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Neural progenitor cells but not astrocytes respond distally to thoracic spinal cord injury in rat models

Neural Regeneration Research 2017年第11期12卷 1885-1894页

作者： Tara Nguyen Yilin Mao theresa Sutherland Catherine Anne Gorrie School of Life Sciences Faculty of ScienceUniversity of Technology SydneyNew South WalesAustralia

Traumatic spinal cord injury （SCI） is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells, astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI （n = 9）, sham surgery （n = 8）, or no surgery （n = 8）. Spinal cord and brain tissues were fixed and cut at six regions of the neuroaxis. Immunohistochem- istry showed increased reactivity of neural progenitor cell marker nestin in the central canal at all levels of the spinal cord. Increased reactivity of astrocyte-specific marker glial fibrillary acidic protein was found only at the lesion epicenter. The number of activated microglia was significantly increased at the lesion site, and activated microglia extended to the lumbar enlargement. Phagocytic microglia and macrophages were significantly increased only at the lesion site. There were no changes in nestin, glial fibrillary acidic protein, microglia and macrophage response in the third ventricle of rats subjected to mild-contusion thoracic SCI compared to the sham surgery or no surgery. These findings indicate that neural progenitor cells, astrocytes and microglia respond differently to a localized SCI, presumably due to differences in inflammatory signaling. These different cellular responses may have implications in the way that neural progenitor cells can be manipulated for neuroregeneration after SCI. This needs to be further investigated.

关键词： nerve regeneration contusion spinal cord neuroinflammatory ependymal cell glial fibrillary acidic protein microglia nestin neuroaxis tanycyte third ventricle trauma neural regeneration

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Female sex in experimental traumatic brain injury research:forging a path forward

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Neural Regeneration Research 2022年第3期17卷 550-552页

作者： theresa Currier Thomas Caitlin E.Bromberg Gokul Krishna Department of Child Health University of Arizona College of Medicine-Phoenix BARROW Neurological Institute at Phoenix Children’s Hospital PhoenixAZUSA Phoenix VA Health Care System PhoenixAZUSA Arizona State University TempeAZUSA

Traumatic brain injury(TBI) is a leading cause of death and disability worldwide,with estimates indicating that -50% of the world's population will acquire a head injury at some point in their lifetime(Maas et al.,2017).Mild TBIs account for -80% of all reported cases,with up to 43% of all TBI patients reporting symptoms beyond 2 weeks *** of 2016,only 7% of preclinical TBI experiments included both male and female sexes,and fewer studies analyzed the data using sex as a biological variable(Spani et al.,2018).

关键词： injury death

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IL-17,a new kid on the block of tertiary lymphoid organs

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Cellular & Molecular Immunology 2012年第1期9卷 3-4页

作者： theresa T Lu Hajeong Kim Xiaojing Ma Autoimmunity and Inflammation Program and Pediatric Rheumatology Hospital for Special SurgeryNew YorkNYUSA Department of Microbiology and Immunology Weill Cornell Medical CollegeNew YorkNYUSA

T ertiary lymphoid organs(TLOs)are structures that resemble lymph nodes that can be found in chronically inflamed tissues in a number of inflammatory *** can host ongoing immune responses that can potentially contribute to disease *** development of TLOs has been thought in large part to recapitulate the development of secondary lymphoid organs,but the regulation of TLO development has not been well *** a recent article in Nature Immunology,Troy Randall and colleagues1 identify IL-17,a cytokine that contributes to the pathogenesis of a number of inflammatory diseases,as a novel critical player in TLO formation in inflamed *** can be found in the joints of patients with rheumatoid arthritis,in the inflamed salivary glands of patients with Sjogren’s syndrome,in the meninges of patients with multiple sclerosis,and in the lungs of patients with pulmonary inflammation or *** the lungs,induced bronchus-associated lymphoid tissues(iBALTs)are TLOs that are located along the small airways.

关键词： organs lymphoid pathogenesis

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Esophageal squamous papillomas with focal dermal hypoplasia and eosinophilic esophagitis

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World Journal of Gastroenterology 2017年第12期23卷 2246-2250页

作者： Eric A Pasman theresa A Heifert Cade M Nylund Pediatric Residency Program National Capital Consortium Pediatric Gastroenterology Hepatology and Nutrition Fellowship ProgramNational Capital Consortium Department of Pediatrics F.Edward Hebert School of MedicineUniformed Services University

Focal dermal hypoplasia(FDH) is a rare disorder of the mesodermal and ectodermal tissues. Here we present an eight-year-old female known to have FDH who presents with poor weight gain and dysphagia. She was diagnosed with multiple esophageal papillomas and eosinophilic esophagitis. She was successfully treated with argon plasma coagulation and ingested fluticasone propionate, which has not been described previously in a child.

