Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement
作者机构：Instituto de Biologia Molecular y Celular de PlantasUniversidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain
出 版 物：《Molecular Plant》 (分子植物（英文版）)
年 卷 期：2019年第12卷第9期
页 面：1227-1242页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 0901[农学-作物学] 100214[医学-肿瘤学] 0902[农学-园艺学] 10[医学]
基 金：Ministerio de Ciencia Innovación y Universidades MCIU (BFU2015-68199-R RTI2018-098501-B-100)
主 题：folate pathway plant immunity methionine DNA methylation
摘 要：Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.
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