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Methane and nitrous oxide emissions from a subtropical coastal embayment(Moreton Bay, Australia)

Journal of Environmental Sciences 2015年第3期27卷 82-96页

作者： Ronald S.Musenze ursula Werner Alistair Grinham James Udy Zhiguo Yuan Advanced Water Management Centre (AWMC) The University of Queensland Department of Civil and Environmental Engineering College of Engineering Design Arts and Technology Makerere University School of Civil Engineering The University of Queensland Healthy Waterways Ltd.

Surface water methane （CH4） and nitrous oxide （N20） concentrations and fluxes were investigated in two subtropical coastal embayments （Bramble Bay and Deception Bay, which are part of the greater Moreton Bay, Australia）. Measurements were done at 23 stations in seven campaigns covering different seasons during 2010-2012. Water-air fluxes were estimated using the Thin Boundary Layer approach with a combination of wind and currents-based models for the estimation of the gas transfer velocities. The two bays were strong sources of both CH4 and N2O with no significant differences in the degree of saturation of both gases between them during all measurement campaigns. Both CH4 and N2O concentrations had strong temporal but minimal spatial variability in both bays. During the seven seasons, CH4 varied between 500% and 4000% saturation while N2O varied between 128 and 255% in the two bays. Average seasonal CH4 fluxes for the two bays varied between 0.5 ± 0.2 and 6.0 ± 1.5 mg CH4/（m^***） while N20 varied between 0.4 ± 0.1 and 1.6 ± 0.6 mg N2O/（m^2-day）. Weighted emissions （t CO2-e） were 63%-90% N2O dominated implying that a reduction in N2O inputs and/or nitrogen availability in the bays may significantly reduce the bays＇ greenhouse gas （GHG） budget. Emissions data for tropical and subtropical systems is still scarce. This work found subtropical bays to be significant aquatic sources of both CH4 and N2O and puts the estimated fluxes into the global context with measurements done from other climatic regions.

关键词： Greenhouse gas emissions Subtropical aquatic systems Bay Methane Nitrous oxide Uncertainty

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Association mapping for root system architecture traits under two nitrogen conditions in germplasm enhancement of maize doubled haploid lines

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The Crop Journal 2020年第2期8卷 213-226页

作者： Langlang Ma Chunyan Qing ursula Frei Yaou Shen Thomas Lübberstedt Department of Agronomy Iowa State UniversityAmes 50010USA Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region Maize Research InstituteSichuan Agricultural UniversityChengdu 611130China

Root system architecture(RSA)contributes to nitrogen(N)uptake and utilization in *** this study,a germplasm enhancement of maize double haploid population of 226 lines genotyped with 61,634 SNPs was used to investigate the genetic basis of RSA under two N levels using a genome-wide association study(GWAS).GLM+PCA,FarmCPU,and MLM models were utilized to balance false positives and false *** total,33 and 51 significant SNP-trait associations were detected under high and low N conditions,*** high N,SNP S9_2483543 was detected by all *** disequilibrium(LD)regions of some SNPs overlapped with the intervals of QTL for RSA and N response that were detected in previous *** particular,several known genes,Rtcs,Rtcl,Rtcl,and Ms44,were located in the LD regions of S1_9992325,S9_151726472,S9_154381179,and S4_197073985,*** the candidate genes identified by this study,GRMZM2G139811,GRMZM2G314898,GRMZM2G054050,GRMZM2G173682,GRMZM2G470914,GRMZM2G462325,GRMZM2G416184,and GRMZM2G064302 were involved in seedling,seed,and root system development or N metabolism in Arabidopsis or *** markers identified in this study can be used for marker-assisted selection of RSA traits to improve nitrogen use efficiency in maize breeding,and the candidate genes will contribute to further understanding of the genetic basis of RSA under diverse N conditions.

