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Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

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Science China Materials 2020年第6期63卷 1085-1098页

作者： Yanxian Guo Yang Li Wolun Zhang Hongru Zu Haihong Yu Dongling Li Honglian Xiong tristan THormel Chaofan Hu Zhouyi Guo Zhiming Liu Guang Provincial Key Laboratory of Laser Life Science&SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology College of BiophotonicsSouth China Normal UniversityGuangzhou510631China Guangdong Provincial Engineering Technology Research Center for Optical Agriculture College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642China Department of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528000China Casey Eye Institute Oregon Health and Science UniversityPortland97239 OregonUSA

Research on deep-tissue photothermal therapy(PTT)in the near-infrared II(NIR-II,1000–1350 nm)region has bloomed in recent years,owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I(NIR-I,650–950 nm)***,more details need to be uncovered to facilitate a fundamental understanding of NIR-Ⅱ***,a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide(MoO2)nanoaggregates was *** photothermal conversion capabilities of MoO2 in the NIR-I andⅡregions were investigated step by step,from a simple tissue phantom to a three-dimensional cellular system,and further to a tumor-bearing animal ***-Ⅱlaser exhibited a lower photothermal attenuation coefficient(0.541 at1064 nm)in a tissue phantom compared with its counterpart(0.959 at 808 nm),which allows it to be more capable of deeptissue PTT in vitro and in *** profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration ***,the depth-related tumor ablation was also studied by Raman fingerprint analysis,which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues,providing fundamental knowledge to NIR-Ⅱdeeptissue photothermal therapy.

关键词： second near-infrared window photothermal therapy molybdenum oxide depth profile analysis Raman biochemical assay

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Toehold switch based biosensors for sensing the highly trafficked rosewood Dalbergia maritima

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Synthetic and Systems Biotechnology 2022年第2期7卷 791-801页

作者： Paul Soudier Daniel Rodriguez Pinzon tristan Reif-Trauttmansdorff Hassan Hijazi Maeva Cherriere Catia Goncalves Pereira Doriane Blaise Maxime Pispisa Angelyne Saint-Julien William Hamlet Melissa Nguevo Eva Gomes Sophia Belkhelfa Anna Niarakis Manish Kushwaha Ioana Grigoras Evry Paris-Saclay 2020 iGEM team France Universite Paris-Saclay INRAEAgroParisTechMicalis Institute78352Jouy-en-JosasFrance Universite Paris-Saclay Univ EvryLaboratoire Europeen de Recherche pour la Polyarthrite Rhumatoïde-GenhotelEvryFrance Universite Paris-Saclay Univ EvryCNRSCEAGenomique MetaboliqueEvryFrance DNA Script Le Kremlin-BicetreFrance SYNMIKRO Center of Synthetic Microbiology MarburgGermany Universite Grenoble Alpes CEAInsermEDyP-BGEGrenobleFrance National Institute of Industrial Property(INPI) CourbevoieFrance

Nucleic acid sensing is a 3 decades old but still challenging area of application for different biological sub-domains,from pathogen detection to single cell transcriptomics *** many applications of nucleic acid detection and identification are mostly carried out by PCR techniques,sequencing,and their derivatives used at large ***,these methods’limitations on speed,cost,complexity and specificity have motivated the development of innovative detection methods among which nucleic acid biosensing technologies seem *** switches are a particular class of RNA sensing devices relying on a conformational switch of secondary structure induced by the pairing of the detected trigger RNA with a de novo designed synthetic sensing mRNA *** we describe a streamlined methodology enabling the development of such a sensor for the RNA-mediated detection of an endangered plant species in a cell-free reaction *** applied this methodology to help identify the rosewood Dalbergia maritima,a highly trafficked wood,whose protection is limited by the capacity of the authorities to distinguish protected logs from other unprotected but related *** streamlined pipeline presented in this work is a versatile framework enabling cheap and rapid development of new sensors for custom RNA detection.

关键词： Toehold switch Riboregulator Biosensor Rosewood

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Compare and Contrast of Options to Collect Freight Vehicle Data in Order to Inform Traffic Management Systems

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Journal of Civil Engineering and Architecture 2021年第8期15卷 393-407页

作者： Karlson Charlie Hargroves Daisy Shirley tristan Seppelt Natasha Callary Jonathan Tze Wei Yeo Ryan Loxton Curtin University Sustainability Policy Institute Perth 6845Australia University of Adelaide Adelaide 5001Australia Curtin University Perth 6845Australia

