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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 1-66页

作者： Lu, Peilin Ruan, Dongxue Huang, Meiqi tian, mi Zhu, Kangshun Gan, Ziqi Xiao, Zecong Sun Yat Sen Univ Affiliated Hosp 3 Nanomed Res Ctr Guangzhou 510630 Peoples R China Guangzhou Med Univ Affiliated Hosp 2 Dept Minimally Invas Intervent Radiol Guangzhou 510260 Peoples R China Guangzhou Med Univ Affiliated Hosp 2 Lab Intervent Radiol Guangzhou 510260 Peoples R China Guangzhou Med Univ Affiliated Hosp 1 Guangzhou Inst Resp Hlth State Key Lab Resp DisNatl Clin Res Ctr Resp Dis Guangzhou 510120 Peoples R China Chengdu Second Peoples Hosp Dept Stomatol Chengdu 610021 Peoples R China Sun Yat Sen Univ Hosp Stomatol Guanghua Sch Stomatol Guangdong Prov Key Lab Stomatol Guangzhou 510055 Peoples R China

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications, focusing primarily on two areas: emerging cell-based therapies and promising non-cell therapeutic modalities. Within the context of cell therapy, we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms, provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy, as well as list specific examples of their applications in different disease scenarios. We then explore the potential of hydrogels in drug delivery, physical intervention therapies, and other non-cell therapeutic areas (e.g., bioadhesives, artificial tissues, and biosensors), emphasizing their utility beyond mere delivery vehicles. Additionally, we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions, particularly in terms of integration with advanced biomanufacturing technologies. This review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and non-cell therapies, tailored to meet the therapeutic requirements of diverse diseases and situations.

关键词： MESENCHYMAL STEM-CELLS GELATIN-METHACRYLOYL HYDROGELS CROSS-LINKABLE HYDROGELS DRUG-DELIVERY SYSTEM T-CELL GROWTH-FACTOR MECHANICAL-PROPERTIES PHOTODYNAmiC THERAPY INJECTABLE HYDROGEL PLASmiD DNA

Establishment of a rat model of severe spontaneous intracerebral hemorrhage

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Journal of Intensive Medicine 2024年第1期4卷 108-117页

作者： Shuixiang Deng Shengjie Feng Yuewen Xin Yu He Yao Wang mi tian Ye Gong Department of Critical Care Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiChina

Background:Severe intracerebral hemorrhage(ICH)is the most devastating subtype of stroke resulting in high mortality and *** present,the development of targeted treatments to minimize the high morbidity and mortality is limited partly due to the lack of a severe ICH animal *** this study,we aimed to establish an accurate severe ICH model in rats and examine the pathological and physiological changes associated with ***:A rat model of severe ICH model was established by intrastriatal injection of autologous blood using different blood volumes(ICH 100μL group,ICH 130μL group,ICH 160μL group,ICH 170μL group,and ICH 180μL group).The mortality was assessed during the 28-day post-ICH ***-and long-term neurological deficits were evaluated using the Longa method,foot fault,falling latency,and Morris water maze *** water content,hematoma volume,hemoglobin content,and magnetic resonance imaging were assessed to determine the extent of brain *** staining was conducted to examine microglial activation and neuronal *** and eosin(H&E)staining,lung water content,and western blotting were used to assess lung injury following ***:The mortality of ICH rats increased significantly with an increase in autologous blood *** 28-day mortality in the 100μL,130μL,160μL,170μL,and 180μL ICH groups were 5%,20%,40%,75%,and 100%,respectively.A significantly higher 28-day mortality was observed in the ICH 160μL group compared to the ICH 100μL *** ICH 160μL group exhibited significantly increased neurological deficits,brain edema,hematoma volume,and hemoglobin content compared to the sham *** with the sham operation group,the activation of microglia and neuronal death in ICH 160μL rats *** use of H&E staining and western blotting demonstrated that disruption of the intra-alveolar structure,alveolar edema,and infiltration of inflammatory cells and cytokines into the lung tissu

关键词： Severe spontaneous intracerebral hemorrhage Animal model Autologous blood injection Animal behavior Lung injury

FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

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military Medical Research 2024年第4期11卷 521-542页

