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Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam

Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 795-800页

作者： thu Dang Kim Hai Nguyen Thanh Duong Nguyen thuy Loi Vu Duc thu Vu thi Hung Vu Manh Patcharee Boonsiri Tung Bui Thanh Department of Pharmacology and Clinical Pharmacy School of Medicine and PharmacyVietnam National University Department of Pharmaceutics and Pharmaceutical Technology School of Medicine and PharmacyVietnam National University Department of Pharmacology Hanoi University of Pharmacy Department of Pharmacognosy and Traditional Pharmacy School of Medicine and PharmacyVietnam National University Faculty of Biology VNU University of Science Key Laboratory of Enzyme and Protein Technology VNU University of Science Department of Pharmacology School of PharmacyLac Hong University Department of Biochemistry Faculty of MedicineKhon Kaen University

Objective:To evaluate the antitumor activity both in vitro and in vivo of saponin–phospholipid complex of Panax ***:The in vitro cytotoxic effect of saponins extract and saponin–phospholipid complex against human lung cancer NCI-H460 and breast cancer cell lines BT474 was examined using MTS *** in vivo evaluation of antitumor potential,saponin and saponin–phospholipid complex were administered orally in rats induced mammary carcinogenesis by 7,12-dimethylbenz(a)anthracene,for 30 ***:Our data showed that saponin–phospholipid complex had stronger anticancer effect compared to saponin *** IC50 values of saponin–phospholipid complex and saponin extract for NCI-H460 cell lines were 28.47 mg/m L and 47.97 mg/mL,respectively and these values for BT474 cells were 53.18 mg/mL and 86.24 mg/mL,*** vivo experiments,administration of saponin,saponin–phospholipid complex and paclitaxel(positive control) effectively suppressed 7,12-dimethylbenz(a) anthracene-induced breast cancer evidenced by a decrease in tumor volume,the reduction of lipid peroxidation level and increase in the body weight,and elevated the enzymatic antioxidant activities of superoxide dismutase,catalase,glutathione peroxidase in rat breast ***:Our study suggests that saponin extract from Panax notoginseng and saponin–phospholipid complex have potential to prevent cancer,especially breast cancer.

关键词： Panax notoginseng Saponin Saponin–phospholipid complex Breast cancer Antitumor

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In vivo anticancer activity of maesopsin 4—O— β—glucoside isolated from leaves of Artocarpus tonkinensis *** Gagnep

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 343-348页

作者： Trinh thi thuy Dao Duc thien tran Quang Hung Nguyen Thanh Tam Nguyen thi Hoang Anh Nguyen thi Nga Nguyen thi Cuc Le Phuong Mai tran Van Sung Domenico V.Delfino Do thi Thao Institute of Chemistry.Vietnam Academy of Science and Technology Institute of Biotechnology Vietnam Academy of Science and Technology National Research Council Canada Measurement Science and Standards1200 Montreal RoadBuilding M-12.Ottatca.Ontario KIA OR6 Department of Medicine University of PerugiaPiazzale Gambuli.S.Andrea delle Fratte

Objective:To investigate the antitumor effect of maesopsin 4-O-β-glucoside(TAT2) isolated from the leaves of Artocarpus tonkinensis(***) *** ***:The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma(LLC) tumor-bearing ***/c mice had tumors induced by implantation with 2× 10~6 LLC cells into the subcutaneous right posterior ***-bearing mice were treated orally with a range of doses of TAT2 and a standard drug,*** were observed for tumor growth and mortality *** was collected to determine hematological and biochemical *** TAT2 was isolated from an ethanolic extract of *** *** structure was determined by MS and NMR spectroscopy,and identified as *** compound did not show acute toxicity at the highest dose tested(2 OIK) mg/kg body weight).TAT2 exhibited antitumor activity by decreasing tumor growth,increasing the survival rale,and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight(P<0.05).Conclusions:These results indicate that TAT2 possesses clear antitumor *** to its bioavailability and low toxicity,and the fact that it could be isolated in a large scale from *** leaves,the compound shows promise as a potential anticancer drug.

