Propagation of TDP-43 proteinopathy in neurodegenerative disorders

作     者：Rachel Keszycki Pouya Jamshidi Allegra Kawles Grace Minogue Margaret E.Flanagan Colleen R.Zaccard M-Marsel Mesulam Tamar Gefen Changiz Geula Rachel Keszycki;Pouya Jamshidi;Allegra Kawles;Grace Minogue;Margaret E.Flanagan;Colleen R.Zaccard;M.-Marsel Mesulam;Tamar Gefen;Changiz Geula

作者机构：Mesulam Center for Cognitive Neurology and Alzheimer’s DiseaseFeinberg School of MedicineNorthwestern UniversityChicagoILUSA Department of Psychiatry and Behavioral SciencesFeinberg School of MedicineNorthwestern UniversityChicagoILUSA Department of PathologyFeinberg School of MedicineNorthwestern UniversityChicagoILUSA Department of PhysiologyFeinberg School of MedicineNorthwestern UniversityChicagoILUSA Department of Cell and Developmental BiologyFeinberg School of MedicineNorthwestern UniversityChicagoILUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第7期

页      面：1498-1500页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by grants from the National Institute of Neurological Disorders and Stroke,No.NS085770 National Institute on Deafness and Other Communication Disorders No.DC008552 National Institute on Aging,No.AG062566 and AG065463 an institutional training grant from the National Institute of Neurological Disorders and Stroke,No.NS047987 an Alzheimer’s Disease Center Grant from the National Institute on Aging,No.AG013854 

主　　题：degenerative disorders clinical 

摘      要：Neurodegenerative disorders are characterized by disruptions to neuronal function and circuitry,leading to a variety of clinical syndromes depending on the affected neuroanatomic regions(Geula,1998).Many proteinopathies implicated in neurodegenerative diseases are characterized by the pathologic accumulation of proteins into inclusions that are initially deposited in specific areas of the brain and spread widely with disease progression.