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Virtual screening of flavonoids from Jatropha gossypiifolia *** potential drugs for diabetic complications

Traditional Medicine Research 2022年第2期7卷 34-42页

作者： Yudith Cañizares-Carmenate Roberto Díaz-Amador Mirtha Mayra Gonzalez-Bedia Tan tran quang Nhat Francisco Torrens Juan Alberto Castillo-Garit Unit of Computer-Aided Molecular“Biosilico”Discovery and Bioinformatic Research Departamento de FarmaciaFacultad de Química-FarmaciaUniversidad Central“Marta Abreu”de Las VillasSanta Clara 54830Villa ClaraCuba Departamento de Ciencias de la Computación Facultad de MatemáticaFísica y ComputaciónUniversidad CelaraCuntral“Marta Abreu”de Las VillasSanta Clara 54830Villa ClaraCuba Institut Universitari de Ciència Molecular Universitat de ValènciaEdifici d’Instituts de PaternaP.O.Box 22085ValènciaSpain. Unidad de Toxicología Experimental Universidad de Ciencias Médicas de Villa ClaraSanta Clara 50200Villa ClaraCuba.

Background:Diabetes mellitus is a chronic metabolic disease that is a risk factor for epidemic *** hyperglycemic conditions,the enzyme aldose reductase catalyzes the formation of sorbitol in the metabolism of glucose via polyols,leading to the development of diabetic ***,inhibitors of this enzyme are therapeutic targets for the prophylaxis and treatment of these ***:In this study,a generalized linear regression model was developed to analyze flavonoids-obtained from a database-that have been tested as inhibitors of aldose *** this sense,the molecular descriptors implemented in DRAGON and MATLAB software were used to determine the correlation between the chemical structure of the inhibitors and their pharmacological *** model was validated according to the Organisation for Economic Co-operation and Development Standards and subsequently used for the virtual screening of the flavonoids identified in Jatropha gossypiifolia ***:The proposed model showed a good fit for its statistical parameters(R2=0.95).In addition,it showed good predictive power(R2 ext=0.94)and robustness(Q2 LOO=0.92).The experimental chemical space wherein the predictions were reliable(domain of application)was also ***,the model was used to identify 10 flavonoids from Jatropha gossypiifolia *** candidates for natural *** with a low probability of oral absorption were identified,among which the elagic acid biflavonoid showed the greatest promise(pIC50 predicted=9.75).Conclusion:The Jatropha gossypiifolia *** harbors flavonoids with high potential as inhibitors of the aldose reductase enzyme,in which the biflavonoid ellagic acid was shown to be the most promising inhibitor of the aldose reductase enzyme,suggesting its possible use in the treatment of the late complications of diabetes mellitus.

关键词： Jatropha gossypiifolia L. aldose reductase generalized linear regression model diabetic complications

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Current Status of Sludge Collection, transportation and Treatment in Ho Chi Minh City

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Journal of Environmental Protection 2013年第12期4卷 1329-1335页

作者： Nguyen trung Viet tran Thi My Dieu Nguyen Thi Phuong Loan Department of Environmental Management and Technology Van Lang University Ho Chi Minh City Vietnam.

In the process of construction and development, Ho Chi Minh City is discharging about six types of sludge: 1) sludge from urban wastewater drainage systems;2) sludge from industrial wastewater drainage system;3) sludge from the canal dredging activities periodically;4) sludge from septic tanks;5) sludge from the water treatment station/plant;6) sludge from the construction sites. Sludge’s components are very different among types of sludge, sludge from the sewer network and canal dredging contain mainly sand and soil (70% - 90% dry weight), while the sludge from the wastewater/water treatment station/plant and from septic tanks contain mainly biodegradable organic substances (55% - 80% dry weight). The concentrations of all above-mentioned sludge (except sludge from the hazardous industrial wastewater treatment plant) are lower than toxic threshold. The volume of total sludge is about 3000 - 4000 m3/day (5000 - 6000 tons/day), excepting the amount of sludge generated from the water treatment plant (which is collected and treated separately). Sludge from wastewater treatment plants and septic tanks is collected, transported and recycled to become organic fertilizer. The other types of sludge are collected, transported, and disposed at the “unknown” locations, even though they have different values for use.

