Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution
Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution作者机构：Department of Molecular Gastroenterology and HepatologyGraduate School of Medical ScienceKyoto Prefectural University of Medicine6028566 KyotoJapan
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2011年第17卷第33期
页 面：3802-3809页
核心收录：
基 金：Supported by A GrantinAid for Scientific Research(B)to Toshikazu Yoshikawa(Grant No.21390184) Challenging Exploratory Research to Yuji Naito(No.08101559)from the Japan Society for the Promotion of Science A City Area Program to Toshikazu Yoshikawa and Yuji Naito from Ministry of Education,Culture,Sports,Science and Technology,Japan An Adaptable and Seamless Technology Transfer Program through targetdriven R&D to Yuji Naito from Japan Science and Technology Agency
主 题：肠上皮细胞 伤口愈合 结肠炎 复原 溃疡 Wistar大鼠 灌肠治疗 大鼠模型
摘 要：AIM:To investigate the efficacy of rebamipide in a rat model of colitis and restitution of intestinal epithelial cells in vitro.METHODS:Acute colitis was induced with trinitrobenzene sulfonic acid(TNBS)in male Wistar rats.Rats received intrarectal rebamipide treatment daily starting on day 7 and were sacrificed on day 14 after TNBS administration.The distal colon was removed to evaluate the various parameters of inflammation.Moreover,wound healing assays were used to determine the enhanced restitution of rat intestinal epithelial(RIE)cells treated with rebamipide.RESULTS:Intracolonic administration of rebamipide accelerated TNBSinduced ulcer healing.Increases in the wet weight of the colon after TNBS administration were significantly inhibited by rebamipide.The wound assay revealed that rebamipide enhanced the migration of RIE cells through phosphorylation of extracellular signalregulated kinase(ERK)and activation of Rho kinase.CONCLUSION:Rebamipide enema healed intestinal injury by enhancing restitution of RIE cells,via ERK activation.Rebamipide might be a novel therapeutic approach for inflammatory bowel disease.
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