检索结果-南通市图书馆

BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models

引用

Frontiers of Medicine 2023年第6期17卷 1170-1185页

作者： Beibei Jiang tong Zhang Minjuan Deng Wei Jin Yuan hong Xiaotong Chen Xin Chen Jing Wang hongjia Hou Yajuan gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong Shen Xuesong liu Kang Li Lai Wang Ye liu Department of Biology BeiGene(Beijing)Co.Ltd.Beijing 102206China Department of Discovery Biomarkers BeiGene(Beijing)Co.Ltd.Beijing 102206China Department of Clinic Development BeiGene(Beijing)Co.Ltd.Beijing 102206China Department of Biologics BeiGene(Beijing)Co.Ltd.Beijing 102206China

t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T *** ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation and also promotes dendritic cells to mature to enhance their cytokine ***,the use of agonistic anti-Ox40 antibodies for cancer immunotherapy has gained great ***,most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited ***,we discovered that BGB-A445,a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation,induced optimal T cell activation without impairing dendritic cell *** addition,BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular *** the MC38 syngeneic model established in humanized OX40 knock-in mice,BGB-A445 demonstrated robust and dose-dependent antitumor efficacy,whereas the ligand-competitive anti-Ox40 antibody showed antitumor efficacy characterized by a hook ***,BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 *** together,our findings show that BGB-A445,which does not block OX40-OX40L interaction in contrast to clinical-stage anti-OX40 antibodies,shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation.

关键词： BGB-A445 OX40 agonistic antibody OX40L noncompetitive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

QTL Analysis of Traits Related to Melon Stigma and Ovary Size

引用

Journal of Northeast Agricultural University(English Edition) 2023年第2期30卷 43-54页

作者： Zhang bo Li Yu-ting Zhang Yu-tong Guo Hai-yan liu Chen-xin Zhu Zi-cheng gao Peng liu hong-yu Wang Xue-zheng College of Horticulture and Landscape Architecture Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Biology and Genetic Improvement of Horticulture Crops(Northeast Region) Ministry of AgricultureHarbin 150030China

The melon varieties MR-1 and M4-7 were used as the parent materials to produce hybrids.A total of 170 F2 individuals were used as the mapping population to construct a genetic linkage *** this study,240 cleaved amplified polymorphism sequence(CAPS)molecular markers were developed,and 105 of which showed polymorphism between *** map contained 105 markers grouped into 12 linkage groups,spanning a total length of 1998.85 cM,with an average length of 19.04 cM between *** composite interval mapping(CIM)method was used to detect QTLs related with melon stigma and ovary traits:stigma longitudinal diameter(STLD),stigma transverse diameter(STTD),stigma weight(STW),ovary longitudinal diameter(OLD),and ovary transverse diameter(OTD).A total of nine QTLs were identified:six for stigma size and three for ovary size.A total of six loci were detected for stigma size,which included two loci for stigma longitudinal diameter,two loci for stigma transverse diameter,and two loci for stigma *** major effective locus regulating stigma transverse diameter was qSTTD-9-1.A total of three loci were identified for ovary size traits,including one locus for ovary longitudinal diameter and two loci for ovary transverse diameter.

关键词： melon stigma size ovary genetic linkage QTL

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation between the Human Development Index and the Incidence and Mortality of Non-Hodgkin Lymphoma

