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meso-substituted cationic 3-and 4-N-Pyridylporphyrins and their Zn(II)derivatives for antibacterial photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 1-16页

作者： Aram G.Gyulkhandanyan marina H.Paronyan Anna G.Gyulkhandanyan Karapet R.Ghazaryan marina v.Parkhats Boris m.Dzhagarov maria v.Korchenova Ekaterina N.Lazareva Elena S.Tuchina Grigor v.Gyulkhandanyan valery v.Tuchin H.Buniatyan Institute of Biochemistry National Academy of Sciences of Armenia 5/1 Paruir Sevak Street Yerevan 0014Armenia INSERm u1204 Universite d'Evry vald'Essonne-Universite Paris-Saclay 1 Ruedu Pere JarlanBatiment Maupertuis91025Evry-CourcouronnesFrance B.I.Stepanov Institute of Physics National Academy of Sciences of Belarus 68-2 Nezavisimosti AvenueMinsk 220072Belarus Science medical Center Saratov State University 83 Astrakhanskaya StreetSaratov 410012Russia Laboratory of Laser molecular Imaging and machine Learning(LmImL)National Research Tomsk State university 36 Lenin Avenue Tomsk 634050Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision mechanics and Control Russian Academy of Sciences Saratov 410028Russia

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic *** the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate *** of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in *** aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive *** was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant *** *** complexes of porphyrins are more phototoxic than metal-free porphyrin *** e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen *** was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet *** results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.

关键词： Antibacterial photodynamic therapy cationic porphyrins/metalloporphyrins phototoxicity Zn-metalloporphyrins singlet oxygen quantum yield Gram negative and Gram positive bacteria S.aureus mRSA E.coli Salmonella typhimurium.

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Chaotic approach in biomedicine: Individualized medical treatment

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Journal of Biomedical Science and Engineering 2013年第8期6卷 847-853页

作者： valery m. Eskov Alexander A. Khadartsev valery v. Eskov Olga E. Filatova Diana u. Filatova Institute of Techniques and Natural Sciences Surgut State University Surgut Russia

According to classic deterministic-stochastic approaches, we don’t have any possibility for realization of the basic principle in medicine because every human organism has its own specific features. It is evident for us that requirement of medical personification includes two procedures: individual (with uninterrupted procedure of human organism state measurement) diagnostics and the second part which is connected with uninterrupted control of the efficiency of medical treatment and measurements of human organism parameters. We conduct the diagnostics according to behavior of state vector of human organism in phase space of states according to every coordinates of human’s state vector and with calculation of quasiattractors. We can present the results of our observations: what may be good for one person is not necessarily good for another. We present new bioinformational methods and software for calculation of quasiattractors parameters for dissolving such contradictions between deterministic-stochastic medicine and the use of theory of chaos self-organization where the state vector of human organism demonstrates uninterrupted movements. The practical results of such procedure are also presented according to the theory of chaos-self-organization. So there are great distinctions between the classic deterministic-stochastic approach (based on traditional medicine requirements) and the new theory of chaos self-organization which considers every human organism as a unique system with individual properties.

关键词： Personification Phase Space State vector Attractor Complexity Chaos Self-Organization medicine

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欧洲新生儿呼吸窘迫综合征防治指南-2010版

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中华儿科杂志 2011年第1期49卷 27-33页

作者： Sweet DG Carnielli v Greisen G Hallman m Ozek E Plavka R Saugstad OD Simeoni u Speer CP Halliday HL 袁琳(翻译) 陈超(审校) Regional Neonatal unit Royal Maternity HospitalBelfast UK Dipartimento di Neonatologia Ospedale Universitario di Ancona Universita Politecnica delle Marche Ancona Department of Neonatology Rigshospitalet and University of Copenhagen Copenhagen Denmark Department of Pediatrics institute of Clinical Medicine Oulu UniversityHospital University of Oulu Oulu Finland Department of Pediatrics Marmara University Medical Faculty Istanbul Turkey Division of Neonatology Department of Obstetrics and Gynecology General Faculty Hospital and 1st Faculty of MedicineCharles University Prague Czech Republic Department of Pediatric Research Rikshospitalet Medical Center Faculty of MedicineUniversity of Oslo Oslo Norway Service de Neonatologie Hopital de la Conception Assistance Publique-I-Iopitauxde Marseille Marseille France Department of Pediatrics University Children's Hospital Wtirzburg Germany Department of Child Health Queen's University Belfast and RoyalMaternity Hospital Belfast UK 不详

