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一种新的精炼太阳能级多晶硅工艺的热力学分析(英文)

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Transactions of Nonferrous Metals Society of China 2011年第3期21卷 685-690页

作者： Kazuki Morita takeshi yoshikawa Institute of Industrial Science The University of Tokyo

提出了一种新的硅精炼工艺生产太阳能级多晶硅,即Si-Al熔体低温凝固精炼硅技术。通过杂质在固相硅和Si-Al熔体中的分离热力学分析研究了采用Si-Al熔体分区凝固精炼硅的可行性。用温度梯度区域熔炼法来测定磷和硼的分离比,采用热力学计... 详细信息

提出了一种新的硅精炼工艺生产太阳能级多晶硅,即Si-Al熔体低温凝固精炼硅技术。通过杂质在固相硅和Si-Al熔体中的分离热力学分析研究了采用Si-Al熔体分区凝固精炼硅的可行性。用温度梯度区域熔炼法来测定磷和硼的分离比,采用热力学计算金属杂质的分离比。新工艺具有很小的杂质低温分离比,表明其有很好的精炼能力。采用感应加热分区凝固实验进行验证;对Si-Al合金定向凝固中硅晶体生长进行了研究,结果表明,硅晶体的生长过程是受扩散控制的。

关键词：硅 Si-Al熔体精炼太阳能电池偏析热力学凝固

Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma

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World Journal of Hepatology 2015年第1期7卷 1-6页

作者： Chikako Shibata Motoyuki Otsuka Takahiro Kishikawa Motoko Ohno takeshi yoshikawa Akemi Takata Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Japan Science and Technology Agency PRESTOKawaguchiSaitama 332-0012Japan

Micro RNAs(mi RNAs) are small,noncoding RNA molecules that regulate gene expression posttranscriptionally,targeting thousands of messenger RNAs. Long noncoding RNAs(lnc RNAs),another class of noncoding RNAs,have been determined to be also involved in transcription regulation and translation of target genes. Since deregulated expression levels or functions of miR NAs and lncR NAs in hepatocellular carcinoma(HCC) are frequently observed,clinical use of noncoding RNAs for novel diagnostic and therapeutic applications in the management of HCCs is highly and emergently e xpe c t e d. H e r e,we s ummar iz e r e c e nt f indings regarding deregulated mi RNAs and lnc RNAs for their potential clinical use as diagnostic and prognostic biomarkers of HCC. Specifically,we emphasize the deregulated expression levels of such noncoding RNAs in patients' sera as noninvasive biomarkers,a field that requires urgent improvement in the clinical surveillance of HCC. Since nucleotide-based strategies are being applied to clinical therapeutics,we further summarize clinical and preclinical trials using oligonucleotides involving the use of miR NAs and small interfering RNAs against HCC as novel therapeutics. Finally,we discuss current open questions,which must be clarified in the near future for realistic clinical applications of these new strategies.

关键词： MicroRNA Long noncoding RNA Hepatocellularcarcinoma Clinical trials Biomarker

Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA

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World Journal of Gastroenterology 2015年第23期21卷 7084-7088页

作者： Motoko Ohno Motoyuki Otsuka Takahiro Kishikawa takeshi yoshikawa Akemi Takata Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine the University of Tokyo

Hepatitis B virus(HBV) infection is a major global health problem. Although current therapies, such as the use of nucleos(t)ide analogs, inhibit HBV replication efficiently, they do not eliminate covalently closed circular DNA(ccc DNA), which persists in hepatocyte nuclei. As HBV ccc DNA is a viral transcription template, novel therapeutic approaches to directly target HBV ccc DNA are necessary to completely eradicate persistent HBV infections. HBV ccc DNA levels in HBV-infected human liver cells are extremely low; thus, more reliable and simple measurement methods are needed to correctly monitor their levels during therapeutic treatment. Although reverse transcription-polymerase chain reaction or Southern blot procedures are currently used in research studies, these methods are not completely reliable and are also time-consuming and labor-intensive. Genome editing technologies, such as zinc finger nucleases, transcription activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeats/Cas9(CRISPR/Cas9) system, which are designed to target specific DNA sequences, represent highly promising potential therapeutic tools. In particular, the CRISPR/Cas9 system is an easily customizable sequencespecific nuclease with high flexibility and may be the most feasible approach to target HBV ccc DNA. Further research to develop easier, safer, and more effective protocols should be pursued.