引用

Current Medical Science 2023年第2期43卷 255-260页

作者： Wen-fu XU Ping YANG Zhi-wen WEI Jin-sheng liu Ren-lin YAN Qian CHEN Ren-xiang tong Shuang-yun XU Wan-qing gao Wen ZHANG Zhen-zhen CHANG Pei-lin WANG hong-juan fang Yun-yun ZHENG Tao WANG Na-na liu Chao YAO Yan-li liu Wei XIA Wei ZHAO Zhu-jun WANG Department of Pediatrics the Second People’s Hospital of HefeiHefei Hospital Affiliated to Auhui Medical UniversityHefei230011China Quality Control Department the Second People’s Hospital of HefeiHefei Hospital Affiliated to Auhui Medical UniversityHefei230011China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective This study was to examine the relationship between socioeconomic status and the incidence and mortality of non-Hodgkin lymphoma(NHL).Methods We compared the age-standardized incidence rate(ASIR),age-standardized mortality rate(ASMR),and the ASMR to ASIR ratio(MIR)at national and regional levels and studied the correlation between the MIR and the human development index(HDI)in 2012 and *** The highest ASIR was in North America in 2012 and in Australia in 2018,and the lowest ASIR was in Central and South Asia in both 2012 and *** highest ASMR was in North Africa in both 2012 and 2018,and the lowest ASMR was in Eastern Asia and South-Central Asia in 2012 and in South-Central Asia in *** lowest MIR was in Australia in both 2012 and 2018,and the highest MIR was in Western Africa in both 2012 and *** was strongly negatively correlated with MIR(r:−0.8810,P<0.0001,2012;r:−0.8895,P<0.0001,2018).Compared to the 2012 data,the MIR in the intermediate HDI countries significantly deceased and the HDI in low and high HDI countries significantly increased in *** The MIR is negatively correlated with *** the HDI in low and intermediate HDI countries may reduce the MIR and increase the survival of patients with NHL.

关键词： non-Hodgkin lymphoma incidence mortality human development index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

经皮冠状动脉介入术对慢性完全闭塞病变合并左心室射血分数降低冠心病患者的疗效

引用

心脏杂志 2024年第1期36卷 34-39页

作者：杨丽赵帅朱伯达陈焱禹天同刘浩林韩鹏马炳琦王嘉仪魏志宏高好考李成祥廉坤空军军医大学第一附属医院心血管内科陕西西安710032 西部战区空军医院心血管内科四川成都610000 空军航空大学初级飞行训练基地黑龙江哈尔滨150100 中国人民解放军海军第九七一医院心血管内科山东青岛266000 联勤保障部队965医院吉林吉林132011 联勤保障部队981医院河北承德067000 空军军医大学基础医学院陕西西安710032

目的评估成功的经皮冠状动脉介入术(PCI)能否改善慢性完全闭塞病变(chronic total occlusion, CTO)合并左心室射血分数(LVEF)降低的冠心病患者症状。方法连续性纳入2018年4月~2021年5月在空军军医大学第一附属医院接受PCI的CTO患者,... 详细信息

目的评估成功的经皮冠状动脉介入术(PCI)能否改善慢性完全闭塞病变(chronic total occlusion, CTO)合并左心室射血分数(LVEF)降低的冠心病患者症状。方法连续性纳入2018年4月~2021年5月在空军军医大学第一附属医院接受PCI的CTO患者,并将其分为3组:LVEF≥50%组、50%>LVEF>35%组和LVEF≤35%组。收集患者术前基线资料,分别采用Rose呼吸困难量表(Rose dyspnea scale, RDS)和西雅图心绞痛问卷(Seattle angina questionnaire, SAQ)评估患者呼吸困难和心绞痛症状,收集手术资料,分别于1月和1年后对患者进行随访。结果共成功纳入1 076例接受PCI的CTO患者,LVEF≤35%的患者有114例(10.6%),其既往心肌梗死病史较多,NYHA心功能Ⅲ/Ⅳ级、多支血管病变和多支CTO病变的比例较高(P<0.01)。术后1月和1年随访时,CTO合并LVEF≤35%的患者呼吸困难和心绞痛症状均有明显改善(P<0.01),且其改善程度与其他两组相似。结论成功PCI显著改善CTO合并LVEF降低的冠心病患者呼吸困难和心绞痛症状。

关键词：慢性完全闭塞病变左室射血分数呼吸困难心绞痛

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

GridDaEn数据网格中的元数据预取与缓存策略

引用

计算机工程与科学 2009年第A1期31卷 335-339页

作者：洪高旗刘芳刘波肖侬国防科技大学计算机学院湖南长沙410073

因数据网格系统部署在广域网环境,所以网络传输延时将成为影响其服务质量(QoS)的主要因素之一。在对预取技术进行了深入细致的探讨之后,本文利用空间换取时间的思想提出了一种元数据的预取与缓存策略。考虑到Grid-DaEn系统中元数据自身... 详细信息

