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In vivo auditory nerve stimulation with visible light

Journal of Innovative Optical Health Sciences 2017年第5期10卷 77-84页

作者： tian guan Muqun Yang Yonghong He Graduate School at Shenzhen Tsinghua University Shenzhen 518055P.R.China Tsinghua-Berkeley Shenzhen Institute Tsinghua University Shenzhen 518055P.R.China

Background:Infrared laser stimulation has been proposed as an innovative method to elicit an auditory nerve *** studies have focused on usi ng long-wavelength infrared(>980 nm)pulsod lasers with high water absoption *** paper sought to assts8 whether a short-wavelength laser(465 nm)with an absorption cofficient as low as 103 cm^(-1) would activate the auditory nerve and studied its potential ***:Optical compound action potentials(OCAPs)were recorded when synchronous triger laser pulses st imulate the cochlea before and after deafening,varying the pulse durations(from 8001us to 36001us)and the amount of radiant enengy(fom 18.05 mJ/cm^(2) to 107.91 mJ/cm^(2)).A thermal infrared imager was applied to monitor the tempenature change of the guinea pig ***:The results showed that pulsed laser stimulation at 465 nm could invoke OCAPs and had a similar waveform compared to the acoustical compound action *** amplitude of OCAPs had a poaitive correlation with the in-creasi ng laser peak power,while the latency of OCAPs showed a negative *** imager data showed that the temperature in thecochlea rose quickly by about 0.3℃ right after stimulating the cochlea and decreased quickly back to the initial temperature as the stimulation ***-clusions:This paper demonstrates that 465-nm laser st imulation can successfully induce OCAPs outside the cochlea,and that the amplitude and latency of the invoked OCAPs are highly affected by laser peak *** paper proposes that a photothermal efect might be the main mechanism for the auditory nerve response induced by short-wavelength laser stimulation.

关键词： Pulsed laser optical stimulation cochlear implant optical compound action potentials

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Photoacoustic effect invokes auditory response in infrared neuron stimulation

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Journal of Innovative Optical Health Sciences 2019年第1期12卷 54-61页

作者： Muqun Yang tian guan Yonghong He Tsinghua-Berkeley Shenzhen Institute Tsinghua University Nanshan Shenzhen 518071P.R.China Graduate School at Shenzhen Tsinghua University Nanshan Shenzhen 518055P.R.China

Infrared neuron stimulation is regarded as an innovative approach for stimulating cochleae in animals while the exact mechanism still remains *** this paper,we studied compound action potentials of guinea pig cochleae with chronic or acute *** recorded optical compound action potentials and analyzed stretched cochlear preparations by fiuorescence *** signals were measured by hydrophone and microphone,*** our experiment,we observed a switch response effect in vitro and in vivo ***,we proposed photoacoustic effect could invoke auditory response in infrared neuron stimulation.

关键词： Infrared neuron stimulation optical compound action potential photoacoustic effect

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Test Verification and Design of the Bicycle Frame Parameters

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 716-725页

作者： ZHANG Long XIANG Zhongxia LUO Huan tian guan Key Laboratory of Mechanism Theory and Equipment Design of Education Tianjin University

Research on design of bicycles is concentrated on mechanism and auto appearance design, however few on matches between the bike and the rider. Since unreasonable human-bike relationship leads to both riders＇ worn-out joints and muscle injuries, the design of bicycles should focus on the matching. In order to find the best position of human-bike system, simulation experiments on riding comfort under different riding postures are done with the lifemode software employed to facilitate the cycling process as well as to obtain the best position and the size function of it. With BP neural network and GA, analyzing simulation data, conducting regression analysis of parameters on different heights and bike frames, the equation of best position of human-bike system is gained at last. In addition, after selecting testers, customized bikes based on testers＇ height dimensions are produced according to the size function. By analyzing and comparing the experimental data that are collected from testers when riding common bicycles and customized bicycles, it is concluded that customized bicycles are four times even six times as comfortable as common ones. The equation of best position of human-bike system is applied to improve bikes＇ function, and the new direction on future design of bicycle frame parameters is presented.

