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An Analysis of the Potential Benefits of Metformin on Disease Recurrence in Oral and Oropharyngeal Squamous Cell Carcinoma

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Journal of Cancer Therapy 2013年第5期4卷 961-965页

作者： Christopher F. Thompson Marilene B. Wang Yas Sanaiha Chi Lai tristan Grogan David Elashoff Maie A. St. John Department of Head and Neck Surgery University of California Los Angeles USA Department of Medicine Statistics Core University of California Los Angeles USA Department of Pathology and Laboratory Medicine University of Cali- fornia Los Angeles USA

Objective: Diabetes mellitus type 2 has been associated with increased cancer risk and cancer related mortality. Metformin, one of the most widely used anti-diabetic medications, has been found to have important anticancer properties in addition to hypoglycemic effects. The effects of metformin on clinical outcomes in oral cavity (OC) and oropharyngeal (OP) squamous cell carcinoma (SCC) have not been thoroughly analyzed. The purpose of this study was to evaluate the effects of metformin use on cancer recurrence in diabetic patients with oral cavity and oropharyngeal squamous cell carcinoma. Design: Retrospective review. Setting: Academic tertiary medical center. Patients: Seventy-seven patients with diabetes mellitus type 2 and oral cavity or oropharyngeal squamous cell carcinoma were treated and followed at our tertiary academic institution and the Veterans Affairs Greater Los Angeles Healthcare System from 1998 to 2012. Main Outcome Measure: Cox proportional hazards models and Kaplan-Meier curves were constructed to determine if metformin has an effect on disease recurrence after primary cancer treatment. Results: Metformin does not appear to have a significant effect on disease recurrence in patients with OC/OP SCC and diabetes mellitus type 2 (p = 0.53). Even when including only patients with stage I or II disease, metformin still did not decrease recurrence (p = 0.60). Conclusion: Herein, our data suggest that metformin use does not significantly impact time until recurrence for diabetic patients with OC/OP SCC.

关键词： Metformin Head and Neck Cancer Oral Squamous Cell Carcinoma Oropharyngeal Squamous Cell Carcinoma

Thresholds of Instability: Precipitation, Landslides, and Early Warning Systems in Brazil

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International Journal of Geosciences 2023年第10期14卷 895-912页

作者： Maiconn Vinicius de Moraes Luana Albertani Pampuch Cassiano Antonio Bortolozo Tatiana Sussel Gonçalves Mendes Marcio Roberto Magalhães de Andrade Daniel Metodiev tristan Pryer Environmental Engineering Department Institute of Science and Technology S&#227o Paulo State University S&#227o José dos Campos Brazil Cemaden—National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development S&#227o José dos Campos Brazil Department of Mathematical Sciences University of Bath Bath UK

Rainfall accumulation thresholds are crucial for issuing landslide warnings by identifying when soil saturation from rain could potentially trigger a landslide. Two essential types of thresholds are considered: environmental and operational. The environmental threshold indicates the minimum rainfall level required to potentially initiate a landslide. Conversely, the operational threshold is set lower to enable agencies to issue alerts before reaching environmental thresholds. Establishing these thresholds improves the accuracy of landslide predictions in terms of location and timing. This study introduces an innovative approach for determining these thresholds. Our approach employs cluster analysis and historical landslide data from the Metropolitan Region of Recife, Pernambuco State, Brazil. We applied our defined values to a significant landslide event in 2022, validating their robustness as the foundation for the operational threshold used by Cemaden, Brazil’s National Center for Monitoring and Early Warning of Natural Disasters.

关键词： Cluster Analysis Landslides Environmental Thresholds Rainfall Brazil

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上海金融衍生产品交易所

建筑技艺 2010年第3期16卷 117-121页

作者： AREP d'Ascia SMAD Silvio d'Ascia tristan Chapuis 上海现代建筑设计集团

上海金融衍生产品交易所项目（DDDPC）位于上海浦东新区，南面毗邻河流，园区内绿色苍翠，就像铺着一条绿地毯，衬托出整个建筑群层次分明的布局形态。整个项目建筑面积达100000平方米，其中绿化面积34000平方米，分两阶段进行，2009年... 详细信息