作者： mi Zhou Yang-Wu-Yue Liu Yu-Hang He Jing-Yu Zhang Hao Guo Hao Wang Jia-Kui Ren Yi-Xun Su Teng Yang Jia-Bo Li Wen-Hui He Peng-Jiao Ma Man-tian mi Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,multifunctionality,and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly ***:Using the combined single-cell transcriptomics,metabolomics,and proteomics analysis from TBI patients and the TBI mouse model,we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral *** also characterized the underlying mechanisms both invitro and invivo through molecular simulations,signaling detections,gene expression regulation assessments[including dual-luciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cultures or co-cultures of neutrophils and oligodendrocytes,intracellular iron,and lipid hydroperoxide concentration measurements,as well as forkhead box protein O1(FOXO1)conditional knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI,aggravating acute brain inflammatory damage and promoting late TBI-induced *** the acute stage,FOXO1 upregulated cytoplasmic Versican(VCAN)to interact with the apoptosis regulator B-cell lymphoma-2(BCL-2)-associated X protein(BAX),suppressing the mitochondrial translocation of BAX,which mediated the antiapoptotic effect companied with enhancing interleukin-6(IL-6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil ferroptosis,disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein,which contributes to the progression of late depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

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临床研究中的“治疗误解”

中国医学伦理学 2024年第2期37卷 158-162页

作者：田蜜安宁市第一人民医院医学伦理委员会云南昆明650399

治疗误解是指在临床研究中,患者对于研究的本质、目的和可能带来的获益存在误解,其未能认识到参与临床研究不涉及个体化的治疗,而是为了获得可概括的科学知识。探讨了“治疗误解”的定义、原因以及对临床研究的影响,提出应对“治疗误解... 详细信息

治疗误解是指在临床研究中,患者对于研究的本质、目的和可能带来的获益存在误解,其未能认识到参与临床研究不涉及个体化的治疗,而是为了获得可概括的科学知识。探讨了“治疗误解”的定义、原因以及对临床研究的影响,提出应对“治疗误解”的策略。通过深入了解“治疗误解”,可以提高研究参与者的知情同意质量,保护其权益并提升研究的质量。

关键词：治疗误解临床研究知情同意研究伦理

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土默特的领催:清代蒙旗社会的基层小吏

安徽史学 2024年第1期 35-42页

作者：田宓宋瑞晨云南大学历史与档案学院云南昆明650091 内蒙古大学蒙古历史学系内蒙古呼和浩特010021

领催是土默特社会的重要基层小吏,他们向下对接普通百姓,向上沟通蒙旗、道厅各级官员,是蒙旗社会中非常活跃的中间群体。领催以佐领为单位,从“有力能应差”的蒙古兵丁中拣选,担负着清查人丁户口、组织比丁当差、管理公共土地、协调民... 详细信息

领催是土默特社会的重要基层小吏,他们向下对接普通百姓,向上沟通蒙旗、道厅各级官员,是蒙旗社会中非常活跃的中间群体。领催以佐领为单位,从“有力能应差”的蒙古兵丁中拣选,担负着清查人丁户口、组织比丁当差、管理公共土地、协调民众矛盾等各种职责。随着土默特地区生产方式、居住形态和社会结构的转变,领催也与甲头、会首、甲会等村落社会执事人发生关系,在很多基层事务上彼此沟通,相互协作,在维护蒙旗社会秩序方面发挥重要作用。从领催自身“小历史”的变化,可以管窥蒙旗社会“大历史”的转变。

关键词：蒙旗土默特领催基层社会

晚清土默特蒙古社会的户籍赋役制度与立嗣承产纠纷

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原生态民族文化学刊 2024年第2期16卷 94-103,155页

作者：田宓吕洪婷云南大学历史与档案学院昆明650000

清朝通过“户”管控蒙古社会,实现赋役征派。“户”是“壮丁”与“土地”的结合。为了赋役承应的延续性,每户都必须有壮丁不断承受家产。这就使户籍赋役制度和家族立嗣承产发生联系。蒙古人在初次分配财产之后,其家产在最初登记的“户... 详细信息

清朝通过“户”管控蒙古社会,实现赋役征派。“户”是“壮丁”与“土地”的结合。为了赋役承应的延续性,每户都必须有壮丁不断承受家产。这就使户籍赋役制度和家族立嗣承产发生联系。蒙古人在初次分配财产之后,其家产在最初登记的“户”的后世子孙中不断承受。一般是族中分门析分家产,并以合同分单的形式加以约定。但由于家族族人的竞夺、蒙旗官吏的觊觎,立嗣承产的过程有时演变成旷日持久的抢夺战。每当纠纷发生时,清廷关于户籍赋役和立嗣承产的法律规定,就成为各方人士竞争与协商的主要依凭和谈判策略。

关键词：户籍赋役立嗣承产蒙古社会土默特家族

苹果早期瘀伤的近红外光谱和多波段相机成像检测

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光谱学与光谱分析 2024年第5期44卷 1364-1371页

作者：杨增荣王怀彬田密密李军会赵龙莲中国农业大学信息与电气工程学院北京100083 现代精细农业系统集成研究教育部重点实验室北京100083

苹果早期轻微瘀伤是影响苹果品质的重要因素。早期轻微瘀伤在可见光下肉眼无法识别,为寻找一种高效的苹果早期轻微瘀伤识别方法,以红富士苹果为研究对象,通过倒立摆装置人为制造不同程度的苹果瘀伤。首先采用傅里叶变换近红外光谱仪采... 详细信息