关键词： germplasm breeding seedling

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In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds:An Update

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Genomics, Proteomics & Bioinformatics 2017年第4期15卷 236-245页

作者： ursula Catalan Laura Barrubes Rosa Maria Vails Rosa Soila Laura Rubio Functional Nutrition Oxidation and Cardiovascular Diseases Group(NFOC-Salut)Technological Center of Nutrition and Health(CTNS)lnstitut d'lnvestigacio Sanitaria Pere Virgili(IISPV)Faculty of Medicine and ttealth SciencesUniversitat Rovira i VirgiliReus 43201Spain Food Technology Department Universitat de Lleida-AGROTECNIO CenterLleida 25198Spain

Dietary phenolic compounds （PCs） have been receiving intercst lor their presumcd roles ill disease prevention. However, there is a lack of studies on the underlying molecular mechanisnls. In this regard, in vitro metabolomic approaches are suitable for the investigation o1 the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been cxalnined for PCs from rosemary （Rosmarinus officinalis）, olive oil, and reSVCl-atrol using cell-based mctabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vi[ro cell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro-and micro-nutrient meta- bolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerativc diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are nccdcd and testing the physiological conjugated forms of PCs in these cell systems could be of special interest.

关键词： Cell-based Metabolomics Phenolic compounds Mechanism of action Disease prevention

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Validity of studies suggesting preoperative chemotherapy for resectable thoracic esophageal cancer:A critical appraisal of randomized trials

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World Journal of Gastrointestinal Oncology 2020年第1期12卷 113-123页

作者： Giulia Manzini ursula Klotz Doris Henne-Bruns Michael Kremer Department of General and Visceral Surgery University of UlmUlm 89081Germany Department of General and Visceral Surgery Hospital of AarauAarau 5000Switzerland

BACKGROUND In 2015,Kidane published a Cochrane review and meta-analysis to summarise the impact of preoperative chemotherapy versus surgery alone on survival for resectable thoracic esophageal *** authors concluded that preoperative chemotherapy improved overall survival(OS).AIM The aim of this article was to assess the validity of the three most powerful studies included in the Cochrane review and the meta-analysis supporting the advantage of preoperative chemotherapy and to investigate the impact of an exclusion of these three studies on the result of the *** OS was selected as the endpoint of *** the ten included papers which analysed this endpoint,we identified the three publications with the highest weights influencing the final *** validity of these papers was analysed using the CONSORT checklist for randomized controlled *** performed a new meta-analysis without the three studies to assess their impact on the general result of the original *** The three analysed studies revealed several *** answers were found in up to one third of the items of the CONSORT *** information about sample-size calculation and power,unclear or inadequate randomisation,and missing blinded set-up were the most common *** the three criticized studies were excluded in the meta-analysis,preoperative chemotherapy showed no benefit in *** The three most powerful publications in the Cochrane review show substantial *** the exclusion of these studies from the meta-analysis,preoperative chemotherapy does not seem to result in an advantage in *** suggest a more critical appraisal regarding the validity of single studies.

关键词： Esophageal cancer Assessment of validity Meta-analysis CONSORT Overall survival

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Relationship between early nutrition and deep gray matter and lateral ventricular volumes of preterm infants at term-equivalent age

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World Journal of Pediatrics 2023年第5期19卷 460-468页

作者： Felicia Toppe Tobias Rasche Christel Weiss Alexandra Schock ursula Felderhoff-Müser Hanna Müller Department of Pediatrics I NeonatologyPediatric Intensive Careand Pediatric NeurologyUniversity Hospital EssenUniversity of Duisburg-EssenHufelandstr.5545147EssenGermany Department of Medical Statistics Biomathematicsand Information ProcessingMedical Faculty Mannheim of Heidelberg UniversityTheodor-Kutzer-Ufer 1-368167MannheimGermany Pediatric Surgery University Hospital MarburgUniversity of MarburgBaldingerstraße35043MarburgGermany Department of Pediatrics Neonatology and Pediatric Intensive CareUniversity Hospital MarburgUniversity of MarburgBaldingerstraße35043MarburgGermany

Background The survival of preterm infants has improved over the last decade,but impaired brain development leading to poor neurological outcomes is still a major comorbidity associated with *** aim of this study was to evaluate the effect of nutrition on neurodevelopment in preterm infants and identify markers for improved *** Totally 67 premature infants with a gestational age of 24–34 weeks and a birth weight of 450–2085 g were *** parameters and documented diet were collected from medical *** nutritional analysis comprised the protein,fat,carbohydrate,and energy intake during different time *** development was assessed by determining deep gray matter(DGM;basal ganglia and thalamus)and lateral ventricular(LV)volumes as measured on cerebral magnetic resonance imaging scans obtained at term-equivalent age(TEA),and potential associations between nutrition and brain volumetrics were detected by regression *** We observed a negative correlation between mean daily protein intake in the third postnatal week and MRI-measured DGM volume at TEA(P=0.007).In contrast,head circumference at a corrected age of 35 weeks gestation(P<0.001)and mean daily fat intake in the fourth postnatal week(P=0.004)were positively correlated with DGM ***,mean daily carbohydrate intake in the first postnatal week(P=0.010)and intraventricular hemorrhage(P=0.003)were revealed as independent predictors of LV *** The study emphasizes the importance of nutrition for brain development following preterm birth.