关键词： Hepatitis B virus Covalently closed circularHBV DNA Genome editing

Circulating RNAs as new biomarkers for detecting pancreatic cancer

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World Journal of Gastroenterology 2015年第28期21卷 8527-8540页

作者： Takahiro Kishikawa Motoyuki Otsuka Motoko Ohno takeshi yoshikawa Akemi Takata Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine The University of Tokyo Japan Science and Technology Agency PRESTO

Pancreatic cancer remains difficult to treat and has a high mortality rate.It is difficult to diagnose early mainly due to the lack of screening imaging modalities and specific biomarkers.Consequently,it is important to develop biomarkers that enable the detection of early stage tumors.Emerging evidence is accumulating that tumor cells release substantial amounts of RNA into the bloodstream that strongly resist RNases in the blood and are present at sufficient levels for quantitative analyses.These circulating RNAs are upregulated in the serum and plasma of cancer patients,including those with pancreatic cancer,compared with healthy controls.The majority of RNA biomarker studies have assessed circulating microRNAs(miRs),which are often tissue-specific.There are few reports of the tumorspecific upregulation of other types of small noncoding RNAs(ncRNAs),such as small nucleolar RNAs and Piwi-interacting RNAs.Long ncRNAs(IncRNAs),such as HOTAIR and MALAT1,in the serum/plasma of pancreatic cancer patients have also been reported as diagnostic and prognostic markers.Among tissuederived RNAs,some miRs show increased expression even in pre-cancerous tissues,and their expression profiles may allow for the discrimination between a chronic inflammatory state and carcinoma.Additionally,some miRs and IncRNAs have been reported with significant alterations in expression according to disease progression,and they may thus represent potential candidate diagnostic or prognostic biomarkers that may be used to evaluate patients once detection methods in peripheral blood are well established.Furthermore,recent innovations in high-throughput sequencing techniques have enabled the discovery of unannotated tumor-associated ncRNAs and tumor-specific alternative splicing as novel and specific biomarkers of cancers.Although much work is required to clarify the release mechanism,origin of tumor-specific circulating RNAs,and selectivity of carrier complexes,and technical advances must also be achieved,such as creating a consensus normalizat

关键词： MicroRNA Non-coding RNA Pancreaticcancer Biomarkers Early detection

Computer-generated holograms for 3D display(Invited Paper)

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Chinese Optics Letters 2009年第12期7卷 1079-1082页

作者： Hiroshi yoshikawa takeshi Yamaguchi Department of Electronics and Computer Science Nihon University

We have been studying various types of computer-generated holograms for three-dimensional （3D） displays both for a real-time holographic video display and a hard copy, or a printed hologram. For the hard copy output, we have developed a direct fringe printer, which is achieved to print over 100 gigapixels computer-generated hologram with 0.44μm pitch. In this paper, we introduce our recent progresses on the rainbow hologram, the cylindrical holograms, and the disk hologram for 3D display.

关键词： Computer-generated holograms for 3D display Figure

Computer-generated image hologram

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Chinese Optics Letters 2011年第12期9卷 20-23页

作者： takeshi Yamaguchi Hiroshi yoshikawa Department of Electronics and Computer Science College of Science and Technology

We investigate the computer-generated hologram with full parallax and which can be reconstructed with white light. The object of the hologram is processed from three-dimensional computer graphics polygon data and has shaded surface for hidden surface removal. The optically reconstructed image from the printed hologram is evaluated.

关键词： Computer-generated image hologram CGH

Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution

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World Journal of Gastroenterology 2011年第33期17卷 3802-3809页

作者： Tomohisa Takagi Yuji Naito Kazuhiko Uchiyama Toshimitsu Okuda Katsura Mizushima Takahiro Suzuki Osamu Handa takeshi Ishikawa Nobuaki Yagi Satoshi Kokura Hiroshi Ichikawa Toshikazu yoshikawa Department of Molecular Gastroenterology and Hepatology Graduate School of Medical ScienceKyoto Prefectural University of Medicine6028566 KyotoJapan

AIM:To investigate the efficacy of rebamipide in a rat model of colitis and restitution of intestinal epithelial cells in vitro.METHODS:Acute colitis was induced with trinitrobenzene sulfonic acid(TNBS)in male Wistar rats.Rats received intrarectal rebamipide treatment daily starting on day 7 and were sacrificed on day 14 after TNBS administration.The distal colon was removed to evaluate the various parameters of inflammation.Moreover,wound healing assays were used to determine the enhanced restitution of rat intestinal epithelial(RIE)cells treated with rebamipide.RESULTS:Intracolonic administration of rebamipide accelerated TNBSinduced ulcer healing.Increases in the wet weight of the colon after TNBS administration were significantly inhibited by rebamipide.The wound assay revealed that rebamipide enhanced the migration of RIE cells through phosphorylation of extracellular signalregulated kinase(ERK)and activation of Rho kinase.CONCLUSION:Rebamipide enema healed intestinal injury by enhancing restitution of RIE cells,via ERK activation.Rebamipide might be a novel therapeutic approach for inflammatory bowel disease.