呼吸窘迫综合征（RDS）是由于肺表面活性物质（PS）缺乏及肺结构发育不成熟所致，多见于早产儿，自然病程为生后当时或很快发病，并在生后2d内进行性恶化，如不及时治疗，因进行性缺氧和呼吸衰竭而死亡，存活者，在生后2—4d病情开始改... 详细信息

呼吸窘迫综合征（RDS）是由于肺表面活性物质（PS）缺乏及肺结构发育不成熟所致，多见于早产儿，自然病程为生后当时或很快发病，并在生后2d内进行性恶化，如不及时治疗，因进行性缺氧和呼吸衰竭而死亡，存活者，在生后2—4d病情开始改善。胎龄越小，RDS发生率越高，2006年EuroNeoStat的数据显示：胎龄23～25周的早产儿RDS发生率为91％，

关键词：呼吸窘迫综合征肺表面活性物质缺氧呼吸衰竭

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Zircon chemistry and new laser ablation u–Pb ages for uraniferous granitoids in SW Cameroon

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Acta Geochimica 2020年第1期39卷 43-66页

作者： v.F.Embui C.E.Suh J.m.Cottle J.Etame J.mendes C.m.Agyingi A.vishiti E.m.Shemang B.Lehmann Department of Geology University of BueaP.O.Box 63BueaSouth West RegionCameroon Ore Treatment Laboratory Institute of Geological and Mining Research(IRGM)P.O.Box 4110YaoundeNlongkakCameroon Department of Geology Mining and Environmental ScienceUniversity of BamendaP.O.Box 39BambiliCameroon Department of Earth Sciences and Earth Research Institute Webb Hall 2028University of CaliforniaSanta BarbaraCA 93106-9630USA Laboratory of Geosciences Natural resources and Environment Department of Earth SciencesFaculty of ScienceUniversity of DoualaP.O.Box 24157DoualaCameroon Department of Civil Engineering University Institute of TechnologyUniversity of DoualaP.O.Box 8698DoualaCameroon Departamento de Geologia IGEOUniversidade Federal do Rio de JaneiroCidade UniversitariaRio de Janeiro 21910-949Brazil Department of Earth and Environmental Sciences Botswana International University of Science and TechnologyPrivate Bag 16PalapyeBotswana mineral Resources Technical University of ClausthalClausihal-ZellerfeldGermany

The Ekomedion two-mica granite,southwestern Cameroon,has potential for uranium and molybdenum ***,we present LA-ICP-mS u-Pb ages,Lu-Hf isotope characteristics,trace element concentrations and Ti-geothermometry of zircon from this granite hosting u-mo mineralization in pegmatitic *** majority of zircon are CL-dark though some CL-bright cores were also identified.u-Pb zircon age data range from 121±3 to743±11 ma with only 5 of 34 ages being near *** concordant mean age of 603±12 ma is similar to ages of granitic intrusions along the Central African Shear Zone in *** ages with mean of261±6 ma reveal open system behavior with respect to Pb and/or *** e Hfi values range from-20.3 *** implies that u-mo was remobilized during partial melting of the surrounding *** Th/u>0.1 as well as an increasing Hf with decreasing Th/u indicates that fractional crystallization was the main factor that controlled u-mo mineralization in pegmatitic pods.Y and Y/Ho ratios cluster from 29 to 33 close to the chondritic ratio of 28 and indicate fractionation of Y and Ho with low F contents during the earliest stages of *** stage accumulation of F-rich magmatic-hydrothermal fluids impacted u-mo mineralization as a *** contains a prominent negative Eu anomaly pointing to a fractionating system rich in *** Ti-in-zircon temperatures span 672℃to1232℃with the temperatures at the high end reflecting interference from mineral inclusions in the zircon grains while the lower temperature values are linked to crystallization.

