Role of cell-free network communication in alcohol-associated disorders and liver metastasis
作者机构：Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of SurgeryCreighton University School of MedicineOmahaNE 68178United States Research and Development ServiceDetroit VAMCDetroitMI 48201United States Department of MedicineCentral Michigan University College of MedicineDetroitMI 48201United States Research ServiceNebraska-Western Iowa Health Care SystemOmahaNE 68105United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第41期
页 面：7080-7099页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：by Biomedical Laboratory Research and Development VA Office of Research and Development No.BX004127(to McVicker BL and Tobi M)
主 题：Exosomes Extracellular vesicles Alcohol-associated liver disease Colorectal cancer Liver metastasis Interorgan communication
摘 要：The aberrant use of alcohol is a major factor in cancer progression and *** mechanisms include the systemic effects of alcohol and the exchange of bioactive molecules between cancerous and non-cancerous cells along the brain-gut-liver *** interplay leads to changes in molecular,cellular,and biological functions resulting in cancer *** investigations have examined the role of extracellular vesicles(EVs)in cancer mechanisms in addition to their contribution as diagnostic ***,EVs are emerging as novel cell-free mediators in pathophysiological scenarios including alcohol-mediated gut microbiome dysbiosis and the release of nanosized EVs into the circulatory ***,EVs in cancer patients are enriched with oncogenes,miRNA,lipids,and glycoproteins whose delivery into the hepatic microenvironment may be enhanced by the detrimental effects of ***-of-concept studies indicate that alcohol-associated liver disease is impacted by the effects of exosomes,including altered immune responses,reprogramming of stromal cells,and remodeling of the extracellular ***,the culmination of alcoholrelated changes in the liver likely contributes to enhanced hepatic metastases and poor outcomes for cancer *** review summarizes the numerous aspects of exosome communications between organs with emphasis on the relationship of EVs in alcohol-associated diseases and cancer *** potential impact of EV cargo and release along a multi-organ axis is highly relevant to the promotion of tumorigenic mechanisms and metastatic *** is hypothesized that EVs target recipient tissues to initiate the formation of prometastatic niches and cancer *** study of alcohol-associated mechanisms in metastatic cancers is expected to reveal a better understanding of factors involved in the growth of secondary malignancies as well as novel approaches for therapeutic interventions.
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