Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts

作     者：Bandari Uma Mahesh Shweta Shrivastava Rajeswara Rao Pragada V.G.M.Naidu Ramakrishna Sistla Bandari Uma Mahesh;Shweta Shrivastava;Rajeswara Rao Pragada;V.G.M. Naidu;Ramakrishna Sistla;Department of Pharmacology, A.U. College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh, India -530003;Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research (NIPER-Hyderabad), Balanagar, Hyderabad, Andhra Pradesh, India-500037;Pharmacology Division, Indian Institute of Chemical Technology, Habsiguda, Hyderabad, Andhra Pradesh, ndia-500007

作者机构：Department of Pharmacology A.U.College of Pharmaceutical Sciences Andhra University Vishakhapatnam Andhra Pradesh India -530003 Department of Pharmacology & Toxicology National Institute of Pharmaceutical Education & Research (NIPER-Hyderabad) Balanagar Hyderabad Andhra Pradesh India-500037 Pharmacology Division Indian Institute of Chemical Technology Habsiguda Hyderabad Andhra Pradesh ndia-500007 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2014年第12卷第9期

页      面：663-671页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：NIPER-Hyderabad for financial support 

主　　题：extracts peroxidation glutathione dehydrogenase protective alcoholic antioxidant ABTS histology curcumin 

摘      要：Paracetamol(PCM) hepatotoxicity is related to reactive oxygen species(ROS) formation and excessive oxidative stress; natural antioxidant compounds have been tested as an alternative therapy. This study evaluated the hepatoprotective activity of an alcoholic extract of Boswellia ovalifoliolata(BO) bark against PCM-induced hepatotoxicity. BO extract also demonstrated antioxidant activity in vitro, as well as scavenger activity against 2, 2-diphenyl-1-picrylhydrazyl. Administration of PCM caused a significant increase in the release of transaminases, alkaline phosphatase, and lactate dehydrogenase in serum. Significant enhancement in hepatic lipid peroxidation and marked depletion in reduced glutathione were observed after parac intoxication with severe alterations in liver histology. BO treatment was able to mitigate hepatic damage induced by acute intoxication of PCM and showed a pronounced protective effect against lipid peroxidation, deviated serum enzymatic variables, and maintained glutathione status toward control. The results clearly demonstrate the hepatoprotective effect of BO against the toxicity induced by PCM.