检索结果-南通市图书馆

Beneficial effects of splenectomy on liver regeneration in a rat model of massive hepatectomy

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 60-65页

作者： vikram Raut Department of Breast Surgery Graduate School of MedicineKyoto University

BAcKGROUND: Small-for-size syndrome is a widely recognized clinical complication after living donor liver transplantation or extended hepatectomy due to inadequate liver mass. The purpose of this study was to investigate the role of splenectomy in rats after massive hepatectomy, a surrogate model of small-for-size graft. METHODS: Rats were divided into eight groups, each with 20 animals: 50% hepatectomy (50% Hx), 50% hepatectomy+ splenectomy (50% Hx+Sp), 60% Hx, 60% Hx+Sp, 70% Hx, 70% Hx+Sp, 90% Hx and 90% Hx+Sp. The following parameters were evaluated: liver function tests (ALT, AST and TBIL), liver regeneration ratio, DNA synthesis, proliferation cell nuclear antigen, hepatic oxygen delivery (HDO(2)) and hepatic oxygen consumption (HVO(2)). RESULTS: The liver regeneration ratio was enhanced in the Hx+Sp groups (P compared with the Hx groups, the Hx+Sp groups had better liver functions (P cell nuclear antigen were also increased in the Hx+Sp groups compared with the Hx groups (P creased over those in the Hx groups (P correlated with the liver regeneration ratio. cONcLUSIONS: Splenectomy significantly improved liver function, and enhanced DNA synthesis and proliferation cell nuclear antigen after massive hepatectomy in rats. This operation could be mediated through increased HDO(2), and HVO(2) which facilitate liver regeneration. (Hepatobiliary Pancreat Dis Int 2012;11:60-65)

关键词： liver regeneration splenectomy hepatic oxygen delivery hepatic oxygen consumption

Geriatric oncology: problems with under-treatment within this population

在线全文

学校读者我要写书评

暂无评论

cancer Biology & Medicine 2015年第4期12卷 275-283页

作者： Divya Swaminathan vikram Swaminathan Norwich Medical School University of East Anglia Health Education North West

We are currently faced with an aging population, which is rapidly growing worldwide. Two thirds of cancer occurs in the over 65-year age group. Societal conceptions from the past have created ageist stereotypes; old age is associated with frailty and the elderly are perceived to be destined for deterioration and loss of independence. cancer within the elderly is also subject to these stereotypes, with elderly cancer patients considered by some not as likely to recover as younger patients with cancer. We summarise and review the current concerns regarding elderly management and treatments utilised for the management of oncological disease in the elderly, and discuss the impact of under-treatment within this population.

关键词： cancer elderly management geriatric oncology

When the left side knows something happened to the right–sensing injury in neurons contralateral and remote to injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第10期15卷 1854-1855页

作者： Valerie M.K.Verge Jovan c.D.Hasmatali vikram Misra Department of Anatomy Physiology and PharmacologyCameco MS Neuroscience Research CenterUniversity of SaskatchewanSaskatoonSaskatchewanCanada Department of critical care Medicine Rady Faculty of Health SciencesUniversity of ManitobaWinnipegManitobaCanada Department of Veterinary Microbiology University of SaskatchewanSaskatoonSaskatchewanCanada

How sensory neurons encode axonal injury signals has been a longstanding area of neurological *** into the cellular and transcriptional changes in the injured neurons have driven many new therapeutic strategies to improve *** contrast,less focus has been centered on the systemic or transneuronal changes that may arise from these injuries and how they may impact or factor into the alterations in gene expression,physiology and neuropathology,such as mirror image pain,arising in regions either directly contralateral or those remote to the injury *** in this area is clinically *** patients with chronic unilateral pain due to multiple pathologies,many of which involve nerve trauma,there is a very high incidence of bilateral sensory abnormalities reported with 33–50%of patients with mechanical abnormalities reporting contralateral sensory abnormalities(Konopka et al.,2012).This has implications when evaluating sensory abnormalities or pain states in patients,as the contralateral side is often used as the non-affected ***,the bilateral nature of these sensory abnormalities,albeit usually less severe on the contralateral side,support that a systemic or central nervous system component is involved in this aspect of the *** highlights the need to better understand the mechanisms underlying these bilateral responses as this will likely impact therapeutic treatments for these patients.

