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Influence of Interrupted Childhood Biographies on Health Development: Evaluation of the Scientific Literature on the Example of Being Taken into Care*

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Journal of Biosciences and Medicines 2024年第7期12卷 108-119页

作者： Manuela Loderer ursula Gresser Dental Office for Orthodontics Dingolfing Germany Outpatient Clinic for Internal Medicine and Medical Expert reports Munich Germany

Background: An interrupted family history, as is the case after taking someone into care, can complicate collecting family anamnesis data. In addition, the interrupted family history itself could be considered part of a person’s risk profile. Aim and methods: Literature analysis was conducted to examine whether there are scientific studies on health development after placement in out-of-home-care in order to recognise any existing medical characteristics that may be relevant for internal medical care. results: There are few scientific publications on the health development of people after being placed in out-of-home-care. Direct reactions to the stress of being taken into custody include nausea and fever. However, effects that go beyond the acute situation and last into adulthood have also been described, such as AD(H)D, asthma, diabetes, cancer, hypertension and cardiovascular diseases (myocardial infarction, stroke), epilepsy and increased overall mortality in adulthood. Studies show that not only previous experience but also the stress of being taken into care is triggers for this. Conclusion: Information about a previous institutionalisation can hence be important for internal medical practice. The available scientific literature shows heterogeneous study methodology and no group of people with experience of out-of-home-placement has yet been scientifically accompanied for a long time period. Further studies on this could help to better weigh up the consequences of omitting and conducting an intervention for child/youth protection as well as to improve the medical care for this group of people.

关键词： Taking into Care Out-of-Home-Care Interrupted Family History Physical Outcomes Internal Medicine

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Suppression of MyD88 disturbs gut microbiota and activates the NLr pathway and hence fails to ameliorate DsS-inducedcolitis

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Precision Clinical Medicine 2024年第2期7卷 146-158页

作者： Jun-hua Li Yu Chen Zheng-hao Ye Li-ping Chen Jia-xin Xu Jian Han Lin Xie Shuai Xing De-an Tian ursula Seidler Jia-zhi Liao Fang Xiao Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany

Background:Myeloid differentiation factor 88(MyD88)is the core adaptor for Toll-like receptors defending against microbial invasion and initiating a downstream immune response during microbiota-host ***,the role of MyD88 in the pathogenesis of inflammatory bowel disease is *** study aims to investigate the impact of MyD88 on intestinal inflammation and ***:MyD88 knockout(MyD88^(-/-))mice and the MyD88 inhibitor(TJ-M2010-5)were used to investigate the impact of MyD88 on acute dextran sodium sulfate(Dss)-induced *** activity index,colon length,histological score,and inflammatory cytokines were examined to evaluate the severity of *** transcriptome analysis and 16S rDNA sequencing were used to detect the potential ***:In an acute DSS-colitis model,the severity of colitis was not alleviated in MyD88^(-/-)mice and TJ-M2010-5-treated mice,despite significantly lower levels of NF-kB activation being exhibited compared to control ***,16S rDNA sequencing and rNA transcriptome analysis revealed a higher abundance of intestinal Proteobacteria and an up-regulation of the nucleotide oligomerization domain-like receptors(NLrs)signaling pathway in colitis mice following MyD88 *** blockade of the NLrs signaling pathway or elimination of gut microbiota with broad-spectrum antibiotics in DsS-induced colitis mice treated with TJ-M2010-5 ameiorated the disease severity,which was not improved solely by MyD88 *** treatment with broad-spectrum antibiotics,downregulation of the NLr signaling pathway was ***:Our study suggests that the suppression of MyD88 might be associated with unfavorable changes in the composition of gut microbiota,leading to NLr-mediated immune activation and intestinal inflammation.