因数据网格系统部署在广域网环境,所以网络传输延时将成为影响其服务质量(QoS)的主要因素之一。在对预取技术进行了深入细致的探讨之后,本文利用空间换取时间的思想提出了一种元数据的预取与缓存策略。考虑到Grid-DaEn系统中元数据自身的特点,还提出了一种新颖的元数据预取算法DHMP。

关键词：数据网格元数据预取算法元数据服务器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population

引用

Neuroscience Bulletin 2018年第5期34卷 867-869页

作者： hong Pan Jun-Yi Shen Juan-Juan Du Shi-Shuang Cui Jin liu Yi-Qi Lin Yi-Xi He Yang Fu Chao gao Gen Li Sheng-Di Chen Jian-fang Ma Laboratory of Neurodegenerative Diseases Institute of Health Sciences Shanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Neurology and Collaborative Innovation Center for Brain Science Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Recently, several single nucleotide polymorphisms （SNPs; rs34094401 on RAD51B, rs41309351 on CPXM1, rs143555311 on MPHOSPHIO, rs141620200 on SER- PINA1, and rs2424913 on DNMT3B） have been associated with Parkinson＇s disease （PD） in Caucasians [1-3]. Con- sidering the genetic variance among different ethnic populations, it is essential to know whether these candidate SNPs are also associated with PD in other ethnic cohorts. Therefore, we investigated these newly-reported risk SNPs in 249 PD patients and 239 controls to test their association with PD.

关键词： ALPHA-SYNUCLEIN METHYLATION DNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Initial experience of laparoendoscopic single-site radical prostatectomy with a novel purpose-built robotic system

引用

Asian Journal of Urology 2023年第4期10卷 467-474页

作者： Zheng Wang Chao Zhang Chengwu Xiao Yang Wang Yu fang Baohua Zhu Shouyan Tang Xiaofeng Wu hong Xu Yi Zhou Lingfen Wu Zhenjie Wu bo Yang Yi He Yi liu Linhui Wang Department of Urology Changhai HospitalNaval Medical UniversityShanghaiChina Department of Anesthesiology Changhai HospitalNaval Medical UniversityShanghaiChina Department of Urology The Affiliated Hospital of Jiaxing UniversityZhejiangChina

Objective This prospective single-arm clinical trial aimed to evaluated the feasibility and safety of the application of the SHURUI system(Beijing Surgerii Technology Co.,Ltd.,Beijing,China),a novel purpose-built robotic system,in single-port robotic radical *** Sixteen patients diagnosed with prostate cancer were prospectively enrolled in and underwent robotic radical prostatectomy from October 2021 to August 2022 by the SHURUI single-port robotic surgical *** demographic and baseline data,surgical,oncological,and functional outcomes as well as follow-up data were *** The mean operative time was 226.3(standard deviation[SD]52.0)min,and the mean console time was 183.4(SD 48.3)min,with the mean estimated blood loss of 116.3(SD 90.0)*** mean length of postoperative hospital stay was 4.50(SD 0.97)*** patients had postoperative complications(Clavien-Dindo Grade II),and both patients improved after conservative *** patients’postoperative prostate-specific antigen levels decreased to below 0.2 ng/mL 1 month after *** mean prostate-specific antigen level further decreased to a mean of 0.0219(SD 0.0641)ng/mL 6 months after *** days postoperatively,12 out of 16 patients reported using no more than one urinary pad per day,and all patients reported satisfactory urinary control without the need for pads 6 months after *** The SHURUI system is safe and feasible in performing radical prostatectomy via both transperitoneal and extraperitoneal *** control and urinary continence were satisfying for patients enrolled *** next phase involves conducting a large-scale,multicenter randomized controlled trial to thoroughly assess the effectiveness and safety of the new technology in a broader population.