苹果早期轻微瘀伤是影响苹果品质的重要因素。早期轻微瘀伤在可见光下肉眼无法识别,为寻找一种高效的苹果早期轻微瘀伤识别方法,以红富士苹果为研究对象,通过倒立摆装置人为制造不同程度的苹果瘀伤。首先采用傅里叶变换近红外光谱仪采集80个无损样品、60个轻度损伤样品以及60个重度损伤样品各自在损伤后0、10、20和30 min的近红外漫反射光谱;采用SNV作为光谱数据预处理方法,谱区范围选择4000~9000 cm^(-1);主成分个数为9,采用偏最小二乘法-判别分析(PLS-DA)和支持向量机(SVM)两种方法建立“无损-有损”二分类模型,预测集的平均识别率分别为85.00%和89.80%,模型识别效果有待提高。在以上实验结果的基础上,使用波段范围为1000~2350 nm的近红外相机采集无损、轻度瘀伤、中度瘀伤和重度瘀伤的100个苹果样品的近红外图像,相机加装1150和1400 nm的滤光片后分别再次采集这些苹果样品的近红外图像,所有图像均在瘀伤产生后立即采集。共采集3个波段、4种瘀伤程度的苹果样本图像共1200张。提取图像吸光度信息并分别建立KNN、SVM和DT分类模型,DT法“无损-损伤”二分类模型和“无损-轻度-重度”三分类模型的识别率最高,分别为99.00%和94.67%。相比基于近红外光谱的苹果早期外部瘀伤识别方法,近红外相机多波段成像法在苹果表面早期瘀伤和瘀伤程度分类的应用中都有更高的识别准确率。与此同时近红外相机成像方法方便确定瘀伤的位置,这为苹果表面瘀伤的实时在线检测与分类提供了一种快速高效的新思路。

关键词：近红外光谱近红外相机成像苹果早期瘀伤

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近三十年来中共三大研究述评

肇庆学院学报 2024年第1期45卷 61-67页

作者：田密中山大学马克思主义学院广东广州510275

中共三大促成了国共第一次合作,改变了中国革命的格局,是中国共产党历史上一次十分重要的代表大会。近三十年来,对中共三大的研究仍是中共会议问题研究的热点,产生了一系列新成果。内容包含中共三大的会址、主题、评价、人物、与共产国... 详细信息

中共三大促成了国共第一次合作,改变了中国革命的格局,是中国共产党历史上一次十分重要的代表大会。近三十年来,对中共三大的研究仍是中共会议问题研究的热点,产生了一系列新成果。内容包含中共三大的会址、主题、评价、人物、与共产国际关系等方面,促使中共三大研究向多方面、多层次、多维度方向发展。在新时代,对中共三大的研究应该放在第一次国共合作的大背景、中共历次会议的大视野下,坚持大历史观,为新时代党的建设提供历史启示。

关键词：中共三大国共合作共产国际国民大革命

基于超扭曲滑模的双定子绕组感应电机转速磁通控制

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电源学报 2024年第4期22卷 327-338页

作者：贺银平田密郑田娟李密成都航空职业技术学院航空装备制造产业学院成都610100 南京审计大学金审学院信息科学与工程学院南京210058 东南大学电气工程学院南京210096

针对双定子绕组感应电机DSWIMs(dual-stator winding induction machines)在传统直接转矩和磁通控制下转矩、磁通和电流纹波大,在低速下控制磁通难度大、噪声大等问题,提出1种基于超扭曲滑模控制器STSMC(super twisting sliding mode co... 详细信息

针对双定子绕组感应电机DSWIMs(dual-stator winding induction machines)在传统直接转矩和磁通控制下转矩、磁通和电流纹波大,在低速下控制磁通难度大、噪声大等问题,提出1种基于超扭曲滑模控制器STSMC(super twisting sliding mode controller)的DSWIMs新型转速和磁通直接控制方法。通过设计满足李雅普诺夫稳定条件的有限时间收敛误差为0的非线性控制器,提出1种DSWIMs新型转矩分配算法,可使DSWIMs在较宽的转速范围内运行,并包括零转速,所需电磁转矩由2组绕组根据其额定功率提供。此外,针对DSWIMs设计了1种基于滑模控制的全阶观测器,能够高精度地估计绕组磁通、磁通角和转子转速,以实现最优磁通状态。最后,在1个3.3 kWDSWIM驱动系统上进行实验测试,评估所提DSWIM控制方案的性能,实验结果证明了所提控制方法、转矩分配算法和全阶观测器在不同速度区域的有效性。

关键词：双定子绕组感应电机超扭滑模控制器滑模全阶观测器转矩分配算法