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Chinese Chemical Letters 2021年第3期32卷 1111-1116页

作者： Meiling Wang tianyuan zhang Mingzhu Cui Weifeng Liu Xuguang Liu Jianwei Zhao Jiadong Zhou Institute of New Carbon Materials Taiyuan University of TechnologyTaiyuan 030024China College of Material and Textile Engineering Jiaxing UniversityJiaxing 314001China Department of Chemistry University of WashingtonSeattleWashington 98195United States School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Institute of Crystalline Materials Shanxi UniversityTaiyuan 030006China

A template-free carbonization-activation route is developed to fabricate sub-nanopore-containing porous carbon by using a novel polypyrrole(PPy)hydrogel as a *** design of PPy hydrogel precursor containing molecular-scale grids(diameter~2.0 nm)allows for homogeneous N,O-codoping into the porous carbon scaffold during the pyrolysis process.A subsequent activation step produces activated porous carbons(APCs)with tailored pore structures,which renders the APCs abundant subnanopores on their surface to increase the specific capacitance as extra capacitance *** with large specific surface area and abundant heteroatoms,the optimized APC4/1 displays excellent specific capacitance of 379 F/g for liquid-state supercapacitor and 230 F/g for solid-state *** solid-state supercapacitor shows a high energy density of 22.99 Wh/kg at power density of 420 W/kg,which is higher than most reported porous carbon materials and satisfy the urgent requirements of elementary power source for electric ***,this method can be easily modified to fabricate sub-nanopore-containing porous carbons with preferred structures and compositions for many applications.

关键词： Hydrogel Sub-nanopores Carbonization-activation Porous carbon Heteroatomdoping Solid-state supercapacitor

Foamed microemulsion nanodroplets loaded with chlorin e6 for epidermal-targeted treatment against psoriasis

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Nano Research 2024年第11期17卷 9920-9931页

作者： Xiaolu Ma Qiong Bian Yihua Xu Jingyi Hu Weitong Hu Ruxuan Wang Yunting zhang Yuxian Ye Xiaoxia Sheng tianyuan zhang Jianqing Gao Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Jiangsu Engineering Research Center for New-type External and Transdermal Preparations Changzhou 213149 China Hangzhou SoliPharma Co. Ltd. Hangzhou 310058 China

Psoriasis is a chronic skin disease characterized by the hyperproliferation of keratinocytes and an overactive autoimmune response. Photodynamic therapy (PDT) has been established as a promising intervention for alleviating psoriasis. However, the current transdermal delivery of photosensitizers is inefficient and imprecise. In this study, we developed a foamed microemulsion nanodroplets system containing chlorin e6 (Ce6 FM), exhibiting precise epidermal targeting and retention, which targeted the aberrantly proliferating epidermal cells at psoriatic skin lesions and avoided the damage to the normal cutaneous cells. Upon application in a psoriatic mouse model, Ce6 FM efficiently induced keratinocyte apoptosis by generating reactive oxygen species under laser. Furthermore, Ce6 FM-based PDT activated the cyclooxygenase-2-induced immunosuppressive pathway in keratinocytes, resulting in the amelioration of the autoimmune microenvironment in psoriatic skin. Additionally, Ce6 FM-based PDT did not induce skin damage or atrophy associated with non-targeted halometasone treatment. Overall, Ce6 FM-based PDT holds promise as an effective, safe and compliant strategy for psoriasis treatment.

关键词： transdermal drug delivery foamed microemulsion nanodroplets psoriasis photodynamic therapy

Spatiotemporal patterns of the daily relative risk of COVID-19 in China

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Journal of Geographical Sciences 2021年第7期31卷 1039-1058页

作者： CHENG Changxiu JIANG Yifan SONG Changqing SHEN Shi WU Yunfeng zhang tianyuan State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster Beijing Normal UniversityBeijing 100875China Center for Geodata and Analysis Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China National Tibetan Plateau Data Center Beijing 100101China

The coronavirus disease 2019(COVID-19)pandemic continues to threaten lives and the economy around the *** the risk of COVID-19 can help in predicting spreading trends,identifying risk areas,and making public health *** this study,we proposed a comparative risk assessment method to estimate comprehensive and dynamic COVID-19 risks by considering the pandemic severity and the healthcare system pressure and then employing the z-order curve and fractal *** took the COVID-19 cases from January 19-March 10,2020 in China as our research *** results and analysis revealed that(1)the proposed method demonstrated its feasibility to assess and illustrate pandemic risk;(2)the temporal patterns of the daily relative risk indices of 31 provinces were clustered into four groups(high-value,fluctuating-increase,inverted U-shaped,and low-stable);(3)the spatial distribution of the relative pandemic risk indicated a significant circular pattern centered on Hubei Province;and(4)healthcare system capacity is the key to reducing relative pandemic risk,and cases imported from abroad should be given more *** methods and results of this study will provide a methodological basis and practical guidance for regional pandemic risk assessment and public health decision-making.