关键词： Artocarpus tonkinensis BALB/c Hematological parameters Lewis lung carcinoma Maesopsin 4-0-β-glucoside

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Study on Extraction and Conversion Annatto （Bixa orellana L.） Color into Norbixin to Prepare Food Grade Water-Soluble Norbixin Powder

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Journal of Life Sciences 2017年第2期11卷 97-104页

作者： tran thi Ha Dao Phan Thoai Le thi thu thuy Phan The Dong The Department of Food- Environment & Nursing Dong Nai Technology University Dong Nai 810000 Viet Nam The Faculty of Science & Engineering Hoa Sen University Ho Chi Minh 700000 Viet Nam

Response surface methodology was used in this research to optimize the technical parameters of the extraction and conversion color compound in armatto seeds into norbixin. Parameters affected the extraction efficiency and norbixin recovery yield were solvent concentration, rate of solvent/seed, incubation time, and incubation temperature. The optimization results including： concentration of ethanol is 51.82°; concentration of NaOH is 0.52 M; ratio of solvent/seed is 7.1/1; incubation time is 33.12 minutes, incubation temperature is 58.6℃, and the rate of 36% HCl/color solution is 0.5/5 （v/v）.

关键词： Achiote Bixa orellana L. bixin norbixin extraction conversion food color.

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Use of Stance Adverbs in Academic English:A Comparison of L1 English and L1 Vietnamese Authors’ Writing

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外语教育 2016年第1期 83-93页

作者： Nguyen thi thu thuy School of Foreign Languages Huazhong University of Science and Technology

The present study investigates authorial stance in research articles of native and non-native academic authors of English. It aims to analyze evaluation adverbs in research articles written by native authors of English(NAEs) and Vietnamese-speaking authors of English(VAEs) between 2012 and 2015. The data of 120 articles was investigated to examine whether there is a significant difference in using stance adverbs between the two groups of authors. It was found that NAEs and VAEs used stance adverbs in a considerably different way. Most of the stance adverb categories were variously overused by NAEs against VAEs. It was also found that English native authors of research articles preferred indirect approaches of expressing their evaluation by an illocutionary way of manner-of-speaking,metalinguistic and expectation markers,while Vietnamese authors favored an epistemic way of modal adverbs.

关键词： Stance adverbs Academic writing Corpus-based L1 English authors L1 Vietnamese authors

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Electrochemical Immunosensor for Detection of Atrazine Based on Polyaniline/Graphene

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Journal of Materials Science & Technology 2016年第6期32卷 539-544页

作者： Nguyen Van Chu Nguyen Hai Binh Cao thi Thanh Nguyen Van Tu Nguyen Le Huy Nguyen Tuan Dzung Phan Ngoc Minh Vu thi thu tran Dai Lam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau Giay.HanoiViet Nam School of Chemical Engineering.Hanoi University of Science and Technology 1 Dai Co VietHanoiViet Ham Institute for Tropical Technology.Vietnam Academy of Science and Technology 18 Hoang Quoc VietHanoiViet Nam Center for High Technology Development Vietnam Academy of Science and Technology18 Hoang Quoc VietHanoiViet Nam University of Science and Technology of Hanoi.18 Hoang Quoc Viet HanoiViet Ham Graduate University of Science and Technology.Vietnam Academy of Science and Technology 18 Hoang Quoc Viet.HanoiViet Nam

In this study, a novel layer-by-layer polyaniline/graphene （PANi/Gr） structure for electrochemical detec- tion of atrazine was developed. Gr film was synthesized by thermal chemical vapor deposition （CVD） method and transferred onto the PANi-predeposited microelectrode. The properties of PANi/Gr film were thoroughly investigated by high-resolution transmission electron microscopy and Raman techniques. The most attractive feature of this system is a suitable microenvironment, which could provide an amplifi- cation of the conductive signal, thus may contribute to enhancing electron transfer and subsequently improve the sensitivity in electrochemical measurements. With low detection limit （- 43 × 10 -12 g/L）, ac-ceptable stability and good reproducibility, the proposed electrochemical immunosensor could be advantageously extended for multiplexed detection of other agents of environmental pollution.

