Tolerance limit of rats to normothermic hepatic inflow occlusion under portal blood bypass

作     者：Jia-Hong Dong Xiao-Dong He Kun Li Heng-Chun Duan Zhi-Ming Peng Jing-Xiu Cai From the Hepatobiliary Surgery Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China 

作者机构：Hepatobiliary Surgery Center Southwest Hospital Third Military Medical University Chongqing 400038 China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2002年第1卷第1期

页      面：57-62页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：liver hepatic inflow occlusion rats ischemia-reperfusion injury 

摘      要：Objective: To evaluate the tolerance limit of rats tonormothermic hepatic inflow occlusion under portalblood ***: A new rat model of normothermic hepaticinflow occlusion under portal blood bypass was estab-lished by clamping temporarily the pedicles of all liverlobes while the caudal lobe was kept as a passage ofthe portal blood flow. After hepatic blood flow re-stored, the caudal lobe was cut off. On the 7th postop-erative day, survival rate, hepatic morphological changes,and the severity and reversibility of the injured energymetabolism of the liver were ***: All rats that had been subjected to 30, 60 and90 minutes of hepatic inflow occlusion under portalblood bypass survived on the 7th postoperativeday. Ischemia-reperfusion injury of the liver was re-versible and compensatory in rats with hepatic inflowocclusion within 90minutes. However, the survivalrates of rats with 100, 110 and 120 minutes of hepaticinflow occlusion were 50%, 30% and 20% respective-ly. Liver injury of rats with 120 minutes of hepatic in-flow occlusion was severe and ***: The tolerance limit of rats to normother-mic hepatic inflow occlusion is enhanced significantlyunder portal blood bypass and the upper limit is 90minutes.