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Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain

Neural Regeneration Research 2025年第1期20卷 184-185页

作者： Teruyuki Ishikura tatsusada okuno Department of Molecular Neuroscience Graduate School of MedicineOsaka UniversityOsakaJapan Department of Neurology Osaka University Graduate School of MedicineOsaka UniversityOsakaJapan

In this article, we present our previous research, which highlighted adenosine triphosphate(ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder(NMOSD). In NMOSD pathology, damageassociated molecular patterns(DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD.

关键词： pain acute pathology

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Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology

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Neural Regeneration Research 2025年第9期20卷 2589-2590页

作者： Mikio Shimizu tatsusada okuno Department of Neurology Osaka University Graduate School of MedicineSuitaJapan Department of Neurology Osaka General Medical CenterOsakaJapan

Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal *** with ALS develop skeletal muscle weakness,resulting in death from respiratory paralysis,which usually occurs 2-4 years after clinical onset(Goutman et al.,2022).

关键词： paralysis sclerosis

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Functional imaging of astrocyte activity

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Neural Regeneration Research 2021年第6期16卷 1206-1207页

作者： Hiroki Kato tatsusada okuno Department of Nuclear Medicine and Tracer Kinetics Osaka University Graduate School of Medicine2-2 Yamadaoka SuitaOsakaJapan Department of Neurology Osaka University Graduate School of Medicine2-2 Yamadaoka SuitaOsakaJapan

Astrocytes have become known to play a central role in various neuroinflammatory *** evaluation of astrocyte activity using functional imaging is becoming more *** metabolism or oxygen metabolism in the brain can be assessed using the established clinical imaging methods of F-18 fluorodeoxyglucose positron emission tomography(PET)and O-15 PET,***,until recently,the highly specific evaluation of metabolic activity in astrocytes has never been applied *** acetate is selectively taken up and metabolized by astrocytes,its usefulness as a tracer for measuring astrocyte activity has been proposed in basic research.

关键词： metabolism assessed clinical

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Regulation of immune cell responses by semaphorins and their receptors

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Cellular & Molecular Immunology 2010年第2期7卷 83-88页

作者： Hyota Takamatsu tatsusada okuno Atsushi Kumanogoh Department of Immunopathology Research Institute for Microbial Diseases Osaka University Suita Osaka Japan World Premier International Immunology FrontierResearch Center Osaka University Suita Osaka Japan

Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several members of semaphorins, so-called ＇immune semaphorins＇, are crucially involved in various phases of immune responses. These semaphorins regulate both immune cell interactions and immune cell trafficking during physiological and pathological immune responses. Here, we review the following two functional aspects of semaphorins and their receptors in immune responses： their functions in cell-cell interactions and their involvement in immune cell trafficking.

关键词： semaphorin immune regulation immune cell trafficking tumorigenesis autoimmune diseases

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