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Tumor Receptor-Seeking Dyes for Rapid Intraoperative Definition of Tumor Margin and Histopathological Morphology

CCS Chemistry 2024年第10期6卷 2577-2593页

作者： Yajun Wang Feiran Zhang Yunlong Jia tianyang han Chengbin Zhang Limei Qu Yuewei Zhang Shoujun Zhu State Key Laboratory of Supramolecular Structure and Materials Center for Supramolecular Chemical BiologyCollege of ChemistryJilin UniversityChangchun 130012 Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry The First Hospital of Jilin UniversityChangchun 130021 School of Chemistry and Pharmaceutical Engineering Jilin Institute of Chemical TechnologyJilin 132022 Department of Pathology The First Hospital of Jilin UniversityChangchun 130021

Histopathological diagnosis is a crucial part of surgical treatment,as it determines further treatment decisions and prognosis for *** to the heterogeneity of tumors,traditional histopathological diagnosis relies on histological and cytological morphological analysis of cryo-slides by well-trained pathologists,which is subjective,time-consuming,and lacks considerable ***,we engineer a series of tumor receptor-seeking dyes to automatically label and visually depict the tumor contour with antibody-free *** meso-chlorine on the cyclohexyl ring of dyes can covalently react with specific thiol groups in various tumor signature proteins to form stable dye@protein *** dye@protein complexes have significantly amplified fluorescence signals in tumor sites,enabling highresolution delineation of tumormargins and providing histological morphology information to potentially determine tumor *** orthogonal effect not only avoids errors caused by individual signature proteins,but also amplifies the fluorescence difference between tumor and normal ***,our method is easy to operate with a minimal detection time of only 4 *** tumor receptor-seeking dyes successfully assess tumor-positive margins from 66 resected breast tumor samples and 25 intraoperative cancer patients with 100%accuracy,providing a newgeneration technique for intraoperative pathologic diagnosis of tumor biopsy.

关键词： tumor receptor-seeking dyes tumor-positive margins chemoselective covalent labeling nearinfrared imaging histopathological morphology

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Direct observation of ultrafast plasmonic hot electron transfer in the strong coupling regime

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Light(Science & Applications) 2019年第1期8卷 1099-1107页

作者： hangyong Shan Ying Yu Xingli Wang Yang Luo Shuai Zu Bowen Du tianyang han Bowen Li Yu Li Jiarui Wu Feng Lin Kebin Shi Beng Kang Tay Zheng Liu Xing Zhu Zheyu Fang School of Physics State Key Lab for Mesoscopic Physics/Academy for Advanced Interdisciplinary Studies/Collaborative Innovation Center of Quantum MatterPeking University100871 BeijingChina CNRS International-NTU-Thales Research Alliance(CINTRA) Nanyang Technological UniversitySingapore 637553Singapore Centre for Micro-/Nano-Electronics(NOVITAS) School of Electrical and Electronic Engineering/Centre for Programmed MaterialsSchool of Materials Science and EngineeringNanyang Technological UniversitySingapore 637553Singapore

Achieving strong coupling between plasmonic oscillators can significantly modulate their intrinsic optical ***,we report the direct observation of ultrafast plasmonic hot electron transfer from an Au grating array to an MoS_(2) monolayer in the strong coupling regime between localized surface plasmons(LSPs)and surface plasmon polaritons(SPPs).By means of femtosecond pump-probe spectroscopy,the measured hot electron transfer time is approximately 40 fs with a maximum external quantum yield of 1.65%.Our results suggest that strong coupling between LSPs and SPPs has synergetic effects on the generation of plasmonic hot carriers,where SPPs with a unique nonradiative feature can act as an‘energy recycle bin’to reuse the radiative energy of LSPs and contribute to hot carrier *** energy exchange between plasmonic modes in the strong coupling regime can further enhance the vertical electric field and promote the transfer of hot electrons between the Au grating and the MoS_(2) *** proposed plasmonic strong coupling configuration overcomes the challenge associated with utilizing hot carriers and is instructive in terms of improving the performance of plasmonic opto-electronic devices.

关键词： properties coupling transfer

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京西旗营:外火器营史话

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北京档案 2022年第7期 50-52页

作者：韩天阳中央民族大学历史文化学院

在北京地区广为流传的民间小曲《探清水河》中唱道:“桃叶儿尖上尖柳叶儿就遮满了天,在其位的这个明啊公细听我来言呐,此事哎出在了京西蓝靛厂啊,蓝靛厂火器营儿有一个……”此曲中的京西蓝靛厂火器营,即为今北京市海淀区蓝靛厂北火器... 详细信息

在北京地区广为流传的民间小曲《探清水河》中唱道:“桃叶儿尖上尖柳叶儿就遮满了天,在其位的这个明啊公细听我来言呐,此事哎出在了京西蓝靛厂啊,蓝靛厂火器营儿有一个……”此曲中的京西蓝靛厂火器营,即为今北京市海淀区蓝靛厂北火器营路附近,其营房大多已经无处寻觅。但早在二百多年前,这里曾是京师八旗禁旅外火器营的旗营驻地。火器营为何有内外之分?外火器营在清朝北京城中留下了怎样的足迹?我们通过历史文本和档案资料来回溯这座旗营的历史往事。

