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Inhibitory effect of different Dendrobium species on LPS-induced inflammation in macrophages via suppression of MAPK pathways

第十四届全国中药和天然药物学术研讨会

作者： Yongliang Jia Siu-wai leung University of Macau University of Edinburgh

Objective There was no systematic review,let alone meta-analysis,of the randomized controlled trials(RCT)on comparing beta-blockers and tongxinluo capsule(TXL)those are highly efficacy in treating angina pectoris amon...

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Chinese Journal of Natural Medicines 2018年第7期16卷 481-489页

作者： ZENG Qiang Chun-Hay Ko Wing-Sum Siu LI Kai-Kai Chun-wai Wong HAN Xiao-Qiang YANG Liu Clara Bik-San Lau HU Jiang-Miao Ping-Chung leung Institute of Chinese Medicine The Chinese University of Hong Kong State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Shenzhen Research Institute The Chinese University of Hong Kong Kunming Institute of Botany Chinese Academy of Sciences

Dendrobii Caulis(DC), named ‘Shihu' in Chinese, is a precious herb in traditional Chinese medicine. It is widely used to nourish stomach, enhance body fluid production, tonify "Yin" and reduce heat. More than thirty Dendrobium species are used as folk medicine. Some compounds from DC exhibit inhibitory effects on macrophage inflammation. In the present study, we compared the anti-inflammatory effects among eight Dendrobium species. The results provided evidences to support Dendrobium as folk medicine, which exerted its medicinal function partially by its inhibitory effects on inflammation. To investigate the anti-inflammatory effect of Dendrobium species, mouse macrophage cell line RAW264.7 was activated by lipopolysaccharide. The nitric oxide(NO) level was measured using Griess reagent while the pro-inflammatory cytokines were tested by ELISA. The protein expressions of inducible NO synthase(iNOS), cyclooxygenase-2(COX-2) and mitogen-activated protein kinases(MAPKs) phosphorylation were evaluated by Western blotting analysis. Among the eight Dendrobium species, both water extracts of D. thyrsiflorum ***(DTW) and D. chrysotoxum Lindl(DCHW) showed most significant inhibitory effects on NO production in a concentration-dependent manner. DTW also significantly reduced TNF-α, MCP-1, and IL-6 production. Further investigations showed that DTW suppressed iNOS and COX-2 expression as well as ERK and JNK phosphorylation, suggesting that the inhibitory effects of DTW on LPS-induced macrophage inflammation was through the suppression of MAPK pathways. In conclusion, D. thyrsiflorum *** was demonstrated to have potential to be used as alternative or adjuvant therapy for inflammation.

关键词： Dendrobium species Anti-inflammation Macrophage MAPK pathways

Outcome of severely injured trauma patients at a designated trauma centre in the hong Kong Special Administrative Region

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Chinese Medical Journal 2010年第10期123卷 1251-1254页

作者： leung Ka Kit Gilberto HO Wendy TONG King Hung Daniel YUEN wai Key Trauma Service Queen Mary Hospital and The University of Hong Kong The Hong Kong Special Administrative Region (HKSAR) China

Background The hong Kong Special Administrative Region （HKSAR） of the People＇s Republic of China （PRC） has seen significant changes in its trauma service over the last ten years including the implementation of a regional trauma system. The author＇s institution is one of the five trauma centres designated in 2003. This article reports our initial clinical experience. Methods A prospective single-centre trauma registry from January 2004 to December 2008 was reviewed. The primary clinical outcome measure was hospital mortality. The Trauma and Injury Severity Score （TRISS） methodology was used for bench-marking with the North America Major Trauma Outcome Study （MTOS） database. Results There were 1451 patients. The majority （83.9%） suffered from blunt injury. The overall mortality rate was 7.8%. Severe injury, defined as the Injury Severity Score 〉15, occurred in 22.5% of patients, and was associated with a mortality rate of 31.6%. A trend of progressive improvement was noted. The M-statistic was 0.99, indicating comparable case-mix with the MTOS. The Z- and W-statistics of each individual year revealed fewer, but not significantly so, number of survivors than expected. Conclusions Trauma centre designation was feasible in the HKSAR and was associated with a gradual improvement in patient care. Trauma system implementation may be considered in regions equipped with the necessary socio-economic and organizational set-up.