关键词： injuries injury something

STOcHASTIc SYNcHRONIZATION OF cIRcADIAN RHYTHMS

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & complexity 2010年第5期23卷 978-988页

作者： RajKumar Brojen SINGH vikram SINGH Ram RAMASWAMY centre for Interdisciplinary Research in Basic Sciences Jamia Milia Islamia New Delhi 110025 India center for computational Biology and Bioinformatics School of Information Technology Jawaharlal Nehru University New Delhi 110067 India center for computational Biology and Bioinformatics School of Information Technology and School of Physical Sciences Jawaharlal Nehru University New Delhi 110067 India

Models of circadian genetic oscillators involving interlinked feedback processes in molecular level genetic networks in Drosophila melanogaster and Neurospora crassa are studied, and mechanisms whereby synchronization can arise in an assembly of cells are examined. The individual subcellular circadian oscillatory processes are stochastic in nature due to the small numbers of molecules that are involved, and are subject to large fluctuations. The authors investigate and present the simulations of the stochastic dynamics of ensembles of clock-regulating proteins in different nuclei that communicate via ancillary small molecules, environmental parameters, additive cellular noise, or through diffusive processes. The results show that the emergence of collective oscillations is a macroscopic observable which has its origins in the microscopic coupling between distinct cellular oscillators.

关键词： coupling stochastic dynamics synchrony.

Tensor-structured algorithm for reduced-order scaling large-scale Kohn–Sham density functional theory calculations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj computational Materials 2021年第1期7卷 448-456页

作者： chih-chuen Lin Phani Motamarri vikram Gavini Department of Mechanical Engineering University of MichiganAnn ArborMIUSA Department of computational and Data Sciences Indian Institute of ScienceBangaloreIndia Department of Materials Science&Engineering University of MichiganAnn ArborMIUSA

We present a tensor-structured algorithm for efficient large-scale density functional theory(DFT)calculations by constructing a Tucker tensor basis that is adapted to the Kohn–Sham Hamiltonian and localized in *** proposed approach uses an additive separable approximation to the Kohn–Sham Hamiltonian and an L1 localization technique to generate the 1-D localized functions that constitute the Tucker tensor *** results show that the resulting Tucker tensor basis exhibits exponential convergence in the ground-state energy with increasing Tucker ***,the proposed tensor-structured algorithm demonstrated sub-quadratic scaling with system-size for both systems with and without a gap,and involving many thousands of *** reduced-order scaling has also resulted in the proposed approach outperforming plane-wave DFT implementation for systems beyond 2000 electrons.

关键词： tensor scaling functional

Influences of Freshwater from Major Rivers on Global Ocean circulation and Temperatures in the MIT Ocean General circulation Model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2010年第3期27卷 455-468页

作者： vikram M.MEHTA The center for Research on the changing Earth System

Responses of global ocean circulation and temperature to freshwater runoff from major rivers were studied by blocking regional runoff in the global ocean general circulation model （OGcM） developed at the Massachusetts Institute of Technology. Runoff into the tropical Atlantic, the western North Pacific, and the Bay of Bengal and northern Arabian Sea were selectively blocked. The blocking of river runoff first resulted in a salinity increase near the river mouths （2 practical salinity units）. The saltier and, therefore, denser water was then transported to higher latitudes in the North Atlantic, North Pacific, and southern Indian Ocean by the mean currents. The subsequent density contrasts between northern and southern hemispheric oceans resulted in changes in major ocean currents. These anomalous ocean currents lead to significant temperature changes （I^c -2~c） by the resulting anomalous heat transports. The current and temperature anomalies created by the blocked river runoff propagated from one ocean basin to others via coastal and equatorial Kelvin waves. This study suggests that river runoff may be playing an important role in oceanic salinity, temperature, and circulations; and that partially or fully blocking major rivers to divert freshwater for societal purposes might significantly change ocean salinity, circulations, temperature, and atmospheric climate. Further studies are necessary to assess the role of river runoff in the coupled atmosphere-ocean system.