关键词：火器营京师八旗档案资料历史文本蓝靛厂北京市海淀区京西清水河

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用户生成内容影响传统电商与社交电商销售额的机理分析

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商业经济研究 2022年第1期 101-104页

作者：韩天阳镐鑫谢菲尔德大学英国谢菲尔德S102TN

顾客在社交电商平台中分享购物体验,能够在一定程度上影响其他顾客的购买行为,这将会对传统电商与社交电商平台的商品销售额产生重要影响。因此,探究社交电商中用户生成内容(UGC)对传统电商与社交电商商品销售额的影响机制,对于电商把... 详细信息

顾客在社交电商平台中分享购物体验,能够在一定程度上影响其他顾客的购买行为,这将会对传统电商与社交电商平台的商品销售额产生重要影响。因此,探究社交电商中用户生成内容(UGC)对传统电商与社交电商商品销售额的影响机制,对于电商把握发展机遇,提升口碑、销量以及绩效而言具有重要现实意义。本文通过实证分析得出以下结论:社交电商平台中某商品销售额受到该商品帖子数量和帖子点赞数量显著的积极影响;传统电商平台中某商品销售额受到社交电商平台中该商品帖子数量显著的积极影响;传统电商平台中某商品销售额受到社交电商平台中该商品销售额显著的积极影响。

关键词：社交电商传统电商平台 UGC 商品销售额

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超声波辅助法提取生姜油的工艺研究

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食品工程 2020年第2期 11-13,34页

作者：樊迎郭科阳赵洁许晋伟韩天洋山西农业大学信息学院山西太谷030800

采用单因素和正交试验,进行了超声波辅助提取生姜油的工艺研究,得到最佳提取工艺条件。结果表明,选用体积浓度80%乙醇作为萃取溶剂,在超声时间35min,超声温度60℃,料液比1g:50mL,超声功率135W时提取效果最佳,生姜油最高得率为11.82%。... 详细信息

采用单因素和正交试验,进行了超声波辅助提取生姜油的工艺研究,得到最佳提取工艺条件。结果表明,选用体积浓度80%乙醇作为萃取溶剂,在超声时间35min,超声温度60℃,料液比1g:50mL,超声功率135W时提取效果最佳,生姜油最高得率为11.82%。在最佳条件下连续进行3次提取,累计得率可达12.91%。

关键词：超声波辅助提取法生姜油提取工艺研究

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Deep Spatiotemporal Convolutional-Neural-Network-Based Remaining Useful Life Estimation of Bearings

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Chinese Journal of Mechanical Engineering 2021年第3期34卷 115-129页

作者： Xu Wang tianyang Wang Anbo Ming Qinkai han Fulei Chu Wei Zhang Aihua Li State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China High-Tech Research Institute of Xi’an Xi’an 710025China

The remaining useful life(RUL)estimation of bearings is critical for ensuring the reliability of mechanical *** to the rapid development of deep learning methods,a multitude of data-driven RUL estimation approaches have been proposed ***,the following problems remain in existing methods:1)Most network models use raw data or statistical features as input,which renders it difficult to extract complex fault-related information hidden in signals;2)for current observations,the dependence between current states is emphasized,but their complex dependence on previous states is often disregarded;3)the output of neural networks is directly used as the estimated RUL in most studies,resulting in extremely volatile prediction results that lack ***,a novel prognostics approach is proposed based on a time-frequency representation(TFR)subsequence,three-dimensional convolutional neural network(3DCNN),and Gaussian process regression(GPR).The approach primarily comprises two aspects:construction of a health indicator(HI)using the TFR-subsequence-3DCNN model,and RUL estimation based on the GPR *** raw signals of the bearings are converted into TFR-subsequences by continuous wavelet transform and a dislocated overlapping ***,the 3DCNN is applied to extract the hidden spatiotemporal features from the TFR-subsequences and construct ***,the RUL of the bearings is estimated using the GPR model,which can also define the probability distribution of the potential function and prediction *** on the PRONOSTIA platform demonstrate the superiority of the proposed TFR-subsequence-3DCNN-GPR *** use of degradation-related spatiotemporal features in signals is proposed herein to achieve a highly accurate bearing RUL prediction with uncertainty quantification.