关键词： trauma, nervous system outcome trauma and injury severity score hong Kong, China

Performance of a prehospital trauma diversion system in hong Kong, China

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Chinese Journal of Traumatology 2015年第3期18卷 137-140页

作者： Tak-wai Lui Kit-Ling Fan Ling-Pong leung Department of Medidne Queen Mary Hospital Hong Kong China Emergency Medicine Unit Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China

Purpose： To evaluate the performance of a prehospital trauma diversion system in hong Kong, China. Methods： A retrospective analysis of prospectively collected data in the trauma registry of Queen Mary Hospital, hong Kong from I January 2009 to 31 December 2013 was done. All adult patients aged 18 years or above, either primarily or secondarily diverted to Queen Mary Hospital according to the trauma patient diversion protocol, were recruited. Need for trauma center level of care was based on a consensus-based criterion standard published in 2014. Performance of the protocol in terms of over-diversion and under-diversion was determined. Results： A total of 209 patients were included for analysis. About 30% of the patients required trauma center level of care. The most common reason was the need for vascular, neurologic, abdominal, thoracic, pelvic, spine or limb-conserving surgery within 24 h of presentation. The over-diversion rate and under-diversion rate were 69.6% and 19.7% respectively. Conclusion： The trauma patient diversion protocol currently in use in hong Kong is not accurate enough. Further revision and refinement is needed.

关键词： Trauma diversion Triage Prehospital care hong Kong

Tp receptor activation impairs endothelial nitric oxide-dependent vasorelaxation to isoprenaline:role of rho kinase in endothelium

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Tp receptor activation impairs endothelial nitric oxide-depe...

Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

浙江省生理科学会2008年学术年会

作者： Fung Ping leung Chi wai Lau Department of Physiology Chinese University of Hong KongChina

Activation of TP receptors causes potent vasoconstriction,which contributes to increased vascular tone and blood *** present study was designed to examine the hypothesis that stimulation of TP receptor impairs endothe... 详细信息

关键词： Endothelium Isoprenaline Nitric oxide TP receptor

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1031-1042页

作者： Ka-On Lam Man-Chi Fu Kin-Sang Lau Kam-Mo Lam Cheuk-wai Choi Wan-Hang Chiu Cheng-Man Yuen Lai-Han Kwok Fong-Kit Tam Wing-Lok Chan Sum-Yin Chan Pui-Ying Ho To-wai leung Ho-Fun Lee Department of Clinical Oncology LKS Faculty of MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology Queen Mary HospitalHong KongChina Clinical Oncology Centre The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Pharmacy Queen Mary HospitalHong KongChina Department of Diagnostic Radiology LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Cetuximab in combination with oral fluoropyrimidine(FP)remains controversial in metastatic colorectal cancer(mCRC).In view of the regional variation in the tolerability of FP,we conducted a retrospective analysis to compare oral FP with infusional FP in combination with cetuximab in Chinese *** To compare the efficacy and safety profile of cetuximab in combination with oral FP and infusional FP in Chinese population in the real-world *** A retrospective cohort study was done to analyse consecutive patients with Kras wild-type mCRC who received first-line treatment with cetuximab and FP-based chemotherapy in our unit from January 2010 to December ***-five eligible patients were *** median follow-up of our cohort was 65.0 *** The median progression-free survival(mPFS)and median overall survival(mOS)of the entire cohort were 9.66 mo(95%CI:7.72–12.5)and 25.8 mo(95%CI:18.7–35.6),*** oral FP and infusional FP,there was no statistical significant difference in the mPFS[9.79 mo(95%CI:7.49–12.7)vs 9.63 mo(95%CI:6.34–13.4);P=0.72]and mOS[25.8 mo(95%CI:15.2–35.6)vs 26.3 mo(95%CI:18.7–41.2);P=0.63].Grade 3 or above adverse events were reported in 28.4%of patients,being similar with oral and infusional FP,and included 10.5%of neutropenia and 2.1%of diarrhoea *** The current analysis demonstrates comparable efficacy and safety profiles of cetuximab in combination with oral and infusional FP in Chinese *** results expand treatment options for Chinese patients and invite revision of existing treatment guidelines to incorporate oral FP-based chemotherapy plus cetuximab.

