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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1892-1894页

作者： tao Chen Ruiyuan Zhao Jian Chen Zichao zhang College of Engineering China Agricultural UniversityBeijing 100083China Key Laboratory of Smart Agricultural Technology in Tropical South China Ministry of Agriculture and Rural AffairsGuangzhou 510642China

Dear Editor,This letter proposes a fuzzy indirect iterative learning(FIIL)active disturbance rejection control(ADRC)scheme to address the impact of uncertain factors of plant-protection unmanned ground vehicle(UGV),in which ADRC is a data-driven model-free control algorithm that only relies on the input and output data of the *** on the established nonlinear time-varying dynamic model including dynamic load(medicine box),the FIIL technology is adopted to turn the bandwidth and control channel gain online,in which the fuzzy logic system is used to update the gain parameters of iterative learning in real *** and experiment show the FIIL-ADRC scheme has better control performance.

关键词： Active scheme iterative

The potential of herbal drugs to treat heart failure:The roles of Sirt1/AMPK

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Journal of Pharmaceutical Analysis 2024年第2期14卷 157-176页

作者： tao zhang Lei Xu Xiaowei Guo Honglin tao Yue Liu Xianfeng Liu Yi zhang Xianli Meng State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu611137China Meishan Hospital of Chengdu University of Traditional Chinese Medicine MeishanSichuan620032China

Heart failure(HF)is a highly morbid syndrome that seriously affects the physical and mental health of patients and generates an enormous socio-economic *** addition to cardiac myocyte oxidative stress and apoptosis,which are considered mechanisms for the development of HF,alterations in cardiac energy metabolism and pathological autophagy also contribute to cardiac abnormalities and ultimately *** information regulator 1(Sirt1)and adenosine monophosphate-activated protein kinase(AMPK)are nicotinamide adenine dinucleotide(NAD+)-dependent deacetylases and phosphorylated kinases,*** play similar roles in regulating some pathological processes of the heart through regulating targets such as peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α),protein 38 mitogen-activated protein kinase(p38 MAPK),peroxisome proliferator-activated receptors(PPARs),and mammalian target of rapamycin(mTOR).We summarized the synergistic effects of Sirt1 and AMPK in the heart,and listed the traditional Chinese medicine(TCM)that exhibit cardioprotective properties by modulating the Sirt1/AMPK pathway,to provide a basis for the development of Sirt1/AMPK activators or inhibitors for the treatment of HF and other cardiovascular diseases(CVDs).

关键词： Heart failure Silent information regulator 1 Adenosine monophosphate-activated protein kinase Traditional Chinese medicine

Multilevel Attention Unet Segmentation Algorithmfor Lung Cancer Based on CT Images

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Computers, Materials & Continua 2024年第2期78卷 1569-1589页

作者： Huan Wang Shi qiu Benyue zhang Lixuan Xiao Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’anChina School of Biomedical Engineering Fourth Military Medical UniversityXi’anChina University of Illinois at Urbana Champion ChampaignUSA

Lung cancer is a malady of the lungs that gravely jeopardizes human ***,early detection and treatment are paramount for the preservation of human *** computed tomography(CT)image sequences can explicitly delineate the pathological condition of the *** meet the imperative for accurate diagnosis by physicians,expeditious segmentation of the region harboring lung cancer is of utmost *** utilize computer-aided methods to emulate the diagnostic process in which physicians concentrate on lung cancer in a sequential manner,erect an interpretable model,and attain segmentation of lung *** specific advancements can be encapsulated as follows:1)Concentration on the lung parenchyma region:Based on 16-bit CT image capturing and the luminance characteristics of lung cancer,we proffer an intercept histogram algorithm.2)Focus on the specific locus of lung malignancy:Utilizing the spatial interrelation of lung cancer,we propose a memory-based Unet architecture and incorporate skip connections.3)Data Imbalance:In accordance with the prevalent situation of an overabundance of negative samples and a paucity of positive samples,we scrutinize the existing loss function and suggest a mixed loss *** results with pre-existing publicly available datasets and assembled datasets demonstrate that the segmentation efficacy,measured as Area Overlap Measure(AOM)is superior to 0.81,which markedly ameliorates in comparison with conventional algorithms,thereby facilitating physicians in diagnosis.

