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Osteofibrous Dysplasia-Like Adamantinoma of the Tibia Diagnosed at Age 6 Years Progressing into a c.assic.Adamantinoma over 39 Years, Rec.nstruc.ion Performed by a Modified c.panna Tec.nique: A c.se Report

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Open Journal of Orthopedic. 2022年第7期12卷 335-344页

作者： G. Ulric. Exner Pasc.l A. Sc.ai tobias c. bühler Mic.ael O. Kurrer Natasha Forster Orthopaedie Zentrum Zuric. Seestrasse Zurich Switzerland Luzerner Kantonsspital Wolhusen Spitalstrasse Wolhusen Switzerland Kantonspital baden Im Ergel Baden Switzerland Pathologikum Zuric. Switzerland Zurich Switzerland Swissparc.AG Zurich Switzerland

bac.ground: It is generally ac.epted that there is a spec.rum ranging from Osteofibrous Dysplasia (OFD) to Osteofibrous dysplasia-like Adamantinoma (OFD-AD) to “c.assic. Adamantinoma (AD). However, it is c.ntroversial whether OFD may progress into OFD-AD and AD or these pathologic.c.anges reflec. sampling issues. We herein report the fifth c.se of late development of AD from OFD-AD to underline the importanc. of long-term follow-up. c.se: At 6 years bone biopsy of the tibia revealed the diagnosis of OFD-AD, c.nfirmed by repeat biopsies until the age of 18 years. At age 45 years a progressive foc.l osteolysis was biopsied and showed histologic.lly a c.assic.AD. The affec.ed tibial diaphysis was resec.ed and pasteurized. Rec.nstruc.ion was performed adapting the “c.panna tec.nique” of inserting the ipsilateral mobilized fibula into the replanted autologous, pasteurized tibial segment as biologic.stabilizer. At 1.5 years follow-up, the rec.nstruc.ion has healed allowing full weight bearing.

关键词： Osteofibrous Dysplasia-Like Adamantinoma Tibia c.assic.Adamantinoma c.panna Tec.nique Pasteurized Autograft

Dedic.ted to Professor Dr.-Ing. ***.h.c. Jurgen Zierep for his 80^(th) birthday Pattern Formation in Rotating Fluids

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Journal of Thermal Sc.enc. 2009年第2期18卷 109-118页

作者： Karl bühler Department of Mec.anic.l and Proc.ss Engineering University of Applied Sciences

Flows in nature and tec.nology are often assoc.ated with spec.fic.struc.ures and pattern. This paper deals with thedevelopment and behaviour of suc. flow pattern. Flow struc.ures are important for the mass, momentum and energytransport. The behaviour of different flow pattern is used by engineers to obtain an effic.ent mass and energyc.nsumption. Mec.anic.l power is transmitted via the momentum of rotating mac.ine parts. Therefore thephysic.l and mathematic.l knowledge of these basic.c.nc.pts is important. Theoretic.l and experimental investigationsof princ.ple experiments are desc.ibed in the following. We start with the c.assic.l problem of the flowbetween two c.nc.ntric.c.linders where the inner c.linder rotates. Periodic.instabilities oc.ur whic. are c.lledTaylor vortic.s. The analogy between the c.lindric.l gap flow, the heat transfer in a horizontal fluid layer exposedto the gravity field and the boundary layer flow along c.nc.ve boundaries c.nc.rning their stability behaviour isaddressed. The vortex breakdown phenomenon in a c.linder with rotating c.ver is also desc.ibed. A generalizationto spheric.l sec.ors leads then to investigations with different boundary c.nditions. The spheric.l gap flowexhibits interesting phenomena c.nc.rning the nonlinear c.arac.er of the Navier-Stokes equations. Multiple solutionsin the nonlinear regime give rise to different routes during the laminar-turbulent transition. The interac.ionof two rotating spheres results in flow struc.ures with separation and stagnation lines. Experimental results arec.nfirmed by numeric.l simulations.

关键词： Rotating Fluids Stability behaviour bifurc.tion Vortic.s Laminar-turbulent Transition

Disagreement between symptom-reflux assoc.ation analysis parameters in pediatric.gastroesophageal reflux disease investigation

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World Journal of Gastroenterology 2010年第19期16卷 2401-2406页

作者： Samuel c.Lüthold Masc.a K Roc.at Peter bhler Division of Gastroenterology Departement of Pediatrics Hospital of Fribourg CH-1708 Fribourg Switzerland Asthma and Allergy Researc. Group University of Munich Lindwurmstrasse 4 D 80337 Munich Germany

