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Membrane progesterone receptors(mPRs/PAQRs)in Schwann cells represent a promising target for the promotion of neuroregeneration

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Neural Regeneration Research 2021年第2期16卷 281-282页

作者： Luca F.Castelnovo peter thomas Valerio Magnaghi Marine Science Institute University of Texas at AustinPort AransasTXUSA Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanItaly

Schwann cells and neuroregeneration:Peripheral nerve injury is a common cause of morbidity,which affects millions of people *** peripheral nervous system,differently from the central nervous system,has an intrinsic ability to regenerate after ***,in most cases the regenerative outcome is not completely satisfactory,in particular for long-gap peripheral nerve injuries in which the microsurgical approach is not *** these cases。

关键词： injuries progesterone cases

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Role of cell-free network communication in alcohol-associated disorders and liver metastasis

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World Journal of Gastroenterology 2021年第41期27卷 7080-7099页

作者： Murali R Kuracha peter thomas Martin Tobi Benita L McVicker Department of Internal Medicine University of Nebraska Medical CenterOmahaNE 68198United States Department of Surgery Creighton University School of MedicineOmahaNE 68178United States Research and Development Service Detroit VAMCDetroitMI 48201United States Department of Medicine Central Michigan University College of MedicineDetroitMI 48201United States Research Service Nebraska-Western Iowa Health Care SystemOmahaNE 68105United States

The aberrant use of alcohol is a major factor in cancer progression and *** mechanisms include the systemic effects of alcohol and the exchange of bioactive molecules between cancerous and non-cancerous cells along the brain-gut-liver *** interplay leads to changes in molecular,cellular,and biological functions resulting in cancer *** investigations have examined the role of extracellular vesicles(EVs)in cancer mechanisms in addition to their contribution as diagnostic ***,EVs are emerging as novel cell-free mediators in pathophysiological scenarios including alcohol-mediated gut microbiome dysbiosis and the release of nanosized EVs into the circulatory ***,EVs in cancer patients are enriched with oncogenes,miRNA,lipids,and glycoproteins whose delivery into the hepatic microenvironment may be enhanced by the detrimental effects of ***-of-concept studies indicate that alcohol-associated liver disease is impacted by the effects of exosomes,including altered immune responses,reprogramming of stromal cells,and remodeling of the extracellular ***,the culmination of alcoholrelated changes in the liver likely contributes to enhanced hepatic metastases and poor outcomes for cancer *** review summarizes the numerous aspects of exosome communications between organs with emphasis on the relationship of EVs in alcohol-associated diseases and cancer *** potential impact of EV cargo and release along a multi-organ axis is highly relevant to the promotion of tumorigenic mechanisms and metastatic *** is hypothesized that EVs target recipient tissues to initiate the formation of prometastatic niches and cancer *** study of alcohol-associated mechanisms in metastatic cancers is expected to reveal a better understanding of factors involved in the growth of secondary malignancies as well as novel approaches for therapeutic interventions.

关键词： Exosomes Extracellular vesicles Alcohol-associated liver disease Colorectal cancer Liver metastasis Interorgan communication

THE IN VITRO EFFECTS OF STEROIDS, HUMAN CHORIONIC GONADOTROPIN AND CYANOKETONE ON GERMINAL BREAKDOWN OF STRIPED MULLET (MUGIL CEPHALUS L.)OOCYTES

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Journal of Oceanology and Limnology 1987年第1期5卷 1-8页

作者：洪万树,peter thomas Department of Oceanology Xiamen University Fujian China Marine Science Institute University of Texas at Austin TX 78373 U.S.A

The in vitro effects of steroids, human chorionic gonadotropin (HCG) and cyanoketone on germinal vesicle breakdown (GVBD) of striped mullet (Mugil cephalus L.) oocytes were investigated. All concentrations of HCG (5,10,50 I.U./ml), progesterone and pregnenolone at the highest concentrations(lug/ml) were moderately effective in inducing GVBD, whereas 17B-estrodiol, cortisol, testosterone, 11B-hydroxyandrostenedione and 11-ketotestosterone did not stimulate GVBD. 17a, 20Bdihydroxy-4-pregnen-3-one (17a, 20BdiOHprog) and deoxycorticosterone (DOC) were the most potent steroids in stimulating final oocyte maturation. The results indicate that C21 hydroxylated steroids are potent inducers of final maturation in mullet. Further, co-incubations with 17B-eslradiol, cortisol and testosterone did not alter the maturation-inducing effects of HCG or 17a,200diOHprog. Cyanoketone, a blocker of 3BHSD activity, was only partially effective in blocking GVBD induced by HCG. This suggests that A5 (pregnenolone derived) and

关键词： GVBD HUMAN CHORIONIC GONADOTROPIN AND CYANOKETONE ON GERMINAL BREAKDOWN OF STRIPED MULLET MUGIL CEPHALUS L OOCYTES THE IN VITRO EFFECTS OF STEROIDS