关键词： Deep gray matter Lateral ventricles Magnetic resonance imaging Nutrition Prematurity

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Complex derivatives valuation: applying the Least-Squares Monte Carlo Simulation Method with several polynomial basis

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Financial Innovation 2016年第1期2卷 1-14页

作者： ursula Silveira Monteiro de Lima Carlos Patricio Samanez Department of Industrial Engineering Pontifical Catholic University of Rio de JaneiroMarquês de São Vicente Street225/22453-900 GáveaRio de JaneiroBrazil

Background:This article investigates the Least-Squares Monte Carlo Method by using different polynomial basis in American Asian Options *** standard approach in the option pricing literature is to choose the basis *** comparing four different polynomial basis we show that the choice of basis interferes in the option's ***:We assess Least-Squares Method performance in pricing four different American Asian Options by using four polynomial basis:Power,Laguerre,Legendre and Hermite *** every American Asian Option priced,three sets of parameters are used in order to evaluate it ***:We show that the choice of the basis interferes in the option's price by showing that one of them converges to the option's value faster than any other by using fewer simulated *** the case of an Amerasian call option,for example,we find that the preferable polynomial basis is Hermite *** an Amerasian put option,the Power polynomial basis is *** empirical outcome is theoretically unpredictable,since in principle all basis can be indistinctly used when pricing the ***:In this article The Least-Squares Monte Carlo Method performance is assessed in pricing four different types of American Asian Options by using four different polynomial basis through three different sets of *** results suggest that one polynomial basis is best suited to perform the method when pricing an American Asian *** all basis can be indistinctly used when pricing the ***,our results does not confirm *** find that when pricing an American Asian put option,Power A is better than the other basis we have studied here whereas when pricing an American Asian call,Hermite A is better.

关键词： Complex derivatives valuation Least-Squares Monte Carlo Method Amerasian options Polynomial basis

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Management of cataract surgery in Lowe syndrome

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1198-1202页

作者： Katharina Eibenberger Sandra Rezar-Dreindl Franz Pusch ursula Schmidt-Erfurth Eva Stifter Department of Ophthalmology and Optometry Medical University of ViennaVienna 1090Austria Department of Anesthesiology Medical University of ViennaVienna 1090Austria

AIM: To evaluate the ophthalmic and anesthesiologic management of cataract surgery in children with Lowe syndrome receiving lens removal, the development and management of secondary ***: This retrospective case series included 12 eyes of 6 children with genetically verified Lowe syndrome receiving cataract removal. Information regarding the type and duration of surgery and total anesthesia time were recorded. Additionally, intra-and postoperative complications were noted as well as clinical examinations such as visual acuity and funduscopy. RESULTS: all children received simultaneous bilateral cataract surgery at the mean age of 8.98±3.58 wk. Lensectomy combined with posterior capsulotomy and anterior vitrectomy was performed in all children. The mean time for cataract surgery per eye was 35.83±8.86 min, whereas the total time of surgery was 153.33±22.11 min. The mean extubation time and duration at recovery room was 42.33±22.60 min and 130.00±64.37 min, respectively. During surgery, a decrease of oxygen saturation below 93% was found in only one child. During the postoperative followup, nystagmus(6 children) and strabismus(5 children) was commonly found in contrast to no case of visual axis opacification. Secondary glaucoma developed in five eyes of three children, which was treated with topical eye drops in only one child. A trabeculectomy was performed in both eyes of one child, whereas removal of syechia and an iridectomy in one eye of one child. CONCLUSION: Bilateral simultaneous cataract surgery under general anesthesia is a safe surgical procedure in Lowe syndrome children. The glaucoma screening with intraocular pressure measurements is crucial in the postoperative management of Lowe syndrome patients to avoid additional visual impairment.

