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Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea

Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 147-150页

作者： Ezeja Maxwell I Ezeigbo Ihechiluru I Madubuike Kelechi G Udeh Nkiru E ukweni iheanacho a Akomas Stella C Ifenkwe Daniel C Department of Veterinary Physiology Pharmacology and BiochemistryCollege of Veterinary MedicineMichael Okpara University of AgricultureUmudikeAbia StateNigeria

Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in ***:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea,charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar *** activity of the extract at different doses were compared to diphenoxylate(3 mg/kg) and atropine sulphate(3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of ***:The extract at the doses used caused a significant(P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea,decreased the distance travelled by the charcoal meal by up to 54.8%and also caused a dose dependent and significant(P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. Conclusions:Our results indicate that Pterocarpits erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.

关键词： Pterocarpus erinaceus Castor oil Entropooling Diarrhea Charcoal meal Diphenoxylate Atropine sulphate

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Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 430-432页

作者： Ezeigbo II Ezeja MI Madubuike KG Ifenkwe DC ukweni IA Udeh NE Akomas SC Department of Veterinary Physiology Biochemistry and Pharmacology College of Veterinary Medicine Michael Okpara University of Agriculture

Objective:To evaluate the antidiarrhoeal property of methanol extract of the leaves of Rauwolfia serpentina(R. serpentina) in experimental diarrhoea induced by castor oil in ***:Doses of 100, 200 and 400 mg/kgR. serpentinaleaf methanol extracts were administered to castor oil induced diarrhoea mice to determine its antidiarrhoeal ***:All doses of the extract and the reference drug atropine sulphate(3 mg/kg, i.p.) produced a dose-dependent reduction in intestinal weight and fluid volume. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to diphenoxylate Hcl(5 mg/kg, p.o.).Conclusions:The results show that the extract of R. serpentin a leaves has a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.

关键词： Rauwolfia serpentina Castor oil Antidiarrhoeal activity Intestinal transit

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