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Impact of Helicobacter pylori virulence markers on clinical outcomes in adult populations

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World Journal of Gastroenterology 2023年第1期29卷 190-199页

作者： Halim Roshrosh Hanan Rohana Maya Azrad tamar Leshem Segula Masaphy Avi Peretz Applied Mycology and Microbiology MigalKiryat Shemona 1101202Israel Department of Microbiology Padeh Poriya Medical CenterTiberias 111508Israel

BACKGROUND In recent years,associations between specific virulence markers of Helicobacter pylori(***)and gastrointestinal disorders have been *** To investigate the presence of virulence factors including vacuolating cytotoxin A genotypes(s1m1,s1m2,s2m1,and s2m2),cytotoxin-associated gene A(CagA),and urease activity in *** strains isolated from Arab and Jewish populations in northern Israel and to assess associations between these factors and patients’demographics and clinical *** Patients(n=108)who underwent gastroscopy at the Baruch Padeh Medical Center,Poriya due to symptomatic gastroduodenal pathologies as part of *** diagnosis were enrolled in the *** biopsy specimens were collected from the antrum of the *** condition was assessed by clinical pathology *** were isolated on modified BD Helicobacter Agar(BD Diagnostics,Sparks,MD,United States).Bacterial DNA was extracted,and PCR was performed to detect CagA and vacuolating cytotoxin A *** activity was assessed using a rapid urease *** A significant correlation was found between disease severity and patient ethnicity(P=0.002).A significant correlation was found between CagA presence and the s1m1 genotype(P=0.02),which is considered the most virulent ***,a higher level of urease activity was associated with isolates originating from the Jewish ***,higher urease activity levels were measured among CagA-/s1m1 and CagA-/s2m2 *** Our study highlights the importance of incorporating molecular methods for detection of virulence markers of *** in order to tailor optimal treatments for each *** investigation should be performed regarding associations between *** virulence factors and ethnicity.

关键词： Helicobacter pylori Virulence factors Vacuolating cytotoxin A Cytotoxin-associated gene A Urease activity

Geomorphological Zoning of Racha Region for Geopark Planning

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Open Journal of Geology 2022年第3期12卷 179-187页

作者： tamar Chichinadze Ivane Javakhishvili Tbilisi State University Tbilisi Georgia

Geomorphological zoning and complex relief research were conducted in the Racha region, which is located In the Caucasus, in the northwestern part of Georgia, south of the Greater Caucasus, in the central part of which there are Precambrian and Paleozoic crystalline substrates (gneisses, migmatites, crystalline shales) and granitoid intrusions of different ages. The Caucasus axis and higher massifs are built of granitoid, gneiss, and metamorphic shales. The oldest rocks (600 million years old) are found at the highest points and the age of the rocks decreases in the vicinity of the hypsometry steps (70 - 30 million rocks). The geological structure of the region has made a significant contribution to the formation of relief landscapes. Karst, erosion-denudation, volcanic, periglacial relief, and various interesting forms are formed here: caves, valleys, canyons, glacial and rocky lakes, waterfalls, deep valleys, mineral waters, and more. The peculiarity of the relief also influenced the mining geological history (5000 AD) and the creation of ancient settlements. Here, still in ancient Racha, at the head of the main river, Rioni, ancient settlements were formed due to iron, gold, and copper metal, which is confirmed by archeological monuments.

关键词： Geopark Geomorphology Geology Natural Monuments Tourism Sustainable Development

The Depletion of the Red Supergiant Envelope Radiative Zone During Common Envelope Evolution

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Research in Astronomy and Astrophysics 2023年第6期23卷 252-259页

作者： tamar Cohen Noam Soker Department of Physics TechnionHaifa3200003Israel

We conduct one-dimensional stellar evolution simulations of red supergiant(RSG)stars that mimic common envelope evolution(CEE)and find that the inner boundary of the envelope convective zone moves into the initial envelope radiative *** envelope convection practically disappears only when the RSG radius decreases by about an order of magnitude or *** implication is that one cannot split the CEE into one stage during which the companion spirals-in inside the envelope convective zone and removes it,and a second slower phase when the companion orbits the initial envelope radiative zone and a stable mass transfer takes *** best,this might take place when the orbital separation is about several solar ***,by that time other processes become *** conclude that as of yet,the commonly used alpha-formalism that is based on energy considerations is the best phenomenological formalism.