关键词： microbiota innate immunity myeloid differentiation factor 88,MyD88 inhibitor NOD-like receptor inflammatory bowel disease

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灰盖鬼伞中过表达的碱性真菌漆酶在高盐染料废水中的应用潜力

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微生物学报 2024年第8期64卷 3014-3029页

作者：王先华朱雪玲林嘉钇谷贤富彭齐霞肖亚中 ursula Kües 方泽民安徽大学生命科学学院安徽合肥230601 安徽省现代生物制造重点实验室安徽合肥230601 安徽省微生物与生物催化工程技术研究中心安徽合肥230601 University of Goettingen Goettingen 237077Germany

【目的】本研究利用双孢菇(Agaricus bisporus)gpdII启动子,实现了碱性真菌漆酶PIE5(CcPIE5)在灰盖鬼伞(Coprinopsis cinerea)FA2222中的同源过表达。【方法】在mKjalke液体培养基中37℃培养7 d,漆酶活力达到(24.2±1.1)U/mL。纯化的CcPIE5在pH 8.0和60℃下表现出最佳催化活性。【结果】与已经研究报道的真菌漆酶不同,CcPIE5能耐受高浓度NaCl,当NaCl浓度从0升至1.5 mol/L时,CcPIE5的k_(cat)和K_(m)均呈下降趋势,表示CcPIE5在纺织印染废水脱色中有潜在应用价值。进一步在染料废水脱色应用中,以丁香酸作为介体,CcPIE5在pH 8.5和60℃条件下可高效降解(92.9±2.3)%的靛蓝胭脂红。通过LC-MS分析确认,Isatin 5-sulfonic acid(ISA)是靛蓝胭脂红降解的主要副产物。【结论】CcPIE5在高温、碱性和含盐条件下高效脱色染料,是处理环境和工业特定应用的理想选择。

关键词：真菌漆酶过表达灰盖鬼伞高盐靛蓝胭脂红

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Substitution of Aggregates in Concrete and Mortar with Coltan Mining Waste: Mechanical, Environmental, and Economic Impact Case Study

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Journal of Minerals and Materials Characterization and Engineering 2024年第2期12卷 139-163页

作者： Alinabiwe Nyamuhanga Ally Élodie ruffine Zang Masika Muhiwa Grâce Manjia Marcelline Blanche ursula Joyce Merveilles Pettang Nana Ngapgue François Bella Nabil Chrispin Pettang Laboratory Engineering Civil and Mechanics Doctoral Research Unit for Engineering and Applications University of Yaound&#233 I Yaound&#233 Cameroon Department of Civil Engineering Faculty of Applied Sciences and Technologies Free University of Great Lakes Countries (ULPGL) Goma DRC Department of Civil Engineering National Advanced School of Engineering of Yaoundé University of Yaoundé I Yaoundé Cameroon Department of Civil Engineering Fotso Victor University Institute of Technology University of Dschang Bandjoun Cameroon FIMAS Laboratory Faculty of Technologies Tahri Mohamed University Bechar Algeria

The mining process involves drilling and excavation, resulting in the production of waste rock and tailings. The waste materials are then removed and stored in designated areas. This study aims to evaluate the mechanical strength and the environmental and economic impact of using Coltan Mining Waste (CMW) as a substitute for aggregates in concrete and mortar production. To achieve this, the CMW needs to be characterised. The Dreux Gorisse method was primarily used to produce concrete with a strength of 20 MPa at 28 days. The mortars, on the other hand, were formulated according to the NF P 18-452 standard. The environmental impact of using CMW as substitutes for natural aggregates in the production of concrete and mortar was analysed using SimaPro software. The results showed that mortars and concrete made with CMW have comparable compressive strengths to the reference mortar and concrete;reduce the negative impact on ecosystem quality, human health, resources, and climate change. It has also been shown that the substitution of aggregates by CMW reduces the cost of concrete and mortar as a function of the distance from the aggregate footprint.

