Why is dimerization essential for class-C GPCR function？ New insights from mGluR1 crystal structure analysis

作     者：Xuejun C. Zhang Jianfeng Liu Daohua Jiang 

作者机构：National Laboratory of Macromolecules National Center of Protein Science--Beijing Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China School of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2014年第5卷第7期

页      面：492-495页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 071006[理学-神经生物学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by the National Basic Research Program (973 Program) (to XCZ.) 

主　　题：Linker Peptide Inactive Conformation Extracellular Side Large Conformational Change Cytosolic Side 

摘      要：G-protein coupled receptors （GPCRs） play an essential role in eukaryotic cells signaling. According to phylogenetic analysis, most GPCRs belong to one of four classes, i.e. A, B, C, and Frizzled （Lagerstrom and Schioth, 2008）. The class-C GPCR family contains metabotropic glutamate receptors （mGluR）, y-aminobutyric acid B receptors （GABAB receptor or GBR）, several taste-sensing receptors （e.g.