关键词： bike modeling data mining fatigue dynamics simulation oxygen uptake

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A photoacoustic imaging system with variable gain at different depths

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Journal of Innovative Optical Health Sciences 2018年第5期11卷 1-10页

作者： tian guan Yao Li Muqun Yang Yong Jiang Yonghong He Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Graduate School at Shenzhen Tsinghua University Shenzhen 518055P.R.China Department of Biomedical Engineering Tsinghua University Beijing 100084P.R.China Center of Precision Medicine and Healthcare Tsinghua-Berkeley Shenzhen Institute Shenzhen 518055P.R.China Shenzhen Wisonic Medical Technology Co. Ltd.Taoyuan StreetNanshan DistrictShenzhen 518055P.R.China

We established a photoacoustic imaging(PAI)system that can provide variable gain at different *** PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an imaging-acquisition-and-processing unit with an ultrasound ***-controlled attenuator was used to realize variable gain at different depths when acquiring PAI *** proof-of-concept imaging results for variable gain at different depths were achieved using specic *** resolution and optical contrast obtained through the results of variable gain for a targeted depth range are better than those of constant gain for all *** further testify the function,we imaged the sagittal section of the body of in vivo nude *** addition,we imaged an absorption sample embedded in a chicken breast tissue,reaching a maximum imaging depth of4.6 *** results obtained using the proposed method showed better resolution and contrast than when using 50 dB gain for all *** depth range resolution was1 mm,and the maximum imaging depth of our system reached4.6 ***,blood vessels can be revealed and targeted depth range can be selected in nude mice imaging.

关键词： Photoacoustic imaging variable gain imaging depth

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Optical 2-benzyl-5-hydroxy-4-oxopentanoic acids against carboxypeptidase A:Synthesis,kinetic evaluation and X-ray crystallographic study

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Chinese Chemical Letters 2010年第2期21卷 159-162页

作者： Wang, Shou Feng Jin, Jing-Yi Zeng, Zong Hao tian, guan Rong Yanbian Univ Minist Educ Key Lab Organism Funct Factors Changbai Mt Yanji 133002 Peoples R China Chinese Acad Sci Inst Biophys Beijing 100871 Peoples R China

2-Benzyl-5-hydroxy-4-oxopentanoic acid 1 and its enantiomers were designed,synthesized and assayed for inhibitory activity against carboxypeptidase A(CPA,EC 3.***.17.1).To verify the role of the terminal hydroxyl group in 1 binding to CPA,2-benzyl-5- benzyloxy-4-oxopentanoic acid 2 was also synthesized and *** inhibition constants show that both L-1 and D-1 were shown to have strong binding affinity with L-1 being more potent than its enantiomer by *** the other hand,the inhibition constant ...

关键词： 2-Benzyl-5-hydroxy-4-oxopentanoic acid Carboxypeptidase A X-ray crystallographic study

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Pavement Pothole Detection System Based on Deep Learning and Binocular Vision

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： tian guan Jianyuan Cai Yu Wang Wei Yang Xiaobo Chang Yi Han School of Automobile， Chang'an University China National Heavy Duty Truck Group Company Limited

Due to strong vibrations and the impact on high-speed vehicles， road potholes may cause discomfort to passengers， damaging the durability of the suspension and the integrity of the cargo. Therefore， a road pothole detection system is proposed， which uses deep learning and binocular vision for precise detection in the front. Based on the impact of road surface potholes on human driving behavior decisions of manually driven vehicles， which can cause drivers to slow down or stop， change driving routes， or even increase accident risks， road surface potholes can be divided into three categories: severe potholes (deep and large potholes)， non damaged road surfaces (flat surfaces without obvious potholes or damage)， and completely damaged road surfaces (there may be large areas of potholes， cracks， or other structural damage). 6848 road surface pit condition recognition datasets were constructed using a vehicle mounted binocular camera. Group attention shuffling block (CASB) is designed to enhance the expression of channel and spatial feature information in road images， while improving the existing shuffling network (ShuffleNetv2). This establishes a ShuffleNetv2 (CASB ShuffleNetv2) model based on mixed attention for identifying the state of road potholes. The experimental results show that the model has better accuracy than the basic model and can effectively detect road potholes. Due to the varying sizes of potholes on the road surface， small potholes may only require slight avoidance， while large potholes may cause serious vehicle damage. And there are different visual effects on the vertical distance of the pit. To address the aforementioned issues， the LabelImg image annotation tool was used to manually annotate the pothole areas， in order to construct a dataset for detecting 2029 road pothole areas. We replaced the ordinary convolution in the CenterNet feature extraction network with pyramid convolution with multiple receptive fields， and designed a feature fusion mo

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Pitch perception of harmonic complex tones based on excitation patterns

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Chinese Journal of Acoustics 2013年第2期32卷 189-198页

作者： WANG Jian guan tian YE Datian Department of Biomedical Engineering Tsinghua University Research center of Biomedical Engineering Graduate School at ShenzhenTsinghua University