关键词： Sludge Sludge Collection Sludge transportation Sludge Treatment Sludge Management

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Safe Vegetable Consumption in Hue City:A Case Study of Food Safety Situation in Vietnam

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Journal of Agricultural Science and Technology(A) 2017年第B10期7卷 119-130页

作者： Nguyen Vinh Truong tran Thi Bach Thao tran Thi Anh Tuyet Nguyen Van Khanh tran quang Khanh Van University of Agriculture and Forestry Hue UniversityHue 530000Vietnam Institute of Biotechnology Hue UniversityPhu ThuongPhu VangThua Thien Hue 530000Vietnam

Food safety has become a growing concern for citizens in the modern society when consuming unsafe food that directly impacts public health,life quality and well-being of each *** of Vietnam in general and specially in Hue city have been facing challenge of vegetable unsafety.A survey concerning the consumption of safe vegetables was conducted in Hue city,*** were collected by using a well-structured questionnaire from representative of 30 consumers,30 producers and 10 *** results showed that lettuce,sweet potato and Chinese mustard were identified as the most important vegetables to consumers in Hue *** of the consumers purchased vegetable every *** cost of vegetable in every transaction was about 30,000 *** expenditure has not created a great motivation for developing safe vegetable *** of the consumers in Hue city showed high interest,demand,trust and satisfaction for safe ***,50%of the consumers reported that the price of the safe vegetable was quite expensive and price was not matched with their ***,there were some disadvantages in each stage of vegetable supply *** example,land,seed,capital,cultivation techniques,preliminary processing,preservation,brand name,trademark and place to consume have not met the requirement of high technology production for the supply chain of safe *** chain linking between the production and consumption of vegetables is not *** and consumers do not have closely *** can not be traced to origin and there is no safe *** consumers believe the quality of vegetables depending on the prestige suppliers,such as,the vegetable shops with foreign *** vegetables of farmers are very difficult to be certified for safe *** and suggestions to Hue city are proposed that it is necessary to establish the vegetable production area in Hue *** growers should be supported w

关键词： Food safety vegetable consumption vegetable supplying chain Hue city

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An Analytical Approach for Nonlinear Buckling Analysis of Torsionally Loaded Sandwich Carbon Nanotube Reinforced Cylindrical Shells with Auxetic Core

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Advances in Applied Mathematics and Mechanics 2023年第2期15卷 468-484页

作者： Dang Thuy Dong Nguyen Thi Phuong Vu Hoai Nam Le Ngoc Ly Nguyen Van Tien Vu Minh Duc tran quang Minh Vu Tho Hung Nguyen Thi Huong Giang Faculty of Civil Engineering University of Transport TechnologyHanoi 100000Vietnam Graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-HiroshimaHiroshima 739-8527Japan Faculty of Fundamental Science for Engineering University of Transport TechnologyHanoi 100000Vietnam

The main aim of this paper is to present an analytical approach on the postbuckling for torsionally loaded sandwich carbon nanotube(CNT)reinforced cylindrical shells with the auxetic *** considered shells consist of three layers,external and internal CNT reinforced layers,and the auxetic lattice core made by isotropic *** homogenization model for honeycomb auxetic lattice core is utilized,and the equilibrium equations are formulated based on the nonlinear Donnell’s thin shell theory with von Karman geometrical *** three terms of deflection are considered,the Airy’s stress function and Galerkin’s method are utilized,the explicit expression of critical buckling of torsionally loaded shells and load-deflection expression of postbuckling states are *** effects of two carbon nanotube reinforced layers,the auxetic core layer,the volume fraction of carbon nanotube on the torsional buckling behavior are examined and remarked.

