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基于机器学习的刮板输送机链条预紧力动态控制技术研究

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煤矿机械 2024年第3期45卷 28-30页

作者：王天星成敏沈丰曹伟宁夏天地奔牛实业有限公司刮板机研究分院银川750000

刮板输送机的链条松紧状态是传动系统能否正常高效工作的前提。随着工作面煤层变化、采煤机位置变化和溜槽上物料变化,链条载荷受到多种因素的复合影响,链条受力状态具有随机性、复杂性、时变性和不确定性等特点,各种复杂变化特性造成... 详细信息

刮板输送机的链条松紧状态是传动系统能否正常高效工作的前提。随着工作面煤层变化、采煤机位置变化和溜槽上物料变化,链条载荷受到多种因素的复合影响,链条受力状态具有随机性、复杂性、时变性和不确定性等特点,各种复杂变化特性造成了链条预紧力控制的困难。基于机器学习算法,将人工控制刮板输送机链条预紧力的历史数据作为训练集,建立了基于神经网络的刮板输送机链条预紧力动态控制算法模型。仿真结果表明,在经过大量数据训练后,模型能够较准确地实现链条预紧力控制,具有较好的适用性和先进性。

关键词：机器学习神经元算法刮板输送机链条预紧力控制

软骨细胞中生物钟基因Bmal1对细胞周期相关基因表达的影响

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基础医学与临床 2024年第4期44卷 496-502页

作者：杨春生王添兴张铁成武恒敏王宝兰新疆医科大学第一附属医院康复医学科新疆乌鲁木齐830000 新疆医科大学第一附属医院关节外科新疆乌鲁木齐830000

目的探讨生物钟和细胞周期在骨关节炎(OA)软骨细胞中内在的关系,主要是时钟基因Bmal1对细胞周期相关基因的调控。方法将胰岛素-转铁蛋白-硒(ITS)诱导后的软骨样ATDC5细胞分为normal组、OA组、LV-Bmal1组。采用CCK8法检测各组细胞活力;... 详细信息

目的探讨生物钟和细胞周期在骨关节炎(OA)软骨细胞中内在的关系,主要是时钟基因Bmal1对细胞周期相关基因的调控。方法将胰岛素-转铁蛋白-硒(ITS)诱导后的软骨样ATDC5细胞分为normal组、OA组、LV-Bmal1组。采用CCK8法检测各组细胞活力;RT-qPCR法检测Bmal1、Per1、Wee1、Cdk1、Ccnb1和Mmp13 mRNA在各组中的表达;Western blot检测BMAL1、PER1、WEE1、CDK1、CCNB1和MMP13蛋白在各组中的表达水平;流式细胞测量术分析Bmal1对细胞周期中不同分期及细胞凋亡的影响;分析Bmal1对Per1、Wee1、Cdk1、Ccnb1和Mmp13的调控和它们在OA中发挥的作用。结果与normal组相比,OA组细胞活力提高,Bmal1、Wee1的mRNA相对表达量下降,Per1、Cdk1、Ccnb1、Mmp13的mRNA相对表达量明显增加;LV-Bmal1组细胞活力下降,Bmal1、Wee1的mRNA相对表达量上升,Per1、Cdk1、Ccnb1、Mmp13的mRNA相对表达量下降(P<0.05);相关性分析显示,Bmal1与Wee1呈正相关,二者与Per1、Cdk1、Ccnb1或Mmp13存在负相关;Western blot结果显示,不同组别中蛋白表达水平的结果与PCR趋势一致;细胞周期和细胞凋亡检测结果显示,和normal组相比,OA组S期、G2/M期缩短,细胞比例明显下降,细胞早期和晚期凋亡比例增加,LV-Bmal1组S期、G2/M期延长,细胞比例增加,早期和晚期凋亡比例下降。结论炎性软骨细胞中生物钟基因Bmal1可能参与调节细胞周期相关基因的表达。

关键词：生物钟细胞周期骨关节炎软骨细胞凋亡

Carbon-doping-induced negative differential resistance in armchair phosphorene nanoribbons

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Journal of Semiconductors 2017年第3期38卷 82-87页

作者： Caixia Guo Congxin Xia tianxing wang Yufang Liu College of Physics and Materials Science Henan Normal University Xinxiang 453007 China

By using a combined method of density functional theory and non-equilibrium Green＇s function formalism,we investigate the electronic transport properties of carbon-doped armchair phosphorene nanoribbons（APNRs）.The results show that C atom doping can strongly affect the electronic transport properties of the APNR and change it from semiconductor to ***,obvious negative differential resistance（NDR） behaviors are obtained by tuning the doping position and *** particular,with reducing doping concentration,NDR peak position can enter into m V bias *** results provide a theoretical support to design the related nanodevice by tuning the doping position and concentration in the APNRs.