上海金融衍生产品交易所项目（DDDPC）位于上海浦东新区，南面毗邻河流，园区内绿色苍翠，就像铺着一条绿地毯，衬托出整个建筑群层次分明的布局形态。整个项目建筑面积达100000平方米，其中绿化面积34000平方米，分两阶段进行，2009年已基本完工。

关键词：上海浦东新区衍生产品交易所金融建筑面积绿化面积建筑群平方

High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging

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Light(Science & Applications) 2018年第1期7卷 193-200页

作者： Sergey Turtaev Ivo T.Leite tristan Altwegg-Boussac Janelle M.P.Pakan Nathalie L.Rochefort Tomáš Čižmár Leibniz Institute of Photonic Technology Albert-Einstein-Straße 9Jena 07745Germany School of Life Sciences University of DundeeNethergateDundee DD14HNUK School of Science and Engineering University of DundeeNethergateDundee DD14HNUK Centre for Discovery Brain Sciences University of EdinburghHugh Robson Building 15George SquareEdinburgh EH89XDUK Center for Behavioral Brain Sciences Institute of Cognitive Neurology and Dementia ResearchGerman Center for Neurodegenerative DiseasesLeipziger Straße 44Haus 64Magdeburg 39120Germany Simons Initiative for the Developing Brain University of EdinburghEdinburgh EH89XDUK Institute of Scientific Instruments of CAS Kralovopolska 147Brno 61264Czech Republic

Progress in neuroscience relies on new techniques for investigating the complex dynamics of neuronal *** ongoing challenge is to achieve minimally invasive and high-resolution observations of neuronal activity in vivo inside deep brain *** introduced methods for holographic control of light propagation in complex media enable the use of a hair-thin multimode optical fibre as an ultranarrow imaging *** to endoscopes based on graded-index lenses or fibre bundles,this new approach offers a footprint reduction exceeding an order of magnitude,combined with a significant enhancement in *** designed a compact and high-speed system for fluorescent imaging at the tip of a fibre,achieving a resolution of 1.18±0.04μm across a 50-μm field of view,yielding 7-kilopixel images at a rate of 3.5 frames/***,we demonstrate in vivo observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anaesthetised *** study paves the way for modern microscopy to be applied deep inside tissues of living animal models while exerting a minimal impact on their structural and functional properties.

关键词： multimode fibre vivo

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独立设计

现代装饰（家居） 2012年第2期 117-127页

作者： Nacho Carbonell Elisa Cavani Marco Iannicelli tristan Cochrane 肖俊代照 Danya

独立设计(independent design),根据词面的意思可理解为依靠自己或某单独运营组织的力量去做设计或创新,这样的设计并不依附于主流的价值观,而是以设计师对事物的独特价值观为设计思想。这样的设计,一方面需要设计师从材料工艺等方面进... 详细信息

独立设计(independent design),根据词面的意思可理解为依靠自己或某单独运营组织的力量去做设计或创新,这样的设计并不依附于主流的价值观,而是以设计师对事物的独特价值观为设计思想。这样的设计,一方面需要设计师从材料工艺等方面进行考量;另一方面则需要设计师注重设计语言以及产品功能展示方面的表达。

关键词：材料工艺动力传输设计语言元部件灵感来源原创设计运营组织脚凳玻璃器皿外部结构

High-finesse Fabry-Perot cavities with bidimensional Si_(3)N_(4) photonic-crystal slabs

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Light(Science & Applications) 2016年第1期5卷 320-327页

作者： Xu Chen Clément Chardin Kevin Makles Charles Caër Sheon Chua Rémy Braive Isabelle Robert-Philip tristan Briant Pierre-François Cohadon Antoine Heidmann Thibaut Jacqmin Samuel Deléglise Laboratoire Kastler Brossel UPMC-Sorbonne UniversitésCNRSENS-PSL Research UniversityCollège de France4 place JussieuCase 74F75252 ParisFrance Current address:IBM Research-Zürich Säumerstrasse 48803 RüschlikonSwitzerland Laboratoire de Photonique et de Nanostructures LPN-CNRS/CNRS Route de Nozay91460 MarcoussisFrance UniversitéParis Diderot Sorbonne Paris Cité75207 ParisFrance

