In vivo anticancer activity of maesopsin 4—O— β—glucoside isolated from leaves of Artocarpus tonkinensis *** Gagnep

作     者：Trinh Thi Thuy Dao Duc Thien Tran Quang Hung Nguyen Thanh Tam Nguyen Thi Hoang Anh Nguyen Thi Nga Nguyen Thi Cuc Le Phuong Mai Tran Van Sung Domenico V.Delfino Do Thi Thao 

作者机构：Institute of Chemistry.Vietnam Academy of Science and Technology Institute of BiotechnologyVietnam Academy of Science and Technology National Research Council CanadaMeasurement Science and Standards1200 Montreal RoadBuilding M-12.Ottatca.Ontario KIA OR6 Department of MedicineUniversity of PerugiaPiazzale Gambuli.S.Andrea delle Fratte 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2016年第9卷第4期

页      面：343-348页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Italian Ministerodegli Esteri e della Cooperazione Internazionale Ministry of Science and Technology, MOST, (1/39/2013/NDT) Ministero degli Affari Esteri e della Cooperazione Internazionale, MAECI 

主　　题：Artocarpus tonkinensis BALB/c Hematological parameters Lewis lung carcinoma Maesopsin 4-0-β-glucoside 

摘      要：Objective:To investigate the antitumor effect of maesopsin 4-O-β-glucoside(TAT2) isolated from the leaves of Artocarpus tonkinensis(***) *** ***:The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma(LLC) tumor-bearing ***/c mice had tumors induced by implantation with 2× 10~6 LLC cells into the subcutaneous right posterior ***-bearing mice were treated orally with a range of doses of TAT2 and a standard drug,*** were observed for tumor growth and mortality *** was collected to determine hematological and biochemical *** TAT2 was isolated from an ethanolic extract of *** *** structure was determined by MS and NMR spectroscopy,and identified as *** compound did not show acute toxicity at the highest dose tested(2 OIK) mg/kg body weight).TAT2 exhibited antitumor activity by decreasing tumor growth,increasing the survival rale,and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight(P0.05).Conclusions:These results indicate that TAT2 possesses clear antitumor *** to its bioavailability and low toxicity,and the fact that it could be isolated in a large scale from *** leaves,the compound shows promise as a potential anticancer drug.