Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification

作     者：Yukari Atsumi Hiroshi Sakakibara Yoshihiko Morikawa Koichi Miyata Hiroyuki Yamagishi Masahiro Misawa Masaru Miura Yukari Atsumi;Hiroshi Sakakibara;Yoshihiko Morikawa;Koichi Miyata;Hiroyuki Yamagishi;Masahiro Misawa;Masaru Miura

作者机构：Department of General PediatricsTokyo Metropolitan Children's Medical Center.TokyoJapan Clinical Research Support Center.Tokyo Metropolitan Children's Medical CenterTokyoJapan Department of Cardiology.Tokyo Metropolitan Children's Medical Center.TokyoJapan Department of PediatricsKeio University School of MedicineTokyo.Japan Department of PediatricsTokyo Metropolitan Bokutoh HospitalTokyoJapan National Center for Global Health and Medicine.1-21-1.ToyamaShinjuku-kuTokyo 162-8655.Japan 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2020年第16卷第6期

页      面：623-628页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Tokyo Metropolitan Children’s Medical Center 

主　　题：Anemia Inflammation Hepcidin Kawasaki disease 

摘      要：Background Although Kawasaki disease(KD)is known to cause anemia,the relationship between its prognosis and hemoglobin level is less well *** We herein performed a secondary analysis of data from a previous study(Post-RAISE).Children aged 6 months to 2 years at the time of KD diagnosis were *** hemoglobin was defined as a decrease10%on post-treatment day 2 compared with the level prior to the initial *** Of 1253 KD cases,treatment resistance was observed in 209(17%)and was significantly more frequent in the decreased hemoglobin group(37/167 vs.172/1086,P=0.041).Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment(odds ratio 1.53;95%confidence interval 1.00-2.33;P=0.048).Conclusions Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.