关键词： C atom doping armchair phosphorene nanoribbon negative differential resistance behavior

Nanodevices engineering and spin transport properties of MnBi_(2)Te_(4) monolayer

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npj Computational Materials 2021年第1期7卷 414-421页

作者： Yipeng An Kun wang Shijing Gong Yusheng Hou Chunlan Ma Mingfu Zhu Chuanxi Zhao tianxing wang Shuhong Ma Heyan wang Ruqian Wu Wuming Liu School of Physics&Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials Henan Normal UniversityXinxiangChina Department of Physics and Astronomy Mississippi State UniversityStarkvilleMSUSA Department of Chemistry Mississippi State UniversityStarkvilleMSUSA Key Laboratory of Polar Materials and Devices(MOE)&Department of Optoelectronics East China Normal UniversityShanghaiChina Department of Physics and Astronomy University of CaliforniaIrvineCAUSA School of Physics Sun Yat-Sen UniversityGuangzhouChina School of Physics and Technology Suzhou University of Science and TechnologySuzhouJiangsuChina Hebi National Lighting Co.Ltd HebiChina Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsDepartment of PhysicsJinan UniversityGuangzhouChina Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina

Two-dimensional(2D)magnetic materials are essential for the development of the next-generation spintronic ***,layered van der Waals(vdW)compound MnBi2Te4(MBT)has attracted great interest,and its 2D structure has been reported to host coexisting magnetism and ***,we design several conceptual nanodevices based on MBT monolayer(MBT-ML)and reveal their spin-dependent transport properties by means of the first-principles *** pn-junction diodes and sub-3-nm pin-junction field-effect transistors(FETs)show a strong rectifying effect and a spin filtering effect,with an ideality factor n close to 1 even at a reasonably high *** addition,the pip-and nin-junction FETs give an interesting negative differential resistive(NDR)*** gate voltages can tune currents through these FETs in a large ***,the MBT-ML has a strong response to *** results uncover the multifunctional nature of MBT-ML,pave the road for its applications in diverse next-generation semiconductor spin electric devices.

关键词： temperature ideality transport

A review of the techniques for the mold manufacturing of micro/nanostructures for precision glass molding

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International Journal of Extreme Manufacturing 2021年第4期3卷 23-54页

作者： Tianfeng Zhou Yupeng He tianxing wang Zhanchen Zhu Ruzhen Xu Qian Yu Bin Zhao Wenxiang Zhao Peng Liu Xibin wang School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120People’s Republic of China

Micro/nanostructured components play an important role in micro-optics and optical engineering,tribology and surface engineering,and biological and biomedical engineering,among other *** glass molding technology is the most efficient method of manufacturing micro/nanostructured glass components,the premise of which is meld manufacturing with complementary micro/*** mold manufacturing methods have been developed to fabricate extremely small and high-quality micro/nanostructures to satisfy the demands of functional micro/nanostructured glass components for various ***,the service performance of the mold should also be carefully *** paper reviews a variety of technologies for manufacturing micro/nanostructured *** authors begin with an introduction of the extreme requirements of mold *** following section provides a detailed survey of the existing micro/nanostructured mold manufacturing techniques and their corresponding mold materials,including nonmechanical and mechanical *** paper concludes with a detailed discussion of the authors recent research on nickel-phosphorus(Ni-P)mold manufacturing and its service performance.

关键词： precision glass molding mold manufacturing micro/nanostructure mold material extreme features

A review of the estimation of downward surface shortwave radiation based on satellite data:Methods, progress and problems

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Science China Earth Sciences 2020年第6期63卷 774-789页

作者： Husi LETU Jiancheng SHI Ming LI tianxing wang Huazhe SHANG Yonghui LEI Dabin JI Jianguang WEN Kun YANG Liangfu CHEN Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100010China Deparment of Earth System Science Tsinghua UniversityBeijing 100049China

The estimation of downward surface shortwave radiation(DSSR)is important for the Earth’s energy budget and climate change *** review was organised from the perspectives of satellite sensors,algorithms and future trends,retrospects and summaries of the satellite-based retrieval methods of DSSR that have been developed over the past 10 *** shortwave radiation reaching the Earth’s surface is affected by both atmospheric and land surface *** recent years,studies have given detailed considerations to the factors which affect *** is important to improve the retrieval accuracy of cloud microphysical parameters and aerosols and to reduce the uncertainties caused by complex topographies and high-albedo surfaces(such as snow-covered areas)on DSSR *** review classified DSSR retrieval methods into four categories:empirical,parameterisation,look-up table and machine-learning methods,and evaluated their advantages,disadvantages and *** efforts are needed to improve the calculation accuracy of atmospheric parameters such as cloud,haze,water vapor and other land surface parameters such as albedo of complex terrain and bright surface,organically combine machine learning and other methods,use the new-generation geostationary satellite and polar orbit satellite data to produce highresolution DSSR products,and promote the application of radiation products in hydrological and climate models.

