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Removal of estrogens by electrochemical oxidation process

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Journal of Environmental Sciences 2014年第6期26卷 1355-1360页

作者： Vo Huu Cong Sota Iwaya Yutaka sakakibara Graduate School of Creative Science and Engineering Waseda University

Treatments of estrogens such as Estrone （El）, Estradiol （E2） and Ethinylestradiol （EE2） were conducted using an electrolytic reactor equipped with multi-packed granular glassy carbon electrodes. Experimental results showed that El, E2 and EE2 were oxidized in the range of 0.45-0.85 V and were removed through electro-polymerization. Observed data from continuous experiments were in good agreement with calculated results by a mathematical model constructed based on mass transfer limitation. In continuous treatment of trace estrogens （1 μg/L）, 98% of El, E2 and EE2 were stably removed. At high loading rate （100 μg/L）, removal efficiency of E1 was kept around 74%-88% for 21 days, but removal efficiency reduced due to passivation of electrodes. However, removal efficiency was recovered after electrochemical regeneration of electrodes in presence of ozone. Electric energy consumption was observed in the range of 1-2 Wh/m3. From these results, we concluded that the present electrochemical process would be an alternative removal of estrogens.

关键词： electro-polymerization electrode regeneration endocrine disrupting chemicals estrogen granular reactor

Metabolism and Long-distance Translocationof Cytokinins

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Journal of Integrative Plant Biology 2010年第1期52卷 53-60页

作者： Toru Kudo Takatoshi Kiba Hitoshi sakakibara RIKEN Plant Science Center

During plant development, distantly-located organs must communicate in order to adapt morphological and physiological features in response to environmental inputs. Among the recognized signaling molecules, a class of phytohormones known as the cytokinins functions as both local and long-distance regulatory signals for the coordination of plant development. This cytokinin-dependent communication system consists of orchestrated regulation of the metabolism, translocation, and signal transduction of this phytohormone class. Here, to gain insight into this elaborate signaling system, we summarize current models of biosynthesis, transmembrane transport, and long-distance translocation of cytokinins in higher plants.

关键词： Metabolism and Long-distance Translocationof Cytokinins Figure IPT Long

Efficacy of live attenuated vaccines after two doses of intravenous immunoglobulin for Kawasaki disease

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World Journal of Pediatrics 2022年第10期18卷 706-709页

作者： Yoshihiko Morikawa Hiroshi sakakibara Masaru Miura Clinical Research Support Center Tokyo Metropolitan Children’s Medical Center2-8-29 MusashidaiFuchuTokyo183-8561Japan Department of General Pediatrics Tokyo Metropolitan Children’s Medical CenterTokyoJapan Department of Cardiology Tokyo Metropolitan Children’s Medical CenterTokyoJapan

Kawasaki disease(KD)is a vasculitis of unknown etiology occurring predominantly in children under five years old[1].Coronary artery aneurysm,its most serious complica-tion,occurs in about 25%of untreated patients[2].High-dose intravenous immunoglobulin(IVIG)2 g/kg is used to prevent coronary artery aneurysms[1,3,4],but about 20%of patients are nonresponsive and require a second dose for a total of 4 g/*** appropriate timing of live attenuated vaccine(LAV)administration in such cases is unclear.

关键词： doses attenuated intravenous

Synthetic Study on Polyhydroxyestrogens Modeled for Inagami-Tamura Endogenous Digitalis-like Factor and Their Activity

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复旦学报（自然科学版） 2007年第5期46卷 603-604页

作者： Masayuki sakakibara Lab of Pharmaceutical Resource Discovery Dalian Institute of Chemistry and Physics

1 Results Mammalian possess receptors for digitalis,cardiac glycosides,derived from *** one of the results from studies on a real endogenous ligand for the receptors,so called an endogenous digitalis-like factor (EDF) or substance (EDS),Inagami and Tamura isolated a promising candidate possessing a molecular weight,*** elucidated several possible structures (Fig.1) for the factor and synthesized several modeled compounds,some of which exhibited remarkable constriction at higher concentrations t...

关键词： inagami-tamura endogenous digitalis-like factor (EDF) activity

Refractory gastric ulcer with abundant IgG4-positive plasma cell infiltration: A case report

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World Journal of Gastroenterology 2010年第17期16卷 2183-2186页

作者： Takayoshi Fujita Takafumi Ando Masatoshi sakakibara Waki Hosoda Hidemi Goto Department of Gastroenterology Aichi Cancer Center Aichi HospitalOkazaki CityAichi 444-0011Japan Department of Gastroenterology Nagoya University Graduate School of MedicineNagoya CityAichi 466-8550Japan Department of Pathology and Molecular Diagnostics Aichi Cancer CenterNagoya CityAichi 464-8681Japan

We describe a 77-year-old man with refractory gastric ulcer that worsened after Helicobacter pylori eradication *** showed marked infiltration of IgG4-positive plasma cells in the gastric lesions,which led us to suspect IgG4-related sclerosing *** the best of our knowledge,this is the first report of IgG4-related gastric ulcer without the main manifestation of autoimmune pancreatitis.