Dual mobility cups in total hip arthroplasty

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World Journal of Orthopedics 2014年第3期5卷 180-187页

作者： Ivan De Martino Georgios Konstantinos Triantafyllopoulos peter Keyes Sculco thomas peter Sculco Department of Orthopaedic Surgery Division of Adult Reconstruction and Joint ReplacementHospital for Special SurgeryNew YorkNY 10021United States

Total hip arthroplasty(THA)is considered one of the most successful surgical procedures in *** the increase in the number of THAs performed in the world in the next decades,reducing or preventing medical and mechanical complications such as post-operative THA instability will be of paramount importance,particularly in an emerging health care environment based on quality control and patient *** mobility acetabular component(also known as unconstrained tripolar implant)was introduced in France at the end of the 1970s as an alternative to standard sockets,to reduce the risk of THA dislocation in patients undergoing primary THA in *** mobility cups have recently gained wider attention in the United States as an alternative option in the prevention and treatment of instability in both primary and revision THA and offer the benefit of increased stability without compromising clinical outcomes and implant *** this article,we review the use of dual mobility cup in total hip arthroplasty in terms of its history,biomechanics,outcomes and complications based on more than20 years of medical literature.

关键词： Dual mobility Total hip arthroplasty Dislocation Revision total hip arthroplasty Instability

Titanium allergy or not? “Impurity” of titanium implant materials

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Health 2010年第4期2卷 306-310页

作者： thomas Harloff Wolfgang Honle Ulrich Holzwarth Rainer Bader peter thomas Alexander Schuh Research Unit Neumarkt Clinical CenterNeumarktGermany Orthopedic Clinic Neumarkt NeumarktGermany MedTitan ErlangenGermany Orthopedic Clinic and Polyclinic University of RostockRostockGermany Clinic and Polyclinic for Dermatology and Allergology of the Ludwig-Maximilians-University of Munich MunichGermany

For patients suffering from allergies to nickel, chrome and cobalt, titanium implants are the implants of choice. Nevertheless, titanium implant sensitivity has been reported in the form of “allergies” and an increasing number of patients are confused. This paper aims to use spectral analysis as a diagnostic tool for analyzing different titanium implant alloys in order to determine the percentage of the alloy components and additions that are known to cause allergies. Different materials, such as sponge titanium, TiAl6Nb7, Ti21SRx, TiAl6V4 [forged alloy], TiAl6V4 [cast alloy], TMZF, pure titanium [c. p. 1] and iodide titanium were analyzed for the presence of the elements that have been associated with allergic reactions using spectral analysis. All the implant material samples contained traceable amounts of Be, Cd, Co, up to a maximum of 0.001 percent by weight [wt.%], Cr up to 0.033 wt.%, Cu up to 0.007 wt.%, Hf up to 0.035 wt.%, Mn up to 0.007 wt.%, Ni up to 0.031 wt.%, and Pd up to 0.001 wt.%. This paper demonstrates that all the investigated implant material samples contained a low but consistent percentage of components that have been associated with allergies. For example, low nickel contents are related to the manufacturing pro- cess and are completely dissolved in the titanium grid. Therefore, they can virtually be classified as “impurities”. Under certain circumstances, these small amounts may be sufficient to trigger allergic reactions in patients suffering from the corresponding allergies, such as a nickel, palladium or chrome allergy.

关键词： Allergy Implant Nickel Spectral Analysis Titanium

Rising incidence,progression and changing patterns of liver disease in Wales 1999-2019

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World Journal of Hepatology 2023年第1期15卷 89-106页

作者： thomas peter Ignatius Pembroke Gareth John Berry Puyk Keith Howkins Ruth Clarke Fidan Yousuf Marek Czajkowski Andrew Godkin Jane Salmon Andrew Yeoman Department of Gastroenterology and Hepatology University Hospital of WalesCardiff CF144XNUnited Kingdom Division of Infection and Immunity Cardiff UniversityCardiff CF144XWUnited Kingdom Digital Health and Care Wales NHS WalesCardiff CF119ADUnited Kingdom Gwent Liver Unit Royal Gwent HospitalNewport NP202UBUnited Kingdom Public Health Wales NHS WalesCardiff CF104BZUnited Kingdom

BACKGROUND Liver disease incidence and hence demand on hepatology services is *** To describe trends in incidence and natural history of liver diseases in Wales to inform effective provision of hepatology *** The registry is populated by International Classification of Diseases-10(ICD-10)code diagnoses for residents derived from mortality data and inpatient/day case activity between ***-anonymised linkage of:(1)Causative diagnoses;(2)Cirrhosis;(3)Portal hypertension;(4)Decompensation;and(5)Liver cancer diagnoses enabled tracking liver disease *** The population of Wales in 2019 was 3.1 *** 1999 and 201973054 individuals were diagnosed with a hepatic disorder,including 18633 diagnosed with cirrhosis,10965 with liver decompensation and 2316 with hepatocellular carcinoma(HCC).Over 21 years the incidence of liver diseases increased 3.6 fold,predominantly driven by a 10 fold increase in non-alcoholic fatty liver disease(NAFLD);the leading cause of liver disease from *** incidence of cirrhosis,decompensation,HCC,and allcause mortality ***-related mortality ***-related liver disease(ArLD),autoimmune liver disease and congestive hepatopathy were associated with the highest rates of decompensation and all-cause *** A 10 fold increase in NAFLD incidence is driving a 3.6 fold increase in liver disease in Wales over 21 ***-related morbidity and mortality rose more slowly reflecting the lower progression rate in *** of ArLD remained stable but was associated with the highest rates of liver-related and all-cause mortality.