关键词： stars:massive (stars:)binaries(including multiple):close stars:mass-loss

Depressive symptoms, social support, cognitive function, and stigma: predictors of resilience in caregivers of children with intellectual disabilities

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Frontiers of Nursing 2022年第4期9卷 361-369页

作者： Wattana Tejakum Thitipong Tankumpuan Wanich Suksatan Jirapan Saboonma Supapak Phetrasuwan tamar Rodney Boromarajonani College of Nursing BangkokBangkok 10400Thailand Faculty of Nursing Mahidol UniversityBangkok NoiBangkok 10700Thailand Faculty of Nursing HRH Princess Chulabhorn College of Medical ScienceChulabhorn Royal AcademyBangkokBangkok 10210Thailand Department of Mental Health Ministry of Public HealthRajanukul InstituteNonthaburiNonthaburi 11000Thailand School of Nursing Johns Hopkins UniversityBaltimoreMaryland 21205-2110United States

Objective:Family plays an important role in taking care of children with intellectual disabilities(IDs).Resilience supports coping strategies for caregivers with their children ***,factors influencing the resilience of caregivers with ID in Thailand are yet to be ***,the aim of this study was to identify the predictors of resilience in caregivers of children with moderate to severe ***:A cross-sectional study was implemented in caregivers of children with ID aged 18 years and older who had children diagnosed with ID aged 6–18 years and classified as moderate to severe *** statistic and multiple linear regression were used for data ***:The study sample consisted of 85 caregivers who took care of their children older than 5 years(95.30%).Depression,social support,cognitive function,and stigma could predict the resilience(F[4,80]=26.79,P<0.001)and explain the variability of resilience by 57.3%.Conclusions:Caregivers have to take care of their children for a long period,which could develop a burden to the *** resilience and influencing factors should be monitored and managed by developing a campaign to promote caregivers’health and well-being.

关键词： caregiver cognitive function depressive symptoms intellectual disability social support stigma

Propagation of TDP-43 proteinopathy in neurodegenerative disorders

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Neural Regeneration Research 2022年第7期17卷 1498-1500页

作者： Rachel Keszycki Pouya Jamshidi Allegra Kawles Grace Minogue Margaret E.Flanagan Colleen R.Zaccard M-Marsel Mesulam tamar Gefen Changiz Geula Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Department of Psychiatry and Behavioral Sciences Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Department of Pathology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Department of Physiology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Department of Cell and Developmental Biology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA

Neurodegenerative disorders are characterized by disruptions to neuronal function and circuitry,leading to a variety of clinical syndromes depending on the affected neuroanatomic regions(Geula,1998).Many proteinopathies implicated in neurodegenerative diseases are characterized by the pathologic accumulation of proteins into inclusions that are initially deposited in specific areas of the brain and spread widely with disease progression.

关键词： degenerative disorders clinical

At Long Last： Evidence for Pexophagy in Plants

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Molecular Plant 2014年第8期7卷 1257-1260页

作者： tamar Avin-Wittenberg Alisdair R. Fernie Max-Planck-Institute of Molecular Plant Physiology Am Mühlenberg 1 14476 Potsdam-Golm Germany

Peroxisomes are highly dynamic single-membrane-bound eukaryotic organelles displaying great variability in enzymatic content （Platta and Erdmann, 2007）. Plant peroxisomes function in a plethora of crucial development and stress ameliorating processes. Among the functions of plant peroxisomes are 13-oxidation of fatty acids, phytohormone production, participation in photorespiration, the glyoxyalte cycle, detoxification processes, and signal molecule generation （Hu et al., 2012）.

关键词： AUTOPHAGY PEROXISOMES ARABIDOPSIS DEGRADATION

HOW DOES ANESTHESIA AFFECT VARIOUS LEVELS OF EXPERIMENTAL TRAUMATIC BRAIN INJURY?

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 409-420页

作者： BARBIRO-MICHAELY EFRAT MANOR tamar ROGATSKY GENNADY MAYEVSKY AVRAHAM The Mina and Everard Goodman Faculty of Life-Sciences The Leslie and Susan Gonda Multidisciplinary Brain Research Center Bar-Ilan University Ramat-Gan52900Israel

The use of anesthetics is a well-known treatment for severely injured *** the present study we tested the pathophysiology of several levels of injury damage in a rat model and also tested the effect of Equithesin on brain vitality in these *** Brain Injury(TBI)was induced using thefluid percussion injury model in four levels:mild,moderate and two levels of severe *** real-time evaluation was performed by the multiparametric monitoring assembly(MPA)which enable cerebral bloodflow(CBF)monitoring by laser Dopplerflowmetry,mitochondrial NADH(Nicotinamide adenine dinucleotide)monitoring by thefluorometric technique,ionic homehostasis using special mini-electrodes,intracranial pressure(ICP)by the ICP camino device and needle electrodes for ECoG(Electrocorticogram)*** results showed high correlation between the level of impact and the extent of changes in the physiological properties of the injury as indicated by the changes in all parameters monitored using the MPA ***,Equithesin improved CBF,ionic extracellular level and mitochondrial redox state following mild and moderate TBI while in severe TBI,Equithesin did not improve the metabolic state of the cerebral cortex,although it decreased the mortality rate from 66%to 20%,and following extra-severe TBI level,Equithesin did not improve survival *** conclusion it seems that Equithesin's protective effect exists under mild to moderate levels of injury and not in case of severe injuries.

