata(Willd.)*** *** used to manage and treat diabetes,eye problems,malaria,snake envenomation,malignancies,as well as venereal,gastrointestinal,reproductive,respiratory,dermatological,and odonatological *** date,90 compounds have been isolated and characterized from extracts of Clausena anisata(Willd.)*** *** extracts and isolated compounds from Clausena anisata(Willd.)*** *** anti-inflammatory,antimicrobial,antioxidant,antiplasmodial,antiproliferative,anti-human immunodeficiency virus-1,antimycobacterial,antihypertensive,and antidiabetic *** bioactivities can be attributed to alkaloids,coumarins,limonoids,and phenylpropanoids present in different parts of the *** some studies have indicated moderate toxicity of the extracts,some of the dominant compounds in this species,such as estragole and carbazole alkaloids,are mutagenic or cytotoxic.A clinical trial utilizing a Ghanaian herbal formulation containing Clausena anisata(Willd.)*** *** found to be effective in reducing pain associated with *** progress to date supports the traditional use of this species in herbal ***,these studies do not explain the relationships between traditional uses,pharmacological activities,and mechanisms of ***,further studies should be designed to understand the biochemical properties and physiological effects of Clausena anisata(Willd.)*** ***,facilitating the development and utilization of this medicinal resource.
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