检索结果-南通市图书馆

Efficacy of incremental loads of cow's milk as a treatment for lactose malabsorption in Japan

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第4期11卷 797-808页

作者： Matsuri Hasegawa Kazuko Okada Satoru Nagata Shigetaka sugihara Department of Pediatrics Tokyo Women's Medical University Medical Center EastDepartment of PediatricsTokyo Women’s Medical University Medical Center EastArakawa-ku 116-8561TokyoJapan Department of Pediatrics Okada Pediatric ClinicShinjuku-ku 169-0072TokyoJapan Department of Pediatrics Tokyo Women’s Medical UniversityShinjuku-ku 162-8666TokyoJapan

BACKGROUND Lactose intolerance(LI)is commonly seen in East Asian countries.Several studies showed that lactose or milk loading has been used as a treatment for lactose malabsorption(LM)in Western countries,but there have been no reports regarding this type of treatment in Japan.As lactose or milk loading requires ingestion of large amounts of lactose within a short period,this is considered to be too harsh for Japanese people because of their less habitual milk consumption(175 mL per day in average)than Western people.In this study,we demonstrated lactose tolerance acquisition in a suitable way for Japanese.AIM To examine the efficacy of lactose(cow’s milk)loading treatment in patients with LM.METHODS Individuals with abdominal symptoms induced by milk or dairy products(LI symptoms)were identified with a questionnaire.A 20 g lactose hydrogen breath test(LHBT)was carried out to confirm LM diagnosis and to evaluate co-existence of small intestinal bacterial overgrowth(SIBO).Respondents diagnosed with LM were selected as study subjects and were treated with incremental loads of cow’s milk,starting from 30 mL and increasing up to 200 mL at 4-7 d intervals.After the treatment,changes in symptoms and LM diagnostic value of 20 g LHBT were investigated.Stool samples pre-and post-treatment were examined for changes in intestinal microbiota using 16S rRNA sequencing.Informed consent was obtained prior to each stage of the study.RESULTS In 46 subjects with LI symptoms(10-68 years old,mean age 34 years old)identified with the questionnaire,35(76.1%)were diagnosed with LM by 20 g LHBT,and 6 had co-existing SIBO.The treatment with incremental cow’s milk was carried out in 32 subjects diagnosed with LM(14-68 years old,median age 38.5 years old).The mean period of the treatment was 41±8.6 d.Improvement of symptoms was observed in 29(90.6%;95%confidence interval:75.0%-98.0%)subjects.Although 20 g LHBT indicated that 10(34.5%)subjects had improved diagnostic value of LM,no change was observed in 16(55.2%)subjects.Analysis of the f

关键词： Lactose Intolerance Lactose Malabsorption lactose loading treatment Intestinal bacterial flora Fecal microbiota

Successful embolization of an intrahepatic portosystemic shunt using balloon-occluded retrograde transvenous obliteration:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第6期10卷 2023-2029页

作者： Hidemasa Saito Satoru Murata Fumie sugihara Tatsuo Ueda Daisuke Yasui Izumi Miki Hiromitsu Hayashi Shin-Ichiro Kumita Department of Radiology Nippon Medical SchoolTokyo 113-8602Japan Center for Interventional Radiology Teikyo University Chiba Medical CenterChiba 299-0011Japan

BACKGROUND A congenital intrahepatic portosystemic shunt(IPSVS)is a rare vascular abnormality that is characterized by an anomalous intrahepatic venous tract that connects the intrahepatic portal vein with the hepatic venous system.Hepatic encephalopathy is an indication for IPSVS embolization,which is technically challenging because rapid blood flow through shunts can induce the migration of embolization material to systemic veins.This case report discusses the efficacy of percutaneous balloon-occluded retrograde transvenous obliteration for treating patients with IPSVSs.CASE SUMMARY A 75-year-old woman presented with a six-month history of repeated hepatic encephalopathy due to an IPSVS without liver cirrhosis.We successfully embolized the IPSVS using percutaneous balloon-occluded retrograde transvenous obliteration with interlocking detachable coils.After the procedure,the patient exhibited no symptoms of hepatic encephalopathy for 14 mo.CONCLUSION Balloon-occluded retrograde transvenous obliteration with detachable coils can be effective for the endovascular treatment of an IPSVS.

