Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

作     者：Xin-Chi Jiang Hong-Hui Wu Tianyuan Zhang Yun-Fei Dong Yao-Sheng Li Ting Huang An-Hao Tian Peng-Xiang Chen Xian-Ming Lin Ying-Zhi Huang Chong Liu Xiang-Nan Zhang Zhong Chen Yasuhiko Tabata Jian-Qing Gao Xin-Chi Jiang;Hong-Hui Wu;Tianyuan Zhang;Yun-Fei Dong;Yao-Sheng Li;Ting Huang;An-Hao Tian;Peng-Xiang Chen;Xian-Ming Lin;Ying-Zhi Huang;Chong Liu;Xiang-Nan Zhang;Zhong Chen;Yasuhiko Tabata;Jian-Qing Gao

作者机构：Institute of PharmaceuticsCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative MedicineZhejiang UniversityHangzhou 310058China Department of Pathology and Pathophysiology and Department of Neurosurgery of the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310058China SinoCell Biotechnology Ltd.Ningbo 315000China Key Laboratory of Medical Neurobiology of the Ministry of Health of ChinaInstitute of Pharmacology&ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Laboratory of BiomaterialsDepartment of Regeneration Science and EngineeringInstitute for Frontier Life and Medical SciencesKyoto UniversityKyoto 606-8501Japan 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2023年第16卷第5期

页      面：7413-7421页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.U22A20383 and 82003668) the Natural Science Foundation of Zhejiang Province(Nos.LD22H300002 and LQ21H300002) China Postdoctoral Science Foundation(No.2020M671771) Ningbo Technology Innovation 2025 Major Special Project(No.2022Z150) the innovative team of acupuncture and Chinese herbal medicine for prevention and treatment of senile neurodegenerative diseases 

主　　题：exosomes hypoxia-preconditioning stem cells ischemic stroke microenvironment 

摘      要：Exosomes make a significant contribution during stem cell-based therapy due to the abundant *** evidence implies exosomes can act as potential biological nano *** herein propose hypoxic preconditioning for neural stem cells(NSCs)that could produce hypoxic exosomes for efficient treatment of ischemic *** preconditioning on NSCs significantly altered the miRNAs encapsulated in ***,hypoxic exosomes could target the injured brain to regulate the microenvironment to inhibit neuroinflammation and promote blood–brain barrier permeability ***,the autologous NSCs in Nestin-CreER mice could be activated by hypoxic exosomes to facilitate nerve *** hypoxic preconditioning,exosomes further exerted therapeutic effects on both survival(25%)and behavioral outcomes in ischemic stroke ***,hypoxic preconditioning NSCs can produce effective nano agent and may represent a promising strategy for clinical neurorestorative therapy.