This paper outlines research findings from an investigation into a range of options for generating vehicle data relevant to traffic management *** data from freight vehicles with traffic management systems stands to provide a number of *** include reducing congestion,improving safety,reducing freight vehicle trip times,informing alternative routing for freight vehicles,and informing transport planning and investment *** paper will explore a number of different methods to detect,classify,and track vehicles,each having strengths and weaknesses,and each with different levels of accuracy and associated *** terms of freight management applications,the key feature is the capability to track in real time the position of the *** can be done using a range of technologies that either are located on the vehicle such as GPS(global positioning system)trackers and RFID(Radio Frequency Identification)Tags or are part of the network infrastructure such as CCTV(Closed Circuit Television)cameras,satellites,mobile phone towers,Wi-Fi receivers and RFID *** in this space is advancing quickly having started with a focus on infrastructure based sensors and communications devices and more recently shifting to GPS and mobile *** paper concludes with an overview of considerations for how data from freight vehicles may interact with traffic management systems for mutual *** new area of research and practice seeks to balance the needs of traffic management systems in order to better manage traffic and prevent bottlenecks and congestion while delivering tangible benefits to freight companies stands to be of great interest in the coming *** research has been developed with funding and support provided by Australia’s SBEnrc(Sustainable Built Environment National Research Centre)and its partners.

关键词： Freight vehicles vehicle generate data vehicle tracking

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制定可持续的流动资金策略

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首席财务官 2011年第8期9卷 56-57页

作者： tristan Attenborough Margaret Yao 摩根大通资金管理和证券服务部

金融危机后,CFO们更希望从传统的无风险投资中寻求安全保障。但是繁忙的他们没有时间测试流动资金策略的弹性是否足够,只能越发依靠熟悉和信任的银行排忧解难。

关键词：资金策略无风险投资金融危机安全保障 CFO 银行

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当今的重要事项（四）：制定可持续的流动资金策略

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中国总会计师 2010年第11期 I0020-I0022页

作者： tristan Attenborough Margaret Yao J.P.摩根财资及证券服务部

在本系列文章中，J．P．摩根的专家探讨了自金融危机以来出现的一些值得企业财务主管关注的重要事项，包括风险管理、效率提升、银行关系等等，这些并非新问题，但由于市场变得日益具挑战性，因而受到更多关注。本文探讨流动资金管理问... 详细信息

在本系列文章中，J．P．摩根的专家探讨了自金融危机以来出现的一些值得企业财务主管关注的重要事项，包括风险管理、效率提升、银行关系等等，这些并非新问题，但由于市场变得日益具挑战性，因而受到更多关注。本文探讨流动资金管理问题，这个问题对财务主管具普遍意义，现今变得更引人注目：虽然一直是关注重点，

关键词：资金策略财务主管金融危机风险管理效率提升银行关系管理问题流动资金

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Low phase noise K-band signal generation using polarization diverse single-soliton integrated microcombs

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Photonics Research 2024年第6期12卷 1175-1185页

作者： ALWALEED ALDHAFEERI HSIAO-HSUAN CHIN tristan MELTON DONG IL LEE ALLEN CHU WENTING WANG MINGBIN YU PATRICK GUO-QIANG LO DIM-LEE KWONG CHEE WEI WONG Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Institute of Microelectronics A*STARSingapore 117865Singapore State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technologyand Shanghai Industrial Technology Research InstituteShanghai 200050China

Frequency microcombs with microwave and millimeter-wave repetition rates provide a compact solution for coherent communication and information *** implementation of these microcombs using a CMOS-compatible platform further paves the way for large-scale photonic integration and ***,we demonstrate free-running soliton microcombs with K-band repetition rates with very low phase noise over a 4 GHz pump detuning range reaching−117(−123)dBc/Hz at 10 kHz offset for a 19.7(10)GHz carrier without active pump stabilization,exceeding commercial electronic microwave oscillators at frequency offsets above 40 *** minimum laser noise to soliton microwave signal transduction factor observed is−*** noise performance is achieved using a hybridized dual-mode for soliton generation to achieve passive thermal stabilization and minimal soliton spectrum shift from prior Raman scattering and dispersive wave *** further examine the locking of the repetition rate to an external ultrastable photonic oscillator to illustrate the feasibility of phase noise suppression below the thermorefractive noise limits of microresonator frequency combs.

