Ripping the Ripoptosome: a novel path for blocking allergic inflammation?

作     者：Theresa Neuper Richard Weiss Jutta Horejs-Hoeck 

作者机构：University of SalzburgDepartment of BiosciencesHellbrunner Str.345020 SalzburgAustria. 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2022年第19卷第2期

页      面：136-138页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：supported by the Austrian Science Fund Grant W 1213 and by the Priority program ACBN University of Salzburg 

主　　题：allergic inflammation Th2 

摘      要：Scientists at Cincinnati Children’s Hospital Medical Center report that an innate molecular signaling hub known as the ripoptosome plays a key role in the development of allergic pathologies and suggest that manipulation of this response platform could open new paths for the treatment of allergic diseases[1].Allergies are an unremitting global health care *** the symptoms of affected individuals are well documented for a wide range of allergic disorders,the precise molecular mechanisms that trigger allergic inflammation to innocuous substances remain ***,a key question in allergy research is why certain environmental proteins can trigger the induction of allergic Th2 *** work by Ruslan Medzhitov’s group identified protease activity inherent in many allergens as being critical to eliciting the hypersensitivity response.