关键词： Laparoendoscopic single-site surgery Robotic surgical procedure Prostatectomy Prostatic cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铜及铜合金表面处理技术进展

引用

中国有色金属学报 2021年第5期31卷 1121-1133页

作者：高铭余谢宏斌方攸同王宏涛刘嘉斌浙江大学材料科学与工程学院杭州310027 浙江大学交叉力学中心杭州310027

综述几种铜及铜合金表面处理技术的进展,包括离子液体镀技术、等离子喷涂技术、激光熔覆技术、激光合金化、激光表面淬火与重熔技术。以铜及铜合金为表面处理对象,通过表面处理补强铜材料耐蚀、耐磨等性能,拓宽其应用范围。围绕铜及铜... 详细信息

综述几种铜及铜合金表面处理技术的进展,包括离子液体镀技术、等离子喷涂技术、激光熔覆技术、激光合金化、激光表面淬火与重熔技术。以铜及铜合金为表面处理对象,通过表面处理补强铜材料耐蚀、耐磨等性能,拓宽其应用范围。围绕铜及铜合金基体因高导热、高反射率等特性带来的表面处理难题,对铜及铜合金典型表面处理技术的特点与优劣势进行对比与分析,展望这些技术在铜及铜合金表面处理方向上的趋势与潜力。

关键词：铜铜合金表面处理电镀喷涂激光加工

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

边缘计算中任务卸载研究综述

引用

计算机科学 2021年第1期48卷 11-15页

作者：刘通方璐高洪皓上海大学计算机工程与科学学院上海200444 上海智能计算系统工程技术研究中心上海200444

近年来,随着移动智能设备的普及以及5G等无线通信技术的发展,边缘计算作为一种新兴的计算模式被提出,作为传统的云计算模式的扩展与补充。边缘计算的基本思想是将移动设备上产生的计算任务从卸载到云端转变为卸载到网络边缘端,从而满足... 详细信息

近年来,随着移动智能设备的普及以及5G等无线通信技术的发展,边缘计算作为一种新兴的计算模式被提出,作为传统的云计算模式的扩展与补充。边缘计算的基本思想是将移动设备上产生的计算任务从卸载到云端转变为卸载到网络边缘端,从而满足实时在线游戏、增强现实等计算密集型应用对低延迟的要求。边缘计算中的计算任务卸载是一个关键的研究问题,即计算任务应在本地执行还是卸载到边缘节点或云端。不同的任务卸载方案对任务完成时延和移动设备能耗都有着较大的影响。文中首先介绍了边缘计算的基本概念,归纳了边缘计算的几种系统架构。随后,详细阐述了边缘计算中的计算任务卸载问题。基于对任务卸载方案研究的必要性与挑战的分析,对现有的相关研究工作进行了全面的综述和总结,并对未来的研究方向进行了展望。

关键词：边缘计算任务卸载资源分配任务延迟能量消耗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis

引用

Molecular Plant 2020年第2期13卷 336-350页

作者： Jin liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning hong Guang-Yi Fan Yan tong Dan Zhang Chang-Li Mao Yun-Long liu Shi-Jie Hao Wei-Qing liu Mei-Qi Lv Hai-Bin Zhang Yuan liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin liu Li-Zhi gao Yunnan Institute of Tropical Crops Jinghong 666100China Plant Germplasm and Genomics Center Germplasm Bank of Wild Species in Southwestern ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650204China University of Chinese Academy of Sciences Beijing 100049China BGI-Qingdao Qingdao 266555China lnstitution of Genomics and Bioinformatics South China Agricultural UniversityGuangzhou 510642China Asia-Pacific Tropical Forestry Germplasm Institution Southwest China Forestry UniversityKunming 650224China School of Life Sciences Nanjing UniversityNanjing 210023China Novogene Bioinformatics Institute Beijing 100083China BGI-Shenzhen Shenzhen 518083China State Key Laboratory of Systematic and Evolutionary botany Institute of BotanyChinese Academy of SciencesBeijing 100093China John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Howard Hughes Medical Institute University of WashingtonSeattleWA 98195USA

The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw ***,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the～1.47-Gb genome assembly into 18 *** chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and *** show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by～65.88%(～970 Mbp)of the whole rubber tree genome since the divergence from *** identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains～15.7 million high-quality single-nucleotide *** identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber *** genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production.

关键词： rubber tree rubber biosynthesis chromosome evolution whole-genome duplication domestication

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：