关键词： Focal dermal hypoplasia Papilloma Argon plasma coagulation Eosinophils Eosinophilic esophagitis Esophageal diseases Dysphagia

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Ripping the Ripoptosome: a novel path for blocking allergic inflammation?

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Cellular & Molecular Immunology 2022年第2期19卷 136-138页

作者： theresa Neuper Richard Weiss Jutta Horejs-Hoeck University of Salzburg Department of BiosciencesHellbrunner Str.345020 SalzburgAustria.

Scientists at Cincinnati Children’s Hospital Medical Center report that an innate molecular signaling hub known as the ripoptosome plays a key role in the development of allergic pathologies and suggest that manipulation of this response platform could open new paths for the treatment of allergic diseases[1].Allergies are an unremitting global health care *** the symptoms of affected individuals are well documented for a wide range of allergic disorders,the precise molecular mechanisms that trigger allergic inflammation to innocuous substances remain ***,a key question in allergy research is why certain environmental proteins can trigger the induction of allergic Th2 *** work by Ruslan Medzhitov’s group identified protease activity inherent in many allergens as being critical to eliciting the hypersensitivity response.

关键词： allergic inflammation Th2

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Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age

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World Journal of Cardiology 2023年第5期15卷 262-272页

作者： Julianne theresa Nelson Longjian Liu Department of Epidemiology and Biostatistics Dornsife School of Public HealthDrexel UniversityPhiladelphiaPA 19104United States

BACKGROUND A limited number of studies have been conducted to test the magnitudes of the association between apparent treatment resistant hypertension(aTRH)and risk of cardiovascular disease(CVD).AIM To investigate the association between aTRH and risk of CVD and examine whether sex and age modify this *** We applied an observational analysis study design using data from the United States Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial(ALLHAT).ALLHAT recruited participants(n=25516)from 625 primary care settings throughout the United States,Canada,Puerto Rico,and United States Virgin Islands,aged 55 and older with hypertension and at least one additional risk factor for heart *** was assessed from the year 2 *** event was defined as one of the following from the year 2 follow-up visit:Fatal or non-fatal myocardial infarction,coronary revascularization,angina,stroke,heart failure,or peripheral artery *** proportional hazards regression was used to examine the effect of aTRH on CVD *** modifications of sex and age on this association were examined on the multiplicative scale by interaction term and additive scale by joint effects and relative excess risk for *** Of the total study participants(n=25516),5030 experienced a CVD event during a mean of 4.7 years *** was associated with a 30%increase in risk of CVD compared to non-aTRH[hazards ratio(HR)=1.3,95%CI:1.19-1.42].Sex and age modified this relationship on both multiplicative and additive scales *** by sex,aTRH was associated with a 64%increase in risk of CVD(HR=1.64,95%CI:1.43–1.88)in women,and a 13%increase in risk of CVD(HR=1.13,95%CI:1.01–1.27)in *** by age,aTRH had a stronger impact on the risk of CVD in participants aged<65(HR=1.53,95%CI:1.32–1.77)than it did in those aged≥65(HR=1.18,95%CI:1.05–1.32).Significant two-way interactions of sex and aTRH,and age and aTRH on risk of

关键词： Apparent treatment resistant hypertension Cardiovascular disease outcomes Chronic kidney disease Sex Age

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A Collaborative Approach for Secured Routing in Mobile Ad-Hoc Network

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Intelligent Automation & Soft Computing 2023年第2期35卷 1337-1351页

作者： W.Gracy theresa A.Gayathri P.Rama Department of Computer Science and Engineering Panimalar Institute of TechnologyChennai600123Tamil NaduIndia Department of Information Technology Vellore Institute of TechnologyVellore632014Tamil NaduIndia Department of Computer Science and Engineering Loyola Institute of TechnologyChennai600123Tamil NaduIndia