关键词： Bearing Remaining useful life Continuous wavelet transform Convolution neural network Gaussian process regression

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Wave-Enhanced Sediment-Gravity Flows in Bohai Bay Lacustrine Basin, Eastern China

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Acta Geologica Sinica(English Edition) 2018年第6期92卷 2416-2431页

作者： BAI Chenyang YU Bingsong DONG tianyang han Shujun GE Jia ZHU Donglin School of Geosciences and Resources China University of Geosciences(Beijing) Department of Earth Environmentaland Planetary SciencesRice University Oil & Gas Survey China Geological Survey Bureau of Geophysical Prospecting Inc. China National Petroleum Corp. Department of Geosciences University of Texas at Dallas

Sequences of wave-enhanced sediment-gravity flows(WESGFs) have been widely recognized in the marine shelf environment. In this study, we show observations of WESGF deposits in lacustrine settings using well core and thin section data from the Paleogene in the Jiyang sub-basin, Bohai Bay basin, eastern China. The findings of this study include the following: 1) the sequence of WESGFs in the lacustrine basin is similar to that of marine; it consists of three units, MF1 unit: siltstone with basal erosion surface, MF2 unit: silt-streaked claystone, and MF3 unit: silty-mudstone; and 2) prodelta sand sheets are found in the lacustrine WESGF sequence and are classified as the MFd unit: clay-streaked siltstone. However, because the system size and variability in hydrodynamic conditions are different between the lacustrine and marine basins, lacustrine WESGFs do appear to have three distinguishable features: 1) the sediment grain size and sand content are slightly higher than those of the marine WESGFs; 2) lacustrine WESGFs may contain prodelta sediments or sedimentary sequences of other types of gravity flows, such as hyperpycnal flows; and 3) the scale of the sedimentary structures for lacustrine WESGFs is smaller. The WESGFs found in the continental lacustrine basin provide a new model for sediment dispersal processes in lake environments and may be helpful to explain and predict the distribution of sandy reservoirs for oil and gas exploration.

关键词： wave-enhanced sediment-gravity flows sediment transport lacustrine basin Shahejie Formation Bohai Bay basin

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基于大学生创新创业训练项目的自主学习探索——以“饮用水除氟”项目为例

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化工高等教育 2019年第4期36卷 86-89页

作者：寇满昌冯莉韩天阳许宝康王兆峰谢亚东中国矿业大学化工学院

我们以“新型高效的除氟技术和超滤系统在饮用水处理中的综合应用”为题,申报了“大学生创新创业训练计划”项目。在项目进行过程中,学生通过个人参与、团队协作的方式,不断深入研究,逐步提高自己的理论知识水平、实践能力、团结协作能... 详细信息

我们以“新型高效的除氟技术和超滤系统在饮用水处理中的综合应用”为题,申报了“大学生创新创业训练计划”项目。在项目进行过程中,学生通过个人参与、团队协作的方式,不断深入研究,逐步提高自己的理论知识水平、实践能力、团结协作能力和沟通表达能力,增强了创新意识,培养了大胆创新、小心求证的科研精神。

关键词：大学生创新训练计划学习过程心得体会

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Color myth:anthocyanins reactions and enological approaches achieving their stabilization in the aging process of red wine

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Food Innovation and Advances 2023年第4期2卷 255-271页

作者： Siqi Cheng tianyang Wu Jie Gao Xiaoyu han Weidong Huang Yilin You Jicheng Zhan Beijing Key Laboratory of Viticulture and Enology College of Food Science and Nutritional EngineeringChina Agricultural UniversityTsinghua East Road 17Haidian DistrictBeijing 100083China

Color is a crucial sensory indicator of wine ***,changes in anthocyanin concentration and profile occur during wine aging,resulting in noticeable reductions in chroma and shifts in hue from purple to brick *** is because monomeric anthocyanins degrade and derivative anthocyanins *** rate of color changes can vary depending on complex factors,such as the anthocyanin content of the must,oenological technology,and environmental conditions,which makes the management of red wine color evolution *** address this issue,appropriate winemaking techniques are required to achieve an elegant wine *** review summarizes the mechanisms related to anthocyanin stability,including glycosylation,acetylation,and *** review also discusses factors influencing red wine color fading for specific grape varieties and wine appellations,offering time-and cost-efficient techniques to accelerate anthocyanin derivatization and color stabilization.

关键词： app stabilization offering

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Filamentous morphology engineering of bacteria by iron metabolism modulation through MagR expression

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Synthetic and Systems Biotechnology 2024年第3期9卷 522-530页

作者： Mengke Wei Chenyang han Xiujuan Zhou tianyang Tong Jing Zhang Xinmiao Ji Peng Zhang Yanqi Zhang Yan Liu Xin Zhang Tiantian Cai Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui230032China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang310027China

The morphology is the consequence of evolution and *** coli is rod-shaped bacillus with regular dimension of about 1.5μm long and 0.5μm *** shape-related genes have been identified and used in morphology engineering of this ***,little is known about if specific metabolism and metal irons could modulate bacteria *** in this study,we discovered filamentous shape change of *** cells overexpressing pigeon MagR,a putative magnetoreceptor and extremely conserved iron-sulfur *** transcriptomic analysis strongly suggested that the iron metabolism change and iron accumulation due to the overproduction of MagR was the key to the morphological *** model was further validated,and filamentous morphological change was also achieved by supplement *** cells with iron in culture medium or by increase the iron uptake genes such as entB and *** study extended our understanding of morphology regulation of bacteria,and may also serves as a prototype of morphology engineering by modulating the iron metabolism.

关键词： Morphology regulation Iron accumulation Filamentous bacteria MagR overexpression

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