关键词： COVID-19 risk assessment spatiotemporal patterns z-order curve fractal

A sustainable synthesis of 3,3-disubstituted oxindoles via CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrile

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第3期5卷 180-185页

作者： Mengchu zhang Yukai Li Yuwei Wang Jirong Shu tianyuan zhang Dan zhang Song Cai Taoda Shi Wenhao Hu Guangdong Chiral Drug Engineering Laboratory School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou510000China Shenzhen University Health Science Center Shenzhen518060China

We herein reported a sustainable synthesis of 3,3-disubstituted oxindoles via a Michael-type reaction based on the CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene *** reaction is characterized by a high atom economy and low economic *** catalyst CuBr could be conveniently *** products of the reaction were found to be inhibitory against Na ion *** expect the reaction to shed the light on synthesis of biologically interesting molecules directed by principles of green chemistry.

关键词： Copper catalysis Carboxylic oxonium ylide Sustainable synthesis

Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia

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Stroke & Vascular Neurology 2024年第2期9卷 134-144,I0396-I0413页

作者： Yanfang Liu tianyuan zhang Xing Zou Zhongwen Yuan Yufeng Li Jiankun Zang Niu He Lizhen He Anding Xu Dan Lu Department of Neurology and Stroke Center Jinan University First Affiliated HospitalGuangzhouGuangdongChina Department of Clinical Neuroscience Institute The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Key Lab of Guangzhou Basic and Translational Research of Pan-vascular Diseases The First Affiliated Hospital of Jinan UniversityGuangzhouChina

Background Nanoparticles(NPs)are a class of substances that can be loaded with therapeutic agents delivered to specific *** our earlier research,we identified a neuron-derived circular RNA(circRNA),circular oxoglutarate dehydrogenase(CircOGDH),as a promising therapeutic target for acute ischaemic *** study dedicated to explore a prospective preliminary strategy of CircOGDH-based NP delivered to the ischaemic penumbra region in middle cerebral artery occlusion/reperfusion(MCAO/R)*** Immunofluorescence in primary cortex neurons and in vivo fluorescence imaging revealed endocytosis of Poly(lactide-co-glycolide)(PLGA)poly amidoamine(PAMAM)@CircOGDH small interfering RNA(siRNA)*** blotting analysis and CCK8 assay were performed to evaluate the apoptotic level in ischaemic neurons treated with PLGA–PAMAM@CircOGDH siRNA *** reverse transcription PCR experiments,mice behaviour test,T2 MRI analysis,Nissl and TdT-mediated dUTP nick end labeling(TUNEL)co-staining were performed to evaluate the apoptosis level of ischaemic penumbra neurons in MCAO/R *** evaluation of NPs in MCAO/R mice was detected by blood routine examination,liver and kidney function examination and HE *** PLGA–PAMAM@CircOGDH siRNA NPs were successfully *** of PLGA–PAMAM@CircOGDH siRNA NPs in ischaemic neurons alleviated neuronal apoptotic level in vitro and in ***,mice behaviour test showed that the neurological defects of MCAO/R mice were significantly alleviated after the tail injection of PLGA–PAMAM@CircOGDH siRNA NPs,and no toxic effects were *** In conclusion,our results suggest that PLGA–PAMAM@CircOGDH siRNA NPs can be delivered to the ischaemic penumbra region and alleviate neuron apoptosis in MCAO/R mice and in ischaemic neurons;therefore,our study provides a desirable approach for using circRNA-based NPs for the treatment of ischaemic stroke.

关键词： OGD routine loaded

Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

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Nano Research 2023年第5期16卷 7413-7421页

作者： Xin-Chi Jiang Hong-Hui Wu tianyuan zhang Yun-Fei Dong Yao-Sheng Li Ting Huang An-Hao Tian Peng-Xiang Chen Xian-Ming Lin Ying-Zhi Huang Chong Liu Xiang-Nan zhang Zhong Chen Yasuhiko Tabata Jian-Qing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Department of Pathology and Pathophysiology and Department of Neurosurgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China The Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310058China SinoCell Biotechnology Ltd. Ningbo 315000China Key Laboratory of Medical Neurobiology of the Ministry of Health of China Institute of Pharmacology&ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Laboratory of Biomaterials Department of Regeneration Science and EngineeringInstitute for Frontier Life and Medical SciencesKyoto UniversityKyoto 606-8501Japan

Exosomes make a significant contribution during stem cell-based therapy due to the abundant *** evidence implies exosomes can act as potential biological nano *** herein propose hypoxic preconditioning for neural stem cells(NSCs)that could produce hypoxic exosomes for efficient treatment of ischemic *** preconditioning on NSCs significantly altered the miRNAs encapsulated in ***,hypoxic exosomes could target the injured brain to regulate the microenvironment to inhibit neuroinflammation and promote blood–brain barrier permeability ***,the autologous NSCs in Nestin-CreER mice could be activated by hypoxic exosomes to facilitate nerve *** hypoxic preconditioning,exosomes further exerted therapeutic effects on both survival(25%)and behavioral outcomes in ischemic stroke ***,hypoxic preconditioning NSCs can produce effective nano agent and may represent a promising strategy for clinical neurorestorative therapy.