关键词： Lung cancer computed tomography computer-aided diagnosis Unet segmentation

A gel polymer electrolyte based on IL@NH_(2)-MIL-53(Al)for high-performance all-solid-state lithium metal batteries

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Chinese Journal of Chemical Engineering 2024年第5期69卷 47-55页

作者： Sijia Wang Ye Liu Liang He Yu Sun Qing Huang Shoudong Xu Xiangyun qiu tao Wei School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China Power&Energy Storage System Research Center College of Mechanical and Electrical EngineeringQingdao UniversityQingdao 266071China

Solid polymer composite electrolytes possess the benefits of superior compatibility with electrodes and good thermal characteristics for more secure energy storage ***,a new gel polymer electrolyte(GPE)containing NH_(2)-MIL-53(Al),[PP_(13)][TFSI],LiTFSI,and PVDF-HFP was prepared using a simple method of solution *** effects of encapsulating different ratios of ionic liquid([PP_(13)][TFSI])into the micropores of functionalized metal-organic frameworks(NH_(2)-MIL-53(Al))on the electrochemical properties were ***,SEM,nitrogen adsorption-desorption isotherms,and electrochemical measurements were *** GPE demonstrates a superior ionic conductivity of 8.08×10^(-4)S·cm^(-1)at 60℃and can sustain a discharge specific capacity of 156.6 mA·h·g^(-1)at 0.2 C for over 100 *** work might offer a potential approach to alleviate the solid-solid contact with the solid-state electrolyte and electrodes and broaden a new window for the creation of all-solid-state batteries.

关键词： Metal-organic frameworks(MOFs) All solid-state lithium batteries(ASSLBs) Ionic liquid NH_(2)-MIL-53(Al) Solid-state electrolytes(SSEs)

Hydrogel-Assisted Electrokinetics for High-Resolution and Non-invasive Flow Monitoring in Microfluidic Chips

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Chinese Journal of Chemistry 2024年第6期42卷 571-577页

作者： Na Zhao Yanni Ma Zehua Yu Jun Huang Xiangqian Fu tao qiu Kang Liu MOE Key Laboratory of Hydraulic Machinery Transients School of Power and Mechanical EngineeringWuhan UniversityWuhanHubei430072 China Department of Urology Renmin Hospital of Wuhan UniversityWuhanHubei430072 China Department of Organ Transplantation Renmin Hospital of Wuhan UniversityWuhanHubei430072 China

Convenient non-invasive flow monitoring would facilitate the operation and control in microfluidic chips,but is challenging due to the small space of microchannels and complex operation required in traditional optical *** this work,we propose a novel non-invasive strategy to probe microfluidic flows via streaming potential *** sealing one side of the microchannel with a piece of hydrogel film,streaming potential inside the channel can be clearly detected by electrodes at outer surface of the hydrogel due to ion diffusion in the *** is detected without sensors contacting with the internal ***,the electrodes shape like a tiny probe,which can move around mapping the flow distribution in a chip with the spatial resolution of 1 mm and flow rate detection limit of 3μL·min–*** inside the channels can also be detected,due to the fluctuation of streaming voltage when gas-liquid interface flows through the electrode,showing an easy and potential way for multi-functional flow monitoring in microfluidic chips.

关键词： Microfluidics Hydrogels Electrokinetics Flow monitoring Non-invasive Sensor Charge transport

Excellent energy storage properties in non-stoichiometric Bi_(0.5)Na_(0.5)TiO_(3)-based relaxor ferroelectric ceramics

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Chinese Chemical Letters 2024年第7期35卷 470-472页

作者： Shunshun Jiang Ji zhang Jing Wang Shan-tao zhang School of Materials Science and Engineering Nanjing University of Science&TechnologyNanjing 210094China State Key Laboratory of Mechanics and Control of Mechanical Structures College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China National Laboratory of Solid State Microstructures Department of Materials Science and EngineeringCollege of Engineering and Applied Science&Jiangsu Key Laboratory of Artificial Functional Materials&Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

The rapid development of high-power and pulsed-power techniques inspires extensive investigates on high-performance ceramic-based ***,the low recoverable energy density(Wrec)hampers their wider ***,the non-stoichiometric Bi_(0.5)Na_(0.5)TiO_(3)-based ceramics were designed and *** proper introduction of oxygen vacancies facilitated activating defect dipole,giving rise to reduced remanent ***,the optimal composition exhibited an exceptional high Wrec of 8.3 J/cm^(3),a high efficiency of 85%,and excellent anti-fatigue and thermal *** work provides an efficient approach to explore ceramic capacitors with high capacitive energy storage performances.

关键词： Non-stoichiometric Bi_(0.5)Na_(0.5)TiO_(3) Ceramic capacitor Energy density Thermal stability

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-Gang Linghu Tian zhang Guang-tao zhang Peng Lv Wen-Jun zhang Guan-Ding Zhao Shi-Hang Xiong qiu-Shuo Ma Ming-Ming Zhao Meiwan Chen Yuan-Jia Hu Chang-Sheng zhang Hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination

Preparation of(Lu,Y)_(3)(Al,Sc,Cr)_(2)Al_(3)O_(12)phosphor ceramics with high thermal stability for near-infrared LED/LD

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Journal of Advanced Ceramics 2024年第3期13卷 354-363页

