Relationship between early nutrition and deep gray matter and lateral ventricular volumes of preterm infants at term-equivalent age

作     者：Felicia Toppe Tobias Rasche Christel Weiss Alexandra Schock Ursula Felderhoff-Müser Hanna Müller Felicia Toppe;Tobias Rasche;Christel Weiss;Alexandra Schock;Ursula Felderhoff-Müser;Hanna Müller

作者机构：Department of Pediatrics INeonatologyPediatric Intensive Careand Pediatric NeurologyUniversity Hospital EssenUniversity of Duisburg-EssenHufelandstr.5545147EssenGermany Department of Medical StatisticsBiomathematicsand Information ProcessingMedical Faculty Mannheim of Heidelberg UniversityTheodor-Kutzer-Ufer 1-368167MannheimGermany Pediatric SurgeryUniversity Hospital MarburgUniversity of MarburgBaldingerstraße35043MarburgGermany Department of PediatricsNeonatology and Pediatric Intensive CareUniversity Hospital MarburgUniversity of MarburgBaldingerstraße35043MarburgGermany 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2023年第19卷第5期

页      面：460-468页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Deep gray matter Lateral ventricles Magnetic resonance imaging Nutrition Prematurity 

摘      要：Background The survival of preterm infants has improved over the last decade,but impaired brain development leading to poor neurological outcomes is still a major comorbidity associated with *** aim of this study was to evaluate the effect of nutrition on neurodevelopment in preterm infants and identify markers for improved *** Totally 67 premature infants with a gestational age of 24–34 weeks and a birth weight of 450–2085 g were *** parameters and documented diet were collected from medical *** nutritional analysis comprised the protein,fat,carbohydrate,and energy intake during different time *** development was assessed by determining deep gray matter(DGM;basal ganglia and thalamus)and lateral ventricular(LV)volumes as measured on cerebral magnetic resonance imaging scans obtained at term-equivalent age(TEA),and potential associations between nutrition and brain volumetrics were detected by regression *** We observed a negative correlation between mean daily protein intake in the third postnatal week and MRI-measured DGM volume at TEA(P=0.007).In contrast,head circumference at a corrected age of 35 weeks gestation(P0.001)and mean daily fat intake in the fourth postnatal week(P=0.004)were positively correlated with DGM ***,mean daily carbohydrate intake in the first postnatal week(P=0.010)and intraventricular hemorrhage(P=0.003)were revealed as independent predictors of LV *** The study emphasizes the importance of nutrition for brain development following preterm birth.