Efficacy of incremental loads of cow's milk as a treatment for lactose malabsorption in Japan

作     者：Matsuri Hasegawa Kazuko Okada Satoru Nagata Shigetaka Sugihara 

作者机构：Department of PediatricsTokyo Women's Medical University Medical Center EastDepartment of PediatricsTokyo Women’s Medical University Medical Center EastArakawa-ku 116-8561TokyoJapan Department of PediatricsOkada Pediatric ClinicShinjuku-ku 169-0072TokyoJapan Department of PediatricsTokyo Women’s Medical UniversityShinjuku-ku 162-8666TokyoJapan 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第4期

页      面：797-808页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Supported by Grants of J-milk(Japan Dairy Association) 

主　　题：Lactose Intolerance Lactose Malabsorption lactose loading treatment Intestinal bacterial flora Fecal microbiota 

摘      要：BACKGROUND Lactose intolerance(LI)is commonly seen in East Asian *** studies showed that lactose or milk loading has been used as a treatment for lactose malabsorption(LM)in Western countries,but there have been no reports regarding this type of treatment in *** lactose or milk loading requires ingestion of large amounts of lactose within a short period,this is considered to be too harsh for Japanese people because of their less habitual milk consumption(175 mL per day in average)than Western *** this study,we demonstrated lactose tolerance acquisition in a suitable way for *** To examine the efficacy of lactose(cow’s milk)loading treatment in patients with *** Individuals with abdominal symptoms induced by milk or dairy products(LI symptoms)were identified with a questionnaire.A 20 g lactose hydrogen breath test(LHBT)was carried out to confirm LM diagnosis and to evaluate co-existence of small intestinal bacterial overgrowth(SIBO).Respondents diagnosed with LM were selected as study subjects and were treated with incremental loads of cow’s milk,starting from 30 mL and increasing up to 200 mL at 4-7 d *** the treatment,changes in symptoms and LM diagnostic value of 20 g LHBT were *** samples pre-and post-treatment were examined for changes in intestinal microbiota using 16S rRNA *** consent was obtained prior to each stage of the *** In 46 subjects with LI symptoms(10-68 years old,mean age 34 years old)identified with the questionnaire,35(76.1%)were diagnosed with LM by 20 g LHBT,and 6 had co-existing *** treatment with incremental cow’s milk was carried out in 32 subjects diagnosed with LM(14-68 years old,median age 38.5 years old).The mean period of the treatment was 41±8.6 *** of symptoms was observed in 29(90.6%;95%confidence interval:75.0%-98.0%)*** 20 g LHBT indicated that 10(34.5%)subjects had improved diagnostic value of LM,no change was