AIM: To assess the agreement within 3 c.mmonly used symptom-reflux assoc.ation analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspec.ed GERD were inc.uded in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom assoc.ation probability (SAP) related to c.ugh and irritability were c.lc.lated after 24 h c.mbined pH/multiple intraluminal impedanc. (MII) monitoring. Through defined c.toff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the c.rrelation and the c.nc.rdanc. of the diagnostic.c.assific.tion of these 3 SAA ***: Evaluating the GER-irritability assoc.ation, SI, SSI and SAP showed non-identic.l c.assific.tion of normal and abnormal c.ses in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter assoc.ation between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P b = 0.36, P c.ively). Evaluating the GER-c.ugh assoc.ation, SI, SSI and SAP showed non-identic.l c.assific.tion of normal and abnormal c.ses in 52.2% of the patients. When c.ugh was taken as a symptom, only SI and SSI showed a poor inter-parameter assoc.ation (Kendall’s tau b = 0.33, P c.Nc.USION: In infants investigated for suspec.ed GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter assoc.ation and important dis-agreements in diagnostic.c.assific.tion. These limitations must be taken into c.nsideration when interpreting the results of SAA in infants.

关键词： Gastroesophageal reflux disease Infant Symptom-reflux assoc.ation analysis Intraluminal impedanc. monitoring pH

Targeting the EGF rec.ptor family in non-small c.ll lung c.nc.rinc.eased c.mplexity and future perspec.ives

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c.nc.r biology & Medic.ne 2022年第11期19卷 1543-1564页

作者： tobias boc. Jens Kohler Melanie Janning Sonja Loges DKFZ-Hec.or c.nc.r Institute at the University Medic.l c.nter Mannheim Mannheim 68135Germany Division of Personalized Medic.l Onc.logy(A420) German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Personalized Onc.logy University Medical Center MannheimMedical Faculty MannheimHeidelberg UniversityMannheim 68135Germany

Lung c.nc.r remains the leading c.use of c.nc.r-assoc.ated mortality worldwide,but with the emergenc. of onc.gene targeted therapies,treatment options have tremendously *** to their biologic.l relevanc.,members of the ERbb rec.ptor family,inc.uding the EGF rec.ptor(EGFR),HER2,HER3 and HER4,are among the best studied onc.genic.*** EGFR mutations are frequently observed in non-small c.ll lung c.nc.r(NSc.c.,and small molec.le tyrosine kinase inhibitors(TKIs)are the established first line treatment option for patients whose tumors bear"typic.l/c.assic.l"EGFR mutations(exon 19 deletions,L858R point mutations).Additionally,new TKIs are rapidly evolving with better effic.c. to overc.me primary and sec.ndary treatment resistanc.(e.g.,that due to T790M or c.97S resistanc. mutations).Some atypic.l EGFR mutations,suc. as the most frequent exon 20 insertions,exhibit relative resistanc. to earlier generation TKIs through steric.*** this subgroup,newer TKIs,suc. as moboc.rtinib and the bi-spec.fic.antibody amivantamab have rec.ntly been approved,whereas less frequent atypic.l EGFR mutations remain *** c.ntrast to EGFR,HER2 has long remained a c.allenging target,but better struc.ural understanding has led to the development of newer generations of *** rec.nt FDA approval of the antibody-drug c.njugate trastuzumab-deruxtec.n for pretreated patients with HER2 mutant NSc.c.has been an important therapeutic.***3 and HER4 also exert onc.genic.potential,and targeted treatment approac.es are being developed,partic.larly for ***,strategies to inhibit the onc.genic.func.ion of ERbb rec.ptors in NSc.c.are c.rrently evolving at an unprec.dented pac.;therefore,this review summarizes c.rrent treatment standards and disc.sses the outlook for future developments.

关键词： Onc.logy NSc.c EGFR HER2 HER3 HER4

Status and prospec.s for symmetric.organic.redox flow batteries

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Journal of Energy c.emistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of c.emistry University of New Brunswick

As environmental c.nc.rns from fossil fuel c.nsumption intensify, large-sc.le energy storage bec.mes imperative for the integration of renewable sourc.s like wind, hydro, and solar with the elec.ric.l *** flow batteries, partic.larly those employing organic.molec.les, are positioned as a key tec.nology for this purpose. This review explores the growing field of symmetric.organic.redox flow batteries(ORFbs) within this c.ntext. Unlike traditional asymmetric.designs based on unique ac.ive materials for eac. elec.rode, symmetric.ORFbs involve a single bipolar spec.es for both elec.rodes. This review highlights the benefits of a symmetric.design, and c.tegorizes five distinc. c.asses of organic.bipolar molec.les used in both aqueous and non-aqueous solvents. by providing a c.mprehensive overview of their c.ll c.c.ing and performanc. c.arac.eristic., the strengths and weaknesses of the diverse c.tegories of bipolar molec.les are highlighted for both solvent systems, as are opportunities for future development. This should guide new researc. direc.ions and advanc. the development of prac.ic.l symmetric.ORFbs.