关键词： Zircons uranium-molybdenum Cameroon

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Propagation of kink–antikink pair along microtubules as a control mechanism for polymerization and depolymerization processes

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Chinese Physics B 2014年第9期23卷 556-570页

作者： L.Kavitha A.muniyappan S.Zdravkovi m.v.Satari A.marlewski S.Dhamayanthi D.Gopi Department of Physics School of Basic and Applied SciencesCentral University of Tamilnadu (CUTN) The Abdus Salam International Center for Theoretical Physics Department of Physics Periyar University Institut za nuklearne nauke vinca Laboratorija za atomsku fiziku 040Univerzitet u Beogradu Fakultet tehnickih nauka Univerzitet u Novom Sadu Institute of mathematics Poznan University of Technology Center for Nanoscience and Nanotechnology Periyar University Department of Chemistry Periyar University

Among many types of proteinaceous filaments, microtubules （mTs） constitute the most rigid components of the cellular cytoskeleton. microtubule dynamics is essential for many vital cellular processes such as intracellular transport, metabolism, and cell division. We investigate the nonlinear dynamics of inhomogeneous microtubulin systems and the mT dynamics is found to be governed by a perturbed sine-Gordon equation. In the presence of various competing nonlinear inhomogeneities, it is shown that this nonlinear model can lead to the existence of kink and antikink solitons moving along mTs. We demonstrate kink-antikink pair collision in the framework of Hirota＇s bilinearization method. We conjecture that the collisions of the quanta of energy propagating in the form of kinks and antikinks may offer a new view of the mechanism of the retrograde and anterograde transport direction regulation of motor proteins in microtubulin systems.

关键词： microtubules solitons solitary solutions partial differential equations

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Boundary Plasma Turbulence Simulations for Tokamaks

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Communications in Computational Physics 2008年第10期4卷 949-979页

作者： X.Q.Xu m.v.umansky B.Dudson P.B.Snyder Lawrence Livermore National Laboratory L-630P.O.Box 8087000 East Ave.LivermoreCA 94550USA Institute of Fusion Theory and Simulation ZhejiangUniversityHangzhou 310027China Department of Physics University of YorkHeslingtonYorkYO105DDUK General Atomics 13-303P.O.Box 85608San DiegoCA 92186-5608USA.

The boundary plasma turbulence code BOuT models tokamak boundaryplasma turbulence in a realistic divertor geometry usingmodified Braginskii equations for plasma vorticity,density(ni),electron and ion temperature(Te,Ti)and *** BOuT code solves for the plasma fluid equations in a three dimensional(3D)toroidal segment(or a toroidal wedge),including the region somewhat inside the separatrix and extending into the scrape-off layer;the private flux region is also *** this paper,a description is given of the sophisticated physical models,innovative numerical algorithms,and modern software design used to simulate edgeplasmas in magnetic fusion energy *** BOuT code’s unique capabilities and functionality are exemplified via simulations of the impact of plasma density on tokamak edge turbulence and blob dynamics.

关键词： Plasma turbulence simulation plasma two-fluids equation field-aligned coordinates plasma blobs

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Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts

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Chinese Journal of Natural medicines 2014年第9期12卷 663-671页

作者： Bandari uma mahesh Shweta Shrivastava Rajeswara Rao Pragada v.G.m.Naidu Ramakrishna Sistla Department of Pharmacology A.U.College of Pharmaceutical Sciences Andhra University Vishakhapatnam Andhra Pradesh India -530003 Department of Pharmacology & Toxicology National Institute of Pharmaceutical Education & Research (NIPER-Hyderabad) Balanagar Hyderabad Andhra Pradesh India-500037 Pharmacology Division Indian Institute of Chemical Technology Habsiguda Hyderabad Andhra Pradesh ndia-500007

Paracetamol(PCm) hepatotoxicity is related to reactive oxygen species(ROS) formation and excessive oxidative stress; natural antioxidant compounds have been tested as an alternative therapy. This study evaluated the hepatoprotective activity of an alcoholic extract of Boswellia ovalifoliolata(BO) bark against PCm-induced hepatotoxicity. BO extract also demonstrated antioxidant activity in vitro, as well as scavenger activity against 2, 2-diphenyl-1-picrylhydrazyl. Administration of PCm caused a significant increase in the release of transaminases, alkaline phosphatase, and lactate dehydrogenase in serum. Significant enhancement in hepatic lipid peroxidation and marked depletion in reduced glutathione were observed after parac intoxication with severe alterations in liver histology. BO treatment was able to mitigate hepatic damage induced by acute intoxication of PCm and showed a pronounced protective effect against lipid peroxidation, deviated serum enzymatic variables, and maintained glutathione status toward control. The results clearly demonstrate the hepatoprotective effect of BO against the toxicity induced by PCm.

