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Surgical outcome of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass for resolution of type 2 diabetes mellitus:A systematic review and meta-analysis

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World Journal of Gastroenterology 2020年第8期26卷 865-876页

作者： Salman Yousuf Guraya tim strate Clinical Sciences Department College of MedicineUniversity of SharjahSharjah 27272United Arab Emirates Department of Surgery Reinbek HospitalAcademic Teaching Hospital of the University of HamburgReinbek D-21465Germany

BACKGROUND Bariatric procedures are considered superior to medical therapies in managing type 2 diabetes mellitus(T2DM).Laparoscopic Roux-en-Y gastric bypass(LRYGB)and laparoscopic sleeve gastrectomy(LSG)are the most commonly used procedures for weight loss and comorbidity resolution ***,it is not yet known whether the degree of T2DM is influenced by the choice of bariatric *** To quantitatively compare T2DM resolution over 1-5 years follow-up by LRYGB and LSG in morbidly obese *** We searched the selected databases for full-text English language clinical studies that compared the effectiveness of LRYGB and LSG for T2DM *** manager 5.3 was used for data analysis,and the overall effect summary was represented in a forest *** From 1,650 titles retrieved by an initial search,we selected nine studies for this *** found insignificant differences for T2DM resolution by LRYGB and LSG,with an odds ratio of 0.93(95%CI:0.64-1.35,Z statistics=0.38,P=0.71).Additionally,subset analyses for T2DM resolution showed insignificant differences after 24 mo(χ^2=1.24,df=4,P=0.87,overall Z effect=0.23),36 mo(χ^2=0.41,df=2,P=0.81,overall Z effect=0.51),and 60 mo(χ^2=4.75,df=3,P=0.19,overall Z effect=1.20)by LRYGB and *** study reports a T2DM remission rate of 82.3%by LRYGB and 80.7%by *** This study reports similar T2DM resolution rates by both LRYGB and LSG during 1-5 years of ***,long-term follow-up of 10 years is needed to further substantiate these findings.

关键词： Morbid obesity Type 2 diabetes mellitus Laparoscopic sleeve gastrectomy Laparoscopic Roux-en-Y gastric bypass

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Prolonged hyperthermic intraperitoneal chemotherapy duration with 90 minutes cisplatin might increase overall survival in gastric cancer patients with peritoneal metastases

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World Journal of Gastroenterology 2023年第18期29卷 2850-2863页

作者： Heinrich Steinhoff Miklos Acs Sebastian Blaj Magdolna Dank Magdolna Herold Zoltan Herold Jonas Herzberg Patricia Sanchez-Velazquez tim strate Attila Marcell Szasz Pompiliu Piso Department of General and Visceral Surgery Hospital Barmherzige BrüderRegensburg 93049Germany Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest 1083Hungary Department of Internal Medicine and Hematology Semmelweis UniversityBudapest 1088Hungary Department of Surgery Krankenhaus Reinbek St.Adolf-StiftReinbek 21465Germany Department of General Surgery Hospital del MarBarcelona 08003Spain

BACKGROUND Advanced gastric cancer with synchronous peritoneal metastases(GC-PM)is associated with a poor *** cytoreductive surgery with hyperthermic intraperitoneal chemotherapy(CRS-HIPEC)is a promising approach,only a limited number of Western studies *** To investigate the clinicopathological outcomes of patients who underwent CRSHIPEC for *** A retrospective analysis of patients with GC-PM was *** patients were seen at the Department of General and Visceral Surgery,Hospital Barmherzige Brüder,Regensburg,Germany between January 2011 and July 2021 and underwent *** laboratory results,the use of neoadjuvant trastuzumab,and the details of CRS-HIPEC,including peritoneal carcinomatosis index,completeness of cytoreduction,and surgical procedures were ***-specific(DSS),and overall survival(OS)of patients were *** A total of 73 patients were included in the *** treated with neoadjuvant trastuzumab(n=5)showed longer DSS(P=0.0482).Higher white blood cell counts(DSS:P=0.0433)and carcinoembryonic antigen levels(OS and DSS:Ptimes[60-min(n=59):12.86 mo;90-min(n=14):27.30 mo],but without statistical *** obtain additional data from this observation,further separation of the study population was ***,propensity score-matched patient pairs(n=14 in each group)were *** different DSS was found between patient pairs(hazard ratio=0.2843;95%confidence interval:0.1119-0.7222;P=0.0082).Second,those patients who were treated with trastuzumab and/or had human epidermal growth factor receptor 2 positivity(median survival:12.68 mo vs 24.02 mo),or had to undergo the procedure before 2016(median survival:12.68 mo vs 27.30 mo;P=0.0493)were removed from the orig

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal metastasis Stomach neoplasms Gastric cancer

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Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin

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World Journal of Gastroenterology 2006年第18期12卷 2914-2918页

作者： Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki tim strate Department of General- Visceral- and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfMartinistrasse 52D-20246 HamburgGermany

瞄准：Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物，但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的... 详细信息

瞄准：Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物，但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法：在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) ， hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后，胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果：HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外，在 GSH 层次的差别都没被检测。结论：不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环，在类脂化合物的没有差别每氧化，产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。

关键词：胰腺炎实验研究血红蛋白病理机制

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肺泡复张策略复合高水平呼气末正压通气不影响血容量充足的病态肥胖患者的血流动力学

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麻醉与镇痛 2011年第3期7卷 66-69页

作者： Stephan H. Bohm, MD Oliver C. Thamm, MD Alexandra von Sandersleben, MD Katrin Bangert, MD Thomas E. Langwieler, MD Gerardo Tusman, MD tim G. strate, MD, PhD Thomas G. Standl, MD, PhD 邓希锦(译) Clinics of Anesthesiology Hospital Privado de Comunidad Mar del Plata Argentina General Visceral and Thoracic Surgery University Hospital Hamburg-Eppendorf Germany Hospital Privado de Comunidad Mar del Plata Argentina Department of Anesthesiology Hospital Privado de Comunidad Mar del Plata Argentina 不详

我们观察了20例血容量充足，准备行腹腔镜手术的病态肥胖（体重指数为50±9kg/m^2）患者，评估肺泡复张策略复合高水平呼气末正压通气（posidveend-expiratorypressure，PEEP）对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的... 详细信息

我们观察了20例血容量充足，准备行腹腔镜手术的病态肥胖（体重指数为50±9kg/m^2）患者，评估肺泡复张策略复合高水平呼气末正压通气（posidveend-expiratorypressure，PEEP）对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的情况下序贯进行，将PEEP水平逐渐升高，使平台压达到50—60cmH2O，呼吸10次／分，然后将PEEP水平逐渐降低。通过体循环和肺动脉导管的监测，没有发现肺泡复张及高水平PEEP对血流动力学产生显著的影响。经食管超声心动图显示左室舒张末期面积未发生变化，也无局部室壁运动异常的迹象。

关键词：呼气末正压通气血流动力学肥胖患者病态肥胖 P水平血容量肺泡复合

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