关键词： Downward surface shortwave radiation Satellite remote sensing Cloud optical property Terrain correction

A biosensing system employing nanowell microelectrode arrays to record the intracellular potential of a single cardiomyocyte

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Microsystems & Nanoengineering 2022年第3期8卷 185-198页

作者： Yuting Xiang Haitao Liu Wenjian Yang Zhongyuan xu Yue Wu Zhajian Tang Zhjing Zhu Zhiyong Zeng Depeng wang tianxing wang Ning Hu Diming Zhang Department of Obstetrics and Gynecology Affiliated Dongguan People's HospitalSouthern Medical UniversityDongguan 523058China Research Center for Inelligent Sensing Systems Zhejiang LaboratoryHangzhou 311100China Research Center for Humanoid Sensing Zhejiang LaboratoryHangzhou 311100China Key Laboratory of Novel Target and Drug Study for Neural Repair of Zhejiang Province School of MedicineSchool of Computer&Computing ScienceZhejiang University City CollegeHangzhou 310015China School of Brain Science and Brain Medicine Zhejiang UniversityHangzhou 310058China School of Automation Nanjing University of Science and TechnologyNanjing 210094China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China E-Link Care Meditech Co. LtdHangzhou 310011China ZJU-Hangzhou Global Scientific and Technological Innovation Center Department of ChemitryZhejiang UniversityHangzhou 310058China

Electrophysiological recording is a widely used method to investigate cardiovascular pathology,pharmacology and developmental *** arrays record the electrical potential of cells in a minimally invasive and highthroughput ***,commonly used microelectrode arays primarily employ planar microelectrodes and cannot work in applications that require a recording of the intracellular action potential of a single *** this study,we proposed a novel measuring method that is able to record the intracellular action potential of a single cardiomyocyte by using a nanowell patterned microelectrode array(NWMEA).The NWMEA consists of five nanoscale wells at the center of each circular planar *** pulse electroporation was applied to the NWMEA to penetrate the cardiomyocyte membrane,and the intracellular action potential was continuously *** intracellular potential recording of cardiomyocytes by the NWMEA measured a potential signal with a higher quality(213.76±25.85%),reduced noise root-mean-square(~33%),and higher signal-to-noise ratio(254.36±12.61%)when compared to those of the extracellular *** to previously reported nanopillar microelectrodes,the NWMEA could ensure single cell electroporation and acquire high-quality action potential of cardiomyocytes with reduced fabrication *** NWMEA-based biosensing system is a promising tool to record the intracellular action potential of a single cell to broaden the usage of microelectrode arrays in electrophysiological investigation.

关键词： arrays potential record

DESIGN OF MICROPHYSIOMETER BASED ON MULTIPARAMETER CELL-BASED BIOSENSORS FOR QUICK DRUG ANALYSIS

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Journal of Innovative Optical Health Sciences 2012年第1期5卷 36-47页

作者： NING HU DA HA CHENGXIONG WU GONG CHENG HUI YU tianxing wang JIEYING WU HUA CAI QINGJUN LIU PING wang Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027P.R.China ACEA Bioscience Inc.West Lake Technology and Economy Park Hangzhou 310030 P.R.China

Cellular metabolism arouses the changes of substance in extracellular physiological microenvironment,and the metabolic level reflects the physiological state of *** paper developed a novel microphysiometer automatic analysis instrument based on multiparameter cell-based biosensors for quick drug *** study included the multiparameter cell-based biosensors,cell culture chamber,drug auto-injection detection and *** analysis instrument was capable of real-time detection for the acidic product and other chemical parameters generated by the cellular metabolism in the ***,the paper employs human breast cancer cell line MCF-7 and drug experiments to verify the performance of microphysiometer,and study effects of different drugs on cell ***,the research explores drug analysis method of the multiparameter *** results showed that the cell-based microphysiometer system provides a utility platform for rapid,long-term and automatic cell physiological environment detection and drug analysis.

关键词： Microphysiometer multiparameter cell-based biosensor extracellular acidification cancer cells drug analysis

Algorithm of Micro-Grooving and Imaging Processing for the Generation of High-Resolution Structural Color Images

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Nanomanufacturing and Metrology 2020年第3期3卷 187-198页

作者： Tianfeng Zhou Yupeng He tianxing wang Xiaobin Dong Peng Liu Wenxiang Zhao Yao Hu Jiwang Yan Key Laboratory of Fundamental Science for Advanced Machining.Beijing Institute of Technology Beijing 100081China Beijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology Beijing Institute of TechnologyBeijing 100081China Department of Mechanical Engineering Faculty of Science and TechnologyKeio UniversityYokohama 223-8522Japan

The use of submicron structures for structural coloration of surfaces has broad applications for color filters,projection displays,virtual reality,and ***,structural color images lack high resolution due to low manufacturing *** this study,the axial-feed fly cutting(AFC)method is proposed to fabricate submicron grooves for the diffraction of visible light to create structural color *** establish the relationship between the color information in the pixels of the original image and the parameters of the array units corresponding to the *** algorithm to determine groove spacing and the tool path is established,and array units with the desired groove spacing are machined to reproduce the structural color *** submicron grooves fabricated by AFC have high quality and good *** to the excellent diffraction performance of the machined grooves,images with high saturation and resolution can be *** is verified that images with various colors can be efficiently fabricated using the proposed method and algorithm.

关键词： Subniicron structure Microgroove Structural coloration Structural-color image Fly cutting Micromachining