关键词： extracts peroxidation glutathione dehydrogenase protective alcoholic antioxidant ABTS histology curcumin

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依据信息指标控制跳高运动员的专项身体训练的研究

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首都体育学院学报 2017年第4期29卷 289-291页

作者： В·С·勃科夫 Е·А·契列波夫 E·m·扬奇克 v·u·泽利晓夫姚颂平(译) 南乌拉尔国立大学竞技旅游和服务学院不详

优化控制运动训练要求借助于评价能反映运动技能水平的模式评定结果。研究目的:为了揭示反映不同技能水平的跳高运动员专项身体训练程度最具信息价值的指标。在纪念Ю·鲁科谢维奇的比赛前2年间进行研究。由跳高一级运动员和候补运动健... 详细信息

优化控制运动训练要求借助于评价能反映运动技能水平的模式评定结果。研究目的:为了揭示反映不同技能水平的跳高运动员专项身体训练程度最具信息价值的指标。在纪念Ю·鲁科谢维奇的比赛前2年间进行研究。由跳高一级运动员和候补运动健将组成的第1组、由跳高运动健将和国际运动健将组成的第2组,共29名运动员参加测试,为了确定专项训练程度的水平,使用了能评定速度、力量、速度-力量能力、大腿和小腿肌群放松和紧张水平的肌张力测定仪,获取人体测量指标,分析运动员在从90 cm高度跳下"(跳深练习")后蹬跳张力的力量特点和时间特点。在下落后蹬地起跳"跳深练习"情况下获得的反映动作幅度特征(力量和速度)的结果,从而揭示不同训练程度水平的田径运动员上述指标变化的特点。

关键词：综合监督专项训练程度速度-力量能力肌力测量仪跳深练习

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Cenozoic basin evolution of the Central Patagonian Andes:Evidence from geochronology, stratigraphy, and geochemistry

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Geoscience Frontiers 2019年第3期10卷 1139-1165页

作者： A.Encinas A.Folguera R.Riffo P.molina L.Fernández Paz v.D.Litvak D.A.Colwyn v.A.valencia m.Carrasco Departamento de Ciencias de la Tierra Facultad de Ciencias Químicas Universidad de Concepción Instituto de Estudios Andinos Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales Departamento de Ciencias Geológicas CONICET-universidad de Buenos Aires Instituto de Estudios Andinos Don Pablo Groeber (IDEAN) Department of Geology & Geophysics Yale University School of the Environment Washington State University

The Central Patagonian Andes is a particular segment of the Andean Cordillera that has been subjected to the subduction of two spreading ridges during Eocene and Neogene times. In order to understand the Cenozoic geologic evolution of the Central Patagonian Andes, we carried out geochronologic(u-Pb and^(40)Ar/^(39)Ar), provenance, stratigraphic, sedimentologic, and geochemical studies on the sedimentary and volcanic Cenozoic deposits that crop out in the meseta Guadal and Chile Chico areas(～47°S). Our data indicate the presence of a nearly complete Cenozoic record, which refutes previous interpretations of a hiatus during the middle Eocene-late Oligocene in the Central Patagonian Andes. Our study suggests that the fluvial strata of the Ligorio marquez Formation and the flood basalts of the Basaltos Inferiores de la meseta Chile Chico Formation were deposited in an extensional setting related to the subduction of the Aluk-Farallon spreading ridge during the late Paleocene-Eocene. Geochemical data on volcanic rocks interbedded with fluvial strata of the San Jose Formation suggest that this unit was deposited in an extensional setting during the middle Eocene to late Oligocene. Progressive crustal thinning allowed the transgression of marine waters of Atlantic origin and deposition of the upper Oligocene-lower miocene Guadal Formation. The fluvial synorogenic strata of the Santa Cruz Formation were deposited as a consequence of an important phase of compressive deformation and Andean uplift during the early-middle miocene. Finally, alkali flood basalts of the late middle to late miocene Basaltos Superiores de la meseta Chile Chico Formation were extruded in the area in response to the suduction of the Chile Ridge under an extensional regime. Our studies indicate that the tectonic evolution of the Central Patagonian Andes is similar to that of the North Patagonian Andes and appears to differ from that of the Southern Patagonian Andes, which is thought to have been the s