关键词： Electrochemical immunosensor Polyaniline Graphene Atrazine

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Simultaneous Quantitative Analysis of Five Components in Angelica sinensis and Angelica acutiloba Acclimatized Growing in Vietnam by High-Performance Liquid Chromatography with Photodiode Array Detector

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 6-10页

作者： thi Minh Tam Pham thi thu Cuc Le Van Thanh Nguyen Viet Hung tran Departments of Microbiology Institute of Drug Quality ControlHo Chi Minh City Departments of Instrumental Analysis Institute of Drug Quality ControlHo Chi Minh City Institute of Drug Quality Control Ho Chi Minh City Faculty of Pharmacy Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam

Background:Chinese Danggui(Angelica sinensis)and Japanese Danggui(Angelica acutiloba)are evaluated as the same in using and critical of quality control in Vietnamese *** Vietnam,Japanese Danggui were acclimatized and cultivated in several regions in recent *** the huge climatic difference between Vietnam and Japan,Japanese Danggui grows very well in ***,there are no studies to assess the overall quality of this medicinal *** and Objectives:The aim of this study is to develop a method to identify and assay simultaneously 5 component compounds of these crude herbs:chlorogenic acid,ferulic acid,scopoletin,xanthotoxin and ligustilide by high-performance liquid chromatography with photodiode array detector(HPLC-PDA).Materials and Methods:The procedure was optimized by using column Phenomenex Gemini 5μm PR C18,15 x 4,6 mm with the detection wavelength set at 321 nm for detector PDA and mobile phase was composed of(A)ACN and(B)aqueous solution 1%of acid acetic using a gradient *** were performed at 30°C with a flow rate of 1.0 mL/***:The developped method were fully validated for linearity,accuracy,recovery and met the validation requirements,proved practical applicability for the quality control of these herbs and related ***:The method was successfully applied to the quantification of five markers simultaneously from collected samples.

关键词： Chlorogenic acid Danggui ferulic acid ligustilide scopoletin xanthotoxin

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Predicting shear strength of slender beams without reinforcement using hybrid gradient boosting trees and optimization algorithms

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Frontiers of Structural and Civil Engineering 2022年第10期16卷 1267-1286页

作者： thuy-Anh NGUYEN Hai-Bang LY Van Quan tran Department of Civil Engineering University of Transport TechnologyHanoi 100000Vietnam

Shear failure of slender reinforced concrete beams without stirrups has surely been a complicated occurrence that has proven challenging to adequately *** primary purpose of this work is to develop machine learning models capable of reliably predicting the shear strength of non-shear-reinforced slender beams(SB).A database encompassing 1118 experimental findings from the relevant literature was compiled,containing eight distinct *** Boosting(GB)technique was developed and evaluated in combination with three different optimization algorithms,namely Particle Swarm Optimization(PSO),Random Annealing Optimization(RA),and Simulated Annealing Optimization(SA).The findings suggested that GB-SA could deliver strong prediction results and effectively generalizes the connection between the input and output *** values and two-dimensional PDP analysis were then carried *** may use the findings in this work to define beam’s geometrical components and material used to achieve the desired shear strength of SB without reinforcement.