关键词： pump polarization millimeter

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Understanding diarrhoeal diseases in response to climate variability and drought in Cape Town, South Africa: a mixed methods approach

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Infectious Diseases of Poverty 2023年第4期12卷 105-105页

作者： tristan Taylor Lee Mohamed Aqiel Dalvie Martin Röösli Sonja Merten Marek Kwiatkowski Hassan Mahomed Neville Sweijd Guéladio Cissé Swiss Tropical and Public Health Institute Allschwil Switzerland University of Basel Basel Switzerland Centre for Environmental and Occupational Health Research School of Public Health University of Cape Town Cape Town South Africa Metro Health Services Western Cape Government: Health and Wellness Western Cape South Africa Division of Health Systems and Public Health Department of Global Health Faculty of Medicine and Health Sciences Stellenbosch University Stellenbosch South Africa Alliance for Collaboration on Climate and Earth Systems Science Council for Scientific and Industrial Research Pretoria South Africa

BackgroundThe climate of southern Africa is expected to become hotter and drier with more frequent severe droughts and the incidence of diarrhoea to increase. From 2015 to 2018, Cape Town, South Africa, experienced a severe drought which resulted in extreme water conservation efforts. We aimed to gain a more holistic understanding of the relationship between diarrhoea in young children and climate variability in a system stressed by water *** a mixed-methods approach, we explored diarrhoeal disease incidence in children under 5 years between 2010 to 2019 in Cape Town, primarily in the public health system through routinely collected diarrhoeal incidence and weather station data. We developed a negative binomial regression model to understand the relationship between temperature, precipitation, and relative humidity on incidence of diarrhoea with dehydration. We conducted in-depth interviews with stakeholders in the fields of health, environment, and human development on perceptions around diarrhoea and health-related interventions both prior to and over the drought, and analysed them through the framework *** diarrhoeal incidence data, the diarrhoea with dehydration incidence decreased over the decade studied, e.g. reduction of 64.7% in 2019 [95% confidence interval (CI): 5.5–7.2%] compared to 2010, with no increase during the severe drought period. Over the hot dry diarrhoeal season (November to May), the monthly diarrhoea with dehydration incidence increased by 7.4% (95% CI: 4.5–10.3%) per 1 °C increase in temperature and 2.6% (95% CI: 1.7–3.5%) per 1% increase in relative humidity in the unlagged model. Stakeholder interviews found that extensive and sustained diarrhoeal interventions were perceived to be responsible for the overall reduction in diarrhoeal incidence and mortality over the prior decade. During the drought, as diarrhoeal interventions were maintained, the expected increase in incidence in the public health sector di

关键词： routine drought humidity

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一个阶下囚的自我救赎

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商业周刊（中文版） 2016年第13期 106-108页

作者： Bob Parks tristan Wheelock 微微

赫伯特·威廉姆斯（Herbert Williams）回忆到，即使是在缉毒警将装满百元大钞的牛皮纸袋递过来的时候，他满脑子想的都还是那艘船。缉毒警雇威廉姆斯建造一艘超陕双体船，他们说需耍用它将某些货物从哥伦比亚加速运到……德国去。

关键词：自我救赎威廉姆斯哥伦比亚双体船缉毒货物

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探索未知：Louis Nirenberg在偏微分方程方面的工作

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数学译林 2016年第3期35卷 193-200页

作者： tristan Riviere 王兢陆柱家苏黎世联邦理工学院

这是tristan Riviere于2015年5月20日所做Abel（阿贝尔）专题研讨会讲座的一个压缩版本．其详细版及参考文献请参阅***／abs／1505．04930的原始文本．

关键词：偏微分方程专题研讨会参考文献 Abel abs 阿贝尔

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视网膜光凝术联合中药治疗糖尿病性视网膜病变(英文)

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国际眼科杂志 2011年第4期11卷 577-580页

作者：赵宁万超邸平会孙瑞雪王建仓 tristan Bice 徐俊杰中国医科大学附属第一医院眼科中国辽宁省沈阳市110001 石家庄市第一医院中国河北省石家庄市050017 中国医科大学附属第一医院艾滋病实验室中国辽宁省沈阳市110001

目的:探讨口服滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变的临床疗效。方法:采用口服滋阴凉血散瘀汤联合视网膜光凝治疗糖尿病性视网膜病变患者,以单纯视网膜光凝为对照组,对比两组患者在治疗后1,6,12mo的视力、视野及新生血管的变... 详细信息

目的:探讨口服滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变的临床疗效。方法:采用口服滋阴凉血散瘀汤联合视网膜光凝治疗糖尿病性视网膜病变患者,以单纯视网膜光凝为对照组,对比两组患者在治疗后1,6,12mo的视力、视野及新生血管的变化情况。结果:口服滋阴凉血散瘀汤联合光凝治疗组患者12mo时视力提高(62.3%vs43.1%,P=0.037),视野改变(17.0±3.7vs14.9±3.7,P=0.002)及新生血管退缩情况(67.2%vs48.3%,P=0.036)均优于对照组患者。结论:滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变较单纯激光治疗更有效。

关键词：激光光凝滋阴凉血散瘀汤糖尿病性视网膜病变

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