关键词： Central Patagonian Andes u-Pb geochronology Ar-Ar geochronology Geochemistry Stratigraphy Sedimentology

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XAANTAL2 （AGL14） Is an Important Component of the Complex Gene Regulatory Network that underlies Arabidopsis Shoot Apical meristem Transitions

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molecular Plant 2015年第5期8卷 796-813页

作者： Rigoberto v. Perez-R.u.iz Berenice Garcia-Ponce Nayelli marsch-martinez Yamel ugartechea-Chirino mitzi villajuana-Bonequi Stefan de Folter Eugenio Azpeitia Jose Davila-velderrain David Cruz-Sanchez Adriana Garay-Arroyo maria de la Paz Sanchez Juan m. Estevez-Palmas Elena R. Alvarez-Buylla Instituto de Ecologia Universidad Nacionat Autonoma de Moxico 3er Circuito Exterior s/no Junto al Jardin Bot~nico and Centro de Ciencias de la ComplejidadCiudad Universitaria Coyoacan 04510 Mexico D.F. Mexico Laboratorio Nacional de Genemica para la Biodiversidad (Langebio) Centro de Investigaci6n y de Estudios Avanzados del Instituto Polit~cnico Nacional(CINVESTAV-IPN) Km. 9.6 Carretera Irapuato - Leen AP 629 36821 Irapuato Guanajuato Mexico university of California 431 Koshland Hall Berkeley CA 94720 USA These authors contributed equally to this article. present address: Departamento de Biotecnologia y Biquimica Centro de )nvestigaci6n y de Estudios Avanzados del Instituto Polit6cnico Nacional(CINVESTAV-IPN) Km. 9.6 Libramiento Norte Carr. Irapuato-Leen 36821 Irapuato Guanajuato Mexico present address: max Planck Institute for Plant Breeding Research D-50829 Cologne Germany Present address: INRIA Project-Team virtual Plants/CIRAD/INRA UMR AGAP Campus St Priest - BAT 5 CC 05018 860 rue de St Priest 34095 Montpellier Cedex5 France

In Arabidopsis thaliana, multiple genes involved in shoot apical meristem （SAm） transitions have been char- acterized, but the mechanisms required for the dynamic attainment of vegetative, inflorescence, and floral meristem （vm, Im, Fm） cell fates during SAm transitions are not well understood. Here we show that a mADS-box gene, XAANTAL2 （XAL2/AGL14）, is necessary and sufficient to induce flowering, and its regula- tion is important in Fm maintenance and determinacy, xal2 mutants are late flowering, particularly under short-day （SD） condition, while XAL2 overexpressing plants are early flowering, but their flowers have vege- tative traits. Interestingly, inflorescences of the latter plants have higher expression levels of LFY, AP1, and TFL1 than wild-type plants. In addition we found that XAL2 is able to bind the TFL1 regulatory regions. On the other hand, the basipetal carpels of the 35S：：XAL2 lines lose determinacy and maintain high levels of WuS expression under SD condition. To provide a mechanistic explanation for the complex roles of XAL2 in SAm transitions and the apparently paradoxical phenotypes of XAL2 and other mADS-box （SOCl, AGL24） over- expressors, we conducted dynamic gene regulatory network （GRN） and epigenetic landscape modeling. We uncovered a GRN module that underlies vm, Im, and Fm gene configurations and transition patterns in wild- type plants as well as loss and gain of function lines characterized here and previously. Our approach thus provides a novel mechanistic framework for understanding the complex basis of SAm development.

关键词： XAL2/AGL14 mADS-box TFL1 SAm transitions floral reversion gene regulatory networks,epigenetic landscape modeling

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