Rising incidence,progression and changing patterns of liver disease in Wales 1999-2019

作     者：Thomas Peter Ignatius Pembroke Gareth John Berry Puyk Keith Howkins Ruth Clarke Fidan Yousuf Marek Czajkowski Andrew Godkin Jane Salmon Andrew Yeoman 

作者机构：Department of Gastroenterology and HepatologyUniversity Hospital of WalesCardiff CF144XNUnited Kingdom Division of Infection and ImmunityCardiff UniversityCardiff CF144XWUnited Kingdom Digital Health and Care WalesNHS WalesCardiff CF119ADUnited Kingdom Gwent Liver UnitRoyal Gwent HospitalNewport NP202UBUnited Kingdom Public Health WalesNHS WalesCardiff CF104BZUnited Kingdom 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第1期

页      面：89-106页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：University of Otago  Wellington 

主　　题：Epidemiology Cirrhosis Liver failure Non-alcoholic fatty liver disease hepatitis Hepatocellular carcinoma 

摘      要：BACKGROUND Liver disease incidence and hence demand on hepatology services is *** To describe trends in incidence and natural history of liver diseases in Wales to inform effective provision of hepatology *** The registry is populated by International Classification of Diseases-10(ICD-10)code diagnoses for residents derived from mortality data and inpatient/day case activity between ***-anonymised linkage of:(1)Causative diagnoses;(2)Cirrhosis;(3)Portal hypertension;(4)Decompensation;and(5)Liver cancer diagnoses enabled tracking liver disease *** The population of Wales in 2019 was 3.1 *** 1999 and 201973054 individuals were diagnosed with a hepatic disorder,including 18633 diagnosed with cirrhosis,10965 with liver decompensation and 2316 with hepatocellular carcinoma(HCC).Over 21 years the incidence of liver diseases increased 3.6 fold,predominantly driven by a 10 fold increase in non-alcoholic fatty liver disease(NAFLD);the leading cause of liver disease from *** incidence of cirrhosis,decompensation,HCC,and allcause mortality ***-related mortality ***-related liver disease(ArLD),autoimmune liver disease and congestive hepatopathy were associated with the highest rates of decompensation and all-cause *** A 10 fold increase in NAFLD incidence is driving a 3.6 fold increase in liver disease in Wales over 21 ***-related morbidity and mortality rose more slowly reflecting the lower progression rate in *** of ArLD remained stable but was associated with the highest rates of liver-related and all-cause mortality.