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The Initial Research about the ICC Cells as Pacemaker in Guinea-Pig UPPer Urinary Tract

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The Initial Research about the ICC Cells as Pacemaker in Gui...

第十六届全国泌尿外科学术会议

作者： Zhongxiao Liweibing DeP.Urology Southwest HosPital The third military medical university 400038

The ureter is an autorhythmical hollow muscular organ that ProPels urine from kidney to *** anatomy shows that the ureter disPlays sPontaneous contraction at 7-8times/min whatever it is used by the blockers of nerve

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Apoptosis:Initiation and Propagation in the Kinetic Process of Systemic Lups Erythematosus

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Apoptosis:Initiation and Propagation in the Kinetic Process ...

中华医学会第十八次全国皮肤性病学术年会

作者： Na Luo,Fei Hao Department of Dermatology,Southwest Hospital,third military medical university

Apoptosis or programmed cell death is a genetically conserved pathway and a regular feature in normal tissue *** cell apoptosis could result in imbalanced immune regulation and plays an important role in the development of autoimmune diseases,especially in systemic lupus erythematosus(SLE).SLE is a complex,multisystem autoimmune disease characterized by production of

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Immunohistochemical localization of steroid receptor coactivator-1 in the brain of femal mice

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Immunohistochemical localization of steroid receptor coactiv...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Qiyue DENG,Jiqiang ZHANG Department of Neurobiology,third military medical university,Chongqing 400038

＜正＞Steroid hormones,through their receptors known as nuclear receptors,play a crucial role in the brain function and *** regulate transcription,NRs are required to bind to cofactors known as coactivators,among such coactivators,the members of the P160 family,or steroid receptor coactivators（SRCs）,are essential for NR-mediated transcriptional *** SRC gene family contains three members（SRC-1,2,and 3）,which serve as transcriptional coactivators for nuclear receptors and certain other transcription *** have shown that SRC-1 is the most abundant distributed in the brain,SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells,suggesting a crucial role of SRC-1 in the *** further address the role that SRC-1 plays in the brain,we studied its dictribution in th femal mice brain using immunohistochemical *** results showed this coactivator is widely distributed in the brain,the highest expression was detected in the hippocampus especially the dentae gyrus,the cerebral cortex especially the piriform cortex,and cerebellar Purkinje *** level of expression was found in basal forebrain,and some specific nuclei of hypothalamus（medial preoptical,ventrimedial hypothalamus,arcuate, supraoptic）,central nuclear of inferior colliculus,comparatively low level of expression was found in the midbrain,some nuclei of the *** most of the positive materials were localized in the cell nucleus,we still found some extranucleus immunostaning in some area of the *** also noticed the expression of SRC-1 decreased with ageing, since the the expression in the postnatal day 7 brain was higher than in the adult,and ovriectomy dramaticaly decreased the expression in the *** concluded that SRC-1 may exert multiple function in the brain,expecially in the *** the hippocampus has been shown to be one of the focus areas of steroid hormones,receptor proteins and mRNAs

关键词： Steroid receptor coactivator-1 brain development rodent immunohistochemistry

Management of vascular anomalies and complications in liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 330-331页

作者： Jia-Hong Dong Southwest Hospital & Institute of Hepatobiliary Surgery, third military medical university, Chongqing 400038 , China

The liver has an arteriovenous double blood supply system of hepatic arteries and portal veins in addition to one venous return system of hepatic veins. Thus, vascular reconstruction plays a considerably important role in liver transplantation. Nevertheless, vascular anomalies and complications have a significant impact on patient and graft survival, even resulting in allograft dysfunction and patient death. Vascular anomalies in liver transplantation occur in both donor and recipient vessels of hepatic arteries, portal veins and hepatic veins, including vascular variations, lesions and injuries.

关键词： donor graft recipient veins inferior arteries stenosis considerably return anastomosis

Dynamic changes of myocardial nitric oxide formation and cGMP content in the early stage after radiation, burn and combined radiation-burninjuries in rats

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Journal of medical Colleges of PLA(China) 1998年第1期13卷 11-14页

作者： Wang Weidong Chen Zongrong Li Rong(Department of Radiation Medicine, third military medical university, Chongqing,400038)

Nitric oxide formation and cyclic GMP level in the myocardium were studied in the early stage after radiation, bum andcombined radiation-bum injuries in rats. Nitric oxide synthase (NOS) activity was measured in the cytosol of the left ventricularwall. In the controls, the cytosol was found to contain mainly Ca2+ -dependent NOS (cNOS) and a small amount of Ca2+ -inden-pendent NOS (iNOS). After burn and combined radiation-burn injuries, a marked increase of iNOS activity with a peak in the 8thhour postinjury was found but the myocardial cNOS activity declined obviously. Parallel to iNOS activity increase, there was a significant increase of myocardial production of NO and cGMP. The combined effcts of radiation and burn injuries on the rats weremore severe than those of burn injury alone. All the changes could be prevented by the administration of dexamethasone. No obvious changes were observed in the rats after radiation injury alone. Since the increase of cGMP level in the heart is associated withreduced contractility, it is possible that the increased production of NO stimulated by iNOS accounts at least partially, for the depression of myocardial contractility after bum and combined radiation burn injury.