Fundamental frequency difference limens were measured to study whether pitch perception of medium-rank harmonic complex tones depends on the resolvability of the compo- nents and to study the effect of masker tone on discrimination performance. Target tone was presented alone, or mixed with the masker, which were filtered into the same bandpass frequency region （low, medium, or high） to obtain different resolvability. There were five kinds of funda- mental frequency difference and four kinds of phase combination between target and masker. Five young subjects participated in experiments, all of whom had normal hearing （thresholds ≤ 15 dB HL）. Results found fundamental frequency difference limens were increased with up-shift frequency region of the harmonics. The fundamental frequency difference between target and masker had a significant impact on the performance, while phase effects were small. Analysis suggested that resolvability of harmonics had a significant impact on the fundamental frequency difference limens, but pitch perception of medium-rank harmonics was not based on the resolv- ability. Analysis also suggested that most results of pitch perception of target-masker mixture were closely correlated with peaks on the excitation patterns.

关键词： Pitch perception of harmonic complex tones based on excitation patterns

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电子耳蜗的选择性频率幅度调制编码算法

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清华大学学报（自然科学版） 2006年第12期46卷 2057-2060页

作者：关添叶大田清华大学生物医学工程系北京100084

为提高电子耳蜗植入者在噪声下的语音识别能力,提出了一种利用频率调制信息的算法。该算法根据人耳听觉机理,增加了频带选择法则。该法则对不同频带提取出的频率调制信息进行了有选择的传递,并在听觉仿真试验中得到验证:该算法既可以比... 详细信息

为提高电子耳蜗植入者在噪声下的语音识别能力,提出了一种利用频率调制信息的算法。该算法根据人耳听觉机理,增加了频带选择法则。该法则对不同频带提取出的频率调制信息进行了有选择的传递,并在听觉仿真试验中得到验证:该算法既可以比传统幅度信息编码算法更有效地提高电子耳蜗植入者在噪声下的语音识别能力,又降低了不选择频带而全通道传递频率调制信息算法的复杂度(频率调制信息提取的计算量降低了37.5%),减少了内存占用,使之适合在临床上实时实现。

关键词：电子耳蜗频率调制频带选择法则语音信号处理

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Sol-gel preparation and characterization of Co_3O_4 nanocrystals

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Journal of University of Science and Technology Beijing 2003年第1期10卷 54-57页

作者： Jinzhang Gao, Yanchun Zhao, Wu Yang, Jianniao tian, Fei guan. and Yongjun MaChemistry and Chemical Engineering College, Northwest Normal University, Lanzhou 730070, China NW Normal Univ Chem & Chem Engn Coll Lanzhou 730070 Peoples R China

A new citrate acid-hydrazine sol-gel route for preparation of Co3O4 nanoparticles has been developed. Co3O4 nanoparticles with different particle-sizes and morphology were prepared at different heat-treatment temperatures and the pure cubic nanocrystals of Co3O4 were obtained at 600℃. The synthesis process was monitored by infrared spectroscopy (IR), thermal gravimetric and differential thermal analysis (TG-DTA). The structure and morphology of Co3O4 nanocrystals were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM) and X-ray-photoelectron spectroscopy (XPS). The infrared absorption bands blue-shifted with particle size decreasing, which could be attributed to increasing surface effect. XPS results showed that predominant species at surface layers of Co3O4 nanocrystals are octahedral Co (Ⅲ).

关键词： sol-gel route nanocrystals cobalt oxide

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政治哲学语境中的意识形态问题嬗变——基于对柏拉图、卢梭和马克思的考察

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求是学刊 2019年第6期46卷 26-33页

作者：田冠浩吉林大学哲学基础理论研究中心暨哲学社会学院

虽然柏拉图对政治的理性根据的揭示预示着政治哲学的真正诞生,但无可否认政治行动和政治秩序都必须建筑在社会意见的基础上。基督教思想家和卢梭正因为意识到了这一点,才特别强调意识形态教化对于整合政治共同体的重要性。但真正说来,... 详细信息

虽然柏拉图对政治的理性根据的揭示预示着政治哲学的真正诞生,但无可否认政治行动和政治秩序都必须建筑在社会意见的基础上。基督教思想家和卢梭正因为意识到了这一点,才特别强调意识形态教化对于整合政治共同体的重要性。但真正说来,只有马克思对意识形态与现实的关系做出了科学的解释,进而立足于对资本主义社会运行机制和整体结构的深刻认识,破除了资产阶级意识形态的幻想,最终为无产阶级构建一种积极的、自觉参与社会历史变革的新型意识形态提供了科学的根据与方法论原则。

关键词：理性意识形态柏拉图卢梭马克思政治哲学

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