关键词： exosomes hypoxia-preconditioning stem cells ischemic stroke microenvironment

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin tianyuan Fang Yuyu Zhou Chuxia zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

2030—2070年中俄油气资源海运可达性与通航成本演变预估

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地理学报 2021年第5期76卷 1122-1135页

作者：张天媛黄季夏王利北京师范大学地表过程与资源生态国家重点实验室北京100875 中国科学院地理科学与资源研究所中国科学院陆地表层格局与模拟重点实验室北京100101 北京林业大学教育部森林培育与保护重点实验室北京100083

由于社会经济迅速发展,中国对能矿资源的需求量日益增加。因此,中国和资源大国俄罗斯展开了大量的能源贸易。在全球气候变暖、北极航道通航性逐渐提高的背景下,两国港口间的能源运输可通过东北航道完成,在时间、成本、安全性等方面将优... 详细信息

由于社会经济迅速发展,中国对能矿资源的需求量日益增加。因此,中国和资源大国俄罗斯展开了大量的能源贸易。在全球气候变暖、北极航道通航性逐渐提高的背景下,两国港口间的能源运输可通过东北航道完成,在时间、成本、安全性等方面将优于通过传统航道运输。本文采用加权平均旅行时间量化气候变化情景下2030—2070年中国港口到俄罗斯油气资源的可达时间,并建立海运成本体系,计算经由东北航道进行资源运输的成本,得到如下结论:(1)中国港口到达俄罗斯石油资源的可达性优于天然气资源;(2)中国港口的资源可达时间每十年平均减少7 h,南通港到达俄罗斯资源的可达性最佳;(3)中国港口的资源海运成本每10 a平均降低0.5万美元,从南通港出发的航线成本在所有港口中最低;(4)在高排放浓度情景下,以商船作为媒介的中国港口资源可达性提升潜力巨大,应用前景乐观。本文量化并评估了2030—2070年中俄港口间能源贸易的时间与成本,为中俄能源海上贸易运输提供了理论参考。

关键词：中俄油气海运可达性海运成本东北航道冰上丝绸之路

基于鲁棒规划方法的农业水资源多目标优化配置模型

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水利学报 2020年第1期51卷 56-68页

作者：谭倩缑天宇张田媛李然张珊中国农业大学水利与土木工程学院北京100083 四川大学水力学与山区河流开发保护国家重点实验室四川成都610065

在干旱半干旱地区,调整种植结构可以促进农业水资源的高效利用。农业水资源配置需要在多个目标间权衡博弈,对各目标的偏好和赋权直接影响着优化模型的输出和决策方案的制定,但以往研究往往忽略了权重确定过程中因主观等因素的影响而普... 详细信息

在干旱半干旱地区,调整种植结构可以促进农业水资源的高效利用。农业水资源配置需要在多个目标间权衡博弈,对各目标的偏好和赋权直接影响着优化模型的输出和决策方案的制定,但以往研究往往忽略了权重确定过程中因主观等因素的影响而普遍存在的不确定性。针对农业水资源多目标规划中存在的权重不确定性难题,建立了基于鲁棒优化方法的农业水资源多目标优化配置模型方法(MRPWU)。该方法可以把权重中蕴含的复杂不确定性信息纳入建模过程,产生可靠的模型结果;并能提供效益值及风险值均定量化的方案集,便于决策者在权衡效益与风险后确定最优方案。模型以作物种植经济收益和碳吸收量最大化为目标、以水土资源供需平衡等为约束条件,并应用于农业水资源供需矛盾突出的甘肃省民勤县。优化结果表明,随着保护度水平的提高,生态效益上升,经济效益和综合效益下降,系统面临的风险也随之下降。相比于权重为确定参数的模型,MRPWU模型可以在综合效益下降3.7%的同时,较大地提高系统应对权重不确定性以及风险的能力。与2017年的实际情况相比,MRPWU模型可以减少种植面积1.6%、节省灌溉用水3.9%,同时提高生态效益1.6%。

关键词：多目标规划权重不确定性鲁棒性农业水资源管理种植结构

An Effective Genetic Modification of Mesenchymal Stem Cells using Highly Uniform Iron Oxide Nanoparticles

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An Effective Genetic Modification of Mesenchymal Stem Cells ...