Light scattering by a two-dimensional photonic-crystal slab(PCS)can result in marked interference effects associated with Fano *** devices offer appealing alternatives to distributed Bragg reflectors and filters for various applications,such as optical wavelength and polarization filters,reflectors,semiconductor lasers,photodetectors,bio-sensors and non-linear optical *** PCS also have natural applications in the field of optomechanics,where the mechanical modes of a suspended slab interact via radiation pressure with the optical field of a high-finesse *** reflectivity and transmission properties of a defect-free suspended PCS around normal incidence can be used to couple out-of-plane mechanical modes to an optical field by integrating it in a free-space *** we demonstrate the successful implementation of a PCS reflector on a high-tensile stress Si_(3)N_(4) *** illustrate the physical process underlying the high reflectivity by measuring the photonic-crystal band ***,we introduce a clear theoretical description of the membrane scattering properties in the presence of optical *** embedding the PCS inside a high-finesse cavity,we fully characterize its optical *** spectrally,angular-and polarization-resolved measurements demonstrate the wide tunability of the membrane’s reflectivity,from nearly 0 to 99.9470±0.0025%,and show that material absorption is not the main source of optical ***,the cavity storage time demonstrated in this work exceeds the mechanical period of low-order mechanical drum *** so-called resolved-sideband condition is a prerequisite to achieve quantum control of the mechanical resonator with light.

关键词： Fano resonance high-reflectivity membrane low-loss optical reflector nanomembrane resonator photonic-crystal slab quantum optomechanics

The SNAKE System: CEMADEN’s Landslide Early Warning System (LEWS) Mechanism

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International Journal of Geosciences 2023年第11期14卷 1146-1159页

作者： Marcio Roberto Magalhães de Andrade Cassiano Antonio Bortolozo Adenilson Roberto Carvalho Harideva Marturano Egas Klaifer Garcia Daniel Metodiev Tulius Dias Nery Carla Prieto tristan Pryer Silvia Midori Saito Graziela Scofield CEMADEN—National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development S&#227o José dos Campos Brazil Department of Mathematical Sciences University of Bath Bath UK

In Brazil, the prominent climate-induced disasters are floods and mass movements, with the latter being the most lethal. The spate of major landslide events, especially those in 2011, catalyzed the creation of CEMADEN (National Center for Monitoring and Early Warning of Natural Disasters). This article introduces one of CEMADEN’s pivotal systems for early landslide warnings and traces its developmental timeline. The highlighted SNAKE System epitomizes advancements in digital monitoring, forecasting, and alert mechanisms. By leveraging precipitation data from pluviometers in observed municipalities, the system bolsters early warnings related to potential mass movements, like planar slides and debris flows. Its deployment in CEMADEN’s Situation Room attests to its suitability for overseeing high-risk municipalities, attributed primarily to its robustness and precision.

关键词： Natural Disasters Landslide Early Warning System (LEWS) SNAKE System CEMADEN Brazil

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生死同堂:坟墓在清代法律中的意义

法律史译评 2020年第1期8卷 392-418页

作者： [美]张仲思陈煜(译) 麻省理工学院历史系中国政法大学法律史学研究院

前言在明清中国,坟墓除可作为死者的安息之所外,还可作为一种求得土地的有力的机制、获得和隐瞒财富乃至表达社会地位的有力机制。若干因素导致了用坟墓来说事儿,往往可奏奇效。明太祖于1370年发布火葬禁止令,强制民间进行土葬,在之后... 详细信息

前言在明清中国,坟墓除可作为死者的安息之所外,还可作为一种求得土地的有力的机制、获得和隐瞒财富乃至表达社会地位的有力机制。若干因素导致了用坟墓来说事儿,往往可奏奇效。明太祖于1370年发布火葬禁止令,强制民间进行土葬,在之后的几个世纪里,随着宗法制度的在全国范围内的重建,土葬这一与新儒家礼法实践密切相关的做法,亦风行于世。1国家通过法典和行政规章确认了坟墓和长眠于其中的死者的地位,对发冢这一行为施以严厉的刑罚。2对于不幸去世未能入土为安者,各县每年还要举行三次"厉坛"仪式,来超度亡魂。

关键词：南部县风水师地方官员清代法律

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