Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population

作     者：Hong Pan Jun-Yi Shen Juan-Juan Du Shi-Shuang Cui Jin Liu Yi-Qi Lin Yi-Xi He Yang Fu Chao Gao Gen Li Sheng-Di Chen Jian-Fang Ma 

作者机构：Laboratory of Neurodegenerative Diseases Institute of Health Sciences Shanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Neurology and Collaborative Innovation Center for Brain Science Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2018年第34卷第5期

页      面：867-869页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81430022,91332107,and 81371407) the National Key R&D Program of China(2016YFC1306000) 

主　　题：As 

摘      要：Recently, several single nucleotide polymorphisms （SNPs; rs34094401 on RAD51B, rs41309351 on CPXM1, rs143555311 on MPHOSPHIO, rs141620200 on SER- PINA1, and rs2424913 on DNMT3B） have been associated with Parkinson＇s disease （PD） in Caucasians [1-3]. Con- sidering the genetic variance among different ethnic populations, it is essential to know whether these candidate SNPs are also associated with PD in other ethnic cohorts. Therefore, we investigated these newly-reported risk SNPs in 249 PD patients and 239 controls to test their association with PD.