关键词： Aggregate Coltan Mining Waste Concrete Mortar Mechanical Strength Life Cycle Analysis

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Aversive and non-reward learning in the fire-bellied toad using familiar and unfamiliar prey stimuli

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Current Zoology 2011年第6期57卷 709-716页

作者： ursula DICKE： Antje HEIDOrN Gerhard rOTH Brain research Institute University of Bremen 28334 Bremen Germany

The present study investigated how snapping behavior toward familiar and unfamiliar prey is modified by reward omission and aversive conditioning in the f^re-bellied toad Bombina orientalis. Toads were trained to snap at cricket images by rewarding them with live crickets. The task was learned, and the learning criterion （10 snapping responses within 2 minutes） was reached in all individuals investigated. Subsequent reward omission did not alter the frequency of snapping to the familiar cricket stimulus. Snapping decreased only in some individuals, when a mild foot shock was applied at snapping. However, at presenta- tion of images of hitherto unfamiliar meal worms and foot-shock application at snapping to the stimulus, the majority of toads diminished snapping significantly. Snapping responses decreased more rapidly, when snapping at meal worms was not rewarded or a footshock was applied uncorrelated to the presentation of or snapping at meal worms. These results demonstrate that in toads familiarity and unfamiliarity of prey stimuli are important factors in aversive learning, because well-trained responses to familiar stimuli become immune against reward omission. Furthermore, at presentation of unfamiliar stimuli, omission of reward and un- correlated footshock had a stronger aversive effect than correlated footshock [Current Zoology 57 （6）： 709-716, 2011 ].

关键词： Negative conditioning Food preference Amphibian Bombina orientalis response extinction

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Artificial sweetener sucralose: a possible modulator of autoimmune diseases

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5123-5125页

作者： Nicolle Kränkel ursula rauch-Kroehnert Deutsches Herzzentrum der Charité Klinik für KardiologieAngiologie und IntensivmedizinCampus Benjamin-Franklin(CBF)12203BerlinGermany DZHK(German Centre for Cardiovascular research) Partner site BerlinBerlinGermany Friede Springer—Centre of Cardiovascular Prevention@Charité Charité—University Medicine BerlinBerlinGermany

In their research article in Nature in March 2023,Fabio Zani and colleagues reported that high concentrations of the zero-calorie artificial sweetener sucralose affected the proliferation and differentiation of T cells toward interferon-γ-producing subsets,with no effect observed for B cells and myeloid cells.1 The publication has raised high hopes in the lay press on a widely available cure for patients suffering from autoimmune diseases.

关键词： autoimmune interferon diseases

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role of classical conditioning in learning gastrointestinal symptoms

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World Journal of Gastroenterology 2007年第25期13卷 3430-3437页

作者： ursula Stockhorst Paul Enck Sibylle Klosterhalfen Institute of Psychology General Psychology Ⅱ and Biological Psychology University of Osnabrueck Osnabrueck Germany Department of Psychosomatic Medicine and Psychotherapy University Hospital Tuebingen Tuebingen Germany

Nausea and/or vomiting are aversive gastrointestinal （GI） symptoms. Nausea and vomiting manifest unconditionally alter a nauseogenic experience. However, there is correlative, quasiexperimental and experimental evidence that nausea and vomiting can also be learned via classical （Pavlovian） conditioning and might occur in anticipation of the nauseogenic event. Classical conditioning of nausea can develop with chemotherapy in cancer patients. Initially, nausea and vomiting occur during and alter the administration of cytotoxic drugs （post-treatment nausea and vomiting） as unconditioned responses （Ur）. In addition, 20%-30% of cancer patients receiving chemotherapy report these side effects, despite antiemetic medication, when being re-exposed to the stimuli that usually signal the chemotherapy session and its drug infusion. These symptoms are called anticipatory nausea （AN） and/or anticipatory vomiting （ANV） and are explained by classical conditioning. Moreover, there is recent evidence for the assumption that post- chemotherapy nausea is at least partly influenced by learning. Alter summarizing the relevant assumptions of the conditioning model, revealing that a context can become a conditioned stimulus （CS）, the present paper summarizes data that nausea and/or vomiting is acquired by classical conditioning and, consequently, may be alleviated by conditioning techniques. Our own research has focussed on two aspects and is emphasized here. First, a conditioned nausea model was established in healthy humans using body rotation as the nausea- inducing treatment. The validity of this motion-sickness model to examine conditioning mechanisms in the acquisition and alleviation of conditioned nausea and associated endocrine and immunological responses is summarized. results from the rotation-induced motion sickness model showed that gender is an important moderator variable to be considered in further studies. This paper concludes with a review of the application of the demon

