Re-mention of an old neurodegenerative disease:Alzheimer's disease

作     者：ZHANG Peng ADAMS Ursula YUAN ZengQiang 

作者机构：State Key Laboratory of Brain and Cognitive SciencesInstitute of BiophysicsChinese Academy of Sciences Biological SciencesThe University of Chicago 

出 版 物：《Chinese Science Bulletin》 (Chinese Science Bulletin)

年 卷 期：2013年第58卷第15期

页      面：1731-1736页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：supported in part by the National Natural Science Foundation of China (81030025 and 81125010) the National Basic Research Program of China (2009CB918704) 

主　　题：神经退行性疾病 阿尔茨海默氏症 阿尔茨海默氏病 Complex 老年痴呆症 神经细胞死亡 淀粉样蛋白 精神障碍 

摘      要：Alzheimer s disease(AD),the most common form of neuropsychiatric disorder,is characterized by neuronal degeneration and inexorably progressing dementia,especially in the elderly *** a rapidly aging population in both developed and developing countries,AD has emerged as one of the largest growing problems *** drugs improve the symptoms of AD,but do not have any profound intervention to delay its ***,understanding the molecular mechanisms underlying the genes tied to AD will be crucial to the development of therapeutic *** review will summarize the aetiology,pathology,and the evidence for the genetic components in AD,discuss the proposed amyloid cascade and the following tau hyperphosphorylation hypothesises,oxidative stress mediated neuronal cell death,as well as the function of Retromer complex during the developing of *** laboratory s current research progress and the challenges that still remained will be also highlighted.