关键词： Sclerosis Gastric ulcer IgG4 Plasma cells

A Proposal of Hyperbolic Fitting Method by Applying the Properties of Functions for Plateau Surface Analysis in ISO 13565-3

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Nanomanufacturing and Metrology 2021年第2期4卷 86-96页

作者： Ryo sakakibara Ichiro Yoshida Yuki Kondo Munetoshi Numada Kenichi Yamashita HOSEI University Graduate School 3-7-2 KajinochoKoganei-shiTokyo184-8584Japan Faculty of Science and Engineering HOSEI University3-7-2 KajinochoKoganei-shiTokyo184-8584Japan Faculty of Engineering Chukyo University101-2 YagotohonmachiNagoyaShowa-kuAichi466-8666Japan ISUZU Advanced Engineering Center LTD8 TsuchidanaFujisawa-shiFujisawa-shiKanagawa252-0881Japan

ISO 13565-3 provides an evaluation method for plateau structure surfaces used as sliding surfaces in machine tools and automobile *** evaluation method for plateau structure surfaces of ISO 13565-3 has problems,such as the processing procedure has an ambiguous basis,and the calculation method is not *** existing evaluation method that solves these problems requires the implementation of a difficult *** subsequent evaluation methods,these problems were resolved,and the implementation of complicated calculation algorithms became ***,these methods use algorithms that do not conform to the evaluation method of ISO *** lack of adherence to the ISO standard may hinder their application in the industrial ***,in this study,a new method that conforms to the evaluation method of ISO 13565-3 with a more concise algorithm was *** concluded that this proposed method can contribute to the formation of plateau surfaces and production control in the industrial world.

关键词： Stratified functional properties Plateau surface Surface texture Surface roughness Material probability curve

Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification

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World Journal of Pediatrics 2020年第6期16卷 623-628页

作者： Yukari Atsumi Hiroshi sakakibara Yoshihiko Morikawa Koichi Miyata Hiroyuki Yamagishi Masahiro Misawa Masaru Miura Department of General Pediatrics Tokyo Metropolitan Children's Medical Center.TokyoJapan Clinical Research Support Center.Tokyo Metropolitan Children's Medical Center TokyoJapan Department of Cardiology.Tokyo Metropolitan Children's Medical Center.Tokyo Japan Department of Pediatrics Keio University School of MedicineTokyo.Japan Department of Pediatrics Tokyo Metropolitan Bokutoh HospitalTokyoJapan National Center for Global Health and Medicine.1-21-1.Toyama Shinjuku-kuTokyo 162-8655.Japan

Background Although Kawasaki disease(KD)is known to cause anemia,the relationship between its prognosis and hemoglobin level is less well *** We herein performed a secondary analysis of data from a previous study(Post-RAISE).Children aged 6 months to 2 years at the time of KD diagnosis were *** hemoglobin was defined as a decrease>10%on post-treatment day 2 compared with the level prior to the initial *** Of 1253 KD cases,treatment resistance was observed in 209(17%)and was significantly more frequent in the decreased hemoglobin group(37/167 vs.172/1086,P=0.041).Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment(odds ratio 1.53;95%confidence interval 1.00-2.33;P=0.048).Conclusions Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

关键词： Anemia Inflammation Hepcidin Kawasaki disease

Overexpression of INCREASED CAMBIAL ACTIVITY, a putative methyltransferase, increases cambial activity and plant growth

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Journal of Integrative Plant Biology 2016年第11期58卷 874-889页

作者： Hyunsook Kim Mikiko Kojima Daeseok Choi Soyoung Park Minami Matsui Hitoshi sakakibara Ildoo Hwang Department of Life Sciences Pohang University of Science and Technology Pohang 790-784 Korea Synthetic Genomics Research Team Biomass Research Cooperation Division (BMEP) RIKEN Center for Sustainable Resource Science (CSRS) Tsurumi Yokohama 230-0045 Japan Riken Center for Sustainable Resource Science (CSRS) Tsurumi Yokohama 230-0045 Japan

Cambial activity is a prerequisite for secondary growth in plants; however, regulatory factors controlling the activity of the secondary meristem in radial growth remain elusive. Here, we identified INCREASED CAMBIAL ACTIVITY （ICA）, a gene encoding a putative pectin methyltransferase, which could function as a modulator for the meristematic activity of fascicular and interfascicular cambium in Arabidopsis. An overexpressing transgenic line, 35S：＇1CA, showed accelerated stern elongation and radial thickening, resulting in increased accumulation of biomass, and increased levels of cytokinins （CKs） and gibberellins （GAs）. Expression of genes encoding pectin methylesterases involved in pectin modification together with pectin methyltransferases was highly induced in 355：：ICA, which might contribute to an increase of methanol emission as a byproduct in 35S：ICA. Methanol treatment induced the expression of GA- or CK-responsive genes and stimulated plant growth. Overall, we propose that ectopic expression of ICA increases cambial activity by regulating CK and GA homeostasis, and methanol emission, eventually leading to stem elongation and radial growth in the inflorescence stem.

关键词： Cambial activity cytokinin gibberellin methanol methyltransferase pectin shoot growth

Stress Evaluation at the Maximum Strained State by EBSD and Several Residual Stress Measurements for Plastic Deformed Austenitic Stainless Steel

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World Journal of Mechanics 2017年第8期7卷 195-210页

作者： Yohei sakakibara Keiji Kubushiro IHI Corporation Research Laboratory: 1 Shin-Nakahara cho Isogo ku Yokohama shi Japan

This paper studies a method for obtaining the stress with plastic deformation by finding the plastic strain on U-bent specimens of austenitic stainless steel that have been subjected to large plastic deformation using the EBSD (Electron Backscatter Diffraction) method. The Mises stress calculated on the basis of the KAM of the EBSD shows good agreement with the stress that can be geometrically calculated from the U-bent specimens. In contrast, general methods for measuring residual stress on the basis of elastic strain produce residual stress measurement results that differ specimen by specimen. Thus, for true strain not less than 0.05, stress estimation based on the EBSD method produces better results than other general methods.

关键词： Stainless Steel EBSD Plastic Strain Misorientation