关键词： Cancer patients Classical conditioning Anticipatory nausea and vomiting Post chemotherapynausea Motion sickness Cortisol Tumor necrosisfactor-a Gender

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Land Parcel Land Use History as a Key to Site Selectionfor Documenting Soil Contamination risk: a Case Study from Australian Suburbia

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Geo-Spatial Information Science 2005年第4期8卷 257-261,275页

作者： YU Jie ursula Pietrzak Jim Peterson School of remote Sensing and Information Engineering Wuhan University 129 Luoyu Road Wuhan 430079 China 不详

In that orcharding in early to mid twentieth century southeastern Australia involved use of certain heavy metal and As compounds in regular pest control spray procedures, some interest attaches to the possibility that these landparcels are underlain by soils with above background Cu, Pb and As levels. Interpretation of Land cover changes allowed land parcels previously occupied by orchards to be identified in the 1950s through time series air photos. A comparison of soil analysis results referring to soil samples from control sites, and from land parcels formerly occupied by orchardists, shows that contamination (above background) levels of cations in the pesticides can be found in the top 6 cm of former orchard soils. It is clear that digital spatial data handling and culturally informed air photo interpretation has a place in soil contamination studies, land use planning (with particular reference to re development) and in administration of public health.

关键词： aerial photography digital orthophoto image soil contamination soil analysis land-use planning public health

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re-mention of an old neurodegenerative disease:Alzheimer's disease

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Chinese Science Bulletin 2013年第15期58卷 1731-1736页

作者： ZHANG Peng ADAMS ursula YUAN ZengQiang State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences Biological Sciences The University of Chicago

Alzheimer's disease(AD),the most common form of neuropsychiatric disorder,is characterized by neuronal degeneration and inexorably progressing dementia,especially in the elderly *** a rapidly aging population in both developed and developing countries,AD has emerged as one of the largest growing problems *** drugs improve the symptoms of AD,but do not have any profound intervention to delay its ***,understanding the molecular mechanisms underlying the genes tied to AD will be crucial to the development of therapeutic *** review will summarize the aetiology,pathology,and the evidence for the genetic components in AD,discuss the proposed amyloid cascade and the following tau hyperphosphorylation hypothesises,oxidative stress mediated neuronal cell death,as well as the function of retromer complex during the developing of *** laboratory's current research progress and the challenges that still remained will be also highlighted.

关键词：神经退行性疾病阿尔茨海默氏症阿尔茨海默氏病 Complex 老年痴呆症神经细胞死亡淀粉样蛋白精神障碍

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Exploring near-infrared absorbing nanocarriers to overcome cancer drug resistance

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Cancer Drug resistance 2020年第3期3卷 302-333页

作者： Siwei Chu ursula Stochaj Department of Physiology Faculty of MedicineMcGill UniversityMontreal H3G1Y6QuebecCanada.

One of the major obstacles of successful cancer therapy is cancer drug *** unique tools and applications developed by nanomedicine provide new approaches to surmount this common limitation of current treatment *** that absorb light in the near-infrared spectrum are particularly suitable for this *** nanocarriers can produce heat,release drugs or stimulate the production of physiologically relevant compounds when illuminated with near-infrared *** current review summarizes the causes contributing to cancer multidrug *** major types of nanocarriers that have been developed in recent years to overcome these hurdles are *** focus on nanoparticles that are responsive to near-infrared light and suitable to surmount cancer multidrug *** review concludes with the bottlenecks that currently restrict the use of nanocarriers in the clinic and an outlook on future directions.

关键词： Cancer drug resistance chemotherapy nanomedicine near-infrared light combination therapy photothermal therapy photodynamic therapy controlled drug release

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