关键词： slender beam shear strength gradient boosting optimization algorithms

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Surface PEGylation of hollow mesoporous silica nanoparticles via aminated intermediate

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Progress in Natural Science:Materials International 2019年第6期29卷 612-616页

作者： thi Ngoc Tram Nguyen Diem-Huong Nguyen-tran Long Giang Bach tran Hoang Du Truong Ngoc thuy trang Le Dai Hai Nguyen Tra Vinh University Institute of Applied Materials Science Vietnam Academy of Science and Technology Graduate University of Science and Technology Vietnam Academy of Science and Technology Nguyen Tat Thanh University 5. Institute of Research and Development Duy Tan University

A hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin(DOX) was used as a model drug to evaluate the effect of PEGylation on the loading capacity and release pattern of the *** with transmission electron microscopy(TEM) and scanning electron microscopy(SEM), X-ray diffraction(XRD), nitrogen adsorption-desorption, thermogravimetric analysis(TGA) and Fourier transformed infrared(FTIR) confirmed the PEG conjugation, as well as the amorphous mesoporous nature of the synthesized particles. Due to the capping effect of PEG molecules over the pores in the silica structure, the synthesized system was able to retain higher amount of cargo and establish a controlled manner when releasing.

关键词： Hollow mesoporous silica nanoparticles mPEG PEGylation Surface modification

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Isolation and Identification of Two Flavonoid Compounds from Acclimatized Angelica acutiloba Kitagawa Growing in Vietnam

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 413-416页

作者： thi Minh Tam Pham thi thu Cuc Le Viet Hung tran Van Thanh Nguyen Department of Microbiology Institute of Drug Quality ControlDepartment of Analytical Chemistry and Quality ControlUniversity of Medicine and PharmacyHo Chi Minh CityVietnam Department of Analytical Chemistry and Quality Control Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam Department of Microbiology Institute of Drug Quality ControlHo Chi Minh CityVietnam

Traditional Vietnamese Medicine has its own development based on the local endemic herbs,but it also inherits from Traditional Chinese Medicine using Chinese herbal *** the history of cultural exchange between two countries,the adoption of Chinese Danggui,Angelica sinensis(Oliv.)Diels.,has been made by Vietnamese traditional medicine practitioners for a long ***,the acclimatization has never been *** Danggui,or Angelica acutiloba Kitagawa,is recently being acclimatized and cultivated in several Vietnamese *** the huge climate change between the two countries,the herb adapted exquisitely well to the humid tropical ***,so far,there are no studies that have evaluated the effect of acclimatization on the overall quality of this medicinal *** aim of our study is screening secondary metabolites of this acclimatized herb for new natural compound(s),if *** analysis of flavonoid fraction from this herb led to the identification of two known compounds which previously have not been isolated from this species *** detection showed that the herb has reacted to the new environment.

关键词： Abiotic stress Angelica acutiloba danggui isoquercitrin rutin

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Effects of Processing Parameters on Mechanical Properties and Structure of Banana Fiber-Reinforced Composites

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Journal of Renewable Materials 2018年第6期6卷 662-670页

作者： Dan-thuy Van-Pham Minh Tri Nguyen Chanh-Nghiem Nguyen thi Truc Duyen Le thi Yen Nhu Pham Khai thinh Nguyen Yukihiro Nishikawa Qui tran-Cong-Miyata Department of Chemical Engineering Can Tho UniversityCan Tho CityViet Nam Department of Automation Technology Can Tho UniversityCan Tho CityViet Nam Department of Macromolecular Science and Engineering Graduate School of Science and TechnologyKyoto Institute of TechnologyMatsugasakiSakyo-kuKyoto 606-8585Japan

The mechanical properties of unidirectional natural fiber-reinforced composites are generally affected by several processing parameters during compression *** study investigates the effects of processing temperature,time,and pressure on the tensile and flexural properties of acrylonitrile butadiene styrene reinforced by banana fibers.X-ray CT imaging was employed to find the relationship between the mechanical properties and structure of the processed ***,the water absorption of composites was observed and the way in which the mechanical properties evolved after water absorption was *** tensile and flexural properties of the unidirectional banana fiber-reinforced composite were found to be inversely proportional to the *** addition,high-pressure compression molding might result in cracks and floating fibers that would significantly reduce its mechanical *** composite with the highest strength,smallest porosity and lowest water absorption was optimally prepared at T=170℃,t=20 min,and P=100 kg cm^-2.

关键词： Banana fiber composite compression molding porosity X-ray CT

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