关键词： river runoff ocean general circulation freshwater flux

Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第34期30卷 3850-3855页

作者： Swati Katoch vikram Patial Division of Dietetics and Nutrition Technology Institute of Himalayan Bioresource TechnologyPalampur 176061Himachal PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

In this editorial,we comment on the article by Zhou et *** study reveals the connection between ferroptosis and pyroptosis and the effect of silent information regulator sirtuin 1(SIRT1)activation in acute liver failure(ALF).ALF is characterized by a sudden and severe liver injury resulting in significant hepatocyte damage,often posing a high risk of *** predominant form of hepatic cell death in ALF involves apoptosis,ferroptosis,autophagy,pyroptosis,and *** peroxidase 4(GPX4)inhibition sensitizes the cell to ferroptosis and triggers cell death,while Gasdermin D(GSDMD)is a mediator of *** study showed that ferroptosis and pyroptosis in ALF are regulated by blocking the p53/GPX4/GSDMD pathway,bridging the gap between the two *** inhibition of p53 elevates the levels of GPX4,reducing the levels of inflammatory and liver injury markers,ferroptotic events,and GSDMDN protein *** p53 expression and increased GPX4 on deletion of GSDMD indicated ferroptosis and pyroptosis ***1 is a NAD-dependent deacetylase,and its activation attenuates liver injury and inflammation,accompanied by reduced ferroptosis and pyroptosis-related proteins in ***1 activation also inhibits the p53/GPX4/GSDMD axis by inducing p53 acetylation,attenuating LPS/D-GalN-induced ALF.

关键词： Acute liver failure Ferroptosis Gasdermin D Pyroptosis p53 Silent information regulator sirtuin 1

confinement effect on cO_(2)and cH_(4)permeability in shale

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy Geoscience 2024年第1期5卷 256-263页

作者： vikram Vishal Tuli Bakshi computational and Experimental Geomechanics Laboratory Department of Earth SciencesIndian Institute of Technology BombayMumbai400076India National centre of Excellence in carbon capture and Utilization Indian Institute of Technology BombayMumbai400076India

Gas flow in shales follows a number of physical mechanisms that include Knudsen diffusion,Darcy flow,and adsorption in the matrix and micro *** aim of the study is to resolve the interplay of gas transport in these media at increased effective stress as well as net pore *** this research,we investigated the nature of gas transport in the matrix of shale by sending He,cH_(4)and cO_(2)gases through a transient upstream pressure pulse decay instrument.A series of experiments were conducted at constant pore pressures and a gradually increasing confining *** same study was done in three different scenarios,injecting He,cO_(2)and cH_(4).At a constant pore pressure,gas permeability appears to decrease with an increasing confining pressure and effective *** increasing effective stress,the slip factor also decreases along with the *** decrease in slip could be attributed to prestressing,that is likely to create new *** the three purged gases,permeability of shale to cH_(4)is the highest,and that to cO_(2)is the lowest owing to its high *** permeability of cH_(4)against He,could be attributed to the dual transport mechanism.

关键词： Energy Porous media Gas transport Effective stress

Spatial Variability of Mass Movements in the Satluj Valley,Himachal Pradesh during 1990～2006

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2008年第1期5卷 38-51页

作者： vikram GUPTA M.P.SAH Wadia Institute of Himalayan Geology Dehra Dun-24 8 001 (Uttarakhand)

Satluj Valley is known to have a history of landslides and related mass movement activities since the geological times. Geological and geomorphological settings combined with anthropogenic activities constitute a propensity towards slope failure. During the last two decades,the area witnessed substantial increase in athropogenic pressure,mainly due to the exploitation of hydropower potential,changing landuse pattern and population growth. In addition,a shift of the climatic patterns in the form of larger area falling under the influence of rains was observed. These natural as well as anthropogenic changes in the area have resulted in increased spatial coverage of landslide in the area. This paper documents these changes during 1990～2006.

关键词： Landslides Mass movement Satluj Valley Himachal Pradesh India