作者： Yuelong Ma Xingcan Li Lan Wu Chenyang Shao Boqiang zhang tao Pang Lili Lu Hui qiu Ye Tian Guilu Wang Yanbo Hui Qianwen Guo Daqin Chen School of Mechanical and Electrical Engineering Henan University of TechnologyZhengzhou 450001China Huzhou Key Laboratory of Materials for Energy Conversion and Storage College of ScienceHuzhou UniversityHuzhou 313000China College of Physics and Energy Fujian Normal UniversityFuzhou 350117China SongShan Laboratory Zhengzhou 450046China College of Food Science and Engineering Henan University of TechnologyZhengzhou 450046China School of Mechanical Engineering Zhengzhou University of Science and TechnologyZhengzhou 450064China

Near-infrared(NIR)phosphor-converted light-emitting diodes/laser diodes(LEDs/LDs)are prospective lighting sources for NIR ***,developing NIR phosphor materials with desired thermal robustness and high photoelectric efficiency is a crucial challenge for their *** this work,based on the cationic radius matching effect,a series of(Lu,Y)_(3)(Al,Sc,Cr)_(2)Al_(3)O_(12)NIR phosphor ceramics(LuYScCr NIR-PCs)were fabricated by vacuum *** thermal stability(95%@150℃)was obtained in the prepared NIR-PCs,owing to their weak electron-phonon coupling effect(small Huang-Rhys factor).Being excited at 460 nm,NIR-PCs realized a broadband emission(650-850 nm)with internal quantum efficiency(IQE)of 60.68%.Combining NIR-PCs with LED/LD chips,the maximum output power of the encapsulated LED prototype was 447 mW@300 mA with photoelectric efficiency of as high as 18.6%@180 mA,and the maximum output power of the LD prototype was 814 mW@2.5 *** working temperatures of NIR-PCs were 70.8℃@300 mA(LED)and 102.8℃@3 A(LD).Finally,the prepared NIR-PCs applied in food detection were verified in this study,demonstrating their anticipated application prospects in the future.

关键词： thermal stability electron phonon coupling effect photoelectric efficiency near-infrared phosphor ceramics(NIR-PCs) NIR light-emitting diode/laser diode(LED/LD)prototype

Intraspecific floral colour variation in three Pedicularis species

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Plant Diversity 2024年第2期46卷 274-279页

作者： qiu-Yu zhang Zhe Chen Hang Sun Yang Niu State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100049China

Flower constancy describes the phenomenon that pollinators tend to successively visit flowers of a single species during foraging,reducing reproductive interference in natural *** extent of flower constancy is largely determined by the floral traits of co-flowering *** higher inter-specific and lower intraspecific differences of floral traits should contribute to a higher level of flower ***,previous studies mainly focused on interspecific difference,and the intraspecific variation(consistency)of floral traits received much less *** hypothesise that selection may favour lower intraspecific floral trait variation in communities composed of multiple co-flowering *** investigated the floral colour variation of three focal Pedicularis species that share pollinators in 19communities composed of either single or multiple Pedicularis *** was quantified using image-based colour analysis as perceived by *** found that most of the intrapopulation floral colour variation was below the colour discrimination threshold of bumblebees,implying strongly constrained by the visual selection by *** to the hypothesis,there is no significant difference in intraspecific floral colour variation between different community *** may be due to the relatively large interspecific floral colour differences of most co-flowering *** influence of community context on intraspecific variation may be reflected in floral traits other than colours.

关键词： Flower constancy Floral colour variation Plantepollinator interactions Pollinator vision

Investigation of stress-induced progressive failure of mine pillars using a Voronoi grain-based breakable block model

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International Journal of Mining Science and Technology 2024年第5期34卷 713-729页

作者： Shili qiu Shirui zhang Quan Jiang Shaojun Li Hao zhang Qiankuan Wang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The Voronoi grain-based breakable block model(VGBBM)based on the combined finite-discrete element method(FDEM)was proposed to explicitly characterize the failure mechanism and predict the deformation behavior of hard-rock mine *** influence of the microscopic parameters on the macroscopic mechanical behavior was investigated using laboratory-scale *** field-scale pillar models(width-to-height,W/H=1,2 and 3)were calibrated based on the empirically predicted stress-strain curves of Creighton mine *** results indicated that as the W/H ratios increased,the VGBBM effectively predicted the transition from strain-softening to pseudo-ductile behavior in pillars,and explicitly captured the separated rock slabs and the V-shaped damage zones on both sides of pillars and conjugate shear bands in core zones of *** volumetric strain field revealed significant compressional deformation in core zones of *** the peak strains of W/H=1 and 2 pillars were relatively consistent,there were significant differences in the strain energy storage and release mechanism.W/H was the primary factor influencing the deformation and strain energy in the pillar *** friction coefficient of the structural plane was also an important factor affecting the pillar strength and the weakest discontinuity *** fracture surface was controlled by the discontinuity angle and the friction *** study demonstrated the capability of the VGBBM in predicting the strengths and deformation behavior of hard-rock pillars in deep mine design.

关键词： Pillar strength FDEM Voronoi tessellation Spalling Bulking