关键词： Nonlinear postbuckling carbon nanotube reinforced composite cylindrical shell torsion auxetic core

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Dry eye rate and its relationship with disease stage in patients with primary hypertension:a cross-sectional study in Vietnam

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 653-658页

作者： tran Tat Thang Pham Hong Phuong Nguyen Sa Huynh Nguyen trung Kien NguyenDuy Toan Nguyen Thi Thu Ha Le Ha Khoa Nguyen Huu Dung Thai Doan Thang Le Viet Thang Nghe An Eye Hospital Nghe An 43000Vietnam Nghe An Friendship General Hospital Nghe An 43000Vietnam Military Hospital 103 Ha Noi 100000Vietnam Vietnam Military Medical University Ha Noi 100000Vietnam Hanoi Medical University Ha Noi 100000Vietnam Bạch Mai Hospital Ha Noi 100000Vietnam TTH Vinh General Hospital Nghe An 100000Vietnam

AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary ***:A cross-sectional study included 432 patients with primary hypertension(with an equal number of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy subjects as a control *** Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 *** with OSDI scores<13 and Schirmer Ⅰ values equal to or under 10 mm were diagnosed with ***:The ratio of DE in hypertension patients was higher than in the control group(41.7%versus 18.8%;P<0.001).The proportion of patients with DE increased gradually according to the hypertension stage:27.1% in stage Ⅰ,40.3% in stage Ⅱ,and 57.6% in stage Ⅲ,P<***,duration of hypertension,plasma urea,creatinine,and high-sensitivity C-reactive protein(CRP-hs)levels in hypertension patients with DE were higher than those without DE,P<*** age,a long duration of hypertension,diabetes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,P<***:DE is a common disorder associated with advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.

关键词： primary hypertension dry eye stage of hypertension plasma creatinine

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Marker-Assisted Selection of Xa21 Conferring Resistance to Bacterial Leaf Blight in indica Rice Cultivar LT2

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Rice science 2018年第1期25卷 52-56页

作者： Hue Thi NGUYEN quang Hong VU Tan Van MAI Thu Thi NGUYEN Lam Duc VU Tung Thanh NGUYEN Long Viet NGUYEN Hien Thu Thi VU Hue Thi NONG trung Nguyen DINH Nakano TOSHITSUGU Liet Van VU Crop Research and Development Institute Vietnam National University of Agriculture Trau Qui Gia Lam Hanoi 10000 Vietnam Faculty of Agronomy Vietnam National University of Agriculture Trau Qui Gia Lam Hanoi 10000 Vietnam Faculty of Biotechnology Vietnam National University of Agriculture Trau Qui Gia Lam Hanoi 10000 Vietnam Faculty of Land Management Vietnam National University of Agriculture Trau Qui Gia Lam Hanoi 10000 Vietnam Japan International Cooperation Agency 16 Phan Chu Trinh Hoan Kiem Hanoi 10000 Vietnam

Bacterial leaf blight of rice (BLB), caused by Xanthomonas oryzae pv. oryzae, is one of the most destructive diseases in Asian rice fields. A high-quality rice variety, LT2, was used as the recipient ***21, which carries the Xa21 gene, was used as the donor parent. The resistance gene Xa21 was introduced into LT2 by marker-assisted backcrossing. Three Xoo races were used to inoculate the improved lines following the clipping method. Eleven BC_3F_3 lines carrying Xa21 were obtained based on molecular markers and agronomic performance. The 11 lines were then inoculated with the three Xoo races. All the 11 improved lines showed better resistance to BLB than the recipient parent LT2. Based on the level of resistance to BLB and their agronomic performance, five lines (BC_3F_3 5.***.5.1, BC_3F_3 5.***.5.12, BC_3F_3 8.***.6.44, BC_3F_3 9.***.4.1 and BC_3F_3 9.***.4.23) were selected as the most promising for commercial release. These improved lines could contribute to rice production in terms of food security.

关键词： rice backcrossing bacterial leaf blight marker-assisted selection

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Evaluation of the Ability to Apply Near-Infrared Spectroscopy on Direct Assay of Acyclovir in Tablets

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Journal of Pharmacy and Pharmacology 2017年第12期5卷 841-849页

作者： Le Dinh Chi tran Viet Hung Bui Van trung Doan Cao Son . The Department of Analytical Chemistry and Toxicology Hanoi University of Pharmacy Hanoi 110403 Vietnam Director Institute of Drug Quality Control Ho Chi Minh City Ho Chi Minh City 712161 Vietnam The Laboratory of Physical Measurements National Institute of Drug Quality Control Hanoi 110116 Vietnam Director National Institute of Drug Quality Control Hanoi 110116 Vietnam

This paper aimed at developing a simple and fast approach using chemometrics processing for direct assay of acyclovir in tablets by NIR （near infrared） spectroscopy in diffuse reflectance mode. In making trials with 5 different tablet matrices, the experimental results showed that regardless the matrix variation, it was always possible to construct a quantitative model with suitable linear range, accuracy and precision for direct assay of acyclovir in tablet from NIR spectra. Therefore, the approach used in this study was suitable for on-site fast assay of APIs in tablets during manufacturing process or in post-marketing surveillance of drug quality.