Mobile computing is the most powerful application for network com-munication and connectivity,given recent breakthroughs in theﬁeld of wireless networks or Mobile Ad-hoc networks(MANETs).There are several obstacles that effective networks confront and the networks must be able to transport data from one system to another with adequate *** most applications,a frame-work must ensure that the retrieved data reﬂects the transmitted *** driv-ing to other nodes,if the frame between the two nodes is deformed in the data-link layer,it must be *** link-layer protocols immediately disregard the frame and enable the high-layer protocols to transmit it *** other words,because of asset information must be secured from threats,information is a valu-able *** MANETs,some applications necessitate the use of a network method for detecting and blocking these *** a secure intrusion detection system in the network,which provides security to the nodes and route paths in the network,is a major difﬁculty in *** on the network can jeopardize security issues discovered by the intrusion detection system engine,which are then blocked by the network’s intrusion prevention *** bringing the Secure Intrusion Detection System(S-IDS)into the network,a new technique for implementing security goals and preventing attacks will be *** Secure Energy Routing(SER)protocol for MANETs is introduced in this *** protocol addresses the issue of network security by detecting and preventing attacks in the *** data transmission in the MANET is forwarded using Elliptical Curve Cryptography(ECC)with an objective to improve the level of *** Simulator–2 is used to simulate the network and experiments are compared with existing methods.

关键词： Mobile ad-hoc network(MANET) intrusion detection system secure energy routing(SER) elliptical curve cryptography(ECC) security

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Are mitochondria the key to reduce the age-dependent decline in axon growth after spinal cord injury?

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Neural Regeneration Research 2021年第7期16卷 1444-1445页

作者： theresa C.Sutherland Cédric G.Geoffroy Department of Neuroscience and Experimental Therapeutics Texas A&M Health Science CenterBryanTXUSA

Spinal cord injury(SCI) is a debilitating condition resulting in varying degrees of functional impairment and exhibits only limited *** there is no cure for SCI, and no proven treatment to promote restoration of funct... 详细信息

关键词： function. injury impairment

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MicroRNAs in treatment-induced neuroendocrine differentiation in prostate cancer

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Cancer Drug Resistance 2020年第4期3卷 804-818页

作者： theresa Akoto Divya Bhagirath Sharanjot Saini Department of Cellular Biology and Anatomy Augusta UniversityAugustaGA 30912USA Department of Biochemistry and Molecular Biology Augusta UniversityAugustaGA 30912USA

Prostate cancer is a condition commonly associated with men *** deprivation therapy remains one of the targeted ***,after some years,there is biochemical recurrence and metastatic progression into castration-resistant prostate cancer(CRPC).CRPC cases are treated with second-line androgen deprivation therapy,after which,these CRPCs transdifferentiate to form neuroendocrine prostate cancer(NEPC),a highly aggressive variant of *** arises via a reversible transdifferentiation process,known as neuroendocrine differentiation(NED),which is associated with altered expression of lineage markers such as decreased expression of androgen receptor and increased expression of neuroendocrine lineage markers including enolase 2,chromogranin A and *** etiological factors and molecular basis for NED are poorly understood,contributing to a lack of adequate molecular biomarkers for its diagnosis and ***,there is a need to fully understand the underlying molecular basis for this *** studies have shown that microRNAs(miRNAs)play a key epigenetic role in driving therapy-induced NED in prostate *** this review,we briefly describe the role of miRNAs in prostate cancer and CRPCs,discuss some key players in NEPCs and elaborate on miRNA dysregulation as a key epigenetic process that accompanies therapy-induced NED in metastatic *** understanding will contribute to better clinical management of the disease.

关键词： MicroRNAs neuroendocrine differentiation castration-resistant prostate cancer epigenetics oncomirs tumor suppressors androgen deprivation therapy

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Endogenous neural progenitor cells in the repair of the injured spinal cord

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Neural Regeneration Research 2016年第7期11卷 1075-1076页

作者： Yilin Mao Tara Nguyen theresa Sutherland Catherine Anne Gorrie Neural Injury Research Unit School of Life SciencesFaculty of ScienceUniversity of Technology Sydney

Stem cell treatments,and in particular,stem cell transplants have been identified as potential therapeutic strategies for a range of neurodegenerative and acquired conditions of the central nervous system（CNS）.Stem cell transplants are seen as a way of replacing lost neurons,or providing a cellular environment that is more permissible for axon and cell regeneration.

关键词： progenitor repair injured regeneration alternate providing neuronal fibrillary glial acidic

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