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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia la Barbera Paraskevi Krashia Annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： Beatriz Gonzalez Pablo vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

Toward forest ‘‘sprawl'':monitoring and planning a changing landscape for urban sustainability

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Journal of Forestry Research 2016年第1期27卷 175-184页

作者： Luca Salvati Carlotta ferrara Anastasios Mavrakis Andrea Colantoni Consiglio per la Ricerca in Agricoltura e l'analisi dell'Economia Agraria (CREA) Via della Navicella 2-400184 Rome Italy Department of Agriculture Forests Nature and Energy (DAFNE) Viale dell'Agricoltura 02015 Cittaducale (RI)Italy Department of Economic and Regional Development Institute of Urban Environment and Human ResourcesPanteion University 136 Syngrou Avenue 17671 AthensGreece Dipartimento di Science e Tecnologie per l'Agricoltura le Foreste la Natura e l'Energia Universith degli Studi di Viterbo Via S. Camillo de Lellis snc O1100 Viterbo Italy

The present study analyzes the structure and dynamics of the forest landscape in a peri-urban area （Rome, Italy） during the city＇s expansion from 1949 to 2008 using landscape metrics and change detection anal- ysis of digital maps of the area （1500 km2）. While urban settlements increased continuously from 6.5 to 27.5 % of the study area, woodlands changed less clearly, with a moderate increase （from 11.2 to 11.9 % of the total area） and a higher fragmentation as a consequence of Rome＇s expansion. The structure of forest landscape changed along the urban-to-rural gradient with patch size increasing with the distance to the inner city in 1949 and substantial landscape homogeneity in 2008. The indicators proposed in this study inform dedicated measures for conserving forest and maintaining landscape diversity. Measures adopted in Rome＇s forestation plan to counteract woodlandfragmentation were analyzed and discussed. Based on the complex landscape dynamics found for Rome, an inte- grated multiscale planning approach targeting forest con- servation is considered a key contribution to urban sustainability.

关键词： landscape ecology Urban form Forestationplan Rome Mediterranean region

Linking plant metabolism and immunity through methionine biosynthesis

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Molecular Plant 2022年第1期15卷 6-8页

作者： Francisco Escaray Amelia Felipo-Benavent Pablo vera Instituto de Biología Molecular y Celular de Plantas Universidad Politécnica de Valencia-C.S.I.CCiudad Politécnica de la InnovaciónEdificio 8EIngeniero Fausto Elios/n46022 ValenciaSpain

Plants respond to pathogenic cues with a transcriptional reprog-ramming that leads to de novo production of defense-related pro-teins and a huge variety of secondary metabolites(e.g.,phyto-alexins,phenolics,etc.).Activation of these host defenses,which contribute to halt the intruder as part of the resistance,im-plies an increased demand for metabolic energy and carbon skel-etons derived from primary metabolism(Bolton,2009).

关键词： metabolism immunity Bolton

Nerve growth factor catches copper in neuronal inning

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Neural Regeneration Research 2020年第4期15卷 665-666页

作者： Diego la Mendola Department of Pharmacy University of Pisa

The physiological effect of neurotrophic factors and their role in Alzheimer’s disease(AD):Neurotrophins(NTs)are a family of homologues proteins that play an essential role in neuronal cells growth,survival and *** proteins include the nerve growth factor(NGF),the brain derived neurotrophic factor(BDNF),NT-3 and NT-3,also known as NT-4/5.

关键词： Alzheimer copper differentiation.

q-Deformation of W (2 , 2) Lie Algebra Associated with Quantum Groups

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Acta Mathematica Sinica,English Series 2012年第11期28卷 2213-2226页

作者： la Mei YUAN Academy of Fundamental and Interdisciplinary Sciences Harbin Institute of Technology Wu Wen-Tsun Key laboratory of Mathematics University of Science and Technology of China

The q-deformation of W（2, 2） Lie algebra is well defined based on a realization of this Lie algebra by using the famous bosonic and fermionic oscillators in physics. Furthermore, the quantum group structures on the q-deformation of W（2, 2） Lie algebra are completely determined. Finally, the 1-dimensional central extension of the q-deformed W（2, 2） Lie algebra is studied, which turns out to be coincided with the conventional W（2, 2） Lie algebra in the q → 1 limit.

关键词： W(2 2) Lie algebra q-deformation quantum group central extension

On Standard Invariants of Bi-polymatroidal Ideals

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Algebra Colloquium 2014年第2期21卷 267-274页

作者： Monica la Barbiera University of Messina Department of'Mathematics Viale Ferdinando Stagno d'Aleontres 31 98166 Messina Italy

The standard invariants of the bi-polymatroidal ideals of Veronese type are computed.

关键词： bi-polymatroidal ideals linear quotients

Radiomics in pancreatic cancer for oncologist:Present and future

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 356-361页

作者： Carolina de la Pinta Radiation Oncology Department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Radiomics is changing the world of medicine and more specifically the world of *** diagnosis and treatment improve the prognosis of patients with *** treatment,the evaluation of the response will determine future *** oncology,every change in treatment means a loss of therapeutic options and this is key in pancreatic *** has been developed in oncology in the early diagnosis and differential diagnosis of benign and malignant lesions,in the evaluation of response,in the prediction of possible side effects,marking the risk of recurrence,survival and prognosis of the *** studies have validated its use to differentiate normal tissues from tumor tissues with high sensitivity and specificity,and to differentiate cystic lesions and pancreatic neuroendocrine tumor grades with texture *** addition,these parameters have been related to survival in patients with pancreatic cancer and to response to radiotherapy and *** review aimed to establish the current status of the use of radiomics in pancreatic cancer and future perspectives.

关键词： Pancreatic cancer Radiomics Radiogenomics

Stereotactic body radiotherapy in pancreatic adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 14-19页

作者： Carolina de la Pinta Radiation Oncology Department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding *** review aimed at the SBRT application in the treatment of pancreatic *** sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December *** used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were *** articles were assessed for validity and relevant ***:Optimal doses and fractionation have not yet been ***,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to ***,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic ***:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.

关键词： Chemoradiotherapy Pancreatic adenocarcinoma Radiotherapy Stereotactic body radiotherapy Stereotactic ablative radiotherapy