关键词： Epidemiology Cirrhosis Liver failure Non-alcoholic fatty liver disease hepatitis Hepatocellular carcinoma

提高心室晚电位对AMI后一年内猝死的阳性预测值的研究

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临床心血管病杂志 1993年第3期9卷 140-142页

作者：马虹 Eli Gang 王方正徐毓秀 thomas peter 中山医科大学附属第一医院 510080 美国洛杉矶Cedars-sinai医疗中心北京阜外医院安徽省立医院

对254例AMI后有1年随访资料并于AMI后住院10天内作过VLP检查的病人进行分析,结果示VLP阳性65例,检出率为26％,而1年内猝死的阳性预测值为15％;将VLP阳性加CK≥15001U/L或加Killip心功能分级≥2,阳性预测值可分别提高到22％和25％。表明... 详细信息

对254例AMI后有1年随访资料并于AMI后住院10天内作过VLP检查的病人进行分析,结果示VLP阳性65例,检出率为26％,而1年内猝死的阳性预测值为15％;将VLP阳性加CK≥15001U/L或加Killip心功能分级≥2,阳性预测值可分别提高到22％和25％。表明VLP与其他常用变量综合分析预测AMI后1年猝死率比单用VLP更具应用意义。

关键词：心肌梗塞心室晚电位猝死

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急性下壁心肌梗塞伴与不伴右室梗塞的胸前导联ST段偏移

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中华内科杂志 1991年第7期30卷 418-420+456页

作者：马虹 Eli Gang 徐毓秀王方正 thomas peter 中山医科大学附属第一医院美国洛杉矶Cedars-Sinai医疗中心安徽省立医院北京阜外医院

分析58例急性下壁心肌梗塞胸前导联ST段的变化。单纯下壁梗塞组(36例)V2导联ST段压低与aVF导联ST段抬高之间有非常显著的线性负相关关系。合并右室梗塞组(22例)V2导联压低的绝对值与相对值均显著减轻。结果提示:急性下壁心梗的胸前导联S... 详细信息

分析58例急性下壁心肌梗塞胸前导联ST段的变化。单纯下壁梗塞组(36例)V2导联ST段压低与aVF导联ST段抬高之间有非常显著的线性负相关关系。合并右室梗塞组(22例)V2导联压低的绝对值与相对值均显著减轻。结果提示:急性下壁心梗的胸前导联ST段压低是下壁导联ST段抬高的镜面表现,合并右室梗塞能显著改变胸前导联ST段偏移的方向和幅度。ST↓V2/ST↑aVF<0.5可作为判别下壁梗塞伴右室梗塞的指标。

关键词：心肌梗塞心电描记术

非接触球囊标测指导血流动力学不稳定性或非持续性室性心动过速的射频消融

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中华心血管病杂志 2005年第11期33卷 998-1001页

作者：吴素华 C.thomas peter WALTER F.KERWIN ELI S.GANG 马虹中山大学附属第一医院心内科广州510080 美国洛杉矶CEDARS-SINAI医学中心

目的探讨非接触球囊标测在指导血流动力学不稳定性或非持续性室性心动过速(室速)射频消融中的作用。方法17例室速患者,年龄50岁±9岁,经心室刺激诱发血流动力学不稳定性或非持续性室速后,使用非接触标测系统ENSITE3000标测室速的出口和(... 详细信息

目的探讨非接触球囊标测在指导血流动力学不稳定性或非持续性室性心动过速(室速)射频消融中的作用。方法17例室速患者,年龄50岁±9岁,经心室刺激诱发血流动力学不稳定性或非持续性室速后,使用非接触标测系统ENSITE3000标测室速的出口和(或)慢传导区,然后使用温控大头导管在室速出口作环形消融或横跨慢传导区进行线性消融。结果17例患者共诱发18次室速,周长为336MS±58MS。15例患者可确定室速的出口,为QRS波前10MS±16MS;其中5例是心肌梗死后室速,9例为右室流出道室速。5例心肌梗死后室速均可确定舒张期慢传导区,最早的心内膜舒张期电活动在QRS波前60·1MS±42·6MS。3例非持续性室速均可确定最早的心室激动点。18次室速中15次消融成功,1例没有进行消融,2例消融失败。结论非接触球囊心内膜标测能成功指导血流动力学不稳定性或非持续性室速的射频消融。

关键词：心动过速,室性导管消融术电生理学技术,心脏

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