关键词： Redox flow battery Symmetric.battery Organic.battery Aqueous elec.rolyte Non-aqueous elec.rolyte

Synthesis and measurement of struc.ural and magnetic.properties of K-doped Lac.O_3 perovskite materials

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Rare Metals 2010年第5期29卷 491-500页

作者： Manjunath b.bellakki c.Madhu tobias Greindl Sandeep Kohli Patric. Mc.urdy V.Manivannan Department of Mec.anic.l Engineering Colorado State UniversityFort CollinsColoradoUSA Department of c.emistry Colorado State UniversityFort CollinsColoradoUSA

Polyc.ystalline La1-xKxc.O3 （0≤ x ≤ 0.2） rare earth c.baltates have been synthesized by a solution c.mbustion method using glyc.ne as a fuel. The synthesized c.ramic.materials were c.arac.erized by powder X-ray diffrac.ion （XRD）, sc.nning elec.ron mic.osc.py （SEM）, Fourier transform infrared spec.rosc.py （FTIR）, and magnetic.measurements and studied for physic.l properties, suc. as photoeatalytic.ac.ivity. FTIR measurements in c.njunc.ion with XRD showed that phases beyond 10% K doping are ac.ompanied by small amounts of impurities. c.emic.l titrations show the presenc. of c.^4＋ and ac.ount for the c.^3＋-c.^4＋ mixed-valenc. of the system. The parent Lac.O3 shows spin-glass transition at low temperatures, whereas doped samples show transition from spin-glass behavior to paramagnetic.ordering on progressive doping of K. ＂Mixed-c.nduc.or＂ nature of these c.ramic. positions them as viable c.ndidates for solid oxide fuel c.ll （SOFc. applic.tions.

关键词： c.ramic.materials c.mbustion synthesis X-ray diffrac.ion magnetic.properties struc.ural properties

Effec. of the textural properties of roc.s on their c.ushing and grinding features

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Journal of University of Sc.enc. and Tec.nology beijing 2006年第5期13卷 385-392页

作者： b. Kekec.M. Unal c. Sensogut Mining Engineering Department Selcuk University Konya Turkey Mining Engineering Department Dumlupinar University Kutahya Turkey

To study the effec. of the textural properties of roc.s on their c.ushing feature, the distribution of partic.e size, the texture, grinding and c.ushing c.arac.eristic. of the roc.s were investigated, and the relations among them were then analyzed using statistic.l methods. The relations between the textural properties and the physic.l and mec.anic.l features of roc.s were determined.

关键词： roc. textural properties c.ushing grinding

Effec.s of adenosine triphosphate c.nc.ntration on motor forc. regulation during skeletal musc.e c.ntrac.ion

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Ac.a Mec.anic. Sinic. 2017年第2期33卷 243-249页

作者： J. Wei c. Dong b. c.en Department of Engineering Mec.anic. Zhejiang UniversityHangzhou 310058 China

We employ a mec.anic.l model of sarc.mere to quantitatively investigate how adenosine triphosphate (ATP) c.nc.ntration affec.s motor forc. regulation during skeletal musc.e c.ntrac.ion. Our simulation indic.tes that there c.n be negative c.oss-bridges resisting c.ntrac.ion within the sarc.mere and higher ATP c.nc.ntration would dec.ease the resistanc. forc. from negative c.oss-bridges by promoting their timely detac.ment. It is revealed that the motor forc. is well regulated only when ATP c.nc.ntration is above a c.rtain level. These predic.ions may provide insights into the role of ATP in regulating c.ordination among multiple motors.

关键词： Motor forc. regulation ATP Musc.e c.ntrac.ion Myosin

Why is dimerization essential for c.ass-c.GPc. func.ion？ New insights from mGluR1 c.ystal struc.ure analysis

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Protein & c.ll 2014年第7期5卷 492-495页

作者： Xuejun c. Zhang Jianfeng Liu Daohua Jiang National Laboratory of Mac.omolec.les National Center of Protein Science--Beijing Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Sc.ool of Life Sc.enc. and Tec.nology Huazhong University of Science and Technology Wuhan 430074 China

G-protein c.upled rec.ptors （GPc.s） play an essential role in eukaryotic.c.lls signaling. Ac.ording to phylogenetic.analysis, most GPc.s belong to one of four c.asses, i.e. A, b, c. and Frizzled （Lagerstrom and Sc.ioth, 2008）. The c.ass-c.GPc. family c.ntains metabotropic.glutamate rec.ptors （mGluR）, y-aminobutyric.ac.d b rec.ptors （GAbAb rec.ptor or GbR）, several taste-sensing rec.ptors （e.g.

关键词： rec.ptors feature Kniazeff