关键词： Hepatic veins Portal vein Hepatic encephalopathy Endovascular procedures Embolization Therapeutic Case report

Transileocolic endovascular treatment by a hybrid approach for severe acute portal vein thrombosis with bowel necrosis:Two case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第6期10卷 1876-1882页

作者： Sayaka Shirai Tatsuo Ueda Fumie sugihara Daisuke Yasui Hidemasa Saito Hiroyasu Furuki Shiei Kim Hiroshi Yoshida Shoji Yokobori Hiromitsu Hayashi Shin-ichiro Kumita Department of Radiology Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Radiology Nippon Medical School Musashi Kosugi HospitalKawasaki-shi 211-8533KanagawaJapan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School Tamanagayama HospitalTama-shi 206-8512TokyoJapan Department of Emergency and Critical Care Medicine Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan

BACKGROUND Acute portal vein thrombosis(PVT)with bowel necrosis is a fatal condition with a 50%-75%mortality rate.This report describes the successful endovascular treatment(EVT)of two patients with severe PVT.CASE SUMMARY The first patient was a 22-year-old man who presented with abdominal pain lasting 3 d.The second patient was a 48-year-old man who presented with acute abdominal pain.Following contrast-enhanced computed tomography,both patients were diagnosed with massive PVT extending to the splenic and superior mesenteric veins.Hybrid treatment(simultaneous necrotic bowel resection and EVT)was performed in a hybrid operating room(OR).EVTs,including aspiration thrombectomy,catheter-directed thrombolysis(CDT),and continuous CDT,were performed via the ileocolic vein under laparotomy.The portal veins were patent 4 and 6 mo posttreatment in the 22-year-old and 48-year-old patients,respectively.CONCLUSION Hybrid necrotic bowel resection and transileocolic EVT performed in a hybrid OR is effective and safe.

关键词： Bowel necrosis Endovascular treatment Hybrid operating room Hybrid treatment Portal vein thrombosis Transileocolic approach Case report

Automatic Generation of 3D Building Models with Multiple Roofs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2008年第S1期13卷 368-374页

作者： Kenichi sugihara Yoshitugu Hayashi Faculty of Information Media Gifu Keizai University Graduate School of Environmental Studies Nagoya University

Based on building footprints (building polygons) on digital maps, we are proposing the GIS and CG integrated system that automatically generates 3D building models with multiple roofs. Most building polygons’ edges meet at right angles (orthogonal polygon). The integrated system partitions orthogonal building polygons into a set of rectangles and places rectangular roofs and box-shaped building bodies on these rectangles. In order to partition an orthogonal polygon, we proposed a useful polygon expression in deciding from which vertex a dividing line is drawn. In this paper, we propose a new scheme for partitioning building polygons and show the process of creating 3D roof models.

关键词： 3D building model 3D urban model automatic generation CG GIS polygon partitioning

Coaxial boron nitride nanotubes as interfacial dielectric layers to lower interface trap density in carbon nanotube transistors

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第11期16卷 12840-12848页

作者： Keigo Otsuka Taiki sugihara Taiki Inoue Weijie Jia Satoru Matsushita Takanobu Saito Minhyeok Lee Takashi Taniguchi Kenji Watanabe Gregory Pitner Ming-Yang Li Tzu-Ang Chao Rong Xiang Shohei Chiashi Shigeo Maruyama Department of Mechanical Engineering The University of TokyoTokyo 113-8656Japan Department of Applied Physics Osaka UniversityOsaka 565-0871Japan Research Center for Materials Nanoarchitectonics National Institute for Materials ScienceTsukuba 305-0044Japan Research Center for Electronic and Optical Materials National Institute for Materials ScienceTsukuba 305-0044Japan Corporate Research Taiwan Semiconductor Manufacturing CompanySan JoseCA 95134USA Corporate Research Taiwan Semiconductor Manufacturing CompanyHsinchu 30078

A semiconductor/dielectric interface is one of the dominant factors in device characteristics,and a variety of oxides with high dielectric constants and low interface trap densities have been used in carbon nanotube transistors.Given the crystal structure of nanotubes with no dangling bonds,there remains room to investigate unconventional dielectric materials.Here,we fabricate carbon nanotube transistors with boron nitride nanotubes as interfacial layers between channels and gate dielectrics,where a single semiconducting nanotube is used to focus on switching behaviors at the subthreshold regime.The subthreshold swing of 68 mV·dec^(−1)is obtained despite a 100-nm-thick Sio_(2)dielectric,corresponding to the effective interface trap density of 5.2×10^(11)cm^(−2)·eV^(−1),one order of magnitude lower than those of carbon nanotube devices without boron nitride passivation.The interfacial layers also result in the mild suppression of threshold voltage variation and hysteresis.We achieve Ohmic contacts through the selective etching of boron nitride nanotubes with XeF2 gas,overcoming the trade-off imposed by wrapping the inner nanotubes.Negligible impacts of fluorinating carbon nanotubes on device performances are also confirmed as long as the etching is applied exclusively at source/drain regions.Our results represent an important step toward nanoelectronics that exploit the advantage of one-dimensional van der Waals heterostructures.