关键词： combined radiation-burn in injury myocardium nitric oxide

Cornea-like Differentiation of Rat Hair Follicle Stem Cells:Effects of Pax6

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Cornea-like Differentiation of Rat Hair Follicle Stem Cells:...

中国细胞生物学学会第九次会员代表大会暨青年学术大会

作者： Ke Yang (Department of Cell Biology,third military medical university,Chongqin 400038,China)

Background Several ocular surface diseases and injuries cause loss of the corneal limbal epithelium,leading re-epithelialization by bulbar conjunctival cells,resulting in vascularization of the cornea,conjunctival scarring,and loss of visual *** this study,we investigated the potential of rat hair follicle stem cells to undergo corneal epithelial cells differentiation in vitro.

关键词： cornea pax6 hair follicle stem cell

哺乳动物昼夜节律调节的神经基础——昼夜光感受器

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生物化学与生物物理进展 2003年第5期30卷 694-697页

作者：谌小维胡志安第三军医大学神经生物学教研室重庆400038

哺乳动物昼夜光感受器为一组具有直接感光功能的特殊视网膜神经节细胞 ,其基本感光色素为黑视素 .昼夜光感受器具有直接、广谱和稳定感受昼夜光变化的功能特点 .昼夜光感受器的功能是通过导引作用 ,使下丘脑视交叉上核内的昼夜节律活动... 详细信息

哺乳动物昼夜光感受器为一组具有直接感光功能的特殊视网膜神经节细胞 ,其基本感光色素为黑视素 .昼夜光感受器具有直接、广谱和稳定感受昼夜光变化的功能特点 .昼夜光感受器的功能是通过导引作用 ,使下丘脑视交叉上核内的昼夜节律活动与外界明

关键词：哺乳动物昼夜节律调节神经昼夜光感受器导引作用黑视素隐花色素视网膜节细胞

Balance between pro-and anti-inflammation cytokines of atherosclerosis induced by immunological and inflammatory stimulations in rats

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Balance between pro-and anti-inflammation cytokines of ather...

第十五届国际药理学大会

作者： Ji-shan Fan Xiao-hui Li . Basic medical Faculty. third military medical university Chongqing

＜正＞ To observe the changes of rats’aorta induced by immunolgic and inflammatory stimulation and probe cytokine of the aorta with Cytokine Antibody Array. To induce foam cell formation in the aorta of rat by repeat intraperitoneal injections zymosan every 4 days for 8 weeks and ovalbuimn. 2. 5mg/kg BW every one week for 5 times after initial subcutaneous sensitization simultaneously. All rats were feeded with a cholesterol-rich diet including control. Transmission Electron Microscope. Cholesterol Test Kit. Turbidimetry of Polyethylene Glycol and RayBio Rat Cytokine Antibody Array Ⅰ were used to detect ultrastructural changes of aorta, serum total cholesterol（TC） levels, the changes of cytokines respectively. The ultrastructural changes were characterized by monocytes and smooth muscle cell migration with phagocytize lipid granule after 8 weeks. The TC levels were significantly higher than control （p ＜ 0.05）. Proinflammation cytokines for example IL - 6. etc. increased during the process of AS. In conclusion The balance between pro- and anti-inflammation cytokines play an important role in immunological and inflammatory mechanism of AS.

关键词： atherosclerosis immunology inflammation Antibody Array

Anti-inflammatory effects of a novel peptide designed to bind with NF-κB p50 subunit

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Acta Pharmacologica Sinica 2006年第11期27卷 1474-1478页

作者： Zhen-ping WANG~2 Shao-xi CAI~(2,4)Dong-bo LIU~3 Xiang XU~3 Hua-ping LIANG~3 2 Bioengineering College,Chongqing university,Chongqing 400044,China 3 State Key Laboratory of Trauma,Burns and Combined Injury,Department 1,Research Institute of Surgery,Daping Hospital,third military medical university,Chongqing 400042,China Bioengineering College Chongqing University Chongqing China Department 1 State Key Laboratory of Trauma Burns and Combined Injury Research Institute of Surgery Daping Hospital Third Military Medical University Chongqing China

Aim:To explore the anti-inflammatory effects of a novel peptide designed to bindwith the NF-κB p50 ***:The affinity of the peptide binding withp50 was measured with a *** of tumor necrosis factor-α(TNF-α)and interleukin 6(IL-6)from a human acute monocytic leukemia cell line(THP-1)treated with lipopolysaccharide(LPS)were measured using the ELISA method,Invivo anti-inflammatory effects of the peptide were tested with phorbol myristateacetate(PMA)-induced ear edema and zymosan A-induced peritonitis in ***:The peptide has the ability to interact with the NF-κB p50 subunit andcan effectively inhibit TNF-α and IL-6 production in the THP-1 cell line,PMA-induced ear edema and zymosan A-induced peritonitis in ***:Thepeptide may have therapeutic potential for the treatment of local acute inflammation.

关键词： NF-kB anti-inflammatory agents cytokines