关键词： Capecitabine 5-Fluorouracil Cetuximab Metastatic colorectal cancer Chinese

The effects of Spirulina on anemia and immune function in senior citizens

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Cellular & Molecular Immunology 2011年第3期8卷 248-254页

作者： Carlo Selmi Patrick SC leung Laura Fischer Bruce German Chen-Yen Yang thomas P Kenny Gerry R Cysewski M Eric Gershwin Division of Rheumatology Allergy and Clinical ImmunologyUniversity of California at DavisDavisCAUSA Department of Medicine IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Department of Food Science and Technology University of California at DavisDavisCAUSA Cyanotech Kailua-KonaHIUSA

Anemia and immunological dysfunction(***)are commonly found in older subjects and nutritional approaches are sought to counteract these *** is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant *** hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of *** enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic *** took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the *** cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of *** study participants completed the entire study and the data obtained were *** the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both *** addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male *** women appeared to benefit more rapidly from Spirulina ***,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina *** may ameliorate anemia and immunosenescence in older *** encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials.

关键词： functional food immunosenescence red blood cell IDO

An Uncommon Potentially Fatal Complication in a Patient without Predisposing Factor Following Oral Bowel Preparation Commonly Used for Colonoscopy

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Open Journal of Emergency Medicine 2016年第1期4卷 6-10页

作者： Iris wai Sum Li Ling Pong leung Sik Hon Tsui Queen Mary Hospital Hospital Authority Hong Kong China Emergency Medicine Unit Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Accident & Emergency Queen Mary Hospital Hospital Authority Hong Kong Special Administrative Region Hong Kong China

We described the case report of a patient presented with no known predisposing factor, generalized malaise with vomiting, locked jaw, perioral paraesthesia, carpopedal spasm and a positive Chvostek’s sign which resulted from severe electrolyte disturbance at 5 hours after use of oral sodium phosphate solution (NaPO4) as bowel preparation for colonoscopy. On presentation, she developed hyperphosphatemia and symptomatic hypocalcaemia with serum phosphate of 1.84 mmol/L and adjusted calcium level 1.67 mmol/L respectively. Her symptoms subsided after immediate intravenous calcium gluconate followed by oral calcium supplement. The electrolyte disturbances were normalized with an uneventful clinical course. The potentially fatal complications of sodium phosphate solution which commonly prescribed as bowel preparation for conventional colonoscopy could develop though previously reported as uncommon in patients without predisposing factors, and should not be overlooked. Urgent assessment and immediate correction of electrolyte disturbances are needed. Recommendations on patient selection of use of sodium phosphate to minimize risk of developing adverse events are needed to incorporate in clinical protocols.

关键词： Symptomatic Hypocalcaemia Hyperphosphatemia Sodium Phosphate Solution Bowel

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初探澳门中央公积金的政策特征与保障效果

暨南学报（哲学社会科学版） 2019年第11期41卷 75-88页

作者：赖伟良澳门理工学院人文及社会科学高等学校

澳门特区政府在2018年实施中央公积金制度,完成“三层式”的养老保障体系。本文旨在分析这制度的政策特征及推算它日后提供的保障水平。澳门央积金的特征包括非强制性质、“私营公积金”模式及政府承担重要的财政责任。这种制度为不同... 详细信息

澳门特区政府在2018年实施中央公积金制度,完成“三层式”的养老保障体系。本文旨在分析这制度的政策特征及推算它日后提供的保障水平。澳门央积金的特征包括非强制性质、“私营公积金”模式及政府承担重要的财政责任。这种制度为不同年龄、入息等背景的雇员提供不同水平的养老保障。无论从“退休金”数额或入息替代率来看,低收入至中等收入雇员从该制度中只能获得偏低水平的养老保障。在一些理想假设下,中高收入雇员则获得相对较充足的养老保障。因此,笔者提出三项政策建议。第一,提高雇主的供款比率至最高10%。第二,要求“退休基金管理实体”增设“被动型”退休基金。第三,增设公共信托人管理的退休基金。

关键词：澳门中央公积金社会保障养老保障劳工福利