关键词： carbon nanotubes hexagonal boron nitride van der Waals interfaces field-effect transistors subthreshold swing selective etching

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人类胚胎植入过程中的细胞黏附分子(英文)

生理学报 2012年第3期64卷 247-258页

作者： Michiko N.Fukuda Kazuhiro sugihara 桑福德/伯纳姆医学研究所癌症中心拉霍亚加利福尼亚州美国滨松医科大学妇产科学系滨松静冈县日本

人类胚胎植入过程不仅受到在进化上保守的机制调节,而且也受到人类一种独有的机制调节。有证据显示,细胞黏附分子L-选择蛋白和trophinin在人类胚胎植入过程扮演独特的角色。在本文中,我们描述了L-选择素和trophinin的黏蛋白糖配体的双... 详细信息

人类胚胎植入过程不仅受到在进化上保守的机制调节,而且也受到人类一种独有的机制调节。有证据显示,细胞黏附分子L-选择蛋白和trophinin在人类胚胎植入过程扮演独特的角色。在本文中,我们描述了L-选择素和trophinin的黏蛋白糖配体的双重作用,也描述了trophinin相关蛋白bystin和tastin的双重作用。我们随后描述了滋养外胚层细胞和子宫内膜上皮细胞中由trophinin调节的信号转导。本综述也涵盖了钙依粘连蛋白和整合素在人类胚胎植入过程中的作用。

关键词：胚胎植入促性腺激素凋亡

Ambiguous Cylinders: a New Class of Impossible Objects

在线全文

学校读者我要写书评

暂无评论

Computer Aided Drafting,Design and Manufacturing 2015年第4期25卷 19-25页

作者： sugihara Kokichi Meiji Institute for the Advanced Study of Mathematical Sciences Meiji University Japan Science and Technology Agency CREST

This paper presents a new class of surfaces that give two quite different appearances when they are seen from two special viewpoints. The inconsistent appearances can be perceived by simultaneously viewing them directly and in a mirror. This phenomenon is a new type of optical illusion, and we have named it the ＂ambiguous cylinder illusion＂, because it is typically generated by cylindrical surfaces. We consider why this illusion arises, and we present a mathematical method for designing ambiguous cylinders.

关键词： ambiguous cylinder cylindrical surface impossible object optical illusion

ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture system

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2018年第4期10卷 253-262页

作者： Masaharu Noi Ken-Ichi Mukaisho Saori Yoshida Shoko Murakami Shinya Koshinuma Takeshi Adachi Yoshisato Machida Masashi Yamori Takahisa Nakayama Gaku Yamamoto Hiroyuki sugihara Department of Oral and Maxillofacial Surgery Shiga University of Medical Science Department of Pathology Division of Molecular Diagnostic PathologyShiga University of Medical Science Dental Oral Surgery Nagahama Red Cross Hospital

To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase(ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed that ERK and ezrin expressions were significantly higher in invasive squamous cell carcinoma than in carcinoma in situ. To investigate the roles of ERK and ezrin in cancer development, we used the non-woven silica fibre sheet Cellbedwith a structure resembling the loose connective tissue morphology in a novel 3 D culture system. We confirmed that the 3 D system using CellbedTMaccurately mimicked cancer cell morphology in vivo. Furthermore, cell projections were much more apparent in 3 D-cultured tongue cancer cell lines than in 2 D cultures. Typically, under conventional 2 D culture conditions, F-actin and cortactin are colocalized in the form of puncta within cells.However, in the 3 D-cultured cells, colocalization was mainly observed at the cell margins, including the projections. Projections containing F-actin and cortactin colocalization were predicted to be invadopodia. Although suppressing ezrin expression with small interfering RNA transfection caused no marked changes in morphology, cell projection formation was decreased, and the tumour thickness in vertical sections after 3 D culture was markedly decreased after suppressing ERK activity because both the invasion ability and proliferation were inhibited. An association between cortactin activation as well as ERK activity and invadopodia formation was detected. Our novel 3 D culture systems using Cellbed? are simple and useful for in vitro studies before conducting animal experiments. ERK contributes to tongue cancer development by increasing both cancer cell proliferation and migration via cortactin activation.

关键词： ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture sy HSC

Numerical Fitting of Planar Photographic Images with Spherical Voronoi Diagrams

在线全文

学校读者我要写书评

暂无评论

Computer Aided Drafting,Design and Manufacturing 2015年第4期25卷 26-31页

作者： CHAIDEE Supanut sugihara Kokichi Graduate School of Advanced Mathematical Sciences Meiji University

There are many phenomena that generate polygonal tessellations on surfaces of 3D objects. One interesting example is the jackfruit, a multiple fruit found in the tropics. A recent study found the best-fit spherical Voronoi diagram from a photo of jackfruit skin, but the optimization was relative to the radius of the sphere and the height of the spikes. In this study, we propose a method for adjusting the position of the center of the sphere in addition to these parameters. Experiments were conducted using both ideal and real data. However, convergence with real data has not been confirmed due to relaxation of the convergence condition.

关键词： spherical voronoi diagram jackfruit discrepancy circular search method of steepest descent