Synthetic Study on Polyhydroxyestrogens Modeled for Inagami-Tamura Endogenous Digitalis-like Factor and Their Activity

作     者：Masayuki Sakakibara 

作者机构：Lab of Pharmaceutical Resource Discovery Dalian Institute of Chemistry and Physics 

出 版 物：《复旦学报（自然科学版）》 (Journal of Fudan University：Natural Science)

年 卷 期：2007年第46卷第5期

页      面：603-604页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：inagami-tamura endogenous digitalis-like factor (EDF) activity 

摘      要：1 Results Mammalian possess receptors for digitalis,cardiac glycosides,derived from *** one of the results from studies on a real endogenous ligand for the receptors,so called an endogenous digitalis-like factor (EDF) or substance (EDS),Inagami and Tamura isolated a promising candidate possessing a molecular weight,*** elucidated several possible structures (Fig.1) for the factor and synthesized several modeled compounds,some of which exhibited remarkable constriction at higher concentrations t...