关键词： Lowe syndrome congenital cataract pediatric cataract surgery

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18 mots pour comprendre Ce que dit l'islam

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法语学习 2002年第3期 80-87页

作者： ursula Gauthier Marie Lemonnier

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金雀异黄素对脂多糖诱导的巨噬细胞MAPK和TLR信号转导通路的影响

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细胞与分子免疫学杂志 2014年第3期30卷 233-236页

作者：崔树娜 ursula BILITEWSKI 扬州大学医学院江苏扬州225001 亥姆霍兹感染研究中心

目的研究金雀异黄素对脂多糖(LPS)诱导的巨噬细胞丝裂原活化蛋白激酶(MAPK)信号转导通路和Toll样受体(TLR)通路的影响。方法用100 ng/mL脂多糖和金雀异黄素分别处理RAW264.7巨噬细胞不同时间后,采用Western blot法检测对MAPK信号通路蛋... 详细信息

目的研究金雀异黄素对脂多糖(LPS)诱导的巨噬细胞丝裂原活化蛋白激酶(MAPK)信号转导通路和Toll样受体(TLR)通路的影响。方法用100 ng/mL脂多糖和金雀异黄素分别处理RAW264.7巨噬细胞不同时间后,采用Western blot法检测对MAPK信号通路蛋白磷酸化的影响;采用RT2 ProfilerTMPCR芯片检测金雀异黄素对LPS诱导的TLR信号转导通路基因表达的影响。结果 LPS能够显著诱导蛋白p38和p42/44磷酸化,激活MAPK信号通路,金雀异黄素能够加强其作用,同时,LPS能够显著诱导TLR信号转导通路的细胞因子基因表达,包括IFN-β、IL-10、IL-1α、IL-1β、IL-6、TNF-α、集落刺激因子2(CSF-2)、CSF-3、趋化因子CCL2和CXCL10、环氧合酶2(COX-2)、NF-κB1和IκB-α等,金雀异黄素能够显著降低这些上调基因的表达。结论金雀异黄素能够显著增强LPS激活的MAPK信号通路并抑制TLR信号通路的激活。

关键词：金雀异黄素脂多糖 RAW264 7巨噬细胞 MAPK TLR

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脾酪氨酸激酶抑制剂对脂多糖诱导巨噬细胞炎症反应的影响及机制

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细胞与分子免疫学杂志 2013年第10期29卷 1024-1027页

作者：崔树娜 ursula Bilitewski 扬州大学医学院江苏扬州225001 Helmholtz Center for Infection Research Braunschweig Germany 38124

目的研究脾酪氨酸激酶（Syk）在LtX3诱导的Toll样受体4（TLR4）信号转导通路的作用。方法用100ng／mL脂多糖和不同浓度Syk抑制剂分别处理RAW264．7巨噬细胞后，采用Alarmar blue方法检测细胞增殖；采用Griess试剂检测细胞培养液中NO的... 详细信息

目的研究脾酪氨酸激酶（Syk）在LtX3诱导的Toll样受体4（TLR4）信号转导通路的作用。方法用100ng／mL脂多糖和不同浓度Syk抑制剂分别处理RAW264．7巨噬细胞后，采用Alarmar blue方法检测细胞增殖；采用Griess试剂检测细胞培养液中NO的含量；Westernblot法检测诱导型一氧化氮合成酶（iNOS）的蛋白表达；ELISA检测巨噬细胞中TNF-α和IL-6含量，RAW—Blue巨噬细胞检测核因子KB（NF—KB）和激活子蛋白-1（AP-1）的活化。结果Syk抑制剂作用于RAW264．7巨噬细胞24h，（0．5～14．0）μmol／L的Syk抑制剂对细胞增殖无明显影响，但当剂量超过1．5μmol／L时，能显著抑制LPS刺激的RAW264．7巨噬细胞NO的产生和iNOS的蛋白表达，抑制TNF-α和IL-6的产生（P〈0．01）以及NF—KB和AP-1的激活。结论Syk抑制剂降低LPS诱导的巨噬细胞分泌NO和iNOS的蛋白表达及TNF-α和IL-6的释放，通过下调Syk下游TLR4受体信号传导通路的蛋白，进而显著降低转录因子NF-KB和AP-1的激活有关。

关键词： Syk抑制剂脂多糖 RAW264 7巨噬细胞抗炎作用

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