关键词： Cerebral bloodflow mitochondrial NADH multiparametric monitoring

Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas

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Asian Journal of Andrology 2020年第6期22卷 569-577页

作者： Margarita Vigodner Benjamin Lucas Stav Kemeny tamar Schwartz Rebecca Levy Department of Biology Stern CollegeYeshiva UniversityNew YorkNY 10016USA Department of Developmental and Molecular Biology Albert Einstein College of MedicineBronxNY 10461USA

Spermatogenesis is regulated by a complex network of posttranslation ***(a modification by small ubiquiti like modifiers,or SUMO proteins)was identified as an importa nt cellular event in d iff ere nt cell *** proteins are highly expressed in the testis,and their role during spermatogenesis has begun to be *** the important role of sumoylation in the regulation of mitosis and cancer progress!on in other tissues,the aim of the current study was to identify the targets of SUMO in proliferating mouse spermatog onia and huma n semi noma tissues and to in itially exami ne the level of sumoylation in relation to the proliferative activity of the *** freshly purified spermatogonia and Cl8-4 spermatogonia cell line,mass spectrometry analysis identified several SUMO targets implicated into the proliferation of spermatogonia(such as heat shock protein 60[HSP60]and prohibitin).Tissue array and western blot approaches showed that SUMO expression is a prominent feature of human seminomas and that the proliferative activity of the tumor tissues was positively correlated with the level of SUMO *** regulation of sumoylati on with si-RNA was not sufficie nt to sign ificantly affect the proliferation of C18-4 spermatogonia;however,SUMO overexpression in creased the proliferation rate of the *** data suggest that cells are more sensitive to an elevated level of SUMO,and that this situation may lead to an upregulated cellular proliferation and,possibly,*** spectrometry analysis identified around a hundred SUMO targets in seminoma ***,many of the identified proteins(such as proliferating cell nuclear antigen[PCNA],DNA topoisomerase 2-alpha[Top2A],prohibitin,14-3-3 protein,and others)were implicated in oncogenic transformation and cancer progression.

关键词： proliferation seminoma spermatog onia sumoylation

Geophysical Reactions to Remote 2022 Tonga Eruption and to Türkiye Earthquakes in Georgia (Caucasus): Hydrogeology, Geomagnetics and Seismicity

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Open Journal of Earthquake Research 2023年第4期12卷 223-237页

作者： Tamaz Chelidze George Melikadze Genady Kobzev tamar Jimsheladze Nadezhda Dovgal M. Nodia Institute of Geophysics Tbilisi State University Tbilisi Georgia

The paper is devoted to analysis of hydrogeological, geomagnetic and seismic response to the two great remote geophysical events, 2022 Tonga volcano eruption and 2020-2023 Türkiye earthquakes in Georgia (Caucasus). The geophysical observation system in Georgia, namely, water level stations in the network of deep wells, atmospheric pressure and the geomagnetic sensors of the Dusheti Geophysical Observatory (DGO) as well as seismic data in Garni Observatory (Armenia) respond to the Tonga event by anomalies in the time series. These data show that there are two types of respond: infrasound disturbances in atmospheric pressure and seismic waves in the Earth generated by the eruption. After Tonga eruption January 15 at 04:21 UTC three groups of N-shaped waveforms were registered in the water level corresponding to the global propagation characteristics of the N-shaped waveform of infrasound signals on the barograms generated by eruption at the distance ~15,700 km: they were identified as the Lamb wave, a surface wave package running in the atmosphere with a velocity around ~314 m/s. The paper also presents the WL reactions to three strong EQs that occur in Türkiye 2020-2023, namely Elazığ, Van and Türkiye-Syria EQs. WL in Georgian well network reacts to these events by anomalies of different intensity, which points to the high sensitivity of hydrosphere to remote (several hundred km) strong EQs. The intensity and character of WL reactions depend strongly on the local hydrogeological properties of rocks, surrounding the well.

关键词： 2022 Tonga Eruption Türkiye Earthquakes Hydrogeological Geomagnetic and Seismic Reactions in Georgia