关键词：肠上皮细胞伤口愈合结肠炎复原溃疡 Wistar大鼠灌肠治疗大鼠模型

High Yield Synthesis and Characterization of the Structural and Magnetic Properties of Crystalline ErCl_(3) Nanowires in Single-Walled Carbon Nanotube Templates

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Nano Research 2008年第2期1卷 152-157页

作者： Ryo Kitaura Daisuke Ogawa keita Kobayashi takeshi Saito Satoshi Ohshima Tetsuya Nakamura Hirofumi yoshikawa Kunio Awaga Hisanori Shinohara Department of Chemistry and Institute for Advanced Research Graduate School of ScienceNagoya UniversityNagoya 464-8602Japan Nanotube Research Center National Institute of Advanced Industrial Science and TechnologyTsukuba 305-8565Japan PRESTO JapanScience and Technology Agency4-1-8 Honcho kawaguchiSaitama 332-0012Japan Japan Synchrotron Radiation Research Institute Hyogo 679-5198Japan

Crystalline ErCl_(3) nanowires have been fabricated in single-walled carbon nanotubes(SWCNTs)with high yield(~90%),and the structural and magnetic properties of the resulting ErCl_(3) nanowires encapsulated in SWCNTs(ErCl_(3)@SWCNTs)characterized.Encapsulation under high temperature and vacuum using high quality SWCNTs results in a high fi lling-ratio of ErCl_(3) nanowires in the SWCNTs.The high fi lling-ratio of ErCl_(3) nanowires and the use of highly pure SWCNTs with only a small amount of residual Fe catalyst nanoparticles enabled us to observe the magnetic properties of ErCl_(3)@SWCNTs.Structure determination based on simulated annealing calculations and high-resolution transmission electron microscope(HRTEM)image simulations revealed that the structure of the ErCl_(3) nanowires is unusual with respect to the coordination environment of the Eu3+ions.This work opens up new possibilities to fabricate various metal complex nanowires with high yield and may also be of more general importance in understanding and exploring magnetic properties in low-dimensional magnetic systems.

关键词： Low-dimensional nanomaterials carbon nanotubes magnetic properties crystal structure transmission electron microscope

Inactivation of severe fever with thrombocytopenia syndrome virus for improved laboratory safety

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Journal of Biosafety and Biosecurity 2020年第1期2卷 31-35页

作者： Toshihiko Harada Shuetsu Fukushi takeshi Kurosu Tomoki yoshikawa Masayuki Shimojima Kiyoshi Tanabayashi Masayuki Saijo Division of Biosafety Control and Research National Institute of Infectious DiseasesTokyoJapan Department of Virology 1 National Institute of Infectious DiseasesTokyoJapan

Severe fever with thrombocytopenia syndrome(SFTS),a tick-borne infectious disease with high mortality,is diagnosed by the serological testing of serum samples from patients in the acute and convalescent phases and/or by direct detection of the SFTS virus(SFTSV).Conventionally,heat and UV treatments have been used to inactivate the viruses present in serum samples before performing the serological assays.Here,we examined the inactivation conditions optimal for SFTSV-containing serum samples to ensure the safety of laboratory workers while maintaining the accuracy of serological assay results simultaneously.Heating human serum samples spiked with SFTSV to 60C for 30 min or exposing them to UV irradiation for 30 min,reduced the infectious virus titer below the limit of detection.SFTSV in sera from patients in the acute phase of SFTS was completely inactivated by heating to 60C for 30 min,followed by UV irradiation for 10 min.This inactivation procedure had minimal impact on the performance of SFTSV antibody detection tests.The data provided herein can serve as a guide for laboratory workers and researchers working with SFTS serological tests.

关键词： Biosafety Inactivation Severe fever with thrombocytopenia syndrome(SFTSV) Serology