关键词： Near-infrared spectroscopy chemometrics acyclovir tablet partial least square regression direct assay.

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Monte Carlo simulation of a cone-beam CT system for lightweight casts

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Radiation Detection Technology and Methods 2021年第4期5卷 504-512页

作者： Thuy Duong tran Ngoc Ha Bui Kim Tuan tran Ngoc Toan tran Department of Nuclear Engineering and Environmental Physics School of Engineering PhysicsHanoi University of Science and Technology01 Dai Co VietHai Ba TrungHanoiVietnam Vietnam Atomic Energy Institute 59 Ly Thuong KietHoan KiemHanoiVietnam

Cone-beam computed tomography(CBCT),a modern technique with many applications,is becoming increasingly important and essential in many areas of economics and *** equipment has been commercialized in both hardware and ***,having a device system suitable for a specific group of objects will be the *** work used Monte Carlo simulation to optimize the design of a Cone-beam Computed Tomography(CBCT)for lightweight and small-size *** affecting image quality such as radiation-source,flat-panel detector,and geometrical distance were *** results indicate that an X-ray generator with a focal spot size of 4×4µm^(2),high voltage of 240 kV,and a radiation intensity of 10^(13) photon/s with a flat panel CsI(Tl)detector of 0.3 mm thickness and a pixel size of 0.1–0.2 mm,is suitable for a CBCT to inspect small objects in *** Monte Carlo model was validated against experiments and to evaluate some characteristics of the existing system.

关键词： Cone-beam computed technology Monte Carlo simulation Lightweight casts in industry Applied radiation

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Analysis of an Ar plasma jet in a dielectric barrier discharge conjugated with a microsecond pulse

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Plasma Science and Technology 2019年第9期21卷 73-81页

作者： Duc Ba NGUYEN quang Hung TRINH Won Gyu LEE Young Sun MOK Department of Chemical and Biological Engineering Jeju National University Jeju 63243 Republic of Korea Center for Advanced Chemistry Institute of Research and Development Duy Tan University 03 Quang Trung Da Nang Vietnam Division of Chemical Engineering and Bioengineering Kangwon National University Chuncheon Kangwon 24341 Republic of Korea

In this work, an Ar plasma jet generated by an AC-microsecond-pulse-driven dielectric barrier discharge reactor, which had two ring-shaped electrodes isolated from the ambient atmosphere by transformer oil, was investigated. By special design of the oil insulation, a chemically active Ar plasma jet along with a safe and stable plasma process as well as low emission of CO and NOxwere successfully achieved. The results indicated that applied voltage and frequency were basic factors influencing the jet temperature, discharge power, and jet length, which increased significantly with the two operating parameters. Meanwhile, gas velocity affected the jet temperature in a reverse direction. In comparison with a He plasma jet, the Ar plasma jet had relatively low jet temperature under the same level of the input parameters, being preferable for bio-applications. The Ar plasma jet has been tested to interact with human skin within 5 min without the perception of burnt skin and electrical shock.

关键词： Ar plasma jet atmospheric pressure plasma jet OES of Ar gas emission of Ar plasma jet transformer oil

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Molybdate Doped Polypyrrole： Preparation, Properties and Application

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材料科学与工程（中英文A版） 2013年第5期3卷 321-328页

作者： Ha Manh Hung Le Minh Duc tran Vinh Dieu Vu Quoc trung Faculty of Chemistry Hanoi National University of Education Cau Giay District Hanoi Vietnam Faculty of General Education Hanoi University of Mining and Geology Dong Ngac Tu Liem Hanoi Vietnam Faculty of Chemical Engineering Danang University oJ l"echnology Lien Chieu District Danang Vietnam Centre of Polymer Research Hanoi University of